| 11/17/2025 | Woodline Partners LP | 300,499 | $6.15M | 0.0% | -72.7% | 0.506% |  |
| 11/17/2025 | Vestal Point Capital LP | 1,160,000 | $23.75M | 1.1% | +364.0% | 1.955% |  |
| 11/17/2025 | Polar Capital Holdings Plc | 3,095,007 | $63.36M | 0.3% | +1.5% | 5.215% |  |
| 11/17/2025 | Millennium Management LLC | 381,405 | $7.81M | 0.0% | +19.8% | 0.643% |  |
| 11/17/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 19,529 | $0.40M | 0.0% | +10.6% | 0.033% |  |
| 11/17/2025 | HighVista Strategies LLC | 259,135 | $5.30M | 1.3% | +83.1% | 0.437% |  |
| 11/17/2025 | Citadel Advisors LLC | 1,160,503 | $23.76M | 0.0% | -21.1% | 1.955% |  |
| 11/17/2025 | Bank of America Corp DE | 23,543 | $0.48M | 0.0% | -3.9% | 0.040% |  |
| 11/17/2025 | Ameriprise Financial Inc. | 123,336 | $2.53M | 0.0% | +108.2% | 0.208% |  |
| 11/14/2025 | Man Group plc | 13,371 | $0.27M | 0.0% | N/A | 0.023% |  |
| 11/14/2025 | Duquesne Family Office LLC | 947,405 | $19.39M | 0.5% | +104.6% | 1.599% |  |
| 11/14/2025 | UBS AM A Distinct Business Unit of UBS Asset Management Americas LLC | 51,683 | $1.06M | 0.0% | -37.8% | 0.087% |  |
| 11/14/2025 | Squarepoint Ops LLC | 35,845 | $0.73M | 0.0% | N/A | 0.061% |  |
| 11/13/2025 | Marshall Wace LLP | 340,482 | $6.97M | 0.0% | +2.1% | 0.575% |  |
| 11/13/2025 | Landscape Capital Management L.L.C. | 10,301 | $0.21M | 0.0% | N/A | 0.017% |  |
| 11/13/2025 | UBS Group AG | 79,508 | $1.63M | 0.0% | -42.5% | 0.134% |  |
| 11/13/2025 | BNP Paribas Financial Markets | 9,144 | $0.19M | 0.0% | +145.7% | 0.015% |  |
| 11/13/2025 | Legal & General Group Plc | 33,765 | $0.69M | 0.0% | +4.8% | 0.057% |  |
| 11/13/2025 | WINTON GROUP Ltd | 16,458 | $0.34M | 0.0% | N/A | 0.028% |  |
| 11/13/2025 | Russell Investments Group Ltd. | 3,642 | $75K | 0.0% | -87.7% | 0.006% |  |
| 11/12/2025 | Barclays PLC | 70,689 | $1.45M | 0.0% | -2.9% | 0.119% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 160,459 | $3.28M | 0.0% | +242.5% | 0.271% |  |
| 11/12/2025 | Quantbot Technologies LP | 2,146 | $44K | 0.0% | -52.1% | 0.004% |  |
| 11/10/2025 | TD Asset Management Inc | 27,518 | $0.56M | 0.0% | -58.9% | 0.046% |  |
| 11/10/2025 | Patient Square Capital LP | 250,838 | $5.14M | 1.4% | +2.0% | 0.423% |  |
| 11/7/2025 | NEOS Investment Management LLC | 40,314 | $0.83M | 0.0% | +23.7% | 0.068% |  |
| 11/7/2025 | Vanguard Group Inc. | 2,553,014 | $52.26M | 0.0% | +5.9% | 4.310% |  |
| 11/7/2025 | JPMorgan Chase & Co. | 24,818 | $0.51M | 0.0% | +30.2% | 0.042% |  |
| 11/6/2025 | Rhumbline Advisers | 60,160 | $1.23M | 0.0% | +19.6% | 0.102% |  |
| 11/6/2025 | Candriam S.C.A. | 609,352 | $12.47M | 0.1% | +46.3% | 1.029% |  |
| 11/3/2025 | AlphaQuest LLC | 4,701 | $96K | 0.0% | N/A | 0.008% |  |
| 11/3/2025 | New York State Common Retirement Fund | 15,097 | $0.31M | 0.0% | +54.1% | 0.025% |  |
| 11/3/2025 | Federated Hermes Inc. | 10,811 | $0.22M | 0.0% | -32.8% | 0.018% |  |
| 10/23/2025 | SG Americas Securities LLC | 22,242 | $0.46M | 0.0% | -38.9% | 0.038% |  |
| 8/15/2025 | Tower Research Capital LLC TRC | 5,286 | $0.11M | 0.0% | +194.3% | 0.009% |  |
| 8/15/2025 | Duquesne Family Office LLC | 463,000 | $9.29M | 0.2% | N/A | 0.782% |  |
| 8/15/2025 | BNP Paribas Financial Markets | 3,722 | $75K | 0.0% | +33.3% | 0.008% |  |
| 8/15/2025 | Bank of America Corp DE | 24,508 | $0.49M | 0.0% | +20.0% | 0.050% |  |
| 8/15/2025 | 5AM Venture Management LLC | 772,477 | $15.50M | 6.0% | -41.6% | 1.574% |  |
| 8/15/2025 | Adage Capital Partners GP L.L.C. | 96,000 | $1.93M | 0.0% | -78.7% | 0.196% |  |
| 8/15/2025 | Ameriprise Financial Inc. | 59,244 | $1.19M | 0.0% | +150.4% | 0.121% |  |
| 8/14/2025 | Commodore Capital LP | 4,692,809 | $94.14M | 6.6% | +0.4% | 9.563% |  |
| 8/14/2025 | TCG Crossover Management LLC | 498,000 | $9.99M | 1.1% | N/A | 1.015% |  |
| 8/14/2025 | Jane Street Group LLC | 56,981 | $1.14M | 0.0% | +94.1% | 0.116% |  |
| 8/14/2025 | California State Teachers Retirement System | 20,330 | $0.41M | 0.0% | -2.8% | 0.041% |  |
| 8/14/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,656 | $0.35M | 0.0% | -18.7% | 0.036% |  |
| 8/14/2025 | The Manufacturers Life Insurance Company | 44,151 | $0.89M | 0.0% | +242.4% | 0.090% |  |
| 8/14/2025 | HighVista Strategies LLC | 141,516 | $2.84M | 1.0% | +25.8% | 0.288% |  |
| 8/14/2025 | Federated Hermes Inc. | 16,098 | $0.32M | 0.0% | -76.7% | 0.033% |  |
| 8/13/2025 | Affinity Asset Advisors LLC | 400,000 | $8.02M | 1.1% | N/A | 0.815% |  |
| 8/13/2025 | Tema Etfs LLC | 32,579 | $0.65M | 0.2% | +37.8% | 0.066% |  |
| 8/13/2025 | Marshall Wace LLP | 333,333 | $6.69M | 0.0% | +2,886.9% | 0.679% |  |
| 8/13/2025 | Invesco Ltd. | 21,957 | $0.44M | 0.0% | +4.3% | 0.045% |  |
| 8/13/2025 | Quantbot Technologies LP | 4,477 | $90K | 0.0% | +47.1% | 0.009% |  |
| 8/13/2025 | Virtus Investment Advisers LLC | 4,783 | $96K | 0.0% | -33.0% | 0.010% |  |
| 8/13/2025 | Russell Investments Group Ltd. | 29,547 | $0.59M | 0.0% | -72.0% | 0.060% |  |
| 8/12/2025 | XTX Topco Ltd | 11,362 | $0.23M | 0.0% | -48.0% | 0.023% |  |
| 8/12/2025 | Rhumbline Advisers | 50,280 | $1.01M | 0.0% | -4.2% | 0.102% |  |
| 8/12/2025 | Franklin Resources Inc. | 430,240 | $8.63M | 0.0% | +2,029.3% | 0.877% |  |
| 8/12/2025 | Legal & General Group Plc | 32,225 | $0.65M | 0.0% | +52.2% | 0.066% |  |
| 8/12/2025 | JPMorgan Chase & Co. | 19,064 | $0.38M | 0.0% | -12.4% | 0.039% |  |
| 8/12/2025 | Swiss National Bank | 61,873 | $1.24M | 0.0% | +47.8% | 0.126% |  |
| 8/11/2025 | Patient Square Capital LP | 245,838 | $4.93M | 1.8% | -3.2% | 0.501% |  |
| 8/8/2025 | Intech Investment Management LLC | 14,502 | $0.29M | 0.0% | -27.9% | 0.030% |  |
| 8/8/2025 | SG Americas Securities LLC | 36,373 | $0.73M | 0.0% | +177.4% | 0.074% |  |
| 8/8/2025 | Candriam S.C.A. | 416,650 | $8.36M | 0.0% | N/A | 0.849% |  |
| 8/8/2025 | Geode Capital Management LLC | 882,753 | $17.71M | 0.0% | +7.8% | 1.799% |  |
| 7/28/2025 | TD Asset Management Inc | 66,906 | $1.34M | 0.0% | N/A | 0.136% |  |
| 7/23/2025 | KLP Kapitalforvaltning AS | 6,800 | $0.14M | 0.0% | +58.1% | 0.014% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 211,752 | $4.17M | 0.0% | +61.3% | 0.432% |  |
| 5/29/2025 | Rhumbline Advisers | 52,502 | $1.03M | 0.0% | +4.9% | 0.107% |  |
| 5/19/2025 | Jane Street Group LLC | 29,351 | $0.58M | 0.0% | N/A | 0.060% |  |
| 5/16/2025 | Woodline Partners LP | 805,157 | $15.85M | 0.1% | -0.1% | 1.641% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 211,752 | $4.17M | 0.0% | +61.3% | 0.432% |  |
| 5/16/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 21,729 | $0.43M | 0.0% | +8.4% | 0.044% |  |
| 5/16/2025 | Ally Bridge Group NY LLC | 169,774 | $3.34M | 3.0% | +19.8% | 0.346% |  |
| 5/16/2025 | 5AM Venture Management LLC | 1,322,477 | $26.03M | 9.8% | -18.9% | 2.695% |  |
| 5/16/2025 | Adage Capital Partners GP L.L.C. | 450,000 | $8.86M | 0.0% | -30.8% | 0.917% |  |
| 5/15/2025 | Tema Etfs LLC | 23,648 | $0.47M | 0.1% | N/A | 0.048% |  |
| 5/14/2025 | Quantbot Technologies LP | 3,043 | $60K | 0.0% | N/A | 0.006% |  |
| 5/14/2025 | Wellington Management Group LLP | 84,700 | $1.67M | 0.0% | +4.7% | 0.173% |  |
| 5/13/2025 | Lord Abbett & CO. LLC | 197,279 | $3.88M | 0.0% | -48.9% | 0.402% |  |
| 5/13/2025 | Russell Investments Group Ltd. | 105,542 | $2.08M | 0.0% | +148,550.7% | 0.215% |  |
| 5/12/2025 | Nuveen LLC | 104,099 | $2.05M | 0.0% | N/A | 0.212% |  |
| 5/12/2025 | Invesco Ltd. | 21,044 | $0.41M | 0.0% | +39.6% | 0.043% |  |
| 5/9/2025 | Deutsche Bank AG | 27,524 | $0.54M | 0.0% | -9.8% | 0.056% |  |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 259,537 | $5.11M | 0.0% | -0.9% | 0.529% |  |
| 5/9/2025 | Vanguard Group Inc. | 1,972,239 | $38.81M | 0.0% | -0.2% | 4.020% |  |
| 5/9/2025 | BIT Capital GmbH | 19,386 | $0.38M | 0.0% | N/A | 0.040% |  |
| 5/8/2025 | XTX Topco Ltd | 21,849 | $0.43M | 0.0% | N/A | 0.045% |  |
| 5/8/2025 | Federated Hermes Inc. | 69,051 | $1.36M | 0.0% | -41.3% | 0.141% |  |
| 5/1/2025 | New York State Common Retirement Fund | 9,797 | $0.19M | 0.0% | -60.8% | 0.020% |  |
| 4/30/2025 | China Universal Asset Management Co. Ltd. | 9,800 | $0.19M | 0.0% | -5.4% | 0.020% |  |
| 4/29/2025 | Bank of New York Mellon Corp | 93,567 | $1.84M | 0.0% | +4.5% | 0.191% |  |
| 4/17/2025 | Exchange Traded Concepts LLC | 6,055 | $0.12M | 0.0% | -19.1% | 0.012% |  |
| 4/8/2025 | Rhumbline Advisers | 52,502 | $1.03M | 0.0% | +4.9% | 0.107% |  |
| 4/7/2025 | GAMMA Investing LLC | 2,716 | $53K | 0.0% | +3,058.1% | 0.006% |  |
| 3/24/2025 | Wellington Management Group LLP | 80,916 | $1.82M | 0.0% | +15.3% | 0.165% |  |
| 3/18/2025 | California State Teachers Retirement System | 20,914 | $0.47M | 0.0% | +10.2% | 0.043% |  |
| 2/17/2025 | UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 43,714 | $0.98M | 0.0% | +67.1% | 0.089% |  |