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AMLX Insider Trading

Insider Ownership Percentage: 12.30%
Insider Buying (Last 12 Months): $100,845.00
Insider Selling (Last 12 Months): $3,597,796.83

Amylyx Pharmaceuticals Insider Trading History Chart

This chart shows the insider buying and selling history at Amylyx Pharmaceuticals by year and by quarter.

Skip ChartChart Data in Insider Trading History Table

Amylyx Pharmaceuticals Share Price & Price History

Current Price: $13.45
Price Change: ▼ Price Decrease of -0.017 (-0.13%)
As of 03/27/2026 03:01 PM ET

This chart shows the closing price history over time for AMLX up to the past year.

Skip Chart and Table DataPrice Data in Insider Trading History Table
Days: 30 | 90 | 365

Amylyx Pharmaceuticals Insider Trading History

Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionShares Held After TransactionDetails
1/16/2026Joshua B CohenCEOSell1,974$13.83$27,300.423,379,465View SEC Filing Icon  
1/16/2026Justin B KleeCEOSell1,995$13.89$27,710.553,379,398View SEC Filing Icon  
1/15/2026Joshua B CohenCEOSell136,193$13.59$1,850,862.873,378,621View SEC Filing Icon  
1/6/2026James M FratesCFOSell3,326$11.11$36,951.86177,104View SEC Filing Icon  
1/6/2026Joshua B CohenCEOSell7,715$11.09$85,559.353,317,586View SEC Filing Icon  
12/23/2025Karen FirestoneDirectorBuy8,100$12.45$100,845.0063,100View SEC Filing Icon  
12/1/2025Camille L BedrosianInsiderSell6,580$14.35$94,423.00175,756View SEC Filing Icon  
9/30/2025Camille L BedrosianInsiderSell12,039$14.58$175,528.62182,336View SEC Filing Icon  
9/30/2025Gina MazzarielloInsiderSell8,828$14.58$128,712.24148,141View SEC Filing Icon  
9/30/2025James M FratesCFOSell10,558$14.65$154,674.70280,430View SEC Filing Icon  
9/30/2025Joshua B CohenCEOSell29,933$14.35$429,538.553,325,347View SEC Filing Icon  
9/30/2025Justin B KleeCEOSell29,975$14.38$431,040.503,325,301View SEC Filing Icon  
3/31/2025Camille L BedrosianInsiderSell12,425$3.47$43,114.75194,375View SEC Filing Icon  
3/31/2025James M FratesCFOSell10,896$3.47$37,809.12290,988View SEC Filing Icon  
3/31/2025Joshua B CohenCEOSell21,490$3.47$74,570.303,355,280View SEC Filing Icon  
3/20/2025Bernhardt G ZeiherDirectorBuy10,000$3.70$37,000.0010,000View SEC Filing Icon  
2/24/2025Gina MazzarielloInsiderSell4,169$3.15$13,132.35134,921View SEC Filing Icon  
2/3/2025Gina MazzarielloInsiderSell3,678$3.49$12,836.22139,090View SEC Filing Icon  
2/3/2025Joshua B CohenCEOSell11,851$3.47$41,122.973,201,247View SEC Filing Icon  
1/6/2025Justin B KleeCEOSell7,471$4.04$30,182.843,176,788View SEC Filing Icon  
9/30/2024Camille L BedrosianInsiderSell11,442$3.20$36,614.40143,801View SEC Filing Icon  
9/30/2024Justin B KleeCEOSell18,589$3.20$59,484.803,120,569View SEC Filing Icon  
9/12/2024James M FratesCFOBuy40,000$2.53$101,200.00233,464View SEC Filing Icon  
9/3/2024M Milne JrDirectorBuy100,000$2.20$220,000.00858,571View SEC Filing Icon  
5/15/2024Gina MazzarielloInsiderSell10,455$1.88$19,655.40151,477View SEC Filing Icon  
5/14/2024Daphne QuimiDirectorBuy2,750$1.89$5,197.502,750View SEC Filing Icon  
3/5/2024Gina MazzarielloInsiderSell1,540$18.73$28,844.2081,372View SEC Filing Icon  
3/5/2024James M FratesCFOSell1,792$18.73$33,564.16134,784View SEC Filing Icon  
3/5/2024Joshua B CohenCEOSell4,135$18.73$77,448.553,023,002View SEC Filing Icon  
2/23/2024Gina MazzarielloInsiderSell2,838$18.76$53,240.8846,245View SEC Filing Icon  
1/9/2024James M FratesCFOSell2,716$16.33$44,352.28112,035View SEC Filing Icon  
1/9/2024Justin B KleeCEOSell5,841$16.33$95,383.532,836,776View SEC Filing Icon  
1/9/2024Patrick D YeramianInsiderSell2,812$16.33$45,919.96205,605View SEC Filing Icon  
5/16/2023James M FratesCFOSell32,500$26.94$875,550.0055,676View SEC Filing Icon  
5/15/2023Patrick D YeramianInsiderSell11,965$29.03$347,343.95208,417View SEC Filing Icon  
4/17/2023Patrick D YeramianInsiderSell49,579$30.54$1,514,142.66208,417View SEC Filing Icon  
3/29/2023Morningside Venture InvestmentMajor ShareholderSell29,048$30.45$884,511.606,997,302View SEC Filing Icon  
3/27/2023Morningside Venture InvestmentMajor ShareholderSell60,964$30.50$1,859,402.007,126,350View SEC Filing Icon  
See Full Table

SEC Filings (Institutional Ownership Changes) for Amylyx Pharmaceuticals (NASDAQ:AMLX)

95.84% of Amylyx Pharmaceuticals stock is owned by institutions. Institutional ownership can be a sign of analyst confidence in the fundamentals of the stock.

Institutional Buying and Selling by Quarter

This chart shows the instiutional buying and selling at AMLX by year and by quarter.

Skip Institutional Buying and Selling Chart and Table DataRead Chart Data in Institutional Trading History Table

Amylyx Pharmaceuticals Institutional Trading History

Reporting DateHedge FundShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
3/3/2026Caitong International Asset Management Co. Ltd3,859$47K0.0%+954.4%0.004%Search for SEC Filing on Google Icon
2/26/2026Seven Fleet Capital Management LP11,571$0.14M0.1%N/A0.011%Search for SEC Filing on Google Icon
2/19/2026T. Rowe Price Investment Management Inc.4,517$55K0.0%-99.6%0.004%Search for SEC Filing on Google Icon
2/19/2026Invesco Ltd.175,914$2.13M0.0%-78.3%0.160%Search for SEC Filing on Google Icon
2/18/2026ADAR1 Capital Management LLC890,356$10.76M0.8%+2.8%0.811%Search for SEC Filing on Google Icon
2/18/2026XTX Topco Ltd189,673$2.29M0.1%N/A0.173%Search for SEC Filing on Google Icon
2/18/2026Voloridge Investment Management LLC153,363$1.85M0.0%N/A0.140%Search for SEC Filing on Google Icon
2/18/2026Virtus Investment Advisers LLC20,307$0.25M0.1%N/A0.018%Search for SEC Filing on Google Icon
2/18/2026Wellington Management Group LLP225,782$2.73M0.0%-4.4%0.206%Search for SEC Filing on Google Icon
2/18/2026SummitTX Capital L.P.218,399$2.64M0.1%+30.0%0.199%Search for SEC Filing on Google Icon
2/18/2026Tudor Investment Corp ET AL22,402$0.27M0.0%N/A0.020%Search for SEC Filing on Google Icon
2/18/2026Quadrature Capital Ltd15,465$0.19M0.0%-45.3%0.014%Search for SEC Filing on Google Icon
2/18/2026Numerai GP LLC112,648$1.36M0.2%+67.7%0.103%Search for SEC Filing on Google Icon
2/18/2026Perceptive Advisors LLC8,284,882$100.08M1.8%-7.5%7.544%Search for SEC Filing on Google Icon
2/18/2026Millennium Management LLC46,455$0.56M0.0%-88.9%0.042%Search for SEC Filing on Google Icon
2/18/2026Janus Henderson Group PLC4,465,872$53.99M0.0%+76.1%4.067%Search for SEC Filing on Google Icon
2/18/2026Elmind Capital LP112,000$1.35M0.4%N/A0.102%Search for SEC Filing on Google Icon
2/18/2026Engineers Gate Manager LP18,358$0.22M0.0%N/A0.017%Search for SEC Filing on Google Icon
2/18/2026Commodore Capital LP5,650,000$68.25M4.5%+38.6%5.145%Search for SEC Filing on Google Icon
2/18/2026Cormorant Asset Management LP400,000$4.83M0.2%-20.0%0.364%Search for SEC Filing on Google Icon
2/18/2026Balyasny Asset Management L.P.858,684$10.37M0.0%-41.8%0.782%Search for SEC Filing on Google Icon
2/18/2026683 Capital Management LLC1,650,000$19.93M0.9%-6.3%1.502%Search for SEC Filing on Google Icon
2/18/2026ACT Capital Management LLC9,000$0.11M0.1%N/A0.008%Search for SEC Filing on Google Icon
2/17/2026Logos Global Management LP950,000$11.48M0.7%-34.5%0.865%Search for SEC Filing on Google Icon
2/17/2026ADAR1 Capital Management LLC890,356$10.76M0.8%+2.8%0.811%Search for SEC Filing on Google Icon
2/17/2026Schonfeld Strategic Advisors LLC21,052$0.25M0.0%-51.8%0.019%Search for SEC Filing on Google Icon
2/17/2026AQR Capital Management LLC27,847$0.34M0.0%-62.2%0.025%Search for SEC Filing on Google Icon
2/17/2026Trexquant Investment LP48,112$0.58M0.0%-78.4%0.044%Search for SEC Filing on Google Icon
2/17/2026Price T Rowe Associates Inc. MD107,548$1.30M0.0%+7.1%0.098%Search for SEC Filing on Google Icon
2/17/2026Adage Capital Partners GP L.L.C.2,777,055$33.55M0.1%-59.3%2.529%Search for SEC Filing on Google Icon
2/17/2026California State Teachers Retirement System79,090$0.96M0.0%+1,726.1%0.072%Search for SEC Filing on Google Icon
2/17/2026Russell Investments Group Ltd.65,438$0.79M0.0%+18.1%0.060%Search for SEC Filing on Google Icon
2/17/2026Atom Investors LP139,422$1.68M0.1%N/A0.127%Search for SEC Filing on Google Icon
2/17/2026State of Wisconsin Investment Board84,144$1.02M0.0%+506.4%0.077%Search for SEC Filing on Google Icon
2/17/2026Royal Bank of Canada15,643$0.19M0.0%-83.2%0.014%Search for SEC Filing on Google Icon
2/17/2026Persistent Asset Partners Ltd31,147$0.38M0.2%+35.9%0.028%Search for SEC Filing on Google Icon
2/16/2026Squarepoint Ops LLC76,562$0.93M0.0%N/A0.070%Search for SEC Filing on Google Icon
2/16/2026Sofinnova Investments Inc.527,099$6.37M0.3%N/A0.480%Search for SEC Filing on Google Icon
2/16/2026Verition Fund Management LLC29,487$0.36M0.0%-53.9%0.027%Search for SEC Filing on Google Icon
2/16/2026Mariner LLC46,342$0.56M0.0%-3.5%0.042%Search for SEC Filing on Google Icon
2/16/2026Landscape Capital Management L.L.C.12,226$0.15M0.0%+17.5%0.011%Search for SEC Filing on Google Icon
2/16/2026Barclays PLC295,177$3.57M0.0%-28.7%0.269%Search for SEC Filing on Google Icon
2/13/2026Nantahala Capital Management LLC835,684$10.10M0.3%-10.7%0.761%Search for SEC Filing on Google Icon
2/13/2026The Manufacturers Life Insurance Company 26,988$0.33M0.0%+13.4%0.025%Search for SEC Filing on Google Icon
2/13/2026Alpha Wave Global LP317,678$3.84M0.5%-2.9%0.289%Search for SEC Filing on Google Icon
2/13/2026Rafferty Asset Management LLC17,673$0.21M0.0%N/A0.016%Search for SEC Filing on Google Icon
2/13/2026Headlands Technologies LLC30,543$0.37M0.0%N/A0.028%Search for SEC Filing on Google Icon
2/13/2026Charles Schwab Investment Management Inc.712,990$8.61M0.0%+10.5%0.649%Search for SEC Filing on Google Icon
2/13/2026Police & Firemen s Retirement System of New Jersey23,752$0.29M0.0%+23.3%0.022%Search for SEC Filing on Google Icon
2/13/2026State Street Corp2,069,884$25M0.0%+27.7%1.885%Search for SEC Filing on Google Icon
2/13/2026Caitong International Asset Management Co. Ltd4,454$54K0.1%+1,116.9%0.004%Search for SEC Filing on Google Icon
2/13/2026UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC98,838$1.19M0.0%N/A0.090%Search for SEC Filing on Google Icon
2/13/2026Wells Fargo & Company MN146,309$1.77M0.0%+56.2%0.133%Search for SEC Filing on Google Icon
2/12/2026MetLife Investment Management LLC49,654$0.60M0.0%+15.7%0.045%Search for SEC Filing on Google Icon
2/12/2026Aldebaran Capital LLC198,508$2.40M2.2%-2.9%0.181%Search for SEC Filing on Google Icon
2/12/2026Renaissance Technologies LLC192,500$2.33M0.0%+867.3%0.175%Search for SEC Filing on Google Icon
2/12/2026Dimensional Fund Advisors LP771,248$9.32M0.0%+51.3%0.702%Search for SEC Filing on Google Icon
2/12/2026EntryPoint Capital LLC10,487$0.13M0.0%-38.9%0.010%Search for SEC Filing on Google Icon
2/12/2026Integrated Quantitative Investments LLC27,234$0.33M0.1%N/A0.025%Search for SEC Filing on Google Icon
2/12/2026Federated Hermes Inc.457,412$5.53M0.0%+115.4%0.417%Search for SEC Filing on Google Icon
2/12/2026Informed Momentum Co LLC53,256$0.64M0.1%-29.1%0.048%Search for SEC Filing on Google Icon
2/12/2026Patient Square Capital LP350,000$4.23M0.9%+10.7%0.319%Search for SEC Filing on Google Icon
2/12/2026Campbell & CO Investment Adviser LLC78,763$0.95M0.0%+221.7%0.072%Search for SEC Filing on Google Icon
2/12/2026Bank of Montreal Can138,525$1.67M0.0%-3.6%0.126%Search for SEC Filing on Google Icon
2/12/2026Alps Advisors Inc.90,172$1.09M0.0%N/A0.082%Search for SEC Filing on Google Icon
2/12/2026Swiss National Bank161,700$1.95M0.0%N/A0.147%Search for SEC Filing on Google Icon
2/12/2026Nuveen LLC283,948$3.43M0.0%+77.0%0.259%Search for SEC Filing on Google Icon
2/11/2026Meeder Asset Management Inc.2,099$25K0.0%N/A0.002%Search for SEC Filing on Google Icon
2/11/2026Deutsche Bank AG1,333,236$16.11M0.0%-2.4%1.214%Search for SEC Filing on Google Icon
2/11/2026Fox Run Management L.L.C.35,409$0.43M0.1%N/A0.032%Search for SEC Filing on Google Icon
2/11/2026Franklin Resources Inc.1,200,096$14.50M0.0%N/A1.093%Search for SEC Filing on Google Icon
2/10/2026Goldman Sachs Group Inc.2,613,221$31.57M0.0%+30.0%2.380%Search for SEC Filing on Google Icon
2/10/2026Jupiter Asset Management Ltd.15,574$0.19M0.0%N/A0.014%Search for SEC Filing on Google Icon
2/10/2026Intech Investment Management LLC32,006$0.39M0.0%+64.2%0.029%Search for SEC Filing on Google Icon
2/9/2026Geode Capital Management LLC2,165,534$26.16M0.0%+19.5%1.972%Search for SEC Filing on Google Icon
2/6/2026PSP Research LLC44,223$0.53M0.5%N/A0.040%Search for SEC Filing on Google Icon
2/6/2026ProShare Advisors LLC21,068$0.26M0.0%+40.1%0.019%Search for SEC Filing on Google Icon
2/4/2026Valeo Financial Advisors LLC15,000$0.18M0.0%+50.0%0.014%Search for SEC Filing on Google Icon
1/29/2026UBS Group AG543,323$6.56M0.0%-61.3%0.495%Search for SEC Filing on Google Icon
1/29/2026Vanguard Group Inc.5,804,912$70.12M0.0%+10.1%5.286%Search for SEC Filing on Google Icon
1/29/2026China Universal Asset Management Co. Ltd.17,895$0.22M0.0%+14.5%0.016%Search for SEC Filing on Google Icon
1/28/2026Arizona State Retirement System22,914$0.28M0.0%N/A0.021%Search for SEC Filing on Google Icon
1/27/2026Zurcher Kantonalbank Zurich Cantonalbank 35,877$0.43M0.0%+1,782.3%0.033%Search for SEC Filing on Google Icon
1/26/2026Mirae Asset Global Investments Co. Ltd.5,337$64K0.0%+54.8%0.005%Search for SEC Filing on Google Icon
1/9/2026SG Americas Securities LLC20,846$0.25M0.0%+76.4%0.019%Search for SEC Filing on Google Icon
1/1/2026JPMorgan Chase & Co.35,844$0.49M0.0%-59.3%0.033%Search for SEC Filing on Google Icon
11/20/2025Maven Securities LTD70,000$0.95M0.0%N/A0.064%Search for SEC Filing on Google Icon
11/17/2025Woodline Partners LP845,290$11.49M0.1%-29.6%0.770%Search for SEC Filing on Google Icon
11/17/2025TCG Crossover Management LLC6,243,812$84.85M4.2%+5.0%5.685%Search for SEC Filing on Google Icon
11/17/2025Dark Forest Capital Management LP86,795$1.18M0.0%N/A0.079%Search for SEC Filing on Google Icon
11/17/2025Verition Fund Management LLC63,896$0.87M0.0%N/A0.058%Search for SEC Filing on Google Icon
11/17/2025Qube Research & Technologies Ltd167,106$2.27M0.0%-61.9%0.152%Search for SEC Filing on Google Icon
11/17/2025Paradigm Biocapital Advisors LP1,900,000$25.82M0.7%N/A1.730%Search for SEC Filing on Google Icon
11/17/2025Parkman Healthcare Partners LLC579,174$7.87M0.8%-10.9%0.527%Search for SEC Filing on Google Icon
11/17/2025Nantahala Capital Management LLC935,684$12.72M0.4%-68.1%0.852%Search for SEC Filing on Google Icon
11/17/2025Numerai GP LLC67,153$0.91M0.1%N/A0.061%Search for SEC Filing on Google Icon
11/17/2025Millennium Management LLC417,771$5.68M0.0%-72.4%0.380%Search for SEC Filing on Google Icon
11/17/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.31,999$0.44M0.0%-15.8%0.029%Search for SEC Filing on Google Icon
11/17/2025Fred Alger Management LLC164,042$2.23M0.0%N/A0.149%Search for SEC Filing on Google Icon
11/17/2025First Light Asset Management LLC3,355,882$45.61M4.3%N/A3.056%Search for SEC Filing on Google Icon
Data available starting January 2016

See Full Table
Amylyx Pharmaceuticals logo
Amylyx Pharmaceuticals, Inc., a commercial-stage biotechnology company, engages in the discovery and development of treatment for amyotrophic lateral sclerosis (ALS) and neurodegenerative diseases. The company's products include RELYVRIO, a dual UPR-Bax apoptosis inhibitor composed of sodium phenylbutyrate and taurursodiol for the treatment of ALS in adults in the United States and marketed as ALBRIOZA for the treatment of ALS in Canada. It is also developing AMX0114 for other neurodegenerative diseases. Amylyx Pharmaceuticals, Inc. was founded in 2013 and is headquartered in Cambridge, Massachusetts.
Read More on Amylyx Pharmaceuticals

Today's Range

Now: $13.45
Low: $13.32
High: $13.84

50 Day Range

MA: $14.47
Low: $12.99
High: $16.92

52 Week Range

Now: $13.45
Low: $3.11
High: $17.49

Volume

687,373 shs

Average Volume

1,276,338 shs

Market Capitalization

$1.49 billion

P/E Ratio

N/A

Dividend Yield

N/A

Beta

N/A

Who are the company insiders with the largest holdings of Amylyx Pharmaceuticals?

Amylyx Pharmaceuticals' top insider shareholders include:
  1. Morningside Venture Investment (Major Shareholder)
  2. Joshua B Cohen (CEO)
  3. Justin B Klee (CEO)
  4. Global Investors Lp Viking (Major Shareholder)
  5. George M Milne Jr (Director)
  6. James M Frates (CFO)
  7. Patrick D Yeramian (Insider)
  8. Camille L Bedrosian (Insider)
  9. Gina Mazzariello (Insider)
  10. Karen Firestone (Director)
Learn More about top insider investors at Amylyx Pharmaceuticals.

Who are the major institutional investors of Amylyx Pharmaceuticals?

Amylyx Pharmaceuticals' top institutional investors include:
  1. Perceptive Advisors LLC — 7.54%
  2. Vanguard Group Inc. — 5.29%
  3. Commodore Capital LP — 5.14%
  4. Janus Henderson Group PLC — 4.07%
  5. Adage Capital Partners GP L.L.C. — 2.53%
  6. Goldman Sachs Group Inc. — 2.38%
Learn More about top institutional investors of Amylyx Pharmaceuticals stock.

Which institutional investors are selling Amylyx Pharmaceuticals stock?

During the previous quarter, AMLX stock was sold by these institutional investors:
  1. Adage Capital Partners GP L.L.C.
  2. T. Rowe Price Investment Management Inc.
  3. UBS Group AG
  4. Perceptive Advisors LLC
  5. Invesco Ltd.
  6. Balyasny Asset Management L.P.
  7. Logos Global Management LP
  8. Millennium Management LLC
Within the last year, company insiders that have sold Amylyx Pharmaceuticals company stock include:
  1. Morningside Venture Investment (Major Shareholder)
  2. Joshua B Cohen (CEO)
  3. Justin B Klee (CEO)
  4. Global Investors Lp Viking (Major Shareholder)
  5. George M Milne Jr (Director)
Learn More investors selling Amylyx Pharmaceuticals stock.

Which institutional investors are buying Amylyx Pharmaceuticals stock?

During the previous quarter, AMLX stock was acquired by institutional investors including:
  1. Janus Henderson Group PLC
  2. Commodore Capital LP
  3. Franklin Resources Inc.
  4. Goldman Sachs Group Inc.
  5. Vanguard Group Inc.
  6. Sofinnova Investments Inc.
  7. State Street Corp
  8. Geode Capital Management LLC
During the last year, these company insiders have bought Amylyx Pharmaceuticals stock:
  1. Morningside Venture Investment (Major Shareholder)
  2. Joshua B Cohen (CEO)
  3. Justin B Klee (CEO)
  4. Global Investors Lp Viking (Major Shareholder)
  5. George M Milne Jr (Director)
Learn More investors buying Amylyx Pharmaceuticals stock.

Amylyx Pharmaceuticals Active Insiders

Joshua B Cohen
Joshua B Cohen (Age 34)
CEO
4 recent trades
Justin B Klee
Justin B Klee (Age 35)
CEO
2 recent trades
James M Frates
James M Frates
CFO
2 recent trades
Bernhardt G Zeiher
Bernhardt G Zeiher
Director
Daphne Quimi
Daphne Quimi
Director
George M Milne Jr
George M Milne Jr
Director
Karen Firestone
Karen Firestone
Director
1 recent trades
Mr. Joshua Cohen
Mr. Joshua Cohen
Co-Founder
Mr. Justin Klee
Mr. Justin Klee
Co-Founder
Camille L Bedrosian
Camille L Bedrosian
Insider
2 recent trades
Gina Mazzariello
Gina Mazzariello (Age 54)
Insider
1 recent trades
Patrick D Yeramian
Patrick D Yeramian
Insider