| 11/17/2025 | Verition Fund Management LLC | 6,133 | $0.41M | 0.0% | N/A | 0.016% |  |
| 11/17/2025 | Vestal Point Capital LP | 500,000 | $33.04M | 1.5% | +257.1% | 1.325% |  |
| 11/17/2025 | Palo Alto Investors LP | 224,300 | $14.82M | 2.7% | +54.0% | 0.594% |  |
| 11/17/2025 | Paradigm Biocapital Advisors LP | 247,716 | $16.37M | 0.5% | -79.5% | 0.656% |  |
| 11/17/2025 | Millennium Management LLC | 161,000 | $10.64M | 0.0% | +340.0% | 0.426% |  |
| 11/17/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 12,646 | $0.83M | 0.0% | -15.9% | 0.033% |  |
| 11/17/2025 | Fred Alger Management LLC | 13,726 | $0.91M | 0.0% | N/A | 0.036% |  |
| 11/17/2025 | First Light Asset Management LLC | 231,186 | $15.28M | 1.4% | N/A | 0.612% |  |
| 11/17/2025 | Checkpoint Capital L.P. | 430,000 | $28.41M | 9.5% | +62.3% | 1.139% |  |
| 11/17/2025 | Bank of America Corp DE | 161,184 | $10.65M | 0.0% | -4.5% | 0.427% |  |
| 11/17/2025 | Alliancebernstein L.P. | 24,540 | $1.62M | 0.0% | +1.7% | 0.065% |  |
| 11/17/2025 | Ameriprise Financial Inc. | 74,350 | $4.91M | 0.0% | -38.8% | 0.197% |  |
| 11/14/2025 | Raymond James Financial Inc. | 141,479 | $9.35M | 0.0% | +63.6% | 0.407% |  |
| 11/14/2025 | California State Teachers Retirement System | 22,093 | $1.46M | 0.0% | +9.1% | 0.064% |  |
| 11/14/2025 | Balyasny Asset Management L.P. | 338,101 | $22.34M | 0.0% | N/A | 0.973% |  |
| 11/14/2025 | UBS AM A Distinct Business Unit of UBS Asset Management Americas LLC | 91,380 | $6.04M | 0.0% | -24.8% | 0.263% |  |
| 11/14/2025 | Squarepoint Ops LLC | 5,377 | $0.36M | 0.0% | N/A | 0.015% |  |
| 11/14/2025 | Wellington Management Group LLP | 1,410,077 | $93.18M | 0.0% | -1.5% | 4.056% |  |
| 11/14/2025 | Atlas Venture Life Science Advisors LLC | 2,142,617 | $141.58M | 18.8% | -10.1% | 6.162% |  |
| 11/13/2025 | Kennedy Capital Management LLC | 9,028 | $0.60M | 0.0% | N/A | 0.026% |  |
| 11/13/2025 | UBS Group AG | 171,623 | $11.34M | 0.0% | +17.9% | 0.494% |  |
| 11/13/2025 | BNP Paribas Financial Markets | 37,610 | $2.49M | 0.0% | +699.7% | 0.108% |  |
| 11/13/2025 | Legal & General Group Plc | 25,147 | $1.66M | 0.0% | +4.4% | 0.072% |  |
| 11/13/2025 | Swiss National Bank | 43,600 | $2.88M | 0.0% | +1.6% | 0.125% |  |
| 11/13/2025 | Russell Investments Group Ltd. | 2,438 | $0.16M | 0.0% | +15,137.5% | 0.007% |  |
| 11/13/2025 | Schroder Investment Management Group | 67,196 | $4.37M | 0.0% | -18.5% | 0.193% |  |
| 11/13/2025 | Blue Owl Capital Holdings LP | 102,260 | $6.76M | 2.1% | -16.4% | 0.294% |  |
| 11/12/2025 | Barclays PLC | 107,203 | $7.08M | 0.0% | +23.9% | 0.308% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 230,423 | $15.22M | 0.0% | +19.5% | 0.663% |  |
| 11/12/2025 | Legato Capital Management LLC | 11,287 | $0.75M | 0.1% | +56.2% | 0.032% |  |
| 11/12/2025 | Victory Capital Management Inc. | 149,864 | $9.90M | 0.0% | -24.2% | 0.431% |  |
| 11/12/2025 | Rafferty Asset Management LLC | 37,302 | $2.47M | 0.0% | +18.5% | 0.107% |  |
| 11/12/2025 | Aster Capital Management DIFC Ltd | 576 | $38K | 0.0% | N/A | 0.002% |  |
| 11/12/2025 | DNB Asset Management AS | 5,522 | $0.37M | 0.0% | +20.5% | 0.016% |  |
| 11/12/2025 | Intech Investment Management LLC | 8,006 | $0.53M | 0.0% | -34.5% | 0.023% |  |
| 11/10/2025 | TD Asset Management Inc | 59,248 | $3.92M | 0.0% | +11.7% | 0.170% |  |
| 11/10/2025 | Ameritas Investment Partners Inc. | 1,931 | $0.13M | 0.0% | -23.2% | 0.006% |  |
| 11/10/2025 | China Universal Asset Management Co. Ltd. | 7,094 | $0.47M | 0.0% | +2.0% | 0.020% |  |
| 11/7/2025 | Vanguard Group Inc. | 1,448,059 | $95.69M | 0.0% | +3.7% | 4.165% |  |
| 11/7/2025 | JPMorgan Chase & Co. | 752,879 | $49.75M | 0.0% | -10.8% | 2.165% |  |
| 11/7/2025 | TimesSquare Capital Management LLC | 182,170 | $12.04M | 0.2% | N/A | 0.524% |  |
| 11/6/2025 | Rhumbline Advisers | 34,490 | $2.28M | 0.0% | -3.5% | 0.099% |  |
| 11/6/2025 | Bryce Point Capital LLC | 3,912 | $0.26M | 0.3% | N/A | 0.011% |  |
| 11/6/2025 | Profund Advisors LLC | 8,118 | $0.54M | 0.0% | +20.9% | 0.023% |  |
| 11/6/2025 | ProShare Advisors LLC | 5,188 | $0.34M | 0.0% | -18.2% | 0.015% |  |
| 11/5/2025 | Alps Advisors Inc. | 16,792 | $1.11M | 0.0% | -9.8% | 0.048% |  |
| 11/4/2025 | Atle Fund Management AB | 45,690 | $3.02M | 1.2% | +85.3% | 0.131% |  |
| 11/3/2025 | Arizona State Retirement System | 6,654 | $0.44M | 0.0% | +1.8% | 0.019% |  |
| 11/3/2025 | New York State Common Retirement Fund | 21,490 | $1.42M | 0.0% | +27.5% | 0.062% |  |
| 10/31/2025 | Y Intercept Hong Kong Ltd | 43,287 | $2.86M | 0.1% | +361.4% | 0.124% |  |
| 10/30/2025 | iA Global Asset Management Inc. | 65,512 | $4.33M | 0.1% | +20,245.3% | 0.188% |  |
| 10/30/2025 | Universal Beteiligungs und Servicegesellschaft mbH | 11,438 | $0.76M | 0.0% | +55.1% | 0.033% |  |
| 10/28/2025 | Campbell & CO Investment Adviser LLC | 5,290 | $0.35M | 0.0% | N/A | 0.015% |  |
| 10/23/2025 | SG Americas Securities LLC | 8,064 | $0.53M | 0.0% | N/A | 0.023% |  |
| 10/16/2025 | Avanza Fonder AB | 1,668 | $0.11M | 0.0% | +54.0% | 0.005% |  |
| 10/9/2025 | Voya Investment Management LLC | 4,266 | $0.28M | 0.0% | -36.3% | 0.012% |  |
| 10/7/2025 | Assenagon Asset Management S.A. | 10,433 | $0.69M | 0.0% | N/A | 0.030% |  |
| 8/15/2025 | Tower Research Capital LLC TRC | 3,975 | $0.21M | 0.0% | +383.0% | 0.011% |  |
| 8/15/2025 | Exome Asset Management LLC | 61,356 | $3.25M | 1.7% | -0.5% | 0.177% |  |
| 8/15/2025 | Sofinnova Investments Inc. | 7,312 | $0.39M | 0.0% | -2.3% | 0.021% |  |
| 8/15/2025 | Rafferty Asset Management LLC | 31,489 | $1.67M | 0.0% | -7.5% | 0.091% |  |
| 8/15/2025 | Opaleye Management Inc. | 186,418 | $9.87M | 2.0% | +119.3% | 0.538% |  |
| 8/15/2025 | Frazier Life Sciences Management L.P. | 1,654,834 | $87.64M | 3.5% | -5.7% | 4.779% |  |
| 8/15/2025 | Eventide Asset Management LLC | 308,030 | $16.31M | 0.3% | +69.4% | 0.889% |  |
| 8/15/2025 | BNP Paribas Financial Markets | 4,703 | $0.25M | 0.0% | -54.3% | 0.014% |  |
| 8/15/2025 | Bain Capital Life Sciences Investors LLC | 583,500 | $30.90M | 3.9% | -40.7% | 1.685% |  |
| 8/15/2025 | Bank of America Corp DE | 168,822 | $8.94M | 0.0% | +213.7% | 0.488% |  |
| 8/15/2025 | Adage Capital Partners GP L.L.C. | 450,000 | $23.83M | 0.0% | +50.0% | 1.299% |  |
| 8/15/2025 | Ameriprise Financial Inc. | 121,520 | $6.44M | 0.0% | +79.0% | 0.351% |  |
| 8/14/2025 | Nantahala Capital Management LLC | 287,800 | $15.24M | 0.6% | +93.9% | 0.831% |  |
| 8/14/2025 | Raymond James Financial Inc. | 86,487 | $4.58M | 0.0% | +3.9% | 0.250% |  |
| 8/14/2025 | The Manufacturers Life Insurance Company | 51,836 | $2.75M | 0.0% | +27.7% | 0.150% |  |
| 8/14/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 12,317 | $0.65M | 0.0% | -9.6% | 0.036% |  |
| 8/14/2025 | HighVista Strategies LLC | 6,733 | $0.36M | 0.1% | +4.3% | 0.019% |  |
| 8/14/2025 | Bollard Group LLC | 30,635 | $1.62M | 0.0% | N/A | 0.088% |  |
| 8/13/2025 | Walleye Capital LLC | 14,064 | $0.75M | 0.0% | -36.3% | 0.041% |  |
| 8/13/2025 | First Trust Advisors LP | 10,246 | $0.54M | 0.0% | N/A | 0.030% |  |
| 8/13/2025 | Saturn V Capital Management LP | 396,115 | $20.98M | 8.5% | -23.6% | 1.144% |  |
| 8/13/2025 | Invesco Ltd. | 16,817 | $0.89M | 0.0% | +21.6% | 0.049% |  |
| 8/13/2025 | Sio Capital Management LLC | 284,787 | $15.08M | 5.8% | +287.4% | 0.822% |  |
| 8/13/2025 | New York State Common Retirement Fund | 16,852 | $0.89M | 0.0% | +168.5% | 0.049% |  |
| 8/13/2025 | Schroder Investment Management Group | 82,451 | $4.49M | 0.0% | -5.5% | 0.238% |  |
| 8/13/2025 | Virtus Investment Advisers LLC | 1,784 | $94K | 0.0% | -30.2% | 0.005% |  |
| 8/13/2025 | State Board of Administration of Florida Retirement System | 9,129 | $0.48M | 0.0% | +125.4% | 0.026% |  |
| 8/12/2025 | Ameritas Investment Partners Inc. | 2,515 | $0.13M | 0.0% | +8.9% | 0.007% |  |
| 8/12/2025 | Rhumbline Advisers | 35,755 | $1.89M | 0.0% | +11.2% | 0.103% |  |
| 8/12/2025 | Legal & General Group Plc | 24,097 | $1.28M | 0.0% | +18.0% | 0.070% |  |
| 8/12/2025 | JPMorgan Chase & Co. | 843,616 | $44.68M | 0.0% | +11.1% | 2.436% |  |
| 8/12/2025 | DNB Asset Management AS | 4,583 | $0.24M | 0.0% | N/A | 0.013% |  |
| 8/12/2025 | Swiss National Bank | 42,900 | $2.27M | 0.0% | +19.5% | 0.124% |  |
| 8/12/2025 | Ensign Peak Advisors Inc | 141,545 | $7.50M | 0.0% | +95.2% | 0.409% |  |
| 8/11/2025 | Patient Square Capital LP | 74,000 | $3.92M | 1.4% | -10.8% | 0.214% |  |
| 8/11/2025 | Universal Beteiligungs und Servicegesellschaft mbH | 7,376 | $0.39M | 0.0% | +15.4% | 0.021% |  |
| 8/8/2025 | Intech Investment Management LLC | 12,222 | $0.65M | 0.0% | +11.6% | 0.035% |  |
| 8/8/2025 | Police & Firemen s Retirement System of New Jersey | 5,490 | $0.29M | 0.0% | +12.3% | 0.016% |  |
| 8/8/2025 | Geode Capital Management LLC | 598,589 | $31.71M | 0.0% | +4.7% | 1.728% |  |
| 8/8/2025 | PNC Financial Services Group Inc. | 25,140 | $1.33M | 0.0% | +6.1% | 0.073% |  |
| 8/7/2025 | Profund Advisors LLC | 6,714 | $0.36M | 0.0% | -6.2% | 0.019% |  |
| 8/5/2025 | Bank of Montreal Can | 10,988 | $0.58M | 0.0% | +87.8% | 0.032% |  |
| 8/1/2025 | Teacher Retirement System of Texas | 6,017 | $0.32M | 0.0% | +21.2% | 0.017% |  |