| 2/18/2026 | ADAR1 Capital Management LLC | 5,608,078 | $8.69M | 0.6% | +0.9% | 9.210% |  |
| 2/18/2026 | Ikarian Capital LLC | 303,555 | $0.47M | 0.0% | -8.6% | 0.499% |  |
| 2/18/2026 | Janus Henderson Group PLC | 5,862,212 | $9.06M | 0.0% | N/A | 9.628% |  |
| 2/18/2026 | Balyasny Asset Management L.P. | 2,076,250 | $3.22M | 0.0% | +3.6% | 3.410% |  |
| 2/18/2026 | Boothbay Fund Management LLC | 93,211 | $0.14M | 0.0% | -23.6% | 0.153% |  |
| 2/17/2026 | ADAR1 Capital Management LLC | 5,608,078 | $8.69M | 0.6% | +0.9% | 9.210% |  |
| 2/17/2026 | Schonfeld Strategic Advisors LLC | 25,381 | $39K | 0.0% | -79.7% | 0.042% |  |
| 2/17/2026 | Cantor Fitzgerald L. P. | 562,643 | $0.87M | 0.0% | +32.4% | 0.924% |  |
| 2/17/2026 | Diadema Partners LP | 347,393 | $0.54M | 0.1% | +15.8% | 0.571% |  |
| 2/17/2026 | Royal Bank of Canada | 79,734 | $0.12M | 0.0% | N/A | 0.131% |  |
| 2/17/2026 | Persistent Asset Partners Ltd | 93,123 | $0.14M | 0.1% | +35.0% | 0.153% |  |
| 2/13/2026 | Hudson Bay Capital Management LP | 428,538 | $0.66M | 0.0% | +53.9% | 0.704% |  |
| 2/13/2026 | State Street Corp | 155,420 | $0.24M | 0.0% | +13.0% | 0.255% |  |
| 2/12/2026 | Renaissance Technologies LLC | 733,226 | $1.14M | 0.0% | +19.2% | 1.204% |  |
| 2/9/2026 | Geode Capital Management LLC | 345,310 | $0.54M | 0.0% | +11.1% | 0.567% |  |
| 1/16/2026 | Aberdeen Group plc | 2,366,688 | $3.67M | 0.0% | +523.6% | 3.887% |  |
| 12/15/2025 | Hudson Bay Capital Management LP | 278,538 | $0.40M | 0.0% | N/A | 0.457% |  |
| 12/1/2025 | Cantor Fitzgerald L. P. | 425,000 | $0.61M | 0.0% | N/A | 0.698% |  |
| 11/17/2025 | Woodline Partners LP | 3,508,771 | $5.02M | 0.0% | N/A | 5.762% |  |
| 11/17/2025 | Millennium Management LLC | 24,356 | $35K | 0.0% | N/A | 0.040% |  |
| 11/17/2025 | Cantor Fitzgerald L. P. | 425,000 | $0.61M | 0.0% | N/A | 0.698% |  |
| 11/17/2025 | Boothbay Fund Management LLC | 121,953 | $0.17M | 0.0% | N/A | 0.200% |  |
| 11/14/2025 | Schonfeld Strategic Advisors LLC | 124,823 | $0.18M | 0.0% | N/A | 0.210% |  |
| 11/14/2025 | Virtu Financial LLC | 23,779 | $34K | 0.0% | +133.4% | 0.040% |  |
| 11/14/2025 | ADAR1 Capital Management LLC | 5,559,988 | $7.95M | 0.7% | N/A | 9.345% |  |
| 11/14/2025 | Two Sigma Investments LP | 133,004 | $0.19M | 0.0% | N/A | 0.224% |  |
| 11/10/2025 | Persistent Asset Partners Ltd | 68,991 | $99K | 0.1% | N/A | 0.116% |  |
| 11/7/2025 | Vanguard Group Inc. | 1,313,946 | $1.88M | 0.0% | +59.4% | 2.208% |  |
| 11/7/2025 | Aberdeen Group plc | 379,526 | $0.54M | 0.0% | N/A | 0.638% |  |
| 2/13/2025 | Renaissance Technologies LLC | 261,400 | $0.20M | 0.0% | -18.6% | 0.738% |  |
| 2/12/2025 | Takeda Pharmaceutical Co. Ltd. | 1,824,977 | $1.37M | 5.2% | N/A | 5.151% |  |
| 2/11/2025 | DCF Advisers LLC | 62,947 | $47K | 0.0% | +91.0% | 0.178% |  |
| 8/9/2024 | Renaissance Technologies LLC | 300,400 | $0.21M | 0.0% | +43.6% | 0.852% |  |
| 5/10/2024 | Acadian Asset Management LLC | 108,691 | $0.25M | 0.0% | N/A | 0.308% |  |
| 2/12/2024 | Decheng Capital LLC | 4,447,308 | $3.22M | 0.9% | N/A | 12.663% |  |
| 8/9/2023 | DCF Advisers LLC | 111,623 | $84K | 0.0% | -28.9% | 0.324% |  |
| 5/2/2023 | Victory Capital Management Inc. | 345,861 | $0.25M | 0.0% | -89.2% | 1.005% |  |
| 2/14/2023 | True North Advisors LLC | 265,370 | $0.27M | 0.1% | +50.5% | 0.771% |  |
| 2/13/2023 | Callan Capital LLC | 103,688 | $0.11M | 0.0% | N/A | 0.301% |  |
| 2/9/2023 | Victory Capital Management Inc. | 3,198,745 | $3.52M | 0.0% | -12.4% | 9.296% |  |
| 1/24/2023 | Capital CS Group LLC | 24,000 | $25K | 0.0% | N/A | 0.070% |  |
| 11/7/2022 | Virtu Financial LLC | 24,141 | $54K | 0.0% | N/A | 0.070% |  |
| 11/2/2022 | Victory Capital Management Inc. | 3,651,084 | $8.11M | 0.0% | +2.1% | 10.651% |  |
| 8/11/2022 | DCF Advisers LLC | 114,027 | $0.23M | 0.1% | -31.2% | 0.333% |  |
| 8/1/2022 | Victory Capital Management Inc. | 3,577,211 | $7.30M | 0.0% | -0.6% | 10.436% |  |
| 5/16/2022 | Cota Capital Management LLC | 562,278 | $1.77M | 0.4% | N/A | 1.640% |  |
| 5/10/2022 | Decheng Capital Management III Cayman LLC | 4,447,308 | $14.01M | 4.3% | N/A | 12.975% |  |
| 5/4/2022 | Victory Capital Management Inc. | 3,597,799 | $11.33M | 0.0% | +8.2% | 10.495% |  |
| 2/15/2022 | Samsara BioCapital LLC | 615,541 | $2.32M | 0.5% | -16.6% | 2.094% |  |
| 2/7/2022 | Victory Capital Management Inc. | 3,325,050 | $12.47M | 0.0% | +4.9% | 11.313% |  |
| 11/12/2021 | Geode Capital Management LLC | 154,185 | $1.05M | 0.0% | +2.4% | 0.525% |  |