| 2/18/2026 | Yiheng Capital Management L.P. | 639,769 | $12.26M | 2.5% | -2.5% | 1.593% |  |
| 2/18/2026 | Ikarian Capital LLC | 525,000 | $10.06M | 0.8% | N/A | 1.307% |  |
| 2/18/2026 | Vestal Point Capital LP | 300,000 | $5.75M | 0.2% | N/A | 0.747% |  |
| 2/18/2026 | Squadron Capital Management LLC | 240,000 | $4.60M | 1.9% | N/A | 0.598% |  |
| 2/18/2026 | Millennium Management LLC | 640,885 | $12.29M | 0.0% | +89.7% | 1.596% |  |
| 2/18/2026 | Engineers Gate Manager LP | 24,984 | $0.48M | 0.0% | N/A | 0.062% |  |
| 2/18/2026 | Balyasny Asset Management L.P. | 235,023 | $4.51M | 0.0% | N/A | 0.585% |  |
| 2/18/2026 | Boothbay Fund Management LLC | 163,401 | $3.13M | 0.0% | N/A | 0.407% |  |
| 2/17/2026 | Logos Global Management LP | 25,000 | $0.48M | 0.0% | N/A | 0.062% |  |
| 2/17/2026 | Schonfeld Strategic Advisors LLC | 454,343 | $8.71M | 0.0% | N/A | 1.131% |  |
| 2/17/2026 | Cetera Investment Advisers | 13,115 | $0.25M | 0.0% | N/A | 0.033% |  |
| 2/17/2026 | MPM Bioimpact LLC | 996,825 | $19.11M | 2.2% | -5.5% | 2.482% |  |
| 2/17/2026 | Artisan Partners Limited Partnership | 3,309,055 | $63.44M | 0.1% | +6,273.4% | 8.240% |  |
| 2/17/2026 | ExodusPoint Capital Management LP | 27,211 | $0.52M | 0.0% | N/A | 0.068% |  |
| 2/17/2026 | Royal Bank of Canada | 1,752 | $34K | 0.0% | N/A | 0.004% |  |
| 2/17/2026 | Persistent Asset Partners Ltd | 6,019 | $0.12M | 0.1% | N/A | 0.015% |  |
| 2/16/2026 | Truvestments Capital LLC | 3,892 | $75K | 0.0% | +71.3% | 0.010% |  |
| 2/13/2026 | Marshall Wace LLP | 20,961 | $0.40M | 0.0% | N/A | 0.052% |  |
| 2/13/2026 | Vivo Capital LLC | 2,461,626 | $47.19M | 3.1% | +133.4% | 6.130% |  |
| 2/13/2026 | Siren L.L.C. | 1,857,362 | $35.61M | 1.1% | N/A | 4.625% |  |
| 2/13/2026 | Polymer Capital Management HK LTD | 64,500 | $1.24M | 0.2% | N/A | 0.161% |  |
| 2/12/2026 | Patient Square Capital LP | 359,050 | $6.88M | 1.5% | N/A | 0.894% |  |
| 2/12/2026 | New York State Common Retirement Fund | 223,186 | $4.28M | 0.0% | +6,425.9% | 0.556% |  |
| 2/5/2026 | Allworth Financial LP | 1,683 | $32K | 0.0% | N/A | 0.004% |  |
| 1/29/2026 | UBS Group AG | 244,862 | $4.69M | 0.0% | +165,347.3% | 0.610% |  |
| 1/5/2026 | GAMMA Investing LLC | 2,680 | $51K | 0.0% | +38.4% | 0.007% |  |
| 11/17/2025 | Millennium Management LLC | 337,863 | $3.38M | 0.0% | +26.1% | 0.999% |  |
| 11/17/2025 | Citadel Advisors LLC | 22,049 | $0.22M | 0.0% | N/A | 0.065% |  |
| 11/14/2025 | Two Sigma Investments LP | 16,682 | $0.17M | 0.0% | N/A | 0.049% |  |
| 11/13/2025 | DLD Asset Management LP | 25,000 | $0.25M | 0.0% | N/A | 0.074% |  |
| 11/12/2025 | Artisan Partners Limited Partnership | 51,920 | $0.52M | 0.0% | N/A | 0.154% |  |
| 11/3/2025 | New York State Common Retirement Fund | 3,420 | $34K | 0.0% | N/A | 0.012% |  |
| 8/15/2025 | Octagon Capital Advisors LP | 1,018,021 | $9.32M | 2.0% | N/A | 3.717% |  |
| 8/15/2025 | Adage Capital Partners GP L.L.C. | 1,054,506 | $9.66M | 0.0% | N/A | 3.850% |  |
| 8/14/2025 | MPM Bioimpact LLC | 1,054,504 | $9.65M | 1.7% | N/A | 3.850% |  |
| 8/14/2025 | Vivo Capital LLC | 1,054,506 | $9.66M | 1.0% | N/A | 3.850% |  |
| 8/8/2025 | Nan Fung Trinity HK Ltd. | 37,095 | $0.34M | 0.0% | N/A | 0.135% |  |
| 2/17/2025 | Point72 Asset Management L.P. | 286,250 | $0.89M | 0.0% | -81.6% | 1.392% |  |
| 2/17/2025 | Baker BROS. Advisors LP | 1,461,425 | $4.52M | 0.0% | -80.0% | 7.105% |  |
| 2/14/2025 | Boxer Capital Management LLC | 50,000 | $0.15M | 0.0% | N/A | 0.243% |  |
| 2/14/2025 | Vivo Capital LLC | 32,020 | $99K | 0.0% | -97.6% | 0.156% |  |
| 2/14/2025 | Nan Fung Group Holdings Ltd | 37,095 | $0.12M | 0.1% | -80.0% | 0.180% |  |
| 2/11/2025 | Yiheng Capital Management L.P. | 656,309 | $2.03M | 0.1% | -79.2% | 3.191% |  |
| 11/14/2024 | Braidwell LP | 1,630,542 | $1.14M | 0.0% | -33.2% | 1.690% |  |
| 8/19/2024 | Point72 Asset Management L.P. | 1,556,250 | $1.25M | 0.0% | -50.0% | 1.613% |  |
| 5/15/2024 | Yiheng Capital Management L.P. | 5,568,909 | $4.17M | 0.2% | +6.2% | 2.887% |  |
| 2/15/2024 | Boxer Capital LLC | 500,000 | $0.48M | 0.0% | -49.2% | 0.259% |  |
| 2/14/2024 | Braidwell LP | 7,843,285 | $7.47M | 0.3% | -35.2% | 4.067% |  |
| 2/8/2024 | Cowen AND Company LLC | 50,986 | $49K | 0.0% | N/A | 0.026% |  |
| 11/13/2023 | Optiver Holding B.V. | 274,874 | $0.37M | 0.0% | +595.2% | 0.143% |  |
| 11/8/2023 | Landscape Capital Management L.L.C. | 68,911 | $94K | 0.0% | N/A | 0.036% |  |
| 8/10/2023 | Optiver Holding B.V. | 39,537 | $75K | 0.0% | N/A | 0.021% |  |
| 2/15/2023 | Braidwell LP | 12,107,785 | $18.53M | 0.6% | N/A | 6.431% |  |
| 2/14/2023 | RA Capital Management L.P. | 1,958,957 | $3M | 0.1% | -47.4% | 1.040% |  |
| 2/14/2023 | VR Adviser LLC | 9,300,000 | $29.26M | 4.7% | N/A | 4.940% |  |
| 2/14/2023 | Boxer Capital LLC | 1,450,000 | $2.22M | 0.1% | -32.1% | 0.770% |  |
| 2/10/2023 | Optiver Holding B.V. | 104,599 | $0.16M | 0.0% | +418.5% | 0.056% |  |
| 11/14/2022 | Vivo Capital LLC | 2,708,875 | $4.80M | 0.5% | N/A | 1.441% |  |
| 11/14/2022 | RA Capital Management L.P. | 3,724,740 | $6.59M | 0.1% | N/A | 1.981% |  |
| 11/14/2022 | Optiver Holding B.V. | 20,172 | $36K | 0.0% | N/A | 0.011% |  |
| 11/10/2022 | ExodusPoint Capital Management LP | 181,050 | $0.32M | 0.0% | +31.1% | 0.096% |  |
| 11/9/2022 | Fairmount Funds Management LLC | 7,064,964 | $12.51M | 2.2% | +46.2% | 3.757% |  |
| 8/2/2022 | Advisory Services Network LLC | 10,000 | $26K | 0.0% | N/A | 0.008% |  |
| 2/14/2022 | Boxer Capital LLC | 2,134,598 | $3.42M | 0.1% | -71.7% | 1.937% |  |
| 2/4/2022 | Envestnet Asset Management Inc. | 26,663 | $43K | 0.0% | N/A | 0.024% |  |
| 2/1/2022 | FNY Investment Advisers LLC | 20,000 | $32K | 0.0% | N/A | 0.018% |  |