| 6/27/2025 | Goldman Sachs Group Inc. | 352,669 | $0.89M | 0.0% | +12.2% | 1.217% |  |
| 5/29/2025 | Rhumbline Advisers | 22,750 | $57K | 0.0% | +67.3% | 0.078% |  |
| 5/21/2025 | Acadian Asset Management LLC | 15,980 | $40K | 0.0% | -81.4% | 0.055% |  |
| 5/19/2025 | Jane Street Group LLC | 11,009 | $28K | 0.0% | N/A | 0.038% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 352,669 | $0.89M | 0.0% | +12.2% | 1.217% |  |
| 5/16/2025 | AQR Capital Management LLC | 21,633 | $54K | 0.0% | +14.7% | 0.075% |  |
| 5/16/2025 | Allostery Investments LP | 1,421,568 | $3.57M | 5.1% | +67.1% | 4.904% |  |
| 5/16/2025 | ADAR1 Capital Management LLC | 1,461,234 | $3.67M | 0.7% | +57.5% | 5.041% |  |
| 5/13/2025 | Kovitz Investment Group Partners LLC | 26,514 | $67K | 0.0% | N/A | 0.091% |  |
| 5/13/2025 | Russell Investments Group Ltd. | 32,395 | $81K | 0.0% | +113.3% | 0.112% |  |
| 5/12/2025 | Nuveen LLC | 40,047 | $0.10M | 0.0% | N/A | 0.138% |  |
| 5/12/2025 | Invesco Ltd. | 74,440 | $0.19M | 0.0% | N/A | 0.257% |  |
| 5/9/2025 | PNC Financial Services Group Inc. | 13,962 | $35K | 0.0% | +8,210.7% | 0.048% |  |
| 5/8/2025 | XTX Topco Ltd | 18,739 | $47K | 0.0% | -21.1% | 0.065% |  |
| 4/22/2025 | Deltec Asset Management LLC | 361,804 | $0.91M | 0.2% | +86.4% | 1.248% |  |
| 4/8/2025 | Rhumbline Advisers | 22,750 | $57K | 0.0% | +67.3% | 0.078% |  |
| 2/27/2025 | Jefferies Financial Group Inc. | 600,000 | $1.59M | 0.0% | N/A | 2.078% |  |
| 2/18/2025 | GTS Securities LLC | 10,082 | $27K | 0.0% | N/A | 0.035% |  |
| 2/17/2025 | Squarepoint Ops LLC | 19,564 | $52K | 0.0% | N/A | 0.068% |  |
| 2/17/2025 | Two Sigma Advisers LP | 153,600 | $0.41M | 0.0% | +38.5% | 0.532% |  |
| 2/17/2025 | Two Sigma Investments LP | 226,121 | $0.60M | 0.0% | -27.8% | 0.783% |  |
| 2/17/2025 | Millennium Management LLC | 65,698 | $0.17M | 0.0% | -66.6% | 0.228% |  |
| 2/17/2025 | Jefferies Financial Group Inc. | 600,000 | $1.59M | 0.0% | N/A | 2.078% |  |
| 2/17/2025 | Bridgeway Capital Management LLC | 60,000 | $0.16M | 0.0% | N/A | 0.208% |  |
| 2/17/2025 | Braidwell LP | 1,440,499 | $3.82M | 0.1% | N/A | 4.989% |  |
| 2/17/2025 | Blackstone Inc. | 499,566 | $1.32M | 0.0% | N/A | 1.730% |  |
| 2/17/2025 | Bank of America Corp DE | 231,085 | $0.61M | 0.0% | -11.5% | 0.800% |  |
| 2/17/2025 | BNP Paribas Financial Markets | 54,688 | $0.15M | 0.0% | N/A | 0.189% |  |
| 2/17/2025 | Allostery Investments LP | 850,684 | $2.25M | 2.3% | N/A | 2.946% |  |
| 2/14/2025 | Nantahala Capital Management LLC | 482,928 | $1.28M | 0.1% | N/A | 1.672% |  |
| 2/14/2025 | Northern Trust Corp | 106,692 | $0.28M | 0.0% | +6.3% | 0.369% |  |
| 2/14/2025 | Vazirani Asset Management LLC | 75,000 | $0.20M | 0.6% | N/A | 0.260% |  |
| 2/14/2025 | Harvest Investment Services LLC | 23,919 | $63K | 0.0% | N/A | 0.083% |  |
| 2/13/2025 | Affinity Asset Advisors LLC | 800,000 | $2.12M | 0.3% | +33.3% | 2.770% |  |
| 2/13/2025 | XTX Topco Ltd | 23,745 | $63K | 0.0% | N/A | 0.082% |  |
| 2/13/2025 | Scotia Capital Inc. | 37,210 | $99K | 0.0% | N/A | 0.129% |  |
| 2/13/2025 | Renaissance Technologies LLC | 44,600 | $0.12M | 0.0% | +149.2% | 0.154% |  |
| 2/13/2025 | ADAR1 Capital Management LLC | 928,016 | $2.46M | 0.5% | +720.7% | 3.213% |  |
| 2/13/2025 | Bank of Montreal Can | 59,097 | $0.16M | 0.0% | +86.8% | 0.205% |  |
| 2/13/2025 | Russell Investments Group Ltd. | 15,184 | $40K | 0.0% | +110.7% | 0.053% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 67,165 | $0.18M | 0.0% | +1,021.1% | 0.233% |  |
| 2/10/2025 | Corient Private Wealth LLC | 36,897 | $98K | 0.0% | N/A | 0.128% |  |
| 2/3/2025 | Ieq Capital LLC | 14,377 | $38K | 0.0% | N/A | 0.050% |  |
| 1/27/2025 | Deltec Asset Management LLC | 194,124 | $0.51M | 0.1% | N/A | 0.672% |  |
| 1/13/2025 | FNY Investment Advisers LLC | 75,000 | $0.20M | 0.1% | N/A | 0.260% |  |
| 11/19/2024 | Barclays PLC | 18,972 | $39K | 0.0% | +310.8% | 0.066% |  |
| 11/16/2024 | Geode Capital Management LLC | 291,887 | $0.61M | 0.0% | -8.0% | 1.011% |  |
| 11/15/2024 | Barclays PLC | 18,972 | $39K | 0.0% | +310.8% | 0.066% |  |
| 11/15/2024 | Jane Street Group LLC | 17,805 | $37K | 0.0% | -86.0% | 0.062% |  |
| 11/15/2024 | State Street Corp | 367,468 | $0.77M | 0.0% | +7.7% | 1.272% |  |
| 11/14/2024 | Verition Fund Management LLC | 99,815 | $0.21M | 0.0% | -59.9% | 0.346% |  |
| 11/13/2024 | FMR LLC | 82,919 | $0.17M | 0.0% | +54,095.4% | 0.287% |  |
| 11/12/2024 | Charles Schwab Investment Management Inc. | 29,351 | $61K | 0.0% | -43.7% | 0.102% |  |
| 11/5/2024 | GSA Capital Partners LLP | 413,795 | $0.87M | 0.1% | +226.8% | 1.433% |  |
| 9/16/2024 | Cubist Systematic Strategies LLC | 31,894 | $53K | 0.0% | N/A | 0.111% |  |
| 8/15/2024 | Deerfield Management Company L.P. Series C | 1,411,608 | $2.34M | 0.0% | N/A | 4.898% |  |
| 8/15/2024 | Affinity Asset Advisors LLC | 200,000 | $0.33M | 0.0% | N/A | 0.694% |  |
| 8/14/2024 | Cubist Systematic Strategies LLC | 31,894 | $53K | 0.0% | N/A | 0.111% |  |
| 8/12/2024 | XTX Topco Ltd | 21,143 | $35K | 0.0% | N/A | 0.073% |  |
| 8/9/2024 | Atlas Venture Life Science Advisors LLC | 1,799,232 | $2.99M | 0.3% | -11.8% | 6.243% |  |
| 8/9/2024 | Warberg Asset Management LLC | 67,449 | $0.11M | 0.0% | N/A | 0.234% |  |
| 8/6/2024 | Quest Partners LLC | 32,856 | $55K | 0.0% | +610.2% | 0.114% |  |
| 7/26/2024 | Bank of New York Mellon Corp | 46,988 | $78K | 0.0% | +69.9% | 0.163% |  |
| 7/19/2024 | Values First Advisors Inc. | 15,381 | $26K | 0.0% | N/A | 0.053% |  |
| 7/12/2024 | SG Americas Securities LLC | 179,493 | $0.30M | 0.0% | N/A | 0.623% |  |
| 5/17/2024 | Ikarian Capital LLC | 367,965 | $10.88M | 1.2% | N/A | 1.277% |  |
| 5/16/2024 | California State Teachers Retirement System | 1,124 | $33K | 0.0% | -38.9% | 0.004% |  |
| 5/14/2024 | EntryPoint Capital LLC | 3,126 | $92K | 0.1% | -49.0% | 0.011% |  |
| 5/10/2024 | Vanguard Group Inc. | 672,275 | $19.88M | 0.0% | +7.2% | 2.410% |  |
| 2/20/2024 | Eventide Asset Management LLC | 12,178 | $0.28M | 0.0% | N/A | 0.044% |  |
| 2/15/2024 | Octagon Capital Advisors LP | 403,685 | $9.14M | 1.5% | -18.8% | 1.459% |  |
| 2/15/2024 | Parkwood LLC | 15,786 | $0.36M | 0.0% | -23.6% | 0.057% |  |
| 2/15/2024 | Great Point Partners LLC | 1,037,690 | $23.48M | 4.0% | -4.9% | 3.750% |  |
| 2/14/2024 | Vestal Point Capital LP | 400,000 | $9.05M | 1.0% | N/A | 1.446% |  |
| 11/15/2023 | Alps Advisors Inc. | 20,395 | $0.28M | 0.0% | +11.3% | 0.074% |  |
| 11/14/2023 | Fred Alger Management LLC | 24,747 | $0.34M | 0.0% | -57.2% | 0.090% |  |
| 11/13/2023 | Silverarc Capital Management LLC | 100,000 | $1.36M | 0.4% | N/A | 0.362% |  |
| 11/13/2023 | FMR LLC | 529,544 | $7.19M | 0.0% | -27.2% | 1.915% |  |
| 11/8/2023 | Swiss National Bank | 21,201 | $0.29M | 0.0% | +30.9% | 0.077% |  |
| 9/21/2023 | Barclays PLC | 3,406 | $58K | 0.0% | -27.8% | 0.012% |  |
| 8/15/2023 | HighVista Strategies LLC | 41,803 | $0.72M | 0.3% | +164.0% | 0.151% |  |
| 8/14/2023 | Great Point Partners LLC | 932,158 | $15.99M | 3.1% | +23.4% | 3.377% |  |
| 8/14/2023 | TCG Crossover Management LLC | 2,201,274 | $37.75M | 6.2% | +103.6% | 7.976% |  |
| 8/14/2023 | Driehaus Capital Management LLC | 1,194,091 | $20.48M | 0.3% | N/A | 4.326% |  |
| 7/31/2023 | Strs Ohio | 2,300 | $39K | 0.0% | N/A | 0.008% |  |
| 6/1/2023 | Golden State Equity Partners | 10,530 | $0.21M | 0.1% | N/A | 0.042% |  |
| 5/16/2023 | Great Point Partners LLC | 755,620 | $15.24M | 3.0% | +99.6% | 3.046% |  |
| 5/16/2023 | Atlas Venture Life Science Advisors LLC | 2,039,249 | $41.13M | 5.6% | +1.1% | 8.219% |  |
| 5/16/2023 | Baker BROS. Advisors LP | 1,963,479 | $39.60M | 0.2% | -0.7% | 7.914% |  |
| 5/15/2023 | Ghost Tree Capital LLC | 200,000 | $4.03M | 1.2% | +48.1% | 0.806% |  |
| 5/12/2023 | Nan Fung Group Holdings Ltd | 47,936 | $0.97M | 0.7% | -5.3% | 0.193% |  |
| 5/11/2023 | Skandinaviska Enskilda Banken AB publ | 50,866 | $1.03M | 0.0% | -4.6% | 0.205% |  |
| 3/23/2023 | MetLife Investment Management LLC | 5,228 | $0.15M | 0.0% | N/A | 0.021% |  |
| 2/15/2023 | Eversept Partners LP | 91,252 | $2.67M | 0.2% | N/A | 0.374% |  |
| 2/15/2023 | Atlas Venture Life Science Advisors LLC | 2,017,521 | $59.11M | 7.1% | -13.3% | 8.265% |  |
| 2/15/2023 | Nantahala Capital Management LLC | 15,700 | $0.46M | 0.0% | N/A | 0.064% |  |
| 2/14/2023 | VR Adviser LLC | 747,869 | $21.91M | 3.5% | -10.3% | 3.064% |  |
| 2/14/2023 | Parkwood LLC | 20,560 | $0.60M | 0.1% | -3.7% | 0.084% |  |
| 2/10/2023 | Cheyne Capital Management UK LLP | 18,927 | $0.56M | 1.0% | N/A | 0.078% |  |
| 2/8/2023 | Skandinaviska Enskilda Banken AB publ | 53,340 | $1.56M | 0.0% | -5.5% | 0.219% |  |