| 12/1/2025 | Cantor Fitzgerald L. P. | 80,000 | $0.28M | 0.0% | -20.0% | 0.045% |  |
| 11/21/2025 | CIBC Bancorp USA Inc. | 10,600 | $37K | 0.0% | N/A | 0.006% |  |
| 11/17/2025 | Vivo Capital LLC | 9,545,466 | $33.41M | 2.7% | +57.9% | 5.367% |  |
| 11/17/2025 | Sig Brokerage LP | 26,365 | $92K | 0.0% | -27.6% | 0.015% |  |
| 11/17/2025 | Millennium Management LLC | 3,237,572 | $11.33M | 0.0% | +280.4% | 1.820% |  |
| 11/17/2025 | Focus Partners Wealth | 15,805 | $56K | 0.0% | +16.2% | 0.009% |  |
| 11/17/2025 | Citadel Advisors LLC | 233,271 | $0.82M | 0.0% | -1,981.2% | 0.131% |  |
| 11/17/2025 | Brevan Howard Capital Management LP | 45,877 | $0.16M | 0.0% | N/A | 0.026% |  |
| 11/17/2025 | Bank of America Corp DE | 73,801 | $0.26M | 0.0% | +126.7% | 0.041% |  |
| 11/17/2025 | Cantor Fitzgerald L. P. | 80,000 | $0.28M | 0.0% | -20.0% | 0.045% |  |
| 11/17/2025 | Caxton Corp | 53,503 | $0.19M | 0.8% | +23.1% | 0.030% |  |
| 11/17/2025 | Alliancebernstein L.P. | 104,160 | $0.37M | 0.0% | -10.7% | 0.059% |  |
| 11/14/2025 | Creative Planning | 60,927 | $0.21M | 0.0% | +430.5% | 0.034% |  |
| 11/14/2025 | Schonfeld Strategic Advisors LLC | 476,291 | $1.67M | 0.0% | N/A | 0.268% |  |
| 11/14/2025 | Virtu Financial LLC | 12,681 | $44K | 0.0% | N/A | 0.009% |  |
| 11/14/2025 | Burkehill Global Management LP | 700,000 | $2.45M | 0.1% | N/A | 0.506% |  |
| 11/14/2025 | ADAR1 Capital Management LLC | 50,000 | $0.18M | 0.0% | +100.0% | 0.036% |  |
| 11/14/2025 | Acuta Capital Partners LLC | 840,090 | $2.94M | 3.0% | N/A | 0.608% |  |
| 11/14/2025 | Balyasny Asset Management L.P. | 2,826,362 | $9.89M | 0.0% | N/A | 2.044% |  |
| 11/14/2025 | Squarepoint Ops LLC | 87,853 | $0.31M | 0.0% | +322.9% | 0.064% |  |
| 11/14/2025 | Suvretta Capital Management LLC | 14,101,159 | $49.35M | 1.3% | +97.2% | 10.197% |  |
| 11/13/2025 | UBS Group AG | 198,271 | $0.69M | 0.0% | -24.8% | 0.143% |  |
| 11/13/2025 | BNP Paribas Financial Markets | 19,523 | $68K | 0.0% | +105.8% | 0.014% |  |
| 11/13/2025 | Russell Investments Group Ltd. | 7,785 | $27K | 0.0% | +3,933.7% | 0.006% |  |
| 11/13/2025 | CM Management LLC | 150,000 | $0.53M | 0.4% | N/A | 0.108% |  |
| 11/12/2025 | Barclays PLC | 222,418 | $0.78M | 0.0% | -8.0% | 0.161% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 175,556 | $0.62M | 0.0% | +1.9% | 0.127% |  |
| 11/12/2025 | Victory Capital Management Inc. | 12,652 | $44K | 0.0% | +20.6% | 0.009% |  |
| 11/12/2025 | Monashee Investment Management LLC | 1,250,000 | $4.38M | 2.2% | +657.6% | 0.904% |  |
| 11/12/2025 | Rafferty Asset Management LLC | 70,959 | $0.25M | 0.0% | N/A | 0.051% |  |
| 11/12/2025 | Intech Investment Management LLC | 38,936 | $0.14M | 0.0% | -12.0% | 0.028% |  |
| 11/7/2025 | Vanguard Group Inc. | 7,062,799 | $24.72M | 0.0% | +45.6% | 5.108% |  |
| 11/7/2025 | JPMorgan Chase & Co. | 1,999,278 | $7M | 0.0% | -5.9% | 1.446% |  |
| 11/6/2025 | Rhumbline Advisers | 139,313 | $0.49M | 0.0% | +22.8% | 0.101% |  |
| 11/6/2025 | Profund Advisors LLC | 16,468 | $58K | 0.0% | N/A | 0.012% |  |
| 11/5/2025 | Alps Advisors Inc. | 83,007 | $0.29M | 0.0% | +11.3% | 0.060% |  |
| 11/4/2025 | Welch & Forbes LLC | 15,000 | $52K | 0.0% | N/A | 0.011% |  |
| 10/30/2025 | Simplicity Wealth LLC | 37,034 | $0.13M | 0.0% | -56.2% | 0.027% |  |
| 10/23/2025 | SG Americas Securities LLC | 149,313 | $0.52M | 0.0% | -59.9% | 0.108% |  |
| 10/17/2025 | Apollon Wealth Management LLC | 10,015 | $35K | 0.0% | N/A | 0.007% |  |
| 10/9/2025 | Voya Investment Management LLC | 17,214 | $60K | 0.0% | -36.6% | 0.012% |  |
| 8/19/2025 | Marex Group plc | 23,600 | $61K | 0.0% | N/A | 0.017% |  |
| 8/15/2025 | Bank of America Corp DE | 32,549 | $85K | 0.0% | -91.5% | 0.024% |  |
| 8/15/2025 | Adage Capital Partners GP L.L.C. | 4,424,868 | $11.51M | 0.0% | +11.3% | 3.200% |  |
| 8/14/2025 | MPM Bioimpact LLC | 5,622,505 | $14.62M | 2.5% | -33.4% | 4.066% |  |
| 8/14/2025 | Orbimed Advisors LLC | 15,219,994 | $39.57M | 1.1% | -31.9% | 11.006% |  |
| 8/14/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 50,164 | $0.13M | 0.0% | -17.8% | 0.036% |  |
| 8/14/2025 | The Manufacturers Life Insurance Company | 35,553 | $92K | 0.0% | -10.0% | 0.026% |  |
| 8/14/2025 | Vivo Capital LLC | 6,043,466 | $15.71M | 1.6% | +70.0% | 4.370% |  |
| 8/13/2025 | Invesco Ltd. | 58,735 | $0.15M | 0.0% | +58.1% | 0.042% |  |
| 8/13/2025 | Panagora Asset Management Inc. | 15,840 | $41K | 0.0% | -90.7% | 0.011% |  |
| 8/12/2025 | XTX Topco Ltd | 32,415 | $84K | 0.0% | N/A | 0.023% |  |
| 8/12/2025 | American Century Companies Inc. | 27,607 | $72K | 0.0% | -62.5% | 0.020% |  |
| 8/12/2025 | Rhumbline Advisers | 113,487 | $0.30M | 0.0% | -5.5% | 0.082% |  |
| 8/12/2025 | JPMorgan Chase & Co. | 2,125,717 | $5.53M | 0.0% | -2.7% | 1.537% |  |
| 8/8/2025 | Intech Investment Management LLC | 44,223 | $0.12M | 0.0% | -43.5% | 0.032% |  |
| 8/8/2025 | Creative Planning | 11,484 | $30K | 0.0% | N/A | 0.008% |  |
| 8/8/2025 | SG Americas Securities LLC | 372,681 | $0.97M | 0.0% | -60.4% | 0.270% |  |
| 8/8/2025 | Geode Capital Management LLC | 2,319,132 | $6.03M | 0.0% | -1.9% | 1.677% |  |
| 7/25/2025 | Sequoia Financial Advisors LLC | 16,485 | $43K | 0.0% | -41.0% | 0.012% |  |
| 7/22/2025 | Simplicity Wealth LLC | 84,636 | $0.22M | 0.0% | +81.8% | 0.061% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 233,522 | $0.44M | 0.0% | -40.2% | 0.169% |  |
| 5/29/2025 | Rhumbline Advisers | 120,029 | $0.23M | 0.0% | -7.0% | 0.087% |  |
| 5/28/2025 | Strs Ohio | 17,900 | $34K | 0.0% | N/A | 0.013% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 233,522 | $0.44M | 0.0% | -40.2% | 0.169% |  |
| 5/16/2025 | Adage Capital Partners GP L.L.C. | 3,975,000 | $7.55M | 0.0% | -33.7% | 2.875% |  |
| 5/15/2025 | Birchview Capital LP | 24,000 | $46K | 0.0% | N/A | 0.017% |  |
| 5/15/2025 | MPM Bioimpact LLC | 8,442,783 | $16.04M | 2.8% | -1.5% | 6.105% |  |
| 5/15/2025 | Baker BROS. Advisors LP | 547,498 | $1.04M | 0.0% | -64.9% | 0.396% |  |
| 5/15/2025 | Propel Bio Management LLC | 228,317 | $0.43M | 0.5% | N/A | 0.165% |  |
| 5/14/2025 | MetLife Investment Management LLC | 37,167 | $71K | 0.0% | -41.1% | 0.027% |  |
| 5/14/2025 | Walleye Trading LLC | 25,000 | $48K | 0.0% | N/A | 0.018% |  |
| 5/14/2025 | Walleye Capital LLC | 52,478 | $100K | 0.0% | N/A | 0.038% |  |
| 5/14/2025 | Wellington Management Group LLP | 222,505 | $0.42M | 0.0% | N/A | 0.161% |  |
| 5/13/2025 | American Century Companies Inc. | 73,682 | $0.14M | 0.0% | N/A | 0.053% |  |
| 5/12/2025 | Nuveen LLC | 304,504 | $0.58M | 0.0% | N/A | 0.220% |  |
| 5/9/2025 | Deutsche Bank AG | 102,041 | $0.19M | 0.0% | N/A | 0.074% |  |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 297,880 | $0.57M | 0.0% | +4.1% | 0.215% |  |
| 5/1/2025 | New York State Common Retirement Fund | 30,407 | $58K | 0.0% | -20.4% | 0.022% |  |
| 4/29/2025 | Bank of New York Mellon Corp | 243,565 | $0.46M | 0.0% | +2.3% | 0.176% |  |
| 4/28/2025 | Vontobel Holding Ltd. | 29,882 | $57K | 0.0% | N/A | 0.022% |  |
| 4/21/2025 | Catalina Capital Group LLC | 16,938 | $32K | 0.0% | -65.4% | 0.012% |  |
| 4/17/2025 | Exchange Traded Concepts LLC | 54,207 | $0.10M | 0.0% | -44.6% | 0.039% |  |
| 4/15/2025 | SG Americas Securities LLC | 940,784 | $1.79M | 0.0% | +138.2% | 0.680% |  |
| 4/15/2025 | Simplicity Wealth LLC | 46,543 | $88K | 0.0% | N/A | 0.034% |  |
| 4/8/2025 | Rhumbline Advisers | 120,029 | $0.23M | 0.0% | -7.0% | 0.087% |  |
| 2/17/2025 | Squarepoint Ops LLC | 24,072 | $35K | 0.0% | N/A | 0.017% |  |
| 2/17/2025 | Two Sigma Advisers LP | 51,000 | $74K | 0.0% | -41.0% | 0.037% |  |
| 2/17/2025 | Two Sigma Investments LP | 145,238 | $0.21M | 0.0% | -24.8% | 0.106% |  |
| 2/17/2025 | Tang Capital Management LLC | 5,900,000 | $8.56M | 0.6% | +225.4% | 4.288% |  |
| 2/17/2025 | ProShare Advisors LLC | 28,722 | $42K | 0.0% | +49.0% | 0.021% |  |
| 2/17/2025 | MPM Bioimpact LLC | 8,567,896 | $12.42M | 1.8% | +51.9% | 6.227% |  |
| 2/17/2025 | Millennium Management LLC | 33,857 | $49K | 0.0% | -80.0% | 0.025% |  |
| 2/17/2025 | Enavate Sciences GP LLC | 7,788,150 | $11.29M | 8.1% | N/A | 5.660% |  |
| 2/17/2025 | DAFNA Capital Management LLC | 158,394 | $0.23M | 0.1% | +35.5% | 0.115% |  |
| 2/17/2025 | Cantor Fitzgerald L. P. | 100,000 | $0.15M | 0.0% | -44.4% | 0.073% |  |
| 2/17/2025 | Bank of America Corp DE | 113,020 | $0.16M | 0.0% | +36.6% | 0.082% |  |
| 2/17/2025 | BNP Paribas Financial Markets | 18,562 | $27K | 0.0% | N/A | 0.013% |  |
| 2/14/2025 | Monashee Investment Management LLC | 448,164 | $0.65M | 0.1% | -10.4% | 0.326% |  |
| 2/14/2025 | Northern Trust Corp | 801,225 | $1.16M | 0.0% | -5.1% | 0.582% |  |