| 2/15/2024 | Blackstone Inc. | 815,000 | $9.27M | 0.0% | N/A | 4.813% |  |
| 2/14/2024 | Commodore Capital LP | 1,500,000 | $17.06M | 1.5% | N/A | 8.859% |  |
| 2/14/2024 | New Leaf Venture Partners L.L.C. | 1,859,168 | $21.14M | 17.0% | +489.0% | 10.982% |  |
| 2/9/2024 | Franklin Resources Inc. | 1,492,368 | $16.97M | 0.0% | +1,027.8% | 8.815% |  |
| 1/31/2024 | abrdn plc | 25,991 | $0.30M | 0.0% | N/A | 0.154% |  |
| 11/15/2023 | Kennedy Capital Management LLC | 52,987 | $0.21M | 0.0% | -90.0% | 1.366% |  |
| 11/14/2023 | MPM Bioimpact LLC | 319,670 | $1.29M | 0.3% | -90.0% | 8.239% |  |
| 11/13/2023 | Acadian Asset Management LLC | 7,670 | $29K | 0.0% | -90.0% | 0.198% |  |
| 8/8/2023 | Sequoia Financial Advisors LLC | 63,955 | $45K | 0.0% | -36.0% | 0.199% |  |
| 8/7/2023 | Acadian Asset Management LLC | 76,710 | $53K | 0.0% | -32.5% | 0.239% |  |
| 5/8/2023 | Bailard Inc. | 63,200 | $47K | 0.0% | N/A | 0.168% |  |
| 5/1/2023 | CM Wealth Advisors LLC | 50,354 | $29K | 0.0% | N/A | 0.134% |  |
| 4/25/2023 | Sequoia Financial Advisors LLC | 100,000 | $74K | 0.0% | +66.7% | 0.267% |  |
| 2/13/2023 | Levin Capital Strategies L.P. | 330,000 | $0.24M | 0.0% | N/A | 0.997% |  |
| 11/15/2022 | Piper Sandler & CO. | 580,815 | $0.56M | 0.5% | N/A | 1.754% |  |
| 11/14/2022 | Ergoteles LLC | 70,054 | $68K | 0.0% | -23.8% | 0.212% |  |
| 9/16/2022 | Federated Hermes Inc. | 132,791 | $0.25M | 0.0% | +45.0% | 0.401% |  |
| 8/12/2022 | Franklin Resources Inc. | 1,324,504 | $2.53M | 0.0% | -20.4% | 4.003% |  |
| 5/20/2022 | International Biotechnology Trust PLC | 151,445 | $2.77M | 0.6% | -29.6% | 0.458% |  |
| 5/13/2022 | Tekla Capital Management LLC | 259,910 | $1.29M | 0.0% | N/A | 0.786% |  |
| 5/12/2022 | Connor Clark & Lunn Investment Management Ltd. | 14,872 | $74K | 0.0% | -37.0% | 0.045% |  |
| 2/15/2022 | Sender Co & Partners Inc. | 14,252 | $0.11M | 0.1% | N/A | 0.044% |  |
| 2/15/2022 | Kennedy Capital Management Inc. | 129,766 | $0.98M | 0.0% | N/A | 0.396% |  |
| 2/14/2022 | Point72 Asset Management L.P. | 650,000 | $4.91M | 0.0% | N/A | 1.985% |  |
| 2/14/2022 | GSA Capital Partners LLP | 35,266 | $0.27M | 0.0% | +42.0% | 0.108% |  |
| 2/10/2022 | Candriam Luxembourg S.C.A. | 809,568 | $6.11M | 0.0% | +65.4% | 2.472% |  |
| 2/10/2022 | Panagora Asset Management Inc. | 85,059 | $0.64M | 0.0% | +113.0% | 0.260% |  |
| 2/10/2022 | Connor Clark & Lunn Investment Management Ltd. | 23,595 | $0.18M | 0.0% | +110.2% | 0.072% |  |
| 2/8/2022 | Northern Trust Corp | 191,251 | $1.44M | 0.0% | -3.4% | 0.584% |  |
| 1/28/2022 | Allspring Global Investments Holdings LLC | 4,621 | $34K | 0.0% | N/A | 0.014% |  |
| 11/16/2021 | Schonfeld Strategic Advisors LLC | 84,272 | $0.67M | 0.0% | +41.1% | 0.258% |  |
| 11/16/2021 | Squarepoint Ops LLC | 14,703 | $0.12M | 0.0% | N/A | 0.045% |  |
| 11/16/2021 | Two Sigma Advisers LP | 377,500 | $2.98M | 0.0% | N/A | 1.155% |  |
| 11/16/2021 | Two Sigma Investments LP | 406,470 | $3.21M | 0.0% | N/A | 1.244% |  |
| 11/16/2021 | Laurion Capital Management LP | 305,954 | $2.42M | 0.0% | -51.5% | 0.936% |  |
| 11/16/2021 | Millennium Management LLC | 602,752 | $4.76M | 0.0% | +994.7% | 1.845% |  |
| 11/15/2021 | Cubist Systematic Strategies LLC | 45,121 | $0.36M | 0.0% | +356.9% | 0.138% |  |
| 11/15/2021 | Dynamic Technology Lab Private Ltd | 23,602 | $0.19M | 0.0% | N/A | 0.072% |  |
| 11/15/2021 | Franklin Resources Inc. | 1,131,753 | $8.94M | 0.0% | -0.5% | 3.464% |  |
| 11/15/2021 | GSA Capital Partners LLP | 24,838 | $0.20M | 0.0% | +40.7% | 0.076% |  |
| 11/12/2021 | Affinity Asset Advisors LLC | 250,000 | $1.98M | 0.5% | +400.0% | 0.765% |  |
| 11/12/2021 | Trexquant Investment LP | 29,435 | $0.23M | 0.0% | N/A | 0.090% |  |
| 11/12/2021 | Renaissance Technologies LLC | 400,788 | $3.17M | 0.0% | N/A | 1.227% |  |
| 11/12/2021 | Jump Financial LLC | 31,200 | $0.25M | 0.0% | N/A | 0.096% |  |
| 11/12/2021 | International Biotechnology Trust PLC | 215,000 | $1.70M | 0.4% | N/A | 0.658% |  |
| 11/12/2021 | Geode Capital Management LLC | 380,213 | $3M | 0.0% | +8.0% | 1.164% |  |
| 11/12/2021 | Connor Clark & Lunn Investment Management Ltd. | 11,225 | $89K | 0.0% | N/A | 0.034% |  |
| 11/10/2021 | Goldman Sachs Group Inc. | 87,398 | $0.69M | 0.0% | -60.8% | 0.268% |  |
| 11/10/2021 | Panagora Asset Management Inc. | 39,929 | $0.32M | 0.0% | -49.5% | 0.122% |  |
| 11/10/2021 | IndexIQ Advisors LLC | 21,491 | $0.17M | 0.0% | +11.1% | 0.066% |  |
| 11/10/2021 | Citigroup Inc. | 3,817 | $30K | 0.0% | -96.4% | 0.012% |  |
| 11/9/2021 | Barclays PLC | 31,167 | $0.25M | 0.0% | -13.7% | 0.095% |  |
| 11/9/2021 | BlackRock Inc. | 1,733,182 | $13.69M | 0.0% | +1.2% | 5.305% |  |
| 11/8/2021 | Summit Global Investments | 10,800 | $85K | 0.0% | N/A | 0.033% |  |
| 11/8/2021 | Los Angeles Capital Management LLC | 55,476 | $0.44M | 0.0% | -8.1% | 0.170% |  |
| 11/4/2021 | Deutsche Bank AG | 11,329 | $89K | 0.0% | -37.4% | 0.035% |  |
| 11/2/2021 | New York State Common Retirement Fund | 5,809 | $46K | 0.0% | -66.5% | 0.018% |  |
| 10/19/2021 | Assenagon Asset Management S.A. | 94,242 | $0.75M | 0.0% | N/A | 0.288% |  |
| 9/3/2021 | Parametric Portfolio Associates LLC | 10,509 | $0.15M | 0.0% | N/A | 0.032% |  |