| 11/17/2025 | Woodline Partners LP | 224,190 | $3.64M | 0.0% | -79.6% | 0.212% |  |
| 11/17/2025 | Qube Research & Technologies Ltd | 555,713 | $9.01M | 0.0% | +11.2% | 0.525% |  |
| 11/17/2025 | RA Capital Management L.P. | 10,428,437 | $169.15M | 2.1% | +5.3% | 9.850% |  |
| 11/17/2025 | Prelude Capital Management LLC | 49,205 | $0.80M | 0.1% | +26.8% | 0.046% |  |
| 11/17/2025 | Paradigm Biocapital Advisors LP | 6,170,131 | $100.08M | 2.8% | +0.5% | 5.828% |  |
| 11/17/2025 | Parkman Healthcare Partners LLC | 550,173 | $8.92M | 0.9% | -15.0% | 0.520% |  |
| 11/17/2025 | Millennium Management LLC | 725,425 | $11.77M | 0.0% | -21.3% | 0.685% |  |
| 11/17/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 31,350 | $0.51M | 0.0% | -21.6% | 0.030% |  |
| 11/17/2025 | HighVista Strategies LLC | 208,101 | $3.38M | 0.8% | +198.5% | 0.197% |  |
| 11/17/2025 | Granahan Investment Management LLC | 339,617 | $5.51M | 0.2% | -16.2% | 0.321% |  |
| 11/17/2025 | First Light Asset Management LLC | 1,414,994 | $22.95M | 2.2% | -17.4% | 1.337% |  |
| 11/17/2025 | Bank of America Corp DE | 321,132 | $5.21M | 0.0% | +26.2% | 0.303% |  |
| 11/17/2025 | Algert Global LLC | 40,963 | $0.66M | 0.0% | +18.0% | 0.039% |  |
| 11/14/2025 | Schonfeld Strategic Advisors LLC | 51,989 | $0.84M | 0.0% | -68.9% | 0.049% |  |
| 11/14/2025 | Creative Planning | 18,036 | $0.29M | 0.0% | +6.7% | 0.017% |  |
| 11/14/2025 | Raymond James Financial Inc. | 13,379 | $0.22M | 0.0% | +758.7% | 0.013% |  |
| 11/14/2025 | Deerfield Management Company L.P. | 765,694 | $12.42M | 0.2% | -63.0% | 0.723% |  |
| 11/14/2025 | California State Teachers Retirement System | 50,793 | $0.82M | 0.0% | +37.7% | 0.048% |  |
| 11/14/2025 | UBS AM A Distinct Business Unit of UBS Asset Management Americas LLC | 139,112 | $2.26M | 0.0% | -27.4% | 0.131% |  |
| 11/14/2025 | Two Sigma Investments LP | 26,266 | $0.43M | 0.0% | N/A | 0.025% |  |
| 11/14/2025 | Squarepoint Ops LLC | 75,276 | $1.22M | 0.0% | N/A | 0.071% |  |
| 11/14/2025 | Integral Health Asset Management LLC | 1,500,000 | $24.33M | 1.6% | +50.0% | 1.417% |  |
| 11/14/2025 | Glenmede Investment Management LP | 11,137 | $0.18M | 0.0% | -11.2% | 0.011% |  |
| 11/13/2025 | Kennedy Capital Management LLC | 250,622 | $4.07M | 0.1% | -0.8% | 0.237% |  |
| 11/13/2025 | Sei Investments Co. | 39,095 | $0.63M | 0.0% | -10.4% | 0.037% |  |
| 11/13/2025 | UBS Group AG | 114,128 | $1.85M | 0.0% | -33.3% | 0.108% |  |
| 11/13/2025 | BNP Paribas Financial Markets | 14,297 | $0.23M | 0.0% | +74.5% | 0.014% |  |
| 11/13/2025 | Franklin Resources Inc. | 48,220 | $0.78M | 0.0% | +5.3% | 0.046% |  |
| 11/13/2025 | Legal & General Group Plc | 55,941 | $0.91M | 0.0% | +6.9% | 0.053% |  |
| 11/13/2025 | Russell Investments Group Ltd. | 7,190 | $0.12M | 0.0% | +29,858.3% | 0.007% |  |
| 11/12/2025 | Barclays PLC | 234,650 | $3.81M | 0.0% | -16.6% | 0.222% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 1,183,136 | $19.19M | 0.0% | +12.8% | 1.118% |  |
| 11/12/2025 | Victory Capital Management Inc. | 498,646 | $8.09M | 0.0% | +12.6% | 0.471% |  |
| 11/12/2025 | American Century Companies Inc. | 1,095,473 | $17.77M | 0.0% | +39.9% | 1.035% |  |
| 11/12/2025 | Handelsbanken Fonder AB | 38,400 | $0.62M | 0.0% | +33.8% | 0.036% |  |
| 11/12/2025 | Artisan Partners Limited Partnership | 718,175 | $11.65M | 0.0% | -47.9% | 0.678% |  |
| 11/12/2025 | Intech Investment Management LLC | 29,179 | $0.47M | 0.0% | -33.8% | 0.028% |  |
| 11/12/2025 | Fox Run Management L.L.C. | 20,471 | $0.33M | 0.1% | N/A | 0.019% |  |
| 11/10/2025 | Quantum Private Wealth LLC | 105,874 | $1.72M | 0.5% | +5.1% | 0.100% |  |
| 11/10/2025 | Ameritas Investment Partners Inc. | 5,638 | $91K | 0.0% | -25.8% | 0.005% |  |
| 11/10/2025 | Citigroup Inc. | 538,453 | $8.73M | 0.0% | -25.7% | 0.509% |  |
| 11/10/2025 | China Universal Asset Management Co. Ltd. | 18,466 | $0.30M | 0.0% | -12.6% | 0.017% |  |
| 11/7/2025 | GSA Capital Partners LLP | 113,243 | $1.84M | 0.2% | +315.2% | 0.107% |  |
| 11/7/2025 | Vanguard Group Inc. | 4,803,941 | $77.92M | 0.0% | -0.8% | 4.560% |  |
| 11/7/2025 | JPMorgan Chase & Co. | 68,720 | $1.12M | 0.0% | -11.5% | 0.065% |  |
| 11/7/2025 | Aberdeen Group plc | 619,878 | $10.05M | 0.0% | +39.8% | 0.588% |  |
| 11/6/2025 | Rhumbline Advisers | 104,829 | $1.70M | 0.0% | -6.8% | 0.100% |  |
| 11/6/2025 | Profund Advisors LLC | 11,809 | $0.19M | 0.0% | -21.7% | 0.011% |  |
| 11/6/2025 | ProShare Advisors LLC | 15,291 | $0.25M | 0.0% | -19.0% | 0.015% |  |
| 11/6/2025 | Candriam S.C.A. | 221,159 | $3.59M | 0.0% | -1.3% | 0.210% |  |
| 11/5/2025 | Alps Advisors Inc. | 51,112 | $0.83M | 0.0% | -10.0% | 0.049% |  |
| 11/5/2025 | Bessemer Group Inc. | 2,350 | $38K | 0.0% | +1,170.3% | 0.002% |  |
| 11/5/2025 | Optimize Financial Inc | 27,283 | $0.44M | 0.2% | N/A | 0.026% |  |
| 11/5/2025 | Envestnet Asset Management Inc. | 10,837 | $0.18M | 0.0% | N/A | 0.010% |  |
| 11/3/2025 | AlphaQuest LLC | 14,274 | $0.23M | 0.0% | -33.3% | 0.014% |  |
| 11/3/2025 | Arizona State Retirement System | 15,549 | $0.25M | 0.0% | +13.1% | 0.015% |  |
| 11/3/2025 | New York State Common Retirement Fund | 83,437 | $1.35M | 0.0% | -11.1% | 0.079% |  |
| 11/3/2025 | Federated Hermes Inc. | 59,256 | $0.96M | 0.0% | -81.3% | 0.056% |  |
| 10/31/2025 | Y Intercept Hong Kong Ltd | 57,300 | $0.93M | 0.0% | N/A | 0.054% |  |
| 10/28/2025 | Campbell & CO Investment Adviser LLC | 11,140 | $0.18M | 0.0% | -90.2% | 0.011% |  |
| 10/23/2025 | SG Americas Securities LLC | 9,881 | $0.16M | 0.0% | N/A | 0.009% |  |
| 10/21/2025 | Moody Aldrich Partners LLC | 82,941 | $1.35M | 0.3% | -16.9% | 0.079% |  |
| 10/20/2025 | HighMark Wealth Management LLC | 53,179 | $0.86M | 0.4% | +2.1% | 0.050% |  |
| 10/9/2025 | Voya Investment Management LLC | 12,417 | $0.20M | 0.0% | -37.6% | 0.012% |  |
| 8/28/2025 | China Universal Asset Management Co. Ltd. | 21,120 | $0.28M | 0.0% | +11.2% | 0.020% |  |
| 8/15/2025 | Tower Research Capital LLC TRC | 9,148 | $0.12M | 0.0% | +14.9% | 0.009% |  |
| 8/15/2025 | Exome Asset Management LLC | 124,470 | $1.63M | 0.9% | +74.2% | 0.118% |  |
| 8/15/2025 | Soleus Capital Management L.P. | 76,493 | $1M | 0.1% | +5.8% | 0.073% |  |
| 8/15/2025 | Sofinnova Investments Inc. | 716,873 | $9.40M | 0.6% | +3,185.7% | 0.680% |  |
| 8/15/2025 | Opaleye Management Inc. | 490,000 | $6.42M | 1.3% | +24.1% | 0.465% |  |
| 8/15/2025 | Perceptive Advisors LLC | 4,639,949 | $60.83M | 5.4% | -34.2% | 4.404% |  |
| 8/15/2025 | Engineers Gate Manager LP | 34,909 | $0.46M | 0.0% | -4.0% | 0.033% |  |
| 8/15/2025 | BNP Paribas Financial Markets | 8,193 | $0.11M | 0.0% | +48.9% | 0.008% |  |
| 8/15/2025 | Braidwell LP | 5,210,831 | $68.31M | 2.3% | +111.9% | 4.946% |  |
| 8/15/2025 | Brevan Howard Capital Management LP | 13,561 | $0.18M | 0.0% | N/A | 0.013% |  |
| 8/15/2025 | Bellevue Group AG | 2,775,997 | $36.39M | 0.8% | +94.3% | 2.635% |  |
| 8/15/2025 | Bank of America Corp DE | 254,429 | $3.34M | 0.0% | -63.4% | 0.242% |  |
| 8/14/2025 | MPM Bioimpact LLC | 1,720,741 | $22.56M | 3.9% | +55.7% | 1.633% |  |
| 8/14/2025 | First Light Asset Management LLC | 1,714,019 | $22.47M | 2.9% | -7.5% | 1.627% |  |
| 8/14/2025 | Orbimed Advisors LLC | 15,518,492 | $203.45M | 5.5% | +3.3% | 14.731% |  |
| 8/14/2025 | Jane Street Group LLC | 50,185 | $0.66M | 0.0% | -65.9% | 0.048% |  |
| 8/14/2025 | California State Teachers Retirement System | 36,878 | $0.48M | 0.0% | +2.4% | 0.035% |  |
| 8/14/2025 | Canada Pension Plan Investment Board | 3,400 | $45K | 0.0% | N/A | 0.003% |  |
| 8/14/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 39,978 | $0.52M | 0.0% | -8.7% | 0.038% |  |
| 8/14/2025 | The Manufacturers Life Insurance Company | 38,328 | $0.50M | 0.0% | -32.7% | 0.036% |  |
| 8/14/2025 | Sei Investments Co. | 43,638 | $0.57M | 0.0% | +8.2% | 0.041% |  |
| 8/14/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 55,292 | $0.73M | 0.0% | -1,208.9% | 0.052% |  |
| 8/14/2025 | Nebula Research & Development LLC | 13,219 | $0.17M | 0.0% | N/A | 0.013% |  |
| 8/14/2025 | HighVista Strategies LLC | 69,723 | $0.91M | 0.3% | -23.6% | 0.066% |  |
| 8/14/2025 | Qube Research & Technologies Ltd | 499,917 | $6.55M | 0.0% | +25.7% | 0.475% |  |
| 8/14/2025 | Federated Hermes Inc. | 316,500 | $4.15M | 0.0% | +395,525.0% | 0.300% |  |
| 8/13/2025 | Jump Financial LLC | 121,705 | $1.60M | 0.0% | N/A | 0.116% |  |
| 8/13/2025 | Kennedy Capital Management LLC | 252,524 | $3.31M | 0.1% | +12.4% | 0.240% |  |
| 8/13/2025 | Invesco Ltd. | 56,158 | $0.74M | 0.0% | +16.7% | 0.053% |  |
| 8/13/2025 | Sio Capital Management LLC | 539,730 | $7.08M | 2.7% | N/A | 0.512% |  |
| 8/13/2025 | Quantbot Technologies LP | 41,463 | $0.54M | 0.0% | N/A | 0.039% |  |
| 8/13/2025 | New York State Common Retirement Fund | 93,808 | $1.23M | 0.0% | +31.3% | 0.089% |  |
| 8/13/2025 | Schroder Investment Management Group | 151,062 | $1.98M | 0.0% | +90.9% | 0.143% |  |
| 8/13/2025 | Norges Bank | 47,755 | $0.63M | 0.0% | N/A | 0.045% |  |
| 8/12/2025 | XTX Topco Ltd | 60,739 | $0.80M | 0.0% | N/A | 0.058% |  |