| 12/1/2025 | Cantor Fitzgerald L. P. | 99,000 | $0.61M | 0.0% | N/A | 1.469% |  |
| 11/17/2025 | Palo Alto Investors LP | 15,047 | $92K | 0.0% | -90.0% | 0.223% |  |
| 11/17/2025 | Millennium Management LLC | 97,354 | $0.60M | 0.0% | -90.8% | 1.444% |  |
| 11/17/2025 | Citadel Advisors LLC | 47,197 | $0.29M | 0.0% | -84.7% | 0.700% |  |
| 11/17/2025 | Baker BROS. Advisors LP | 194,493 | $1.19M | 0.0% | -90.0% | 2.886% |  |
| 11/17/2025 | Bank of America Corp DE | 84,817 | $0.52M | 0.0% | -90.3% | 1.258% |  |
| 11/17/2025 | Cantor Fitzgerald L. P. | 99,000 | $0.61M | 0.0% | N/A | 1.469% |  |
| 11/14/2025 | ADAR1 Capital Management LLC | 22,144 | $0.14M | 0.0% | N/A | 0.329% |  |
| 11/14/2025 | Shay Capital LLC | 10,414 | $64K | 0.0% | N/A | 0.155% |  |
| 11/14/2025 | Two Sigma Investments LP | 12,442 | $76K | 0.0% | -88.3% | 0.185% |  |
| 11/14/2025 | Atlas Venture Life Science Advisors LLC | 827,946 | $5.07M | 0.7% | -90.0% | 12.284% |  |
| 11/13/2025 | UBS Group AG | 148,721 | $0.91M | 0.0% | -83.2% | 2.207% |  |
| 11/10/2025 | TD Asset Management Inc | 26,708 | $0.16M | 0.0% | -92.2% | 0.396% |  |
| 11/7/2025 | Vanguard Group Inc. | 229,833 | $1.41M | 0.0% | -90.0% | 3.410% |  |
| 8/15/2025 | Militia Capital Partners LP | 542,347 | $0.17M | 0.1% | N/A | 8.047% |  |
| 8/15/2025 | Bank of America Corp DE | 871,951 | $0.28M | 0.0% | -32.3% | 12.937% |  |
| 8/13/2025 | Marshall Wace LLP | 116,201 | $37K | 0.0% | N/A | 1.724% |  |
| 8/8/2025 | Geode Capital Management LLC | 498,080 | $0.16M | 0.0% | -55.1% | 7.390% |  |
| 8/1/2025 | Y Intercept Hong Kong Ltd | 148,186 | $47K | 0.0% | N/A | 2.211% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 1,086,098 | $0.44M | 0.0% | -10.1% | 1.620% |  |
| 5/21/2025 | Acadian Asset Management LLC | 1,159,135 | $0.47M | 0.0% | +54.3% | 1.729% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 1,086,098 | $0.44M | 0.0% | -10.1% | 1.620% |  |
| 5/16/2025 | Jacobs Levy Equity Management Inc. | 182,005 | $74K | 0.0% | -41.6% | 0.272% |  |
| 5/16/2025 | AQR Capital Management LLC | 89,014 | $36K | 0.0% | N/A | 0.133% |  |
| 5/12/2025 | Nuveen LLC | 169,265 | $69K | 0.0% | N/A | 0.253% |  |
| 5/9/2025 | Deutsche Bank AG | 108,771 | $45K | 0.0% | -40.9% | 0.162% |  |
| 5/8/2025 | Jefferies Financial Group Inc. | 173,659 | $70K | 0.0% | -92.3% | 0.259% |  |
| 4/22/2025 | EWA LLC | 92,901 | $38K | 0.0% | N/A | 0.139% |  |
| 3/7/2025 | Aegis Wealth Management LLC | 88,890 | $94K | 0.1% | N/A | 0.133% |  |
| 2/27/2025 | Jefferies Financial Group Inc. | 2,261,817 | $2.40M | 0.0% | N/A | 3.386% |  |
| 2/17/2025 | Squarepoint Ops LLC | 65,628 | $70K | 0.0% | N/A | 0.098% |  |
| 2/17/2025 | Two Sigma Investments LP | 120,403 | $0.13M | 0.0% | -19.7% | 0.180% |  |
| 2/17/2025 | Two Sigma Advisers LP | 194,400 | $0.21M | 0.0% | -10.5% | 0.291% |  |
| 2/17/2025 | Millennium Management LLC | 91,578 | $97K | 0.0% | N/A | 0.137% |  |
| 2/17/2025 | Jacobs Levy Equity Management Inc. | 311,535 | $0.33M | 0.0% | +13.9% | 0.466% |  |
| 2/17/2025 | Jefferies Financial Group Inc. | 2,261,817 | $2.40M | 0.0% | N/A | 3.386% |  |
| 2/17/2025 | Deutsche Bank AG | 184,173 | $0.20M | 0.0% | +688.7% | 0.276% |  |
| 2/17/2025 | D. E. Shaw & Co. Inc. | 344,922 | $0.37M | 0.0% | -29.3% | 0.516% |  |
| 2/17/2025 | Bridgeway Capital Management LLC | 246,800 | $0.26M | 0.0% | -23.8% | 0.370% |  |
| 2/14/2025 | The Manufacturers Life Insurance Company | 145,094 | $0.15M | 0.0% | -11.5% | 0.217% |  |
| 2/14/2025 | Integrated Wealth Concepts LLC | 72,720 | $77K | 0.0% | N/A | 0.109% |  |
| 2/14/2025 | Price T Rowe Associates Inc. MD | 9,279,059 | $9.84M | 0.0% | -0.8% | 13.893% |  |
| 2/14/2025 | Dimensional Fund Advisors LP | 396,237 | $0.42M | 0.0% | -10.2% | 0.593% |  |
| 2/13/2025 | Renaissance Technologies LLC | 962,959 | $1.02M | 0.0% | +62.0% | 1.442% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 297,705 | $0.32M | 0.0% | +74.9% | 0.446% |  |
| 2/11/2025 | Intech Investment Management LLC | 23,337 | $25K | 0.0% | N/A | 0.035% |  |
| 2/6/2025 | Charles Schwab Investment Management Inc. | 367,026 | $0.39M | 0.0% | -13.3% | 0.550% |  |
| 2/4/2025 | Los Angeles Capital Management LLC | 245,927 | $0.26M | 0.0% | -16.8% | 0.368% |  |
| 11/19/2024 | Barclays PLC | 76,430 | $0.19M | 0.0% | +165.5% | 0.114% |  |
| 11/15/2024 | Barclays PLC | 76,430 | $0.19M | 0.0% | +165.5% | 0.114% |  |
| 11/15/2024 | XTX Topco Ltd | 17,922 | $44K | 0.0% | -86.5% | 0.027% |  |
| 11/15/2024 | Jane Street Group LLC | 34,783 | $86K | 0.0% | -29.9% | 0.052% |  |
| 11/15/2024 | State Street Corp | 992,188 | $2.45M | 0.0% | +1.2% | 1.486% |  |
| 11/15/2024 | Jacobs Levy Equity Management Inc. | 273,445 | $0.68M | 0.0% | -9.2% | 0.409% |  |
| 11/15/2024 | Baker BROS. Advisors LP | 1,944,945 | $4.80M | 0.0% | +61.1% | 2.912% |  |
| 11/13/2024 | FMR LLC | 5,320,266 | $13.14M | 0.0% | +0.3% | 7.966% |  |
| 11/12/2024 | Charles Schwab Investment Management Inc. | 423,299 | $1.05M | 0.0% | +2.1% | 0.634% |  |
| 11/6/2024 | Cornercap Investment Counsel Inc. | 28,995 | $72K | 0.0% | -49.5% | 0.043% |  |
| 11/4/2024 | Los Angeles Capital Management LLC | 295,727 | $0.73M | 0.0% | -13.5% | 0.443% |  |
| 10/3/2024 | SG Americas Securities LLC | 17,067 | $42K | 0.0% | N/A | 0.026% |  |
| 9/16/2024 | Cubist Systematic Strategies LLC | 19,046 | $54K | 0.0% | +91.0% | 0.029% |  |
| 8/15/2024 | The Manufacturers Life Insurance Company | 164,573 | $0.46M | 0.0% | +8.7% | 0.247% |  |
| 8/14/2024 | Cubist Systematic Strategies LLC | 19,046 | $54K | 0.0% | +91.0% | 0.029% |  |
| 8/12/2024 | XTX Topco Ltd | 132,716 | $0.37M | 0.0% | -20.2% | 0.199% |  |
| 8/9/2024 | Renaissance Technologies LLC | 636,400 | $1.80M | 0.0% | -4.2% | 0.957% |  |
| 8/9/2024 | Dimensional Fund Advisors LP | 485,396 | $1.37M | 0.0% | -3.7% | 0.730% |  |
| 8/8/2024 | Cornercap Investment Counsel Inc. | 57,424 | $0.16M | 0.0% | -22.6% | 0.086% |  |
| 8/8/2024 | American Century Companies Inc. | 31,786 | $90K | 0.0% | +199.3% | 0.048% |  |
| 8/6/2024 | Acadian Asset Management LLC | 594,569 | $1.68M | 0.0% | +23.9% | 0.894% |  |
| 8/6/2024 | Los Angeles Capital Management LLC | 341,861 | $0.96M | 0.0% | -10.4% | 0.514% |  |
| 8/1/2024 | Rhumbline Advisers | 78,903 | $0.22M | 0.0% | +7.4% | 0.119% |  |
| 7/26/2024 | Bank of New York Mellon Corp | 186,756 | $0.53M | 0.0% | +31.2% | 0.281% |  |
| 5/17/2024 | Artal Group S.A. | 2,830,591 | $11.52M | 0.3% | +0.6% | 4.255% |  |
| 5/16/2024 | Jacobs Levy Equity Management Inc. | 32,352 | $0.13M | 0.0% | -63.5% | 0.049% |  |
| 5/15/2024 | Baker BROS. Advisors LP | 371,219 | $1.51M | 0.0% | N/A | 0.558% |  |
| 5/15/2024 | Yiheng Capital Management L.P. | 191,530 | $0.78M | 0.0% | N/A | 0.288% |  |
| 5/15/2024 | Bellevue Group AG | 3,861,575 | $15.72M | 0.2% | +6.8% | 5.808% |  |
| 5/15/2024 | Price T Rowe Associates Inc. MD | 8,878,361 | $36.14M | 0.0% | +28.2% | 13.353% |  |
| 5/10/2024 | Acadian Asset Management LLC | 479,835 | $1.95M | 0.0% | +113.9% | 0.722% |  |
| 5/10/2024 | Vanguard Group Inc. | 2,570,456 | $10.46M | 0.0% | +0.7% | 3.866% |  |
| 5/7/2024 | PFG Advisors | 10,000 | $41K | 0.0% | N/A | 0.015% |  |
| 5/7/2024 | SG Americas Securities LLC | 16,626 | $68K | 0.0% | -65.7% | 0.025% |  |
| 5/1/2024 | Mirae Asset Global Investments Co. Ltd. | 18,259 | $74K | 0.0% | N/A | 0.027% |  |
| 4/5/2024 | Los Angeles Capital Management LLC | 381,661 | $1.55M | 0.0% | +38.4% | 0.574% |  |
| 2/15/2024 | PFM Health Sciences LP | 1,622,487 | $2.68M | 0.2% | -35.5% | 2.455% |  |
| 2/12/2024 | Weiss Asset Management LP | 81,630 | $0.14M | 0.0% | N/A | 0.124% |  |
| 2/8/2024 | Panagora Asset Management Inc. | 29,638 | $49K | 0.0% | N/A | 0.045% |  |
| 2/6/2024 | Los Angeles Capital Management LLC | 275,834 | $0.46M | 0.0% | +315.6% | 0.417% |  |
| 2/5/2024 | Kestra Private Wealth Services LLC | 30,500 | $50K | 0.0% | N/A | 0.046% |  |
| 1/12/2024 | SG Americas Securities LLC | 48,470 | $80K | 0.0% | +260.9% | 0.073% |  |
| 11/13/2023 | FMR LLC | 8,432,773 | $31.96M | 0.0% | -2.2% | 12.790% |  |
| 10/27/2023 | TD Asset Management Inc | 406,598 | $1.54M | 0.0% | +72.1% | 0.617% |  |
| 10/13/2023 | SG Americas Securities LLC | 13,430 | $51K | 0.0% | N/A | 0.020% |  |
| 9/21/2023 | Barclays PLC | 17,395 | $95K | 0.0% | -42.4% | 0.026% |  |
| 8/11/2023 | SVB Financial Group | 27,882 | $0.15M | 0.3% | -31.0% | 0.042% |  |
| 8/11/2023 | Sectoral Asset Management Inc. | 356,740 | $1.96M | 0.3% | -7.4% | 0.541% |  |
| 8/9/2023 | TD Asset Management Inc | 236,255 | $1.30M | 0.0% | +2.1% | 0.358% |  |
| 8/3/2023 | Innovis Asset Management LLC | 10,022 | $55K | 0.0% | -49.6% | 0.015% |  |
| 7/24/2023 | Vontobel Holding Ltd. | 356,740 | $1.96M | 0.0% | -7.4% | 0.543% |  |
| 5/15/2023 | EcoR1 Capital LLC | 1,956,579 | $8.41M | 0.3% | N/A | 3.279% |  |