| 2/18/2026 | ADAR1 Capital Management LLC | 606,000 | $7.19M | 0.5% | N/A | 4.362% |  |
| 2/18/2026 | Vestal Point Capital LP | 1,500,000 | $17.79M | 0.6% | N/A | 10.797% |  |
| 2/18/2026 | Tang Capital Management LLC | 872,398 | $10.35M | 0.5% | +28.3% | 6.279% |  |
| 2/18/2026 | Quadrature Capital Ltd | 13,246 | $0.16M | 0.0% | N/A | 0.095% |  |
| 2/18/2026 | RTW Investments LP | 372,856 | $4.42M | 0.0% | N/A | 2.684% |  |
| 2/18/2026 | Opaleye Management Inc. | 1,178,300 | $13.98M | 1.8% | N/A | 8.483% |  |
| 2/18/2026 | Millennium Management LLC | 61,882 | $0.73M | 0.0% | N/A | 0.446% |  |
| 2/18/2026 | Moore Capital Management LP | 25,000 | $0.30M | 0.0% | N/A | 0.180% |  |
| 2/18/2026 | Balyasny Asset Management L.P. | 111,715 | $1.33M | 0.0% | N/A | 0.804% |  |
| 2/18/2026 | BVF Inc. IL | 2,748,763 | $32.60M | 1.1% | +98.1% | 19.790% |  |
| 2/17/2026 | ADAR1 Capital Management LLC | 606,000 | $7.19M | 0.5% | N/A | 4.363% |  |
| 2/17/2026 | Burkehill Global Management LP | 74,000 | $0.84M | 0.1% | N/A | 0.533% |  |
| 2/17/2026 | Heights Capital Management Inc. | 264,000 | $3.13M | 1.1% | N/A | 1.901% |  |
| 2/17/2026 | Price T Rowe Associates Inc. MD | 338,125 | $4.01M | 0.0% | -11.9% | 2.434% |  |
| 2/17/2026 | Fcpm Iii Services B.V. | 1,677,852 | $19.90M | 2.6% | N/A | 12.080% |  |
| 2/16/2026 | OMERS ADMINISTRATION Corp | 11,600 | $0.14M | 0.0% | N/A | 0.084% |  |
| 2/16/2026 | NEXTBio Capital Management LP | 372,856 | $4.42M | 2.6% | N/A | 2.684% |  |
| 2/13/2026 | Marshall Wace LLP | 21,826 | $0.26M | 0.0% | -50.0% | 0.157% |  |
| 2/13/2026 | Alyeska Investment Group L.P. | 264,000 | $3.11M | 0.0% | N/A | 1.901% |  |
| 2/13/2026 | State Street Corp | 26,217 | $0.31M | 0.0% | +40.8% | 0.189% |  |
| 2/12/2026 | Jane Street Group LLC | 22,965 | $0.27M | 0.0% | N/A | 0.165% |  |
| 2/12/2026 | HRT Financial LP | 13,083 | $0.16M | 0.0% | N/A | 0.094% |  |
| 2/12/2026 | Renaissance Technologies LLC | 46,700 | $0.55M | 0.0% | +73.6% | 0.336% |  |
| 2/10/2026 | Goldman Sachs Group Inc. | 25,245 | $0.30M | 0.0% | -31.7% | 0.182% |  |
| 2/9/2026 | Geode Capital Management LLC | 91,079 | $1.08M | 0.0% | +31.7% | 0.656% |  |
| 2/9/2026 | Jefferies Financial Group Inc. | 64,244 | $0.76M | 0.0% | -37.5% | 0.462% |  |
| 11/17/2025 | Citadel Advisors LLC | 25,593 | $0.30M | 0.0% | N/A | 0.184% |  |
| 11/17/2025 | Commodore Capital LP | 450,829 | $5.36M | 0.3% | -0.6% | 3.245% |  |
| 11/17/2025 | Bank of America Corp DE | 3,863 | $46K | 0.0% | -58.2% | 0.028% |  |
| 11/14/2025 | Two Sigma Investments LP | 28,318 | $0.34M | 0.0% | N/A | 0.204% |  |
| 11/13/2025 | Jefferies Financial Group Inc. | 102,714 | $1.22M | 0.0% | +279.1% | 0.739% |  |
| 11/7/2025 | Vanguard Group Inc. | 657,900 | $7.82M | 0.0% | N/A | 3.365% |  |
| 8/15/2025 | Soleus Capital Management L.P. | 400,000 | $6.46M | 0.4% | N/A | 2.046% |  |
| 8/15/2025 | Perceptive Advisors LLC | 453,686 | $7.32M | 0.7% | N/A | 2.321% |  |
| 8/15/2025 | Frazier Life Sciences Management L.P. | 453,685 | $7.32M | 0.3% | N/A | 2.321% |  |
| 8/15/2025 | Braidwell LP | 261,504 | $4.22M | 0.1% | N/A | 1.338% |  |
| 8/15/2025 | BVF Inc. IL | 1,387,863 | $22.40M | 0.8% | N/A | 7.099% |  |
| 8/15/2025 | Bank of America Corp DE | 9,231 | $0.15M | 0.0% | N/A | 0.047% |  |
| 8/15/2025 | Adage Capital Partners GP L.L.C. | 100,912 | $1.63M | 0.0% | N/A | 0.516% |  |
| 8/14/2025 | Commodore Capital LP | 453,686 | $7.32M | 0.5% | N/A | 2.321% |  |
| 8/13/2025 | Affinity Asset Advisors LLC | 280,031 | $4.52M | 0.6% | N/A | 1.432% |  |
| 8/12/2025 | Jefferies Financial Group Inc. | 27,096 | $0.44M | 0.0% | N/A | 0.139% |  |
| 8/7/2023 | Acadian Asset Management LLC | 144,028 | $50K | 0.0% | -44.5% | 0.381% |  |
| 2/15/2023 | Nantahala Capital Management LLC | 438,055 | $0.23M | 0.0% | -82.9% | 1.392% |  |
| 11/10/2022 | Nantahala Capital Management LLC | 2,554,735 | $1.29M | 0.1% | -7.3% | 8.116% |  |
| 11/7/2022 | Virtu Financial LLC | 189,175 | $95K | 0.0% | +250.5% | 0.601% |  |
| 8/15/2022 | Nantahala Capital Management LLC | 2,755,903 | $4.91M | 0.2% | +13.8% | 8.755% |  |
| 8/13/2022 | Virtu Financial LLC | 53,977 | $96K | 0.0% | N/A | 0.171% |  |
| 2/10/2022 | Acadian Asset Management LLC | 232,400 | $0.21M | 0.0% | N/A | 0.740% |  |
| 2/8/2022 | Raymond James & Associates | 32,800 | $30K | 0.0% | -74.7% | 0.104% |  |
| 2/1/2022 | Assenagon Asset Management S.A. | 512,643 | $0.47M | 0.0% | N/A | 1.632% |  |
| 11/16/2021 | Squarepoint Ops LLC | 25,527 | $0.11M | 0.0% | -45.8% | 0.081% |  |
| 11/16/2021 | Two Sigma Advisers LP | 107,000 | $0.44M | 0.0% | -30.0% | 0.341% |  |
| 11/16/2021 | Millennium Management LLC | 671,224 | $2.76M | 0.0% | -14.8% | 2.140% |  |
| 11/15/2021 | Dimensional Fund Advisors LP | 801,440 | $3.29M | 0.0% | -13.4% | 2.555% |  |
| 11/12/2021 | Geode Capital Management LLC | 351,541 | $1.44M | 0.0% | +5.7% | 1.121% |  |
| 11/10/2021 | Goldman Sachs Group Inc. | 160,701 | $0.66M | 0.0% | -38.4% | 0.512% |  |
| 11/9/2021 | BlackRock Inc. | 270,718 | $1.11M | 0.0% | -4.3% | 0.863% |  |