| 5/30/2024 | Lynx1 Capital Management LP | 2,253,183 | $89.32M | 23.0% | -40.9% | 3.285% |  |
| 5/28/2024 | Boston Partners | 23,101 | $0.92M | 0.0% | N/A | 0.034% |  |
| 5/24/2024 | Farallon Capital Management LLC | 5,900 | $0.23M | 0.0% | N/A | 0.009% |  |
| 5/20/2024 | Virtu Financial LLC | 14,813 | $0.59M | 0.0% | N/A | 0.022% |  |
| 5/17/2024 | Artal Group S.A. | 405,784 | $16.09M | 0.4% | +699.4% | 0.592% |  |
| 5/16/2024 | California State Teachers Retirement System | 32,823 | $1.30M | 0.0% | +5.3% | 0.048% |  |
| 5/16/2024 | Janus Henderson Group PLC | 450,827 | $17.84M | 0.0% | -22.7% | 0.657% |  |
| 5/15/2024 | Baker BROS. Advisors LP | 81,578 | $3.23M | 0.0% | N/A | 0.119% |  |
| 5/15/2024 | Darwin Global Management Ltd. | 1,982,016 | $78.57M | 10.6% | N/A | 2.889% |  |
| 5/15/2024 | First Light Asset Management LLC | 501,243 | $19.87M | 1.5% | N/A | 0.731% |  |
| 5/15/2024 | Price T Rowe Associates Inc. MD | 3,080,220 | $122.10M | 0.0% | +82.6% | 4.490% |  |
| 5/15/2024 | Avoro Capital Advisors LLC | 5,775,000 | $228.92M | 2.7% | N/A | 8.418% |  |
| 5/15/2024 | Lazard Asset Management LLC | 7,518 | $0.30M | 0.0% | +39.0% | 0.011% |  |
| 5/14/2024 | EntryPoint Capital LLC | 1,433 | $57K | 0.1% | +1,239.3% | 0.002% |  |
| 5/14/2024 | Decheng Capital LLC | 8,317,924 | $329.72M | 44.2% | +17.4% | 12.125% |  |
| 5/14/2024 | American International Group Inc. | 18,949 | $0.75M | 0.0% | +17.1% | 0.028% |  |
| 5/13/2024 | Ameritas Investment Partners Inc. | 3,835 | $0.15M | 0.0% | +13.8% | 0.006% |  |
| 5/11/2024 | Hillsdale Investment Management Inc. | 133,960 | $5.31M | 0.4% | N/A | 0.204% |  |
| 5/10/2024 | Vanguard Group Inc. | 2,712,285 | $107.52M | 0.0% | +21.4% | 4.137% |  |
| 5/8/2024 | Entropy Technologies LP | 9,688 | $0.38M | 0.0% | N/A | 0.015% |  |
| 5/8/2024 | ProShare Advisors LLC | 11,502 | $0.46M | 0.0% | N/A | 0.018% |  |
| 5/8/2024 | Russell Investments Group Ltd. | 691 | $27K | 0.0% | N/A | 0.001% |  |
| 5/7/2024 | Sei Investments Co. | 20,058 | $0.80M | 0.0% | -13.6% | 0.031% |  |
| 5/7/2024 | Swiss National Bank | 63,500 | $2.52M | 0.0% | +11.0% | 0.097% |  |
| 5/7/2024 | Oppenheimer & Co. Inc. | 21,538 | $0.85M | 0.0% | N/A | 0.033% |  |
| 5/7/2024 | SG Americas Securities LLC | 2,686 | $0.11M | 0.0% | N/A | 0.004% |  |
| 5/2/2024 | Jennison Associates LLC | 191,974 | $7.61M | 0.0% | +36.1% | 0.293% |  |
| 5/1/2024 | Capstone Investment Advisors LLC | 38,212 | $1.52M | 0.0% | +51.1% | 0.058% |  |
| 5/1/2024 | BNP Paribas Financial Markets | 77,784 | $3.08M | 0.0% | -27.3% | 0.119% |  |
| 5/1/2024 | Mirae Asset Global Investments Co. Ltd. | 14,430 | $0.57M | 0.0% | -28.5% | 0.022% |  |
| 4/30/2024 | Allspring Global Investments Holdings LLC | 6,414 | $0.25M | 0.0% | +331.0% | 0.010% |  |
| 4/29/2024 | China Universal Asset Management Co. Ltd. | 12,630 | $0.50M | 0.1% | +87.9% | 0.018% |  |
| 4/26/2024 | Mesirow Financial Investment Management Inc. | 10,058 | $0.40M | 0.0% | N/A | 0.015% |  |
| 4/23/2024 | Raymond James Financial Services Advisors Inc. | 76,508 | $3.03M | 0.0% | N/A | 0.117% |  |
| 4/22/2024 | Vivo Capital LLC | 520,505 | $20.79M | 1.6% | -36.5% | 0.794% |  |
| 4/19/2024 | Mesirow Financial Investment Management Inc. | 10,058 | $0.40M | 2.0% | N/A | 0.015% |  |
| 4/18/2024 | Allspring Global Investments Holdings LLC | 6,414 | $0.25M | 0.0% | +331.0% | 0.010% |  |
| 4/10/2024 | Banque Cantonale Vaudoise | 20,129 | $0.80M | 0.0% | N/A | 0.031% |  |
| 3/26/2024 | HighPoint Advisor Group LLC | 15,190 | $0.29M | 0.0% | N/A | 0.023% |  |
| 3/5/2024 | Wellington Management Group LLP | 109,882 | $2.09M | 0.0% | +176.6% | 0.189% |  |
| 2/15/2024 | Octagon Capital Advisors LP | 1,241,300 | $23.66M | 3.8% | +65.5% | 2.137% |  |
| 2/15/2024 | Frazier Life Sciences Management L.P. | 3,131,008 | $59.68M | 3.2% | +4.9% | 5.389% |  |
| 2/15/2024 | Great Point Partners LLC | 3,703,433 | $70.59M | 12.1% | +20.3% | 6.374% |  |
| 2/14/2024 | Commodore Capital LP | 1,610,000 | $30.69M | 2.7% | +21.5% | 2.771% |  |
| 2/14/2024 | Ghisallo Capital Management LLC | 65,000 | $1.24M | 0.1% | N/A | 0.112% |  |
| 2/13/2024 | Tower Research Capital LLC TRC | 5,490 | $0.11M | 0.0% | +411.6% | 0.009% |  |
| 2/13/2024 | Rafferty Asset Management LLC | 80,162 | $1.53M | 0.0% | N/A | 0.138% |  |
| 2/12/2024 | Capstone Investment Advisors LLC | 25,289 | $0.48M | 0.0% | N/A | 0.044% |  |
| 2/12/2024 | Monashee Investment Management LLC | 74,792 | $1.43M | 0.3% | N/A | 0.129% |  |
| 2/12/2024 | Decheng Capital LLC | 7,083,288 | $135.01M | 37.7% | N/A | 12.192% |  |
| 2/9/2024 | Franklin Resources Inc. | 1,220,333 | $23.26M | 0.0% | N/A | 2.100% |  |
| 2/9/2024 | Trexquant Investment LP | 53,780 | $1.03M | 0.0% | +88.2% | 0.093% |  |
| 2/7/2024 | Jump Financial LLC | 55,720 | $1.06M | 0.0% | N/A | 0.096% |  |
| 2/7/2024 | BNP Paribas Financial Markets | 106,941 | $2.04M | 0.0% | +691.1% | 0.184% |  |
| 2/7/2024 | Vivo Capital LLC | 819,275 | $15.62M | 1.3% | -10.5% | 1.410% |  |
| 2/6/2024 | Charles Schwab Investment Management Inc. | 297,452 | $5.67M | 0.0% | +27.0% | 0.512% |  |
| 2/6/2024 | AJOVista LLC | 3,371 | $64K | 0.1% | N/A | 0.006% |  |
| 2/6/2024 | Swiss National Bank | 57,200 | $1.09M | 0.0% | +35.5% | 0.098% |  |
| 2/1/2024 | New York State Common Retirement Fund | 14,875 | $0.28M | 0.0% | +54.4% | 0.026% |  |
| 2/1/2024 | Jennison Associates LLC | 141,095 | $2.69M | 0.0% | N/A | 0.243% |  |
| 1/30/2024 | Zurcher Kantonalbank Zurich Cantonalbank | 9,538 | $0.18M | 0.0% | N/A | 0.016% |  |
| 1/25/2024 | Allspring Global Investments Holdings LLC | 1,488 | $28K | 0.0% | +745.5% | 0.003% |  |
| 1/24/2024 | Mirae Asset Global Investments Co. Ltd. | 20,177 | $0.39M | 0.0% | +17.6% | 0.035% |  |
| 1/24/2024 | China Universal Asset Management Co. Ltd. | 6,723 | $0.13M | 0.0% | +429.8% | 0.012% |  |
| 1/11/2024 | Ziegler Capital Management LLC | 22,383 | $0.43M | 0.0% | N/A | 0.039% |  |
| 12/18/2023 | Vanguard Group Inc. | 1,474,879 | $16.89M | 0.0% | +5.1% | 2.539% |  |
| 11/29/2023 | Decheng Capital Management III Cayman LLC | 6,708,288 | $76.81M | 19.3% | N/A | 11.547% |  |
| 11/21/2023 | Walleye Capital LLC | 186,273 | $2.13M | 0.0% | +13.1% | 0.321% |  |
| 11/14/2023 | Schonfeld Strategic Advisors LLC | 90,937 | $1.04M | 0.0% | +604.9% | 0.185% |  |
| 11/14/2023 | Avidity Partners Management LP | 657,280 | $7.53M | 0.3% | -37.9% | 1.336% |  |
| 11/14/2023 | Lynx1 Capital Management LP | 2,404,614 | $27.53M | 18.2% | -10.0% | 4.887% |  |
| 11/14/2023 | Trexquant Investment LP | 28,578 | $0.33M | 0.0% | -33.2% | 0.058% |  |
| 11/14/2023 | Nan Fung Group Holdings Ltd | 182,280 | $2.09M | 1.7% | N/A | 0.370% |  |
| 11/13/2023 | Connor Clark & Lunn Investment Management Ltd. | 45,475 | $0.52M | 0.0% | -2.4% | 0.092% |  |
| 11/13/2023 | Algert Global LLC | 20,010 | $0.23M | 0.0% | N/A | 0.041% |  |
| 11/13/2023 | FMR LLC | 464,812 | $5.32M | 0.0% | -31.2% | 0.945% |  |
| 11/8/2023 | Swiss National Bank | 42,200 | $0.48M | 0.0% | N/A | 0.086% |  |
| 11/7/2023 | New York State Common Retirement Fund | 9,634 | $0.11M | 0.0% | +75.8% | 0.020% |  |
| 11/7/2023 | Barclays PLC | 9,126 | $0.10M | 0.0% | +44.3% | 0.019% |  |
| 10/24/2023 | Bank of New York Mellon Corp | 92,723 | $1.06M | 0.0% | +1.3% | 0.188% |  |
| 10/13/2023 | SG Americas Securities LLC | 9,927 | $0.11M | 0.0% | N/A | 0.020% |  |
| 9/21/2023 | Barclays PLC | 6,325 | $65K | 0.0% | -47.6% | 0.013% |  |
| 8/21/2023 | Affinity Asset Advisors LLC | 118,891 | $1.22M | 0.4% | -52.0% | 0.242% |  |
| 8/15/2023 | RA Capital Management L.P. | 4,691,178 | $48.23M | 0.9% | +0.1% | 9.779% |  |
| 8/14/2023 | Great Point Partners LLC | 3,363,688 | $34.58M | 6.8% | -10.1% | 7.012% |  |
| 8/11/2023 | Westwood Holdings Group Inc. | 43,799 | $0.45M | 0.0% | N/A | 0.091% |  |
| 8/11/2023 | Panagora Asset Management Inc. | 12,394 | $0.13M | 0.0% | N/A | 0.026% |  |
| 8/11/2023 | Trexquant Investment LP | 42,773 | $0.44M | 0.0% | N/A | 0.089% |  |
| 8/11/2023 | ExodusPoint Capital Management LP | 62,839 | $0.65M | 0.0% | N/A | 0.131% |  |
| 8/4/2023 | American International Group Inc. | 15,279 | $0.16M | 0.0% | +33.8% | 0.032% |  |
| 5/16/2023 | Great Point Partners LLC | 3,740,761 | $28.88M | 5.7% | +2.8% | 7.799% |  |
| 5/16/2023 | BVF Inc. IL | 858,339 | $6.63M | 0.2% | -24.4% | 1.789% |  |
| 5/15/2023 | Ghost Tree Capital LLC | 200,000 | $1.54M | 0.5% | N/A | 0.417% |  |
| 5/10/2023 | Connor Clark & Lunn Investment Management Ltd. | 54,237 | $0.42M | 0.0% | -7.0% | 0.113% |  |
| 4/28/2023 | SG Americas Securities LLC | 11,927 | $92K | 0.0% | N/A | 0.025% |  |
| 3/23/2023 | MetLife Investment Management LLC | 12,028 | $88K | 0.0% | N/A | 0.040% |  |
| 2/15/2023 | Avidity Partners Management LP | 1,028,200 | $7.56M | 0.2% | +3.0% | 3.382% |  |
| 2/14/2023 | RA Capital Management L.P. | 4,397,368 | $32.32M | 0.7% | +0.9% | 14.465% |  |
| 2/14/2023 | Pura Vida Investments LLC | 30,924 | $0.23M | 0.0% | N/A | 0.102% |  |
| 2/10/2023 | Cheyne Capital Management UK LLP | 181,886 | $1.34M | 2.3% | N/A | 0.598% |  |