| 11/17/2025 | Susquehanna International Group LLP | 16,642 | $89K | 0.0% | N/A | 0.867% |  |
| 11/14/2025 | Shay Capital LLC | 15,958 | $85K | 0.0% | N/A | 0.831% |  |
| 11/14/2025 | Squarepoint Ops LLC | 14,836 | $79K | 0.0% | +19.8% | 0.773% |  |
| 8/15/2025 | Sofinnova Investments Inc. | 137,721 | $0.80M | 0.0% | -95.0% | 7.173% |  |
| 8/14/2025 | Vivo Capital LLC | 176,064 | $0.99M | 0.1% | -95.0% | 9.170% |  |
| 8/14/2025 | Nan Fung Group Holdings Ltd | 58,347 | $0.34M | 0.5% | -95.0% | 3.039% |  |
| 8/11/2025 | Pfizer Inc | 31,305 | $0.18M | 0.0% | -95.0% | 1.630% |  |
| 8/8/2025 | Geode Capital Management LLC | 18,533 | $0.11M | 0.0% | -95.1% | 0.965% |  |
| 7/31/2025 | Board of Trustees of The Leland Stanford Junior University | 35,978 | $0.21M | 0.0% | -95.0% | 1.874% |  |
| 2/17/2025 | Velan Capital Investment Management LP | 50,000 | $27K | 0.0% | N/A | 0.131% |  |
| 2/17/2025 | Squarepoint Ops LLC | 48,971 | $26K | 0.0% | N/A | 0.128% |  |
| 2/17/2025 | Millennium Management LLC | 47,025 | $25K | 0.0% | N/A | 0.123% |  |
| 2/17/2025 | Citadel Advisors LLC | 78,961 | $42K | 0.0% | N/A | 0.206% |  |
| 11/16/2024 | Geode Capital Management LLC | 352,426 | $0.23M | 0.0% | -5.0% | 0.921% |  |
| 11/13/2024 | FMR LLC | 115,386 | $75K | 0.0% | +33.2% | 0.302% |  |
| 8/9/2024 | Renaissance Technologies LLC | 276,739 | $0.21M | 0.0% | -46.5% | 0.726% |  |
| 8/5/2024 | Acuitas Investments LLC | 630,507 | $0.47M | 0.3% | +21.7% | 1.654% |  |
| 7/18/2024 | Assenagon Asset Management S.A. | 34,488 | $26K | 0.0% | N/A | 0.090% |  |
| 2/15/2024 | Board of Trustees of The Leland Stanford Junior University | 719,546 | $0.81M | 0.1% | -5.0% | 1.895% |  |
| 2/7/2024 | Vivo Capital LLC | 3,521,291 | $3.94M | 0.3% | -9.0% | 9.274% |  |
| 11/14/2023 | Newtyn Management LLC | 1,020,000 | $1.06M | 0.3% | +2.0% | 2.688% |  |
| 7/26/2023 | Privium Fund Management B.V. | 116,516 | $0.15M | 0.0% | N/A | 0.308% |  |
| 7/25/2023 | Assenagon Asset Management S.A. | 158,289 | $0.20M | 0.0% | -29.9% | 0.419% |  |
| 5/8/2023 | Bailard Inc. | 28,500 | $40K | 0.0% | N/A | 0.075% |  |
| 2/15/2023 | Tang Capital Management LLC | 400,000 | $0.52M | 0.1% | +100.0% | 1.062% |  |
| 2/14/2023 | Susquehanna International Group LLP | 20,307 | $26K | 0.0% | N/A | 0.054% |  |
| 2/8/2023 | Russell Investments Group Ltd. | 40,195 | $52K | 0.0% | -38.2% | 0.107% |  |
| 1/12/2023 | Assenagon Asset Management S.A. | 225,816 | $0.29M | 0.0% | -19.3% | 0.600% |  |
| 1/12/2023 | Marquette Asset Management LLC | 97,835 | $0.13M | 0.0% | +53.4% | 0.260% |  |
| 11/15/2022 | Caas Capital Management LP | 116,777 | $0.17M | 0.0% | N/A | 0.310% |  |
| 11/14/2022 | RA Capital Management L.P. | 533,432 | $0.79M | 0.0% | +18.5% | 1.417% |  |
| 11/14/2022 | Ergoteles LLC | 88,174 | $0.13M | 0.0% | -16.5% | 0.234% |  |
| 11/4/2022 | Russell Investments Group Ltd. | 64,995 | $96K | 0.0% | -32.4% | 0.173% |  |
| 11/1/2022 | Privium Fund Management UK Ltd | 116,516 | $0.17M | 0.2% | N/A | 0.310% |  |
| 10/18/2022 | Bailard Inc. | 46,383 | $69K | 0.0% | N/A | 0.123% |  |
| 7/29/2022 | Russell Investments Group Ltd. | 96,100 | $0.20M | 0.0% | N/A | 0.256% |  |
| 7/27/2022 | Assenagon Asset Management S.A. | 275,552 | $0.56M | 0.0% | N/A | 0.735% |  |
| 7/15/2022 | Marquette Asset Management LLC | 63,779 | $0.13M | 0.0% | N/A | 0.170% |  |
| 5/16/2022 | Echo Street Capital Management LLC | 123,804 | $5.49M | 0.0% | N/A | 0.330% |  |
| 5/11/2022 | GSA Capital Partners LLP | 54,038 | $0.15M | 0.0% | N/A | 0.144% |  |
| 5/9/2022 | Qube Research & Technologies Ltd | 19,611 | $54K | 0.0% | -57.0% | 0.052% |  |
| 2/19/2022 | Woodline Partners LP | 403,357 | $1.98M | 0.0% | +2.3% | 1.082% |  |
| 2/14/2022 | Suvretta Capital Management LLC | 2,230,250 | $10.93M | 0.2% | +68.3% | 5.982% |  |
| 2/14/2022 | Eventide Asset Management LLC | 1,449,494 | $7.10M | 0.1% | +171.4% | 3.888% |  |
| 2/11/2022 | Ensign Peak Advisors Inc | 18,500 | $91K | 0.0% | -36.0% | 0.050% |  |
| 2/10/2022 | Qube Research & Technologies Ltd | 45,640 | $0.22M | 0.0% | +204.2% | 0.122% |  |
| 2/8/2022 | ProShare Advisors LLC | 10,249 | $50K | 0.0% | N/A | 0.027% |  |
| 2/8/2022 | Northern Trust Corp | 194,893 | $0.96M | 0.0% | +4.3% | 0.523% |  |
| 2/7/2022 | SG Americas Securities LLC | 10,490 | $51K | 0.0% | -25.5% | 0.028% |  |
| 2/2/2022 | New York State Common Retirement Fund | 10,388 | $51K | 0.0% | +129.5% | 0.028% |  |
| 2/1/2022 | Qube Research & Technologies Ltd | 45,640 | $0.22M | 0.0% | +204.2% | 0.122% |  |
| 11/16/2021 | Suvretta Capital Management LLC | 1,325,500 | $16.77M | 0.3% | +38.9% | 3.555% |  |
| 11/16/2021 | Metropolitan Life Insurance Co NY | 7,197 | $91K | 0.0% | N/A | 0.019% |  |
| 11/16/2021 | Citadel Advisors LLC | 2,879,713 | $36.43M | 0.0% | -2.7% | 7.724% |  |
| 11/15/2021 | Point72 Asset Management L.P. | 93,960 | $1.19M | 0.0% | N/A | 0.252% |  |
| 11/15/2021 | Point72 Hong Kong Ltd | 2,094 | $26K | 0.0% | N/A | 0.006% |  |
| 11/15/2021 | California State Teachers Retirement System | 23,230 | $0.29M | 0.0% | +45.6% | 0.062% |  |
| 11/15/2021 | Rock Springs Capital Management LP | 1,649,248 | $20.86M | 0.4% | +1.9% | 4.423% |  |
| 11/15/2021 | Sectoral Asset Management Inc | 115,925 | $1.47M | 0.1% | -54.7% | 0.311% |  |
| 11/15/2021 | Ensign Peak Advisors Inc | 28,909 | $0.37M | 0.0% | +189.1% | 0.078% |  |
| 11/12/2021 | Renaissance Technologies LLC | 79,300 | $1M | 0.0% | +31.1% | 0.213% |  |
| 11/12/2021 | The Manufacturers Life Insurance Company | 11,017 | $0.14M | 0.0% | N/A | 0.030% |  |
| 11/12/2021 | Geode Capital Management LLC | 345,115 | $4.37M | 0.0% | +64.2% | 0.928% |  |
| 11/10/2021 | Goldman Sachs Group Inc. | 442,766 | $5.60M | 0.0% | +0.2% | 1.190% |  |
| 11/10/2021 | Citigroup Inc. | 2,842 | $36K | 0.0% | +262.0% | 0.008% |  |
| 11/9/2021 | BlackRock Inc. | 1,454,527 | $18.40M | 0.0% | +54.4% | 3.910% |  |
| 11/4/2021 | Deutsche Bank AG | 19,362 | $0.24M | 0.0% | +181.1% | 0.052% |  |
| 11/3/2021 | Dupont Capital Management Corp | 26,748 | $0.34M | 0.0% | N/A | 0.072% |  |
| 11/2/2021 | New York State Common Retirement Fund | 4,526 | $57K | 0.0% | -60.7% | 0.012% |  |
| 11/1/2021 | SG Americas Securities LLC | 14,079 | $0.18M | 0.0% | N/A | 0.038% |  |
| 8/16/2021 | Morgan Stanley | 276,334 | $4.27M | 0.0% | +5,729.8% | 0.760% |  |