| 11/17/2025 | Susquehanna International Group LLP | 308,065 | $40K | 0.0% | +491.5% | 0.116% |  |
| 11/17/2025 | Long Focus Capital Management LLC | 18,577,821 | $2.42M | 0.1% | -21.8% | 7.009% |  |
| 11/17/2025 | Bank of America Corp DE | 1,319,669 | $0.17M | 0.0% | +15.6% | 0.498% |  |
| 11/13/2025 | UBS Group AG | 6,667,358 | $0.87M | 0.0% | +10,490.2% | 2.516% |  |
| 10/31/2025 | B. Riley Wealth Advisors Inc. | 500,000 | $65K | 0.0% | N/A | 0.189% |  |
| 8/14/2025 | MPM Bioimpact LLC | 4,411,821 | $1.06M | 0.2% | -9.9% | 1.665% |  |
| 8/14/2025 | MPM Asset Management LLC | 4,809,677 | $1.15M | 2.7% | -9.9% | 1.815% |  |
| 8/13/2025 | Two Seas Capital LP | 22,580,701 | $5.41M | 0.1% | +10.0% | 8.519% |  |
| 8/11/2025 | Empirical Finance LLC | 800,000 | $0.19M | 0.0% | N/A | 0.302% |  |
| 7/14/2025 | Clear Harbor Asset Management LLC | 145,400 | $35K | 0.0% | -39.6% | 0.055% |  |
| 5/21/2025 | Acadian Asset Management LLC | 2,218,215 | $0.42M | 0.0% | +334.8% | 0.862% |  |
| 5/16/2025 | Two Seas Capital LP | 20,529,685 | $4.04M | 0.1% | +38.4% | 7.981% |  |
| 5/15/2025 | MPM Bioimpact LLC | 4,894,344 | $0.96M | 0.2% | -4.0% | 1.903% |  |
| 5/15/2025 | MPM Asset Management LLC | 5,335,715 | $1.05M | 1.5% | -4.0% | 2.074% |  |
| 5/15/2025 | Long Focus Capital Management LLC | 23,756,687 | $4.68M | 0.2% | +15.9% | 9.236% |  |
| 4/10/2025 | Key Client Fiduciary Advisors LLC | 150,150 | $30K | 0.0% | -41.2% | 0.058% |  |
| 2/18/2025 | Two Seas Capital LP | 14,835,146 | $7.99M | 0.6% | N/A | 5.798% |  |
| 2/17/2025 | Two Sigma Investments LP | 76,347 | $41K | 0.0% | +33.5% | 0.030% |  |
| 2/17/2025 | Two Sigma Advisers LP | 70,735 | $38K | 0.0% | +492.0% | 0.028% |  |
| 2/17/2025 | Bank of America Corp DE | 2,862,330 | $1.54M | 0.0% | -38.5% | 1.119% |  |
| 2/14/2025 | Jane Street Group LLC | 326,937 | $0.18M | 0.0% | +87.7% | 0.128% |  |
| 2/14/2025 | Two Seas Capital LP | 14,835,146 | $7.99M | 0.7% | N/A | 5.798% |  |
| 2/14/2025 | Long Focus Capital Management LLC | 20,494,393 | $11.04M | 0.4% | +54.1% | 8.009% |  |
| 2/14/2025 | Rock Springs Capital Management LP | 2,483,468 | $1.34M | 0.1% | +2.4% | 0.971% |  |
| 2/13/2025 | Renaissance Technologies LLC | 2,526,524 | $1.36M | 0.0% | +52.5% | 0.987% |  |
| 2/13/2025 | Invesco Ltd. | 63,335 | $34K | 0.0% | +82.0% | 0.025% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 916,941 | $0.49M | 0.0% | -12.3% | 0.358% |  |
| 2/11/2025 | LPL Financial LLC | 183,479 | $99K | 0.0% | +106.5% | 0.072% |  |
| 2/11/2025 | Virtu Financial LLC | 122,696 | $66K | 0.0% | +21.5% | 0.048% |  |
| 1/31/2025 | Baillie Gifford & Co. | 11,819,095 | $6.37M | 0.0% | -29.5% | 4.619% |  |
| 11/20/2024 | Virtu Financial LLC | 101,008 | $96K | 0.0% | +27.5% | 0.039% |  |
| 11/15/2024 | Jane Street Group LLC | 174,157 | $0.17M | 0.0% | +130.4% | 0.068% |  |
| 11/15/2024 | Matrix Capital Management Company LP | 37,681,515 | $35.81M | 1.7% | -3.3% | 14.734% |  |
| 11/14/2024 | PFM Health Sciences LP | 10,000,787 | $9.51M | 0.5% | -4.9% | 3.911% |  |
| 11/13/2024 | FMR LLC | 1,740,900 | $1.66M | 0.0% | +3.0% | 0.681% |  |
| 11/5/2024 | Baillie Gifford & Co. | 16,775,860 | $15.94M | 0.0% | +10.7% | 6.560% |  |
| 11/5/2024 | GSA Capital Partners LLP | 99,662 | $95K | 0.0% | N/A | 0.039% |  |
| 10/29/2024 | Fullcircle Wealth LLC | 35,000 | $33K | 0.0% | N/A | 0.014% |  |
| 10/16/2024 | Vontobel Holding Ltd. | 43,000 | $41K | 0.0% | +230.8% | 0.017% |  |
| 8/15/2024 | Long Focus Capital Management LLC | 12,346,417 | $12.04M | 0.5% | +15.6% | 5.002% |  |
| 8/14/2024 | Marshall Wace LLP | 144,880 | $0.14M | 0.0% | -43.0% | 0.059% |  |
| 8/9/2024 | Renaissance Technologies LLC | 1,786,341 | $1.74M | 0.0% | +28.3% | 0.724% |  |
| 7/25/2024 | Baillie Gifford & Co. | 15,149,203 | $14.77M | 0.0% | -4.6% | 6.138% |  |
| 5/15/2024 | Baker BROS. Advisors LP | 10,787,022 | $17.04M | 0.2% | -1.7% | 4.370% |  |
| 5/14/2024 | Boulder Hill Capital Management LP | 90,800 | $0.14M | 0.1% | N/A | 0.037% |  |
| 5/3/2024 | GSA Capital Partners LLP | 370,179 | $0.59M | 0.0% | -27.2% | 0.150% |  |
| 5/1/2024 | Baillie Gifford & Co. | 15,871,875 | $25.08M | 0.0% | -0.3% | 6.431% |  |
| 4/19/2024 | JTC Employer Solutions Trustee Ltd | 26,156 | $41K | 0.0% | N/A | 0.003% |  |
| 4/15/2024 | Key Client Fiduciary Advisors LLC | 268,655 | $0.42M | 0.2% | -20.2% | 0.027% |  |
| 4/15/2024 | Columbia Advisory Partners LLC | 15,585 | $25K | 0.0% | N/A | 0.002% |  |
| 3/5/2024 | Twin Focus Capital Partners LLC | 55,526 | $44K | 0.0% | N/A | 0.006% |  |
| 1/26/2024 | Baillie Gifford & Co. | 15,912,140 | $12.62M | 0.0% | -7.2% | 1.600% |  |
| 1/9/2024 | Key Client Fiduciary Advisors LLC | 336,620 | $0.27M | 0.2% | +6.4% | 0.034% |  |
| 1/8/2024 | Harbor Capital Advisors Inc. | 147,732 | $0.12M | 0.0% | +9.9% | 0.015% |  |
| 11/13/2023 | Baillie Gifford & Co. | 17,147,409 | $13.38M | 0.0% | -0.2% | 1.725% |  |
| 10/27/2023 | Marquette Asset Management LLC | 99,349 | $77K | 0.0% | N/A | 0.010% |  |
| 10/27/2023 | Acuitas Investments LLC | 479,764 | $0.37M | 0.2% | N/A | 0.048% |  |
| 10/20/2023 | Harbor Capital Advisors Inc. | 134,415 | $0.11M | 0.0% | +19.5% | 0.014% |  |
| 9/21/2023 | Barclays PLC | 50,061 | $46K | 0.0% | N/A | 0.005% |  |
| 9/7/2023 | MPM Asset Management LLC | 6,287,101 | $5.82M | 2.9% | N/A | 0.632% |  |
| 8/15/2023 | Black Maple Capital Management LP | 69,839 | $65K | 0.0% | N/A | 0.007% |  |
| 8/14/2023 | X Square Capital LLC | 26,771 | $25K | 0.0% | N/A | 0.003% |  |
| 8/14/2023 | CSS LLC IL | 90,702 | $84K | 0.0% | N/A | 0.009% |  |
| 8/11/2023 | Artal Group S.A. | 1,133,775 | $1.05M | 0.0% | N/A | 0.114% |  |
| 8/7/2023 | Acadian Asset Management LLC | 358,010 | $0.33M | 0.0% | +15.1% | 0.036% |  |
| 8/3/2023 | Oppenheimer & Co. Inc. | 68,171 | $63K | 0.0% | N/A | 0.007% |  |
| 7/28/2023 | Baillie Gifford & Co. | 17,176,135 | $15.89M | 0.0% | +0.4% | 1.728% |  |
| 7/11/2023 | Harbor Capital Advisors Inc. | 112,516 | $0.10M | 0.0% | N/A | 0.073% |  |
| 5/17/2023 | Long Focus Capital Management LLC | 5,435,439 | $5.93M | 0.3% | +2.9% | 3.514% |  |
| 5/12/2023 | Long Focus Capital Management LLC | 2,772,791 | $3.02M | 0.3% | -47.5% | 1.793% |  |
| 5/10/2023 | Simplify Asset Management Inc. | 150,000 | $0.16M | 0.0% | N/A | 0.097% |  |
| 5/3/2023 | Baillie Gifford & Co. | 17,112,002 | $18.65M | 0.0% | -0.3% | 11.064% |  |
| 5/1/2023 | Virtu Financial LLC | 88,234 | $96K | 0.0% | +193.1% | 0.057% |  |
| 4/25/2023 | Key Client Fiduciary Advisors LLC | 321,155 | $0.35M | 0.2% | +8.2% | 0.208% |  |
| 2/15/2023 | Endurant Capital Management LP | 1,733,236 | $2.53M | 1.0% | -3.1% | 1.058% |  |
| 2/14/2023 | Susquehanna International Group LLP | 28,126 | $41K | 0.0% | N/A | 0.017% |  |
| 2/9/2023 | HBK Sorce Advisory LLC | 70,000 | $65K | 0.0% | +100.0% | 0.043% |  |
| 1/17/2023 | Key Client Fiduciary Advisors LLC | 296,740 | $0.43M | 0.3% | -31.9% | 0.181% |  |
| 1/11/2023 | Vigilare Wealth Management | 28,800 | $42K | 0.0% | -21.7% | 0.018% |  |
| 11/15/2022 | PFM Health Sciences LP | 9,320,584 | $10.02M | 0.4% | +2.3% | 5.689% |  |
| 11/15/2022 | Long Focus Capital Management LLC | 4,789,490 | $5.15M | 0.5% | +2.4% | 2.923% |  |
| 11/15/2022 | Endurant Capital Management LP | 1,788,517 | $1.92M | 0.6% | -1.9% | 1.092% |  |
| 11/14/2022 | HBK Sorce Advisory LLC | 35,000 | $32K | 0.0% | N/A | 0.021% |  |
| 11/10/2022 | ExodusPoint Capital Management LP | 370,288 | $0.40M | 0.0% | +23.4% | 0.227% |  |
| 11/7/2022 | Virtu Financial LLC | 40,503 | $44K | 0.0% | +133.7% | 0.025% |  |
| 11/3/2022 | Barclays PLC | 340,068 | $0.37M | 0.0% | +34.6% | 0.208% |  |
| 10/27/2022 | Baillie Gifford & Co. | 14,664,936 | $15.76M | 0.0% | -4.3% | 8.977% |  |
| 10/12/2022 | Key Client Fiduciary Advisors LLC | 435,985 | $0.47M | 0.4% | +4.8% | 0.267% |  |
| 8/12/2022 | Rafferty Asset Management LLC | 217,123 | $0.37M | 0.0% | -59.5% | 0.134% |  |
| 8/11/2022 | Alps Advisors Inc. | 96,110 | $0.16M | 0.0% | N/A | 0.059% |  |
| 8/10/2022 | Hunter Associates Investment Management LLC | 28,500 | $49K | 0.0% | +42.5% | 0.018% |  |
| 8/8/2022 | Baillie Gifford & Co. | 15,321,346 | $26.05M | 0.0% | -0.4% | 9.457% |  |
| 7/11/2022 | Vigilare Wealth Management | 41,800 | $71K | 0.1% | N/A | 0.026% |  |
| 5/17/2022 | Endurant Capital Management LP | 2,160,890 | $4.45M | 1.2% | +140.7% | 1.335% |  |
| 5/16/2022 | Eversept Partners LP | 237,086 | $0.49M | 0.0% | -32.0% | 0.151% |  |
| 5/11/2022 | GSA Capital Partners LLP | 69,612 | $0.14M | 0.0% | -17.3% | 0.044% |  |
| 5/5/2022 | Baillie Gifford & Co. | 15,380,538 | $31.68M | 0.0% | +11.8% | 9.805% |  |
| 5/5/2022 | Levy Wealth Management Group LLC | 17,590 | $36K | 0.0% | N/A | 0.011% |  |
| 4/29/2022 | Daiwa Securities Group Inc. | 35,516 | $73K | 0.0% | +44.9% | 0.023% |  |
| 4/26/2022 | Hunter Associates Investment Management LLC | 20,000 | $41K | 0.0% | +81.8% | 0.013% |  |