| 11/17/2025 | TCG Crossover Management LLC | 1,668,174 | $7.56M | 0.4% | -7.1% | 7.556% |  |
| 11/17/2025 | Qube Research & Technologies Ltd | 21,730 | $98K | 0.0% | -29.2% | 0.098% |  |
| 11/17/2025 | Millennium Management LLC | 324,422 | $1.47M | 0.0% | -5.2% | 1.470% |  |
| 11/14/2025 | Two Sigma Investments LP | 88,670 | $0.40M | 0.0% | +372.7% | 0.423% |  |
| 11/14/2025 | Squarepoint Ops LLC | 11,271 | $51K | 0.0% | -47.9% | 0.054% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 234,541 | $1.06M | 0.0% | -18.0% | 1.118% |  |
| 11/7/2025 | Vanguard Group Inc. | 872,041 | $3.95M | 0.0% | -1.3% | 4.156% |  |
| 10/31/2025 | Vanguard Personalized Indexing Management LLC | 12,805 | $58K | 0.0% | N/A | 0.061% |  |
| 8/15/2025 | Bank of America Corp DE | 41,266 | $89K | 0.0% | -19.4% | 0.198% |  |
| 8/14/2025 | Jane Street Group LLC | 70,931 | $0.15M | 0.0% | N/A | 0.340% |  |
| 8/14/2025 | Qube Research & Technologies Ltd | 30,679 | $66K | 0.0% | N/A | 0.147% |  |
| 8/14/2025 | Pale Fire Capital SE | 358,724 | $0.77M | 0.1% | -2.6% | 1.717% |  |
| 8/13/2025 | Marshall Wace LLP | 49,628 | $0.11M | 0.0% | N/A | 0.238% |  |
| 8/12/2025 | XTX Topco Ltd | 29,755 | $64K | 0.0% | N/A | 0.142% |  |
| 8/11/2025 | BML Capital Management LLC | 3,057,526 | $6.57M | 5.0% | +11.5% | 14.636% |  |
| 8/8/2025 | Geode Capital Management LLC | 184,762 | $0.40M | 0.0% | -59.1% | 0.884% |  |
| 8/1/2025 | Y Intercept Hong Kong Ltd | 21,122 | $45K | 0.0% | N/A | 0.101% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 460,830 | $2.01M | 0.0% | -8.0% | 2.206% |  |
| 5/16/2025 | AQR Capital Management LLC | 33,823 | $0.15M | 0.0% | N/A | 0.162% |  |
| 5/15/2025 | Trexquant Investment LP | 18,694 | $82K | 0.0% | -80.5% | 0.089% |  |
| 5/14/2025 | Pale Fire Capital SE | 368,267 | $1.61M | 0.2% | +16.9% | 1.763% |  |
| 5/12/2025 | Nuveen LLC | 31,847 | $0.14M | 0.0% | N/A | 0.152% |  |
| 5/12/2025 | Invesco Ltd. | 49,831 | $0.22M | 0.0% | N/A | 0.239% |  |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 49,024 | $0.21M | 0.0% | -17.9% | 0.235% |  |
| 5/7/2025 | BML Capital Management LLC | 2,742,317 | $11.98M | 9.2% | +20.9% | 13.127% |  |
| 5/1/2025 | Grant GrossMendelsohn LLC | 160,157 | $0.70M | 0.4% | +90.3% | 0.767% |  |
| 4/11/2025 | Principia Wealth Advisory LLC | 1,696,815 | $7.42M | 6.9% | +27.5% | 8.157% |  |
| 2/17/2025 | Millennium Management LLC | 42,847 | $0.20M | 0.0% | +46.5% | 0.206% |  |
| 2/17/2025 | D. E. Shaw & Co. Inc. | 47,614 | $0.22M | 0.0% | N/A | 0.229% |  |
| 2/17/2025 | Corton Capital Inc. | 32,696 | $0.15M | 0.1% | N/A | 0.157% |  |
| 2/17/2025 | Bank of America Corp DE | 43,576 | $0.20M | 0.0% | +16.3% | 0.210% |  |
| 2/14/2025 | TCG Crossover Management LLC | 1,796,482 | $8.39M | 0.8% | -10.5% | 8.636% |  |
| 2/14/2025 | Northern Trust Corp | 152,577 | $0.71M | 0.0% | -1.6% | 0.733% |  |
| 2/14/2025 | Hsbc Holdings PLC | 10,704 | $49K | 0.0% | -27.3% | 0.051% |  |
| 2/14/2025 | Dimensional Fund Advisors LP | 311,005 | $1.45M | 0.0% | +50.4% | 1.495% |  |
| 2/13/2025 | Marshall Wace LLP | 98,027 | $0.46M | 0.0% | +128.5% | 0.471% |  |
| 2/13/2025 | Barclays PLC | 39,887 | $0.19M | 0.0% | +11.3% | 0.192% |  |
| 2/13/2025 | Renaissance Technologies LLC | 129,605 | $0.61M | 0.0% | +249.6% | 0.623% |  |
| 2/13/2025 | Wells Fargo & Company MN | 12,240 | $57K | 0.0% | +27.8% | 0.059% |  |
| 2/12/2025 | Trexquant Investment LP | 95,997 | $0.45M | 0.0% | +167.9% | 0.462% |  |
| 2/12/2025 | Geode Capital Management LLC | 442,490 | $2.07M | 0.0% | +0.8% | 2.127% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 30,664 | $0.14M | 0.0% | +226.6% | 0.147% |  |
| 2/11/2025 | American Century Companies Inc. | 16,277 | $76K | 0.0% | +36.6% | 0.078% |  |
| 2/7/2025 | Regeneron Pharmaceuticals Inc. | 180,909 | $0.85M | 0.1% | N/A | 0.870% |  |
| 1/15/2025 | Grant GrossMendelsohn LLC | 84,173 | $0.39M | 0.2% | +118.0% | 0.405% |  |
| 11/19/2024 | Barclays PLC | 35,832 | $0.25M | 0.0% | +125.8% | 0.172% |  |
| 11/16/2024 | Geode Capital Management LLC | 439,056 | $3.08M | 0.0% | -3.7% | 2.111% |  |
| 11/15/2024 | Barclays PLC | 35,832 | $0.25M | 0.0% | +125.8% | 0.172% |  |
| 11/15/2024 | Zacks Investment Management | 12,617 | $89K | 0.0% | N/A | 0.061% |  |
| 11/15/2024 | State Street Corp | 369,616 | $2.60M | 0.0% | +32.7% | 1.777% |  |
| 11/14/2024 | Captrust Financial Advisors | 10,115 | $71K | 0.0% | N/A | 0.049% |  |
| 11/14/2024 | MetLife Investment Management LLC | 12,582 | $88K | 0.0% | +129.1% | 0.060% |  |
| 11/13/2024 | BNP Paribas Financial Markets | 4,146 | $29K | 0.0% | +177.0% | 0.020% |  |
| 11/13/2024 | FMR LLC | 234,718 | $1.65M | 0.0% | -63.2% | 1.128% |  |
| 11/8/2024 | Connor Clark & Lunn Investment Management Ltd. | 13,204 | $93K | 0.0% | N/A | 0.063% |  |
| 11/5/2024 | BML Capital Management LLC | 2,268,064 | $15.92M | 9.4% | +15.4% | 10.904% |  |
| 10/23/2024 | Assenagon Asset Management S.A. | 23,413 | $0.16M | 0.0% | -96.2% | 0.113% |  |
| 10/3/2024 | SG Americas Securities LLC | 10,597 | $74K | 0.0% | N/A | 0.051% |  |
| 8/27/2024 | Logos Global Management LP | 416,666 | $2.86M | 0.2% | -72.2% | 2.007% |  |
| 8/14/2024 | Squarepoint Ops LLC | 108,978 | $0.75M | 0.0% | +301.1% | 0.525% |  |
| 8/14/2024 | Marshall Wace LLP | 204,619 | $1.40M | 0.0% | +52.9% | 0.986% |  |
| 8/14/2024 | Logos Global Management LP | 416,666 | $2.86M | 0.2% | -72.2% | 2.007% |  |
| 8/9/2024 | Renaissance Technologies LLC | 136,257 | $0.94M | 0.0% | +2.4% | 0.656% |  |
| 8/9/2024 | Dimensional Fund Advisors LP | 223,427 | $1.53M | 0.0% | +741.8% | 1.076% |  |
| 8/1/2024 | Rhumbline Advisers | 30,821 | $0.21M | 0.0% | +10,419.1% | 0.148% |  |
| 7/26/2024 | Bank of New York Mellon Corp | 64,585 | $0.44M | 0.0% | N/A | 0.311% |  |
| 7/18/2024 | Assenagon Asset Management S.A. | 617,910 | $4.24M | 0.0% | +72.3% | 2.976% |  |
| 5/15/2024 | Avoro Capital Advisors LLC | 416,666 | $5.89M | 0.1% | N/A | 2.007% |  |
| 5/10/2024 | Acadian Asset Management LLC | 2,902 | $41K | 0.0% | -89.6% | 0.014% |  |
| 5/10/2024 | Vanguard Group Inc. | 907,151 | $12.83M | 0.0% | -78.3% | 4.370% |  |
| 5/9/2024 | Picton Mahoney Asset Management | 123,966 | $1.76M | 0.1% | N/A | 0.597% |  |
| 5/3/2024 | Versant Venture Management LLC | 506,822 | $7.17M | 6.9% | -90.0% | 2.442% |  |
| 4/24/2024 | Assenagon Asset Management S.A. | 358,719 | $5.07M | 0.0% | N/A | 1.729% |  |
| 4/23/2024 | BML Capital Management LLC | 833,117 | $11.78M | 7.8% | -81.7% | 4.014% |  |
| 4/22/2024 | Vivo Capital LLC | 1,500,000 | $21.21M | 1.7% | N/A | 7.229% |  |
| 3/5/2024 | Twin Focus Capital Partners LLC | 100,000 | $75K | 0.0% | N/A | 0.099% |  |
| 2/12/2024 | AIGH Capital Management LLC | 3,172,819 | $2.39M | 0.9% | +139.6% | 3.140% |  |
| 2/9/2024 | Worth Venture Partners LLC | 784,346 | $0.59M | 0.3% | +136.5% | 0.776% |  |
| 2/8/2024 | Apexium Financial LP | 60,000 | $45K | 0.0% | N/A | 0.059% |  |
| 2/7/2024 | Monaco Asset Management SAM | 79,234 | $60K | 0.0% | +33.8% | 0.078% |  |
| 1/30/2024 | BML Capital Management LLC | 4,554,252 | $3.43M | 2.6% | +16.3% | 4.508% |  |
| 12/6/2023 | Citigroup Inc. | 476,692 | $0.72M | 0.0% | N/A | 0.472% |  |
| 11/15/2023 | Worth Venture Partners LLC | 331,668 | $0.50M | 0.3% | -10.5% | 0.328% |  |
| 11/14/2023 | Newtyn Management LLC | 1,025,000 | $1.54M | 0.4% | +2.5% | 1.015% |  |
| 11/13/2023 | FMR LLC | 6,691,925 | $10.04M | 0.0% | -13.8% | 6.626% |  |
| 11/13/2023 | AIGH Capital Management LLC | 1,323,985 | $1.99M | 0.9% | -10.8% | 1.311% |  |
| 11/9/2023 | Citigroup Inc. | 476,692 | $0.72M | 0.0% | N/A | 0.472% |  |
| 11/7/2023 | Monaco Asset Management SAM | 59,234 | $89K | 0.0% | -74.8% | 0.059% |  |
| 10/27/2023 | Marquette Asset Management LLC | 60,120 | $90K | 0.0% | -50.5% | 0.060% |  |
| 10/27/2023 | Acuitas Investments LLC | 291,169 | $0.44M | 0.3% | -52.5% | 0.288% |  |
| 10/23/2023 | BML Capital Management LLC | 3,915,000 | $5.87M | 5.4% | -24.1% | 3.877% |  |
| 8/15/2023 | Commodore Capital LP | 10,000,000 | $15.90M | 1.8% | +100.0% | 9.902% |  |
| 8/11/2023 | VR Adviser LLC | 3,886,246 | $6.18M | 1.0% | N/A | 3.864% |  |
| 8/8/2023 | Monaco Asset Management SAM | 235,000 | $0.37M | 0.1% | -64.4% | 0.234% |  |
| 7/24/2023 | BML Capital Management LLC | 5,157,179 | $8.20M | 7.4% | -27.0% | 5.128% |  |
| 5/15/2023 | Commodore Capital LP | 5,000,000 | $3.59M | 0.5% | N/A | 4.971% |  |
| 5/15/2023 | Sonic GP LLC | 2,000,000 | $1.44M | 1.1% | -56.1% | 1.989% |  |
| 5/10/2023 | Connor Clark & Lunn Investment Management Ltd. | 149,856 | $0.11M | 0.0% | -25.3% | 0.149% |  |
| 5/8/2023 | CM Management LLC | 375,000 | $0.27M | 0.3% | +275.0% | 0.373% |  |
| 2/13/2023 | BML Capital Management LLC | 7,067,179 | $4.10M | 3.9% | N/A | 7.086% |  |