| 11/17/2025 | Qube Research & Technologies Ltd | 82,111 | $80K | 0.0% | -23.1% | 0.089% |  |
| 11/17/2025 | Nantahala Capital Management LLC | 1,661,950 | $1.61M | 0.1% | -14.1% | 1.809% |  |
| 11/17/2025 | Citadel Advisors LLC | 103,363 | $100K | 0.0% | N/A | 0.112% |  |
| 11/7/2025 | Vanguard Group Inc. | 3,495,031 | $3.39M | 0.0% | +4.0% | 3.896% |  |
| 10/23/2025 | Clear Harbor Asset Management LLC | 92,804 | $90K | 0.0% | +60.5% | 0.103% |  |
| 8/14/2025 | Qube Research & Technologies Ltd | 106,779 | $70K | 0.0% | -38.7% | 0.119% |  |
| 8/13/2025 | Affinity Asset Advisors LLC | 518,025 | $0.34M | 0.0% | -21.6% | 0.578% |  |
| 8/13/2025 | Walleye Capital LLC | 132,786 | $87K | 0.0% | -21.4% | 0.148% |  |
| 5/16/2025 | Ally Bridge Group NY LLC | 1,157,448 | $0.71M | 0.6% | -26.6% | 1.290% |  |
| 5/15/2025 | Landscape Capital Management L.L.C. | 41,216 | $25K | 0.0% | -54.2% | 0.046% |  |
| 5/14/2025 | Affinity Asset Advisors LLC | 660,589 | $0.40M | 0.0% | -34.9% | 0.736% |  |
| 2/17/2025 | Velan Capital Investment Management LP | 90,000 | $94K | 0.1% | -93.0% | 0.120% |  |
| 2/17/2025 | Shay Capital LLC | 50,000 | $52K | 0.0% | N/A | 0.067% |  |
| 2/17/2025 | MPM Bioimpact LLC | 14,705,882 | $15.44M | 2.2% | N/A | 19.608% |  |
| 2/17/2025 | Millennium Management LLC | 178,718 | $0.19M | 0.0% | +24.2% | 0.238% |  |
| 2/17/2025 | Citadel Advisors LLC | 29,900 | $31K | 0.0% | N/A | 0.040% |  |
| 2/17/2025 | Allostery Investments LP | 950,166 | $1M | 1.0% | N/A | 1.267% |  |
| 2/17/2025 | Ally Bridge Group NY LLC | 1,576,762 | $1.66M | 1.4% | -10.3% | 2.102% |  |
| 2/14/2025 | Jane Street Group LLC | 27,395 | $29K | 0.0% | N/A | 0.037% |  |
| 2/14/2025 | Northern Trust Corp | 113,565 | $0.12M | 0.0% | -34.2% | 0.151% |  |
| 2/14/2025 | Blue Owl Capital Holdings LP | 6,357,928 | $6.68M | 1.6% | +17.5% | 8.477% |  |
| 2/13/2025 | Marshall Wace LLP | 203,286 | $0.21M | 0.0% | N/A | 0.271% |  |
| 2/13/2025 | Affinity Asset Advisors LLC | 1,015,340 | $1.07M | 0.1% | -23.1% | 1.354% |  |
| 2/13/2025 | Walleye Capital LLC | 166,306 | $0.18M | 0.0% | +51.7% | 0.222% |  |
| 2/13/2025 | Renaissance Technologies LLC | 338,435 | $0.36M | 0.0% | +412.8% | 0.451% |  |
| 2/13/2025 | ADAR1 Capital Management LLC | 351,094 | $0.37M | 0.1% | -6.1% | 0.468% |  |
| 2/12/2025 | Landscape Capital Management L.L.C. | 90,000 | $94K | 0.0% | N/A | 0.120% |  |
| 2/12/2025 | Geode Capital Management LLC | 628,729 | $0.66M | 0.0% | +9.2% | 0.838% |  |
| 2/12/2025 | Franklin Resources Inc. | 4,003,380 | $4.20M | 0.0% | +115.9% | 5.338% |  |
| 1/17/2025 | Clear Harbor Asset Management LLC | 57,804 | $61K | 0.0% | +60.6% | 0.077% |  |
| 11/27/2024 | Franklin Resources Inc. | 1,853,988 | $3.69M | 0.0% | N/A | 2.472% |  |
| 11/16/2024 | Geode Capital Management LLC | 575,899 | $1.13M | 0.0% | -6.8% | 0.768% |  |
| 11/15/2024 | Y Intercept Hong Kong Ltd | 45,635 | $89K | 0.0% | N/A | 0.061% |  |
| 11/15/2024 | State Street Corp | 111,907 | $0.22M | 0.0% | +21.5% | 0.149% |  |
| 11/14/2024 | Ally Bridge Group NY LLC | 1,757,524 | $3.45M | 1.8% | -6.8% | 2.343% |  |
| 11/13/2024 | Great Point Partners LLC | 6,934,982 | $13.59M | 4.0% | -6.5% | 9.247% |  |
| 8/20/2024 | Nantahala Capital Management LLC | 1,935,484 | $3.88M | 0.2% | N/A | 2.581% |  |
| 8/16/2024 | Driehaus Capital Management LLC | 2,258,065 | $4.53M | 0.0% | N/A | 3.011% |  |
| 8/15/2024 | Blue Owl Capital Holdings LP | 5,161,290 | $10.35M | 2.9% | N/A | 6.882% |  |
| 8/15/2024 | Affinity Asset Advisors LLC | 1,619,140 | $3.25M | 0.4% | +392.4% | 2.159% |  |
| 8/14/2024 | Great Point Partners LLC | 7,419,355 | $14.88M | 2.8% | N/A | 9.893% |  |
| 8/14/2024 | Ally Bridge Group NY LLC | 1,886,232 | $3.78M | 2.3% | +159.8% | 2.515% |  |
| 8/9/2024 | Renaissance Technologies LLC | 65,200 | $0.13M | 0.0% | +63.4% | 0.087% |  |
| 5/29/2024 | Opaleye Management Inc. | 1,108,357 | $1.53M | 0.3% | +13.7% | 1.478% |  |
| 2/15/2024 | Opaleye Management Inc. | 975,000 | $1.10M | 0.3% | N/A | 6.107% |  |
| 11/15/2023 | Affinity Asset Advisors LLC | 328,817 | $0.50M | 0.1% | +22.9% | 2.059% |  |
| 8/21/2023 | Affinity Asset Advisors LLC | 267,574 | $0.43M | 0.1% | N/A | 1.675% |  |
| 7/21/2023 | Clear Harbor Asset Management LLC | 36,000 | $58K | 0.0% | N/A | 0.225% |  |
| 2/16/2023 | AIGH Capital Management LLC | 1,143,745 | $0.75M | 0.2% | -11.5% | 7.162% |  |
| 2/14/2023 | swisspartners Ltd. | 180,000 | $0.12M | 0.2% | +111.8% | 1.127% |  |
| 11/14/2022 | Worth Venture Partners LLC | 322,628 | $0.36M | 0.2% | +8.4% | 2.021% |  |
| 11/1/2022 | swisspartners Ltd. | 85,000 | $94K | 0.1% | +101.3% | 0.532% |  |
| 8/13/2022 | Virtu Financial LLC | 46,445 | $98K | 0.0% | N/A | 0.291% |  |
| 8/12/2022 | Affinity Asset Advisors LLC | 883,654 | $1.87M | 0.8% | +13.6% | 5.535% |  |
| 5/4/2022 | swisspartners Ltd. | 14,315 | $4.98M | 3.5% | -66.1% | 0.090% |  |
| 2/14/2022 | Altium Capital Management LP | 493,531 | $1.31M | 0.4% | N/A | 4.501% |  |
| 2/11/2022 | QCM Cayman Ltd. | 14,041 | $37K | 0.2% | N/A | 0.128% |  |
| 2/10/2022 | AIGH Capital Management LLC | 762,721 | $2.03M | 0.6% | N/A | 6.955% |  |
| 2/9/2022 | swisspartners Ltd. | 42,235 | $0.11M | 0.1% | N/A | 0.385% |  |