| 6/27/2025 | Goldman Sachs Group Inc. | 26,759 | $0.10M | 0.0% | -86.3% | 0.075% |  |
| 5/29/2025 | Rhumbline Advisers | 9,800 | $37K | 0.0% | +154.0% | 0.027% |  |
| 5/28/2025 | Strs Ohio | 34,100 | $0.13M | 0.0% | N/A | 0.095% |  |
| 5/16/2025 | Woodline Partners LP | 31,565 | $0.12M | 0.0% | -64.3% | 0.088% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 26,759 | $0.10M | 0.0% | -86.3% | 0.075% |  |
| 5/16/2025 | ADAR1 Capital Management LLC | 971,100 | $3.65M | 0.7% | +689.3% | 2.709% |  |
| 5/15/2025 | RA Capital Management L.P. | 1,052,494 | $3.96M | 0.1% | -19.7% | 2.936% |  |
| 5/15/2025 | Siren L.L.C. | 382,406 | $1.44M | 0.1% | -1.4% | 1.067% |  |
| 5/14/2025 | Stonepine Capital Management LLC | 50,000 | $0.19M | 0.2% | N/A | 0.139% |  |
| 5/9/2025 | Deutsche Bank AG | 7,254 | $27K | 0.0% | N/A | 0.020% |  |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 89,977 | $0.34M | 0.0% | +6.0% | 0.251% |  |
| 5/2/2025 | Bailard Inc. | 25,700 | $97K | 0.0% | N/A | 0.072% |  |
| 4/29/2025 | Bank of New York Mellon Corp | 21,534 | $81K | 0.0% | +46.6% | 0.060% |  |
| 4/28/2025 | Vontobel Holding Ltd. | 11,000 | $41K | 0.0% | N/A | 0.031% |  |
| 4/8/2025 | Rhumbline Advisers | 9,800 | $37K | 0.0% | +154.0% | 0.027% |  |
| 3/12/2025 | Wealthedge Investment Advisors LLC | 10,585 | $61K | 0.0% | N/A | 0.030% |  |
| 2/17/2025 | Woodline Partners LP | 88,368 | $0.51M | 0.0% | -29.3% | 0.246% |  |
| 2/17/2025 | Squarepoint Ops LLC | 12,263 | $71K | 0.0% | -66.2% | 0.034% |  |
| 2/17/2025 | Tang Capital Management LLC | 1,318,361 | $7.63M | 0.5% | N/A | 3.677% |  |
| 2/17/2025 | Suvretta Capital Management LLC | 1,452,336 | $8.41M | 0.3% | -0.2% | 4.051% |  |
| 2/17/2025 | Nuveen Asset Management LLC | 15,448 | $89K | 0.0% | N/A | 0.043% |  |
| 2/17/2025 | Orbimed Advisors LLC | 921,959 | $5.34M | 0.1% | -35.2% | 2.572% |  |
| 2/17/2025 | Millennium Management LLC | 14,965 | $87K | 0.0% | -91.0% | 0.042% |  |
| 2/17/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 6,667 | $39K | 0.0% | N/A | 0.019% |  |
| 2/17/2025 | Bank of America Corp DE | 19,819 | $0.12M | 0.0% | +3,675.0% | 0.055% |  |
| 2/14/2025 | RA Capital Management L.P. | 1,310,589 | $7.59M | 0.1% | -40.7% | 3.656% |  |
| 2/14/2025 | Northern Trust Corp | 87,243 | $0.51M | 0.0% | N/A | 0.243% |  |
| 2/14/2025 | Silverarc Capital Management LLC | 39,974 | $0.23M | 0.1% | -60.0% | 0.112% |  |
| 2/14/2025 | MYDA Advisors LLC | 30,000 | $0.17M | 0.0% | N/A | 0.084% |  |
| 2/13/2025 | Barclays PLC | 18,791 | $0.11M | 0.0% | +57.9% | 0.052% |  |
| 2/13/2025 | FIL Ltd | 146,215 | $0.85M | 0.0% | -26.9% | 0.408% |  |
| 2/13/2025 | ADAR1 Capital Management LLC | 123,037 | $0.71M | 0.1% | N/A | 0.343% |  |
| 2/13/2025 | Wells Fargo & Company MN | 6,302 | $36K | 0.0% | N/A | 0.018% |  |
| 2/12/2025 | AH Capital Management L.L.C. | 3,233,170 | $18.72M | 2.5% | +7.3% | 9.019% |  |
| 2/12/2025 | Geode Capital Management LLC | 256,995 | $1.49M | 0.0% | N/A | 0.717% |  |
| 2/12/2025 | Norges Bank | 27,829 | $0.16M | 0.0% | N/A | 0.078% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 5,335 | $31K | 0.0% | -97.3% | 0.015% |  |
| 2/11/2025 | Corebridge Financial Inc. | 6,032 | $35K | 0.0% | N/A | 0.017% |  |
| 2/11/2025 | Virtu Financial LLC | 10,132 | $59K | 0.0% | N/A | 0.028% |  |
| 2/10/2025 | Skandinaviska Enskilda Banken AB publ | 19,074 | $0.11M | 0.0% | N/A | 0.053% |  |
| 2/6/2025 | Charles Schwab Investment Management Inc. | 84,867 | $0.49M | 0.0% | N/A | 0.237% |  |
| 2/4/2025 | Bank of New York Mellon Corp | 14,685 | $85K | 0.0% | N/A | 0.041% |  |
| 12/26/2024 | JPMorgan Chase & Co. | 200,000 | $4.16M | 0.0% | N/A | 0.558% |  |
| 11/19/2024 | Barclays PLC | 11,900 | $0.25M | 0.0% | N/A | 0.033% |  |
| 11/15/2024 | Barclays PLC | 11,900 | $0.25M | 0.0% | N/A | 0.033% |  |
| 11/15/2024 | Zimmer Partners LP | 125,000 | $2.60M | 0.0% | N/A | 0.349% |  |
| 11/15/2024 | Jane Street Group LLC | 43,073 | $0.90M | 0.0% | N/A | 0.120% |  |
| 11/15/2024 | Soros Fund Management LLC | 100,000 | $2.08M | 0.0% | N/A | 0.279% |  |
| 11/15/2024 | RA Capital Management L.P. | 2,210,589 | $45.98M | 0.5% | N/A | 6.166% |  |
| 11/15/2024 | RTW Investments LP | 786,353 | $16.36M | 0.2% | N/A | 2.193% |  |
| 11/15/2024 | Redpoint Management LLC | 383,255 | $7.97M | 1.5% | N/A | 1.069% |  |
| 11/15/2024 | Point72 DIFC Ltd | 55,080 | $1.15M | 0.0% | N/A | 0.154% |  |
| 11/15/2024 | Point72 Asset Management L.P. | 2,700 | $56K | 0.0% | N/A | 0.008% |  |
| 11/15/2024 | Maven Securities LTD | 25,000 | $0.52M | 0.0% | N/A | 0.070% |  |
| 11/15/2024 | Comprehensive Financial Management LLC | 271,842 | $5.65M | 0.2% | N/A | 0.758% |  |
| 11/14/2024 | Wasatch Advisors LP | 254,907 | $5.30M | 0.0% | N/A | 0.711% |  |
| 11/14/2024 | Walleye Capital LLC | 76,875 | $1.60M | 0.0% | N/A | 0.214% |  |
| 11/14/2024 | Suvretta Capital Management LLC | 1,455,000 | $30.26M | 1.0% | N/A | 4.059% |  |
| 11/14/2024 | Howard Hughes Medical Institute | 113,765 | $2.37M | 0.4% | N/A | 0.317% |  |
| 11/14/2024 | Healthcare of Ontario Pension Plan Trust Fund | 150,000 | $3.12M | 0.0% | N/A | 0.418% |  |
| 11/13/2024 | AH Capital Management L.L.C. | 3,013,975 | $62.69M | 4.7% | N/A | 8.407% |  |
| 11/13/2024 | The Manufacturers Life Insurance Company | 26,677 | $0.56M | 0.0% | N/A | 0.074% |  |
| 11/9/2024 | Landscape Capital Management L.L.C. | 12,643 | $0.26M | 0.0% | N/A | 0.037% |  |
| 10/29/2024 | Emerald Advisers LLC | 281,317 | $5.85M | 0.2% | N/A | 0.823% |  |
| 10/29/2024 | Emerald Mutual Fund Advisers Trust | 229,431 | $4.77M | 0.2% | N/A | 0.671% |  |