| 11/13/2024 | FMR LLC | 432,220 | $0.25M | 0.0% | -73.1% | 0.398% |  |
| 9/16/2024 | Point72 DIFC Ltd | 47,648 | $29K | 0.0% | N/A | 0.044% |  |
| 9/16/2024 | Point72 Asia Singapore Pte. Ltd. | 155,915 | $96K | 0.0% | N/A | 0.144% |  |
| 8/15/2024 | Point72 Asia Singapore Pte. Ltd. | 155,915 | $96K | 0.0% | N/A | 0.144% |  |
| 8/14/2024 | Point72 DIFC Ltd | 47,648 | $29K | 0.0% | N/A | 0.044% |  |
| 8/9/2024 | Dimensional Fund Advisors LP | 199,558 | $0.12M | 0.0% | -30.4% | 0.184% |  |
| 8/5/2024 | Victory Capital Management Inc. | 553,150 | $0.34M | 0.0% | +4,598.5% | 0.509% |  |
| 7/30/2024 | Forum Financial Management LP | 250,000 | $0.15M | 0.0% | +63.1% | 0.230% |  |
| 5/17/2024 | Artal Group S.A. | 1,030,952 | $2.65M | 0.1% | N/A | 0.950% |  |
| 5/17/2024 | Tidal Investments LLC | 24,536 | $63K | 0.0% | N/A | 0.023% |  |
| 5/16/2024 | Redmile Group LLC | 5,755,075 | $14.79M | 0.5% | -2.0% | 5.301% |  |
| 5/15/2024 | Lazard Asset Management LLC | 27,461 | $70K | 0.0% | N/A | 0.025% |  |
| 5/10/2024 | Vanguard Group Inc. | 4,733,791 | $12.17M | 0.0% | +7.2% | 4.419% |  |
| 5/7/2024 | Susquehanna Fundamental Investments LLC | 247,607 | $0.64M | 0.0% | N/A | 0.231% |  |
| 5/7/2024 | SG Americas Securities LLC | 23,811 | $61K | 0.0% | -39.1% | 0.022% |  |
| 5/1/2024 | BNP Paribas Financial Markets | 46,237 | $0.12M | 0.0% | +85.2% | 0.047% |  |
| 5/1/2024 | Klingman & Associates LLC | 34,786 | $89K | 0.0% | N/A | 0.035% |  |
| 2/15/2024 | Frazier Life Sciences Management L.P. | 1,030,878 | $2.10M | 0.1% | -28.0% | 1.081% |  |
| 2/8/2024 | Panagora Asset Management Inc. | 201,439 | $0.41M | 0.0% | -4.9% | 0.211% |  |
| 2/7/2024 | Forum Financial Management LP | 90,000 | $0.18M | 0.0% | +405.6% | 0.094% |  |
| 1/17/2024 | Twin Peaks Wealth Advisors LLC | 40,314 | $82K | 0.1% | N/A | 0.042% |  |
| 1/16/2024 | Raymond James Financial Services Advisors Inc. | 22,073 | $45K | 0.0% | -13.7% | 0.023% |  |
| 1/12/2024 | SkyOak Wealth LLC | 36,640 | $75K | 0.0% | -39.8% | 0.038% |  |
| 11/15/2023 | Redmile Group LLC | 8,509,126 | $14.64M | 0.7% | +24.0% | 8.925% |  |
| 11/14/2023 | Avidity Partners Management LP | 2,733,800 | $4.70M | 0.2% | -1.1% | 2.867% |  |
| 11/9/2023 | Houlihan Financial Resource Group Ltd. | 20,000 | $38K | 0.0% | -94.4% | 0.021% |  |
| 11/6/2023 | Assenagon Asset Management S.A. | 867,233 | $1.49M | 0.0% | -30.5% | 0.932% |  |
| 11/6/2023 | Forum Financial Management LP | 17,799 | $31K | 0.0% | +78.0% | 0.019% |  |
| 10/31/2023 | Panagora Asset Management Inc. | 211,789 | $0.36M | 0.0% | +84.2% | 0.228% |  |
| 10/24/2023 | Bank of New York Mellon Corp | 272,783 | $0.47M | 0.0% | -5.9% | 0.293% |  |
| 10/24/2023 | SkyOak Wealth LLC | 60,875 | $0.11M | 0.0% | -18.1% | 0.065% |  |
| 10/13/2023 | SG Americas Securities LLC | 42,240 | $73K | 0.0% | N/A | 0.045% |  |
| 9/21/2023 | Barclays PLC | 38,662 | $75K | 0.0% | -46.8% | 0.042% |  |
| 8/14/2023 | Artia Global Partners LP | 95,170 | $0.19M | 0.1% | N/A | 0.102% |  |
| 8/14/2023 | Graham Capital Management L.P. | 36,991 | $72K | 0.0% | N/A | 0.040% |  |
| 8/11/2023 | Panagora Asset Management Inc. | 114,999 | $0.22M | 0.0% | N/A | 0.129% |  |
| 8/4/2023 | American International Group Inc. | 42,245 | $82K | 0.0% | N/A | 0.048% |  |
| 8/2/2023 | Houlihan Financial Resource Group Ltd. | 360,000 | $0.82M | 0.0% | N/A | 0.405% |  |
| 7/25/2023 | Assenagon Asset Management S.A. | 1,248,264 | $2.43M | 0.0% | -18.9% | 1.404% |  |
| 7/20/2023 | SkyOak Wealth LLC | 74,295 | $0.15M | 0.0% | -41.4% | 0.084% |  |
| 6/1/2023 | Prelude Capital Management LLC | 10,169 | $28K | 0.0% | N/A | 0.011% |  |
| 5/9/2023 | Y Intercept Hong Kong Ltd | 16,459 | $46K | 0.0% | N/A | 0.019% |  |
| 5/3/2023 | Jump Financial LLC | 36,918 | $0.10M | 0.0% | +130.2% | 0.042% |  |
| 5/3/2023 | Integrated Wealth Concepts LLC | 12,021 | $33K | 0.0% | N/A | 0.014% |  |
| 4/19/2023 | Forum Financial Management LP | 10,000 | $28K | 0.0% | N/A | 0.011% |  |
| 4/18/2023 | Assenagon Asset Management S.A. | 1,538,368 | $4.28M | 0.0% | -20.9% | 1.755% |  |
| 4/18/2023 | ETF Managers Group LLC | 27,912 | $78K | 0.0% | +34.3% | 0.032% |  |
| 2/15/2023 | Endurant Capital Management LP | 282,935 | $0.98M | 0.4% | N/A | 0.339% |  |
| 2/14/2023 | 683 Capital Management LLC | 61,761 | $0.21M | 0.0% | N/A | 0.074% |  |
| 2/13/2023 | Artal Group S.A. | 1,856,194 | $6.40M | 0.4% | +147.5% | 2.226% |  |
| 2/9/2023 | Citigroup Inc. | 139,051 | $0.48M | 0.0% | +4,253.5% | 0.167% |  |
| 2/8/2023 | Russell Investments Group Ltd. | 60,597 | $0.21M | 0.0% | -7.4% | 0.073% |  |
| 2/3/2023 | Frazier Life Sciences Management L.P. | 5,162,348 | $17.81M | 1.1% | -1.4% | 6.192% |  |
| 1/26/2023 | SkyOak Wealth LLC | 129,288 | $0.45M | 0.1% | -2.7% | 0.155% |  |
| 1/12/2023 | Assenagon Asset Management S.A. | 1,945,700 | $6.71M | 0.0% | +154.6% | 2.334% |  |
| 11/15/2022 | Caxton Associates LP | 95,190 | $0.25M | 0.0% | N/A | 0.114% |  |
| 11/14/2022 | Ergoteles LLC | 58,700 | $0.15M | 0.0% | -76.2% | 0.070% |  |
| 11/10/2022 | Connor Clark & Lunn Investment Management Ltd. | 123,822 | $0.32M | 0.0% | +642.3% | 0.149% |  |
| 11/7/2022 | Virtu Financial LLC | 51,861 | $0.13M | 0.0% | +205.1% | 0.071% |  |
| 11/4/2022 | Vontobel Holding Ltd. | 50,000 | $0.13M | 0.0% | N/A | 0.069% |  |
| 11/4/2022 | Russell Investments Group Ltd. | 65,412 | $0.17M | 0.0% | -5.3% | 0.090% |  |
| 10/27/2022 | Assenagon Asset Management S.A. | 764,070 | $1.96M | 0.0% | -22.9% | 1.049% |  |
| 8/12/2022 | Ensign Peak Advisors Inc | 120,527 | $0.29M | 0.0% | -14.2% | 0.166% |  |
| 8/12/2022 | Rafferty Asset Management LLC | 49,437 | $0.12M | 0.0% | -75.2% | 0.068% |  |
| 8/5/2022 | Connor Clark & Lunn Investment Management Ltd. | 16,681 | $40K | 0.0% | N/A | 0.023% |  |
| 7/29/2022 | Russell Investments Group Ltd. | 69,040 | $0.17M | 0.0% | -19.2% | 0.095% |  |
| 7/27/2022 | Assenagon Asset Management S.A. | 991,472 | $2.40M | 0.0% | N/A | 1.362% |  |
| 7/26/2022 | SkyOak Wealth LLC | 132,851 | $0.32M | 0.1% | -21.7% | 0.182% |  |
| 7/25/2022 | Institute for Wealth Management LLC. | 13,221 | $32K | 0.0% | N/A | 0.018% |  |
| 7/19/2022 | Key Client Fiduciary Advisors LLC | 10,229 | $25K | 0.0% | N/A | 0.014% |  |
| 5/16/2022 | Palo Alto Investors LP | 2,330,504 | $9.60M | 0.7% | -1.1% | 3.201% |  |
| 5/16/2022 | Pinz Capital Management LP | 280,000 | $1.15M | 0.7% | N/A | 0.385% |  |
| 5/16/2022 | Deep Track Capital LP | 2,985,729 | $12.30M | 0.8% | +68.5% | 4.101% |  |
| 5/16/2022 | Frazier Life Sciences Management L.P. | 5,237,348 | $21.58M | 1.8% | N/A | 7.193% |  |
| 5/12/2022 | Running Point Capital Advisors LLC | 10,000 | $41K | 0.0% | N/A | 0.014% |  |
| 5/11/2022 | ACT Capital Management LLC | 47,500 | $0.20M | 0.2% | +18.8% | 0.065% |  |
| 5/11/2022 | DG Capital Management LLC | 50,000 | $0.21M | 0.0% | N/A | 0.069% |  |
| 5/11/2022 | GSA Capital Partners LLP | 30,939 | $0.13M | 0.0% | N/A | 0.042% |  |
| 5/10/2022 | Steel Peak Wealth Management LLC | 10,859 | $45K | 0.0% | N/A | 0.015% |  |
| 5/10/2022 | Fox Run Management L.L.C. | 15,067 | $62K | 0.0% | +48.0% | 0.021% |  |
| 5/9/2022 | Qube Research & Technologies Ltd | 243,786 | $1M | 0.0% | N/A | 0.335% |  |
| 4/28/2022 | DekaBank Deutsche Girozentrale | 55,000 | $0.23M | 0.0% | +10.0% | 0.076% |  |
| 4/20/2022 | Belvedere Trading LLC | 25,134 | $85K | 0.0% | +14.7% | 0.035% |  |
| 4/18/2022 | SkyOak Wealth LLC | 169,736 | $0.70M | 0.2% | +538.6% | 0.233% |  |
| 2/14/2022 | Itau Unibanco Holding S.A. | 4,058 | $53K | 0.0% | N/A | 0.006% |  |
| 2/14/2022 | Virtus ETF Advisers LLC | 14,346 | $0.18M | 0.1% | -31.2% | 0.021% |  |
| 2/14/2022 | Redmile Group LLC | 3,429,171 | $44.10M | 1.0% | +21.6% | 5.044% |  |
| 2/14/2022 | Corton Capital Inc. | 21,301 | $0.27M | 0.1% | N/A | 0.031% |  |
| 2/14/2022 | Deep Track Capital LP | 1,771,801 | $22.79M | 1.6% | N/A | 2.606% |  |
| 2/14/2022 | Eversept Partners LP | 170,125 | $2.19M | 0.2% | N/A | 0.250% |  |
| 2/14/2022 | ETF Managers Group LLC | 20,646 | $0.27M | 0.0% | N/A | 0.030% |  |
| 2/11/2022 | Ensign Peak Advisors Inc | 140,527 | $1.81M | 0.0% | +39.8% | 0.207% |  |
| 2/10/2022 | Rafferty Asset Management LLC | 469,239 | $6.03M | 0.0% | N/A | 0.690% |  |
| 2/10/2022 | Citigroup Inc. | 215,726 | $2.77M | 0.0% | +4,586.6% | 0.317% |  |
| 2/10/2022 | Acadian Asset Management LLC | 447,611 | $5.76M | 0.0% | -26.0% | 0.658% |  |
| 2/10/2022 | Panagora Asset Management Inc. | 10,987 | $0.14M | 0.0% | -88.2% | 0.016% |  |
| 2/10/2022 | Connor Clark & Lunn Investment Management Ltd. | 130,622 | $1.68M | 0.0% | N/A | 0.192% |  |
| 2/9/2022 | BNP Paribas Arbitrage SA | 16,997 | $0.22M | 0.0% | +87.4% | 0.025% |  |
| 2/9/2022 | Alps Advisors Inc. | 78,678 | $1.01M | 0.0% | N/A | 0.116% |  |
| 2/9/2022 | Dimensional Fund Advisors LP | 225,003 | $2.89M | 0.0% | +26.3% | 0.331% |  |