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AMLX Insider Trading

Insider Ownership Percentage: 12.30%
Insider Buying (Last 12 Months): $37,000.00
Insider Selling (Last 12 Months): $1,666,686.16

Amylyx Pharmaceuticals Insider Trading History Chart

This chart shows the insider buying and selling history at Amylyx Pharmaceuticals by year and by quarter.

Skip ChartChart Data in Insider Trading History Table

Amylyx Pharmaceuticals Share Price & Price History

Current Price: $14.49
Price Change: ▲ Price Increase of +0.28 (1.97%)
As of 12/4/2025 05:00 PM ET

This chart shows the closing price history over time for AMLX up to the past year.

Skip Chart and Table DataPrice Data in Insider Trading History Table
Days: 30 | 90 | 365

Amylyx Pharmaceuticals Insider Trading History

Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionShares Held After TransactionDetails
12/1/2025Camille L BedrosianInsiderSell6,580$14.35$94,423.00175,756View SEC Filing Icon  
9/30/2025Camille L BedrosianInsiderSell12,039$14.58$175,528.62182,336View SEC Filing Icon  
9/30/2025Gina MazzarielloInsiderSell8,828$14.58$128,712.24148,141View SEC Filing Icon  
9/30/2025James M FratesCFOSell10,558$14.65$154,674.70280,430View SEC Filing Icon  
9/30/2025Joshua B CohenCEOSell29,933$14.35$429,538.553,325,347View SEC Filing Icon  
9/30/2025Justin B KleeCEOSell29,975$14.38$431,040.503,325,301View SEC Filing Icon  
3/31/2025Camille L BedrosianInsiderSell12,425$3.47$43,114.75194,375View SEC Filing Icon  
3/31/2025James M FratesCFOSell10,896$3.47$37,809.12290,988View SEC Filing Icon  
3/31/2025Joshua B CohenCEOSell21,490$3.47$74,570.303,355,280View SEC Filing Icon  
3/20/2025Bernhardt G ZeiherDirectorBuy10,000$3.70$37,000.0010,000View SEC Filing Icon  
2/24/2025Gina MazzarielloInsiderSell4,169$3.15$13,132.35134,921View SEC Filing Icon  
2/3/2025Gina MazzarielloInsiderSell3,678$3.49$12,836.22139,090View SEC Filing Icon  
2/3/2025Joshua B CohenCEOSell11,851$3.47$41,122.973,201,247View SEC Filing Icon  
1/6/2025Justin B KleeCEOSell7,471$4.04$30,182.843,176,788View SEC Filing Icon  
9/30/2024Camille L BedrosianInsiderSell11,442$3.20$36,614.40143,801View SEC Filing Icon  
9/30/2024Justin B KleeCEOSell18,589$3.20$59,484.803,120,569View SEC Filing Icon  
9/12/2024James M FratesCFOBuy40,000$2.53$101,200.00233,464View SEC Filing Icon  
9/3/2024M Milne JrDirectorBuy100,000$2.20$220,000.00858,571View SEC Filing Icon  
5/15/2024Gina MazzarielloInsiderSell10,455$1.88$19,655.40151,477View SEC Filing Icon  
5/14/2024Daphne QuimiDirectorBuy2,750$1.89$5,197.502,750View SEC Filing Icon  
3/5/2024Gina MazzarielloInsiderSell1,540$18.73$28,844.2081,372View SEC Filing Icon  
3/5/2024James M FratesCFOSell1,792$18.73$33,564.16134,784View SEC Filing Icon  
3/5/2024Joshua B CohenCEOSell4,135$18.73$77,448.553,023,002View SEC Filing Icon  
2/23/2024Gina MazzarielloInsiderSell2,838$18.76$53,240.8846,245View SEC Filing Icon  
1/9/2024James M FratesCFOSell2,716$16.33$44,352.28112,035View SEC Filing Icon  
1/9/2024Justin B KleeCEOSell5,841$16.33$95,383.532,836,776View SEC Filing Icon  
1/9/2024Patrick D YeramianInsiderSell2,812$16.33$45,919.96205,605View SEC Filing Icon  
5/16/2023James M FratesCFOSell32,500$26.94$875,550.0055,676View SEC Filing Icon  
5/15/2023Patrick D YeramianInsiderSell11,965$29.03$347,343.95208,417View SEC Filing Icon  
4/17/2023Patrick D YeramianInsiderSell49,579$30.54$1,514,142.66208,417View SEC Filing Icon  
3/29/2023Morningside Venture InvestmentMajor ShareholderSell29,048$30.45$884,511.606,997,302View SEC Filing Icon  
3/27/2023Morningside Venture InvestmentMajor ShareholderSell60,964$30.50$1,859,402.007,126,350View SEC Filing Icon  
3/21/2023Morningside Venture InvestmentMajor ShareholderSell63,448$31.91$2,024,625.687,187,314View SEC Filing Icon  
3/16/2023M Milne JrDirectorSell35,000$31.89$1,116,150.00862,021View SEC Filing Icon  
3/16/2023James M FratesCFOSell32,500$31.89$1,036,425.001,509View SEC Filing Icon  
3/16/2023Justin B KleeCEOSell100,000$31.86$3,186,000.002,792,617View SEC Filing Icon  
3/16/2023Morningside Venture InvestmentMajor ShareholderSell9,122$32.55$296,921.107,250,762View SEC Filing Icon  
3/16/2023Patrick D YeramianInsiderSell54,627$31.87$1,740,962.49149,672View SEC Filing Icon  
3/14/2023Morningside Venture InvestmentMajor ShareholderSell70,714$34.54$2,442,461.567,409,884View SEC Filing Icon  
3/2/2023Morningside Venture InvestmentMajor ShareholderSell50,000$33.75$1,687,500.007,480,598View SEC Filing Icon  
2/24/2023Gina MazzarielloInsiderSell3,586$34.49$123,681.1437,414View SEC Filing Icon  
2/22/2023Morningside Venture InvestmentMajor ShareholderSell50,000$34.73$1,736,500.007,530,598View SEC Filing Icon  
See Full Table

SEC Filings (Institutional Ownership Changes) for Amylyx Pharmaceuticals (NASDAQ:AMLX)

95.84% of Amylyx Pharmaceuticals stock is owned by institutions. Institutional ownership can be a sign of analyst confidence in the fundamentals of the stock.

Institutional Buying and Selling by Quarter

This chart shows the instiutional buying and selling at AMLX by year and by quarter.

Skip Institutional Buying and Selling Chart and Table DataRead Chart Data in Institutional Trading History Table

Amylyx Pharmaceuticals Institutional Trading History

Reporting DateHedge FundShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
11/20/2025Maven Securities LTD70,000$0.95M0.0%N/A0.064%Search for SEC Filing on Google Icon
11/17/2025Woodline Partners LP845,290$11.49M0.1%-29.6%0.770%Search for SEC Filing on Google Icon
11/17/2025TCG Crossover Management LLC6,243,812$84.85M4.2%+5.0%5.685%Search for SEC Filing on Google Icon
11/17/2025Dark Forest Capital Management LP86,795$1.18M0.0%N/A0.079%Search for SEC Filing on Google Icon
11/17/2025Verition Fund Management LLC63,896$0.87M0.0%N/A0.058%Search for SEC Filing on Google Icon
11/17/2025Qube Research & Technologies Ltd167,106$2.27M0.0%-61.9%0.152%Search for SEC Filing on Google Icon
11/17/2025Paradigm Biocapital Advisors LP1,900,000$25.82M0.7%N/A1.730%Search for SEC Filing on Google Icon
11/17/2025Parkman Healthcare Partners LLC579,174$7.87M0.8%-10.9%0.527%Search for SEC Filing on Google Icon
11/17/2025Nantahala Capital Management LLC935,684$12.72M0.4%-68.1%0.852%Search for SEC Filing on Google Icon
11/17/2025Numerai GP LLC67,153$0.91M0.1%N/A0.061%Search for SEC Filing on Google Icon
11/17/2025Millennium Management LLC417,771$5.68M0.0%-72.4%0.380%Search for SEC Filing on Google Icon
11/17/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.31,999$0.44M0.0%-15.8%0.029%Search for SEC Filing on Google Icon
11/17/2025Fred Alger Management LLC164,042$2.23M0.0%N/A0.149%Search for SEC Filing on Google Icon
11/17/2025First Light Asset Management LLC3,355,882$45.61M4.3%N/A3.056%Search for SEC Filing on Google Icon
11/17/2025Boxer Capital Management LLC900,000$12.23M3.9%-26.5%0.820%Search for SEC Filing on Google Icon
11/17/2025Brevan Howard Capital Management LP56,667$0.77M0.0%N/A0.052%Search for SEC Filing on Google Icon
11/17/2025Commodore Capital LP4,075,478$55.39M2.7%N/A3.711%Search for SEC Filing on Google Icon
11/17/2025Bank of America Corp DE429,516$5.84M0.0%-4.9%0.391%Search for SEC Filing on Google Icon
11/17/2025Braidwell LP612,841$8.33M0.2%N/A0.558%Search for SEC Filing on Google Icon
11/17/2025Ally Bridge Group NY LLC437,391$5.94M3.6%N/A0.398%Search for SEC Filing on Google Icon
11/17/2025Alliancebernstein L.P.71,500$0.97M0.0%+133.7%0.065%Search for SEC Filing on Google Icon
11/17/2025Ameriprise Financial Inc.133,508$1.81M0.0%+40.2%0.122%Search for SEC Filing on Google Icon
11/14/2025Schonfeld Strategic Advisors LLC43,637$0.59M0.0%-93.2%0.040%Search for SEC Filing on Google Icon
11/14/2025SummitTX Capital L.P.168,000$2.28M0.1%N/A0.153%Search for SEC Filing on Google Icon
11/14/2025Orbimed Advisors LLC750,600$10.20M0.2%+139.7%0.683%Search for SEC Filing on Google Icon
11/14/2025ADAR1 Capital Management LLC866,202$11.77M1.1%-28.1%0.789%Search for SEC Filing on Google Icon
11/14/2025Zurcher Kantonalbank Zurich Cantonalbank 1,906$26K0.0%-32.5%0.002%Search for SEC Filing on Google Icon
11/14/2025Acuta Capital Partners LLC333,258$4.53M4.7%N/A0.303%Search for SEC Filing on Google Icon
11/14/2025Balyasny Asset Management L.P.1,476,302$20.06M0.0%N/A1.344%Search for SEC Filing on Google Icon
11/14/2025Longaeva Partners L.P.200,000$2.72M0.4%N/A0.182%Search for SEC Filing on Google Icon
11/14/2025Two Sigma Investments LP98,416$1.34M0.0%-82.4%0.090%Search for SEC Filing on Google Icon
11/14/2025Alpha Wave Global LP327,312$4.45M0.5%+18.7%0.298%Search for SEC Filing on Google Icon
11/13/2025Landscape Capital Management L.L.C.10,401$0.14M0.0%N/A0.009%Search for SEC Filing on Google Icon
11/13/2025Invesco Ltd.810,640$11.02M0.0%+38.1%0.738%Search for SEC Filing on Google Icon
11/13/2025UBS Group AG1,404,471$19.09M0.0%+12.1%1.279%Search for SEC Filing on Google Icon
11/13/2025Connor Clark & Lunn Investment Management Ltd.1,107,008$15.04M0.0%-4.1%1.008%Search for SEC Filing on Google Icon
11/13/2025BNP Paribas Financial Markets14,609$0.20M0.0%+101.0%0.013%Search for SEC Filing on Google Icon
11/13/2025Legal & General Group Plc67,212$0.91M0.0%+808.0%0.061%Search for SEC Filing on Google Icon
11/13/2025Russell Investments Group Ltd.55,406$0.75M0.0%+789.5%0.050%Search for SEC Filing on Google Icon
11/12/2025Barclays PLC414,112$5.63M0.0%+217.9%0.377%Search for SEC Filing on Google Icon
11/12/2025Dimensional Fund Advisors LP509,780$6.94M0.0%+36.4%0.464%Search for SEC Filing on Google Icon
11/12/2025Kennondale Capital Management LLC108,615$1.48M1.1%+14.1%0.099%Search for SEC Filing on Google Icon
11/12/2025Monashee Investment Management LLC30,000$0.41M0.2%N/A0.027%Search for SEC Filing on Google Icon
11/12/2025Quantbot Technologies LP16,653$0.23M0.0%N/A0.015%Search for SEC Filing on Google Icon
11/12/2025Aster Capital Management DIFC Ltd3,568$48K0.0%N/A0.003%Search for SEC Filing on Google Icon
11/12/2025Intech Investment Management LLC19,494$0.27M0.0%-46.3%0.018%Search for SEC Filing on Google Icon
11/10/2025TD Asset Management Inc40,966$0.56M0.0%N/A0.037%Search for SEC Filing on Google Icon
11/10/2025Aldebaran Capital LLC204,474$2.78M2.6%-6.1%0.186%Search for SEC Filing on Google Icon
11/10/2025Patient Square Capital LP316,312$4.30M1.1%N/A0.288%Search for SEC Filing on Google Icon
11/10/2025Ameritas Investment Partners Inc.5,794$79K0.0%-18.2%0.005%Search for SEC Filing on Google Icon
11/10/2025China Universal Asset Management Co. Ltd.15,630$0.21M0.0%-12.7%0.014%Search for SEC Filing on Google Icon
11/10/2025Persistent Asset Partners Ltd22,913$0.31M0.2%N/A0.021%Search for SEC Filing on Google Icon
11/7/2025Readystate Asset Management LP59,132$0.80M0.0%N/A0.066%Search for SEC Filing on Google Icon
11/7/2025GSA Capital Partners LLP52,107$0.71M0.1%-69.4%0.058%Search for SEC Filing on Google Icon
11/7/2025Vanguard Group Inc.5,273,750$71.67M0.0%+17.2%5.914%Search for SEC Filing on Google Icon
11/7/2025JPMorgan Chase & Co.35,844$0.49M0.0%-59.3%0.040%Search for SEC Filing on Google Icon
11/6/2025Rhumbline Advisers98,657$1.34M0.0%-1.9%0.111%Search for SEC Filing on Google Icon
11/6/2025Profund Advisors LLC13,418$0.18M0.0%N/A0.015%Search for SEC Filing on Google Icon
11/6/2025ProShare Advisors LLC15,038$0.20M0.0%-14.3%0.017%Search for SEC Filing on Google Icon
11/3/2025AlphaQuest LLC13,636$0.19M0.0%N/A0.015%Search for SEC Filing on Google Icon
11/3/2025Federated Hermes Inc.212,379$2.89M0.0%+4.1%0.238%Search for SEC Filing on Google Icon
10/30/2025Strs Ohio3,400$46K0.0%-53.4%0.004%Search for SEC Filing on Google Icon
10/28/2025Campbell & CO Investment Adviser LLC24,482$0.33M0.0%N/A0.027%Search for SEC Filing on Google Icon
10/23/2025SG Americas Securities LLC11,819$0.16M0.0%N/A0.013%Search for SEC Filing on Google Icon
10/22/2025Hennion & Walsh Asset Management Inc.47,898$0.65M0.0%-15.7%0.054%Search for SEC Filing on Google Icon
10/9/2025Voya Investment Management LLC12,990$0.18M0.0%-33.3%0.015%Search for SEC Filing on Google Icon
8/19/2025Marex Group plc20,000$0.13M0.0%N/A0.022%Search for SEC Filing on Google Icon
8/15/2025Perceptive Advisors LLC7,902,365$50.65M4.5%+0.4%8.862%Search for SEC Filing on Google Icon
8/15/2025BNP Paribas Financial Markets7,267$47K0.0%+433.2%0.008%Search for SEC Filing on Google Icon
8/15/2025Bridgeway Capital Management LLC25,700$0.17M0.0%-83.5%0.029%Search for SEC Filing on Google Icon
8/15/2025Bank of America Corp DE451,808$2.90M0.0%-43.1%0.507%Search for SEC Filing on Google Icon
8/15/2025683 Capital Management LLC2,160,000$13.85M0.9%-10.4%2.422%Search for SEC Filing on Google Icon
8/15/2025Adage Capital Partners GP L.L.C.8,800,000$56.41M0.1%+54.5%9.869%Search for SEC Filing on Google Icon
8/15/2025Ameriprise Financial Inc.95,219$0.61M0.0%+643.6%0.107%Search for SEC Filing on Google Icon
8/14/2025Orbimed Advisors LLC313,200$2.01M0.1%-10.0%0.351%Search for SEC Filing on Google Icon
8/14/2025Jane Street Group LLC186,986$1.20M0.0%-43.5%0.210%Search for SEC Filing on Google Icon
8/14/2025California State Teachers Retirement System4,328$28K0.0%N/A0.005%Search for SEC Filing on Google Icon
8/14/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.37,987$0.24M0.0%N/A0.043%Search for SEC Filing on Google Icon
8/14/2025TFG Asset Management GP Ltd218,750$1.40M0.2%N/A0.245%Search for SEC Filing on Google Icon
8/14/2025The Manufacturers Life Insurance Company 25,999$0.17M0.0%N/A0.029%Search for SEC Filing on Google Icon
8/14/2025Qube Research & Technologies Ltd438,026$2.81M0.0%-53.5%0.491%Search for SEC Filing on Google Icon
8/13/2025Jump Financial LLC47,800$0.31M0.0%N/A0.054%Search for SEC Filing on Google Icon
8/13/2025Alpha Wave Global LP275,842$1.77M0.2%+47.3%0.309%Search for SEC Filing on Google Icon
8/13/2025Saturn V Capital Management LP3,260,570$20.90M8.5%+34.4%3.657%Search for SEC Filing on Google Icon
8/13/2025Invesco Ltd.586,883$3.76M0.0%+1,184.4%0.658%Search for SEC Filing on Google Icon
8/13/2025New York State Common Retirement Fund21,900$0.14M0.0%N/A0.025%Search for SEC Filing on Google Icon
8/13/2025Quadrature Capital Ltd29,430$0.19M0.0%+130.9%0.033%Search for SEC Filing on Google Icon
8/13/2025Kennondale Capital Management LLC95,165$0.61M0.6%-53.1%0.107%Search for SEC Filing on Google Icon
8/12/2025Ameritas Investment Partners Inc.7,081$45K0.0%N/A0.008%Search for SEC Filing on Google Icon
8/12/2025American Century Companies Inc.134,380$0.86M0.0%+25.6%0.151%Search for SEC Filing on Google Icon
8/12/2025Rhumbline Advisers100,576$0.65M0.0%N/A0.113%Search for SEC Filing on Google Icon
8/12/2025Legal & General Group Plc7,402$47K0.0%N/A0.008%Search for SEC Filing on Google Icon
8/12/2025JPMorgan Chase & Co.87,989$0.56M0.0%+62.7%0.099%Search for SEC Filing on Google Icon
8/8/2025Intech Investment Management LLC36,315$0.23M0.0%N/A0.041%Search for SEC Filing on Google Icon
8/8/2025Police & Firemen s Retirement System of New Jersey15,992$0.10M0.0%N/A0.018%Search for SEC Filing on Google Icon
8/8/2025Geode Capital Management LLC1,692,413$10.85M0.0%+109.9%1.899%Search for SEC Filing on Google Icon
8/7/2025ProShare Advisors LLC17,551$0.11M0.0%N/A0.020%Search for SEC Filing on Google Icon
8/7/2025Acadian Asset Management LLC569,083$3.65M0.0%+135.1%0.638%Search for SEC Filing on Google Icon
8/7/2025Connor Clark & Lunn Investment Management Ltd.1,154,485$7.40M0.0%-3.8%1.295%Search for SEC Filing on Google Icon
8/7/2025Los Angeles Capital Management LLC23,320$0.15M0.0%N/A0.026%Search for SEC Filing on Google Icon
Data available starting January 2016

See Full Table
Amylyx Pharmaceuticals logo
Amylyx Pharmaceuticals, Inc., a commercial-stage biotechnology company, engages in the discovery and development of treatment for amyotrophic lateral sclerosis (ALS) and neurodegenerative diseases. The company's products include RELYVRIO, a dual UPR-Bax apoptosis inhibitor composed of sodium phenylbutyrate and taurursodiol for the treatment of ALS in adults in the United States and marketed as ALBRIOZA for the treatment of ALS in Canada. It is also developing AMX0114 for other neurodegenerative diseases. Amylyx Pharmaceuticals, Inc. was founded in 2013 and is headquartered in Cambridge, Massachusetts.
Read More on Amylyx Pharmaceuticals

Today's Range

Now: $14.49
Low: $13.91
High: $14.64

50 Day Range

MA: $14.00
Low: $12.18
High: $15.79

52 Week Range

Now: $14.49
Low: $2.60
High: $16.96

Volume

781,740 shs

Average Volume

1,403,731 shs

Market Capitalization

$1.59 billion

P/E Ratio

N/A

Dividend Yield

N/A

Beta

N/A

Who are the company insiders with the largest holdings of Amylyx Pharmaceuticals?

Amylyx Pharmaceuticals' top insider shareholders include:
  1. Joshua B Cohen (CEO)
  2. Justin B Klee (CEO)
  3. George M Milne Jr (Director)
  4. James M Frates (CFO)
  5. Patrick D Yeramian (Insider)
  6. Camille L Bedrosian (Insider)
  7. Gina Mazzariello (Insider)
  8. Bernhardt G Zeiher (Director)
  9. Daphne Quimi (Director)
Learn More about top insider investors at Amylyx Pharmaceuticals.

Who are the major institutional investors of Amylyx Pharmaceuticals?

Amylyx Pharmaceuticals' top institutional investors include:
  1. TCG Crossover Management LLC — 5.69%
  2. Vanguard Group Inc. — 5.91%
  3. Commodore Capital LP — 3.71%
  4. First Light Asset Management LLC — 3.06%
  5. Paradigm Biocapital Advisors LP — 1.73%
  6. Balyasny Asset Management L.P. — 1.34%
Learn More about top institutional investors of Amylyx Pharmaceuticals stock.

Which institutional investors are selling Amylyx Pharmaceuticals stock?

During the previous quarter, AMLX stock was sold by these institutional investors:
  1. Nantahala Capital Management LLC
  2. Millennium Management LLC
  3. Schonfeld Strategic Advisors LLC
  4. Two Sigma Investments LP
  5. Woodline Partners LP
  6. ADAR1 Capital Management LLC
  7. Boxer Capital Management LLC
  8. Qube Research & Technologies Ltd
Within the last year, company insiders that have sold Amylyx Pharmaceuticals company stock include:
  1. Joshua B Cohen (CEO)
  2. Justin B Klee (CEO)
  3. George M Milne Jr (Director)
  4. James M Frates (CFO)
  5. Patrick D Yeramian (Insider)
Learn More investors selling Amylyx Pharmaceuticals stock.

Which institutional investors are buying Amylyx Pharmaceuticals stock?

During the previous quarter, AMLX stock was acquired by institutional investors including:
  1. Commodore Capital LP
  2. First Light Asset Management LLC
  3. Paradigm Biocapital Advisors LP
  4. Balyasny Asset Management L.P.
  5. Vanguard Group Inc.
  6. Braidwell LP
  7. Orbimed Advisors LLC
  8. Ally Bridge Group NY LLC
During the last year, these company insiders have bought Amylyx Pharmaceuticals stock:
  1. Joshua B Cohen (CEO)
  2. Justin B Klee (CEO)
  3. George M Milne Jr (Director)
  4. James M Frates (CFO)
Learn More investors buying Amylyx Pharmaceuticals stock.