| 12/1/2025 | Cantor Fitzgerald L. P. | 85,247 | $1.08M | 0.0% | N/A | 0.470% |  |
| 11/17/2025 | Velan Capital Investment Management LP | 263,642 | $3.35M | 3.1% | +70.1% | 1.454% |  |
| 11/17/2025 | RA Capital Management L.P. | 662,968 | $8.43M | 0.1% | -28.9% | 3.656% |  |
| 11/17/2025 | Prelude Capital Management LLC | 24,628 | $0.31M | 0.0% | N/A | 0.136% |  |
| 11/17/2025 | Nantahala Capital Management LLC | 1,235,000 | $15.70M | 0.5% | +24.1% | 6.810% |  |
| 11/17/2025 | Millennium Management LLC | 137,431 | $1.75M | 0.0% | N/A | 0.758% |  |
| 11/17/2025 | HighVista Strategies LLC | 27,778 | $0.35M | 0.1% | N/A | 0.153% |  |
| 11/17/2025 | Boxer Capital Management LLC | 125,000 | $1.59M | 0.5% | N/A | 0.689% |  |
| 11/17/2025 | Cantor Fitzgerald L. P. | 85,247 | $1.08M | 0.0% | N/A | 0.470% |  |
| 11/17/2025 | Bank of America Corp DE | 605,842 | $7.70M | 0.0% | +49.0% | 3.341% |  |
| 11/17/2025 | Boothbay Fund Management LLC | 228,297 | $2.90M | 0.0% | +1,916.6% | 1.259% |  |
| 11/17/2025 | Ally Bridge Group NY LLC | 178,100 | $2.26M | 1.4% | N/A | 0.982% |  |
| 11/17/2025 | Ameriprise Financial Inc. | 213,572 | $2.71M | 0.0% | N/A | 1.178% |  |
| 11/14/2025 | Deep Track Capital LP | 144,600 | $1.84M | 0.1% | -74.5% | 1.099% |  |
| 11/14/2025 | Caligan Partners LP | 833,333 | $10.59M | 1.4% | N/A | 6.336% |  |
| 11/14/2025 | Orbimed Advisors LLC | 1,349,300 | $17.15M | 0.4% | +39.5% | 10.259% |  |
| 11/14/2025 | ADAR1 Capital Management LLC | 32,393 | $0.41M | 0.0% | -69.1% | 0.246% |  |
| 11/14/2025 | Balyasny Asset Management L.P. | 817,436 | $10.39M | 0.0% | N/A | 6.215% |  |
| 11/14/2025 | Two Sigma Investments LP | 49,242 | $0.63M | 0.0% | +282.0% | 0.374% |  |
| 11/13/2025 | Landscape Capital Management L.L.C. | 33,337 | $0.42M | 0.0% | N/A | 0.254% |  |
| 11/13/2025 | UBS Group AG | 45,208 | $0.58M | 0.0% | -46.0% | 0.344% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 11,215 | $0.14M | 0.0% | N/A | 0.085% |  |
| 11/10/2025 | RWA Wealth Partners LLC | 86,516 | $1.10M | 0.0% | -66.9% | 0.658% |  |
| 11/10/2025 | Patient Square Capital LP | 100,000 | $1.27M | 0.3% | N/A | 0.760% |  |
| 11/10/2025 | BIT Capital GmbH | 1,929 | $25K | 0.0% | N/A | 0.015% |  |
| 11/7/2025 | Vanguard Group Inc. | 692,637 | $8.80M | 0.0% | +314.9% | 5.267% |  |
| 11/7/2025 | Aberdeen Group plc | 72,800 | $0.93M | 0.0% | N/A | 0.554% |  |
| 8/15/2025 | Perceptive Advisors LLC | 139,667 | $0.70M | 0.1% | -73.1% | 1.062% |  |
| 8/15/2025 | Boothbay Fund Management LLC | 11,321 | $56K | 0.0% | N/A | 0.086% |  |
| 8/15/2025 | BVF Inc. IL | 1,028,049 | $5.13M | 0.2% | -0.8% | 7.818% |  |
| 8/15/2025 | Bank of America Corp DE | 406,571 | $2.03M | 0.0% | +7,066.8% | 3.092% |  |
| 8/14/2025 | Nantahala Capital Management LLC | 995,000 | $4.97M | 0.2% | +10.6% | 7.565% |  |
| 8/14/2025 | Velan Capital Investment Management LP | 154,972 | $0.77M | 0.8% | +38.4% | 1.178% |  |
| 8/13/2025 | Affinity Asset Advisors LLC | 607,872 | $3.03M | 0.4% | -7.5% | 4.623% |  |
| 8/13/2025 | Quadrature Capital Ltd | 10,976 | $55K | 0.0% | N/A | 0.083% |  |
| 8/8/2025 | Geode Capital Management LLC | 110,460 | $0.55M | 0.0% | +2.5% | 1.020% |  |
| 8/6/2025 | RWA Wealth Partners LLC | 261,016 | $1.30M | 0.0% | -16.5% | 2.410% |  |
| 5/16/2025 | Allostery Investments LP | 107,141 | $0.86M | 1.2% | +46.1% | 0.989% |  |
| 5/16/2025 | ADAR1 Capital Management LLC | 10,000 | $80K | 0.0% | N/A | 0.092% |  |
| 5/15/2025 | Nantahala Capital Management LLC | 900,000 | $7.21M | 0.3% | N/A | 8.312% |  |
| 5/14/2025 | Affinity Asset Advisors LLC | 657,154 | $5.26M | 0.5% | +19.3% | 6.069% |  |
| 5/14/2025 | RWA Wealth Partners LLC | 312,779 | $2.51M | 0.0% | N/A | 2.889% |  |
| 2/17/2025 | Velan Capital Investment Management LP | 109,972 | $0.82M | 0.7% | N/A | 1.058% |  |
| 2/17/2025 | Deep Track Capital LP | 867,000 | $6.44M | 0.2% | -10.3% | 8.345% |  |
| 2/17/2025 | BVF Inc. IL | 1,036,679 | $7.70M | 0.3% | +7.2% | 9.978% |  |
| 2/17/2025 | Allostery Investments LP | 73,314 | $0.55M | 0.6% | N/A | 0.706% |  |
| 2/14/2025 | Northern Trust Corp | 22,673 | $0.17M | 0.0% | N/A | 0.218% |  |
| 2/14/2025 | Tower Research Capital LLC TRC | 4,130 | $31K | 0.0% | +998.4% | 0.040% |  |
| 2/13/2025 | Marshall Wace LLP | 15,323 | $0.11M | 0.0% | N/A | 0.147% |  |
| 2/13/2025 | Affinity Asset Advisors LLC | 550,765 | $4.09M | 0.5% | +1,123.9% | 5.299% |  |
| 2/13/2025 | Walleye Capital LLC | 19,477 | $0.15M | 0.0% | N/A | 0.187% |  |
| 2/13/2025 | Bank of Montreal Can | 60,000 | $0.45M | 0.0% | N/A | 0.577% |  |
| 2/12/2025 | Geode Capital Management LLC | 104,853 | $0.78M | 0.0% | +937.0% | 1.009% |  |
| 11/15/2024 | RA Capital Management L.P. | 967,000 | $9.19M | 0.1% | N/A | 93.883% |  |
| 11/15/2024 | Ikarian Capital LLC | 970,359 | $9.22M | 1.2% | +1,673.0% | 94.210% |  |
| 8/27/2024 | Logos Global Management LP | 539,079 | $6.72M | 0.5% | N/A | 52.135% |  |
| 8/15/2024 | Affinity Asset Advisors LLC | 45,000 | $0.56M | 0.1% | +350.0% | 4.352% |  |
| 5/17/2024 | Ikarian Capital LLC | 46,648 | $1.02M | 0.1% | N/A | 4.511% |  |
| 5/15/2024 | Affinity Asset Advisors LLC | 10,000 | $0.22M | 0.0% | N/A | 0.971% |  |
| 5/14/2024 | Natixis | 2,512 | $55K | 0.0% | -45.4% | 0.244% |  |
| 11/13/2023 | Acadian Asset Management LLC | 283,306 | $34K | 0.0% | N/A | 1.399% |  |
| 8/11/2023 | VR Adviser LLC | 1,250,000 | $0.44M | 0.1% | +25.0% | 6.173% |  |
| 5/16/2023 | Great Point Partners LLC | 474,639 | $0.83M | 0.2% | N/A | 3.595% |  |
| 5/5/2023 | Monashee Investment Management LLC | 60,000 | $0.11M | 0.0% | N/A | 0.455% |  |
| 2/15/2023 | Nantahala Capital Management LLC | 540,667 | $2.73M | 0.2% | -1.3% | 5.746% |  |
| 11/14/2022 | Armistice Capital LLC | 3,964,666 | $13.16M | 0.2% | -91.7% | 42.115% |  |
| 11/14/2022 | Point72 Asset Management L.P. | 500,737 | $1.66M | 0.0% | -91.7% | 5.319% |  |
| 11/10/2022 | Nantahala Capital Management LLC | 547,814 | $1.82M | 0.1% | -91.8% | 5.819% |  |
| 10/27/2022 | Assenagon Asset Management S.A. | 15,646 | $52K | 0.0% | N/A | 0.166% |  |
| 8/15/2022 | Nantahala Capital Management LLC | 6,710,327 | $3.36M | 0.2% | -2.0% | 71.280% |  |
| 8/15/2022 | Opaleye Management Inc. | 450,000 | $0.23M | 0.1% | -69.1% | 4.780% |  |
| 5/12/2022 | Integral Health Asset Management LLC | 700,000 | $0.51M | 0.1% | -56.9% | 0.621% |  |
| 5/3/2022 | Leo Brokerage LLC | 62,629 | $45K | 0.0% | N/A | 0.056% |  |
| 4/25/2022 | Assenagon Asset Management S.A. | 42,338 | $31K | 0.0% | -92.7% | 0.038% |  |
| 2/15/2022 | Stonepine Capital Management LLC | 1,510,095 | $2.57M | 1.2% | +77.7% | 1.344% |  |
| 2/15/2022 | LGL Partners LLC | 28,850 | $49K | 0.0% | N/A | 0.026% |  |
| 2/14/2022 | Freestone Capital Holdings LLC | 20,000 | $34K | 0.0% | N/A | 0.018% |  |
| 2/14/2022 | Soleus Capital Management L.P. | 770,000 | $1.31M | 0.1% | N/A | 0.686% |  |
| 2/8/2022 | Northern Trust Corp | 533,578 | $0.91M | 0.0% | +3.1% | 0.475% |  |
| 2/1/2022 | Assenagon Asset Management S.A. | 582,718 | $0.99M | 0.0% | -33.7% | 0.519% |  |
| 1/24/2022 | Strs Ohio | 38,400 | $65K | 0.0% | -40.2% | 0.034% |  |
| 1/20/2022 | Minot Wealth Management LLC | 34,645 | $59K | 0.0% | -66.5% | 0.031% |  |
| 12/29/2021 | Hudson Bay Capital Management LP | 197,133 | $0.43M | 0.0% | N/A | 0.176% |  |
| 11/16/2021 | Opaleye Management Inc. | 1,459,400 | $3.18M | 0.6% | N/A | 1.299% |  |
| 11/16/2021 | Squarepoint Ops LLC | 18,657 | $41K | 0.0% | N/A | 0.017% |  |
| 11/16/2021 | Two Sigma Advisers LP | 801,300 | $1.75M | 0.0% | N/A | 0.713% |  |
| 11/16/2021 | Two Sigma Investments LP | 732,931 | $1.60M | 0.0% | N/A | 0.653% |  |
| 11/16/2021 | Laurion Capital Management LP | 330,444 | $0.72M | 0.0% | N/A | 0.294% |  |
| 11/15/2021 | Point72 Asset Management L.P. | 6,008,850 | $13.10M | 0.1% | N/A | 5.350% |  |
| 11/15/2021 | Atom Investors LP | 27,507 | $60K | 0.0% | N/A | 0.024% |  |
| 11/15/2021 | Voya Investment Management LLC | 21,854 | $48K | 0.0% | N/A | 0.019% |  |
| 11/15/2021 | Caas Capital Management LP | 11,812 | $26K | 0.0% | N/A | 0.011% |  |
| 11/12/2021 | Aristides Capital LLC | 48,953 | $0.11M | 0.0% | N/A | 0.044% |  |
| 11/12/2021 | Stonepine Capital Management LLC | 850,000 | $1.85M | 0.8% | N/A | 0.770% |  |
| 11/12/2021 | Geode Capital Management LLC | 1,242,382 | $2.71M | 0.0% | N/A | 1.126% |  |
| 11/12/2021 | Integral Health Asset Management LLC | 1,625,000 | $3.54M | 1.0% | N/A | 1.473% |  |
| 11/10/2021 | Goldman Sachs Group Inc. | 672,664 | $1.47M | 0.0% | N/A | 0.610% |  |
| 11/10/2021 | Creative Planning | 14,814 | $32K | 0.0% | N/A | 0.013% |  |
| 11/10/2021 | Alliancebernstein L.P. | 19,100 | $42K | 0.0% | N/A | 0.017% |  |
| 11/9/2021 | BlackRock Inc. | 3,716,943 | $8.10M | 0.0% | N/A | 3.369% |  |