| 8/15/2025 | Rangeley Capital LLC | 153,790 | $0.31M | 0.4% | N/A | 0.307% |  |
| 8/15/2025 | Militia Capital Partners LP | 71,606 | $0.14M | 0.1% | N/A | 0.143% |  |
| 8/15/2025 | EcoR1 Capital LLC | 2,420,243 | $4.82M | 0.3% | N/A | 4.827% |  |
| 8/15/2025 | Balyasny Asset Management L.P. | 976,297 | $1.94M | 0.0% | -2.6% | 1.947% |  |
| 8/14/2025 | Jane Street Group LLC | 15,106 | $30K | 0.0% | -73.3% | 0.030% |  |
| 8/14/2025 | RBF Capital LLC | 200,000 | $0.40M | 0.0% | N/A | 0.399% |  |
| 8/14/2025 | Qube Research & Technologies Ltd | 49,963 | $99K | 0.0% | N/A | 0.100% |  |
| 8/13/2025 | Marshall Wace LLP | 21,400 | $43K | 0.0% | N/A | 0.043% |  |
| 8/13/2025 | Stonepine Capital Management LLC | 226,009 | $0.45M | 0.4% | -5.4% | 0.451% |  |
| 8/13/2025 | Quadrature Capital Ltd | 30,942 | $62K | 0.0% | N/A | 0.062% |  |
| 8/13/2025 | Russell Investments Group Ltd. | 23,939 | $48K | 0.0% | +38.1% | 0.048% |  |
| 8/12/2025 | XTX Topco Ltd | 42,753 | $85K | 0.0% | +74.6% | 0.085% |  |
| 8/11/2025 | BML Capital Management LLC | 91,913 | $0.18M | 0.1% | +342.7% | 0.183% |  |
| 8/8/2025 | Geode Capital Management LLC | 255,254 | $0.51M | 0.0% | -58.1% | 0.509% |  |
| 8/1/2025 | Y Intercept Hong Kong Ltd | 109,153 | $0.22M | 0.0% | N/A | 0.218% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 655,711 | $0.95M | 0.0% | -6.2% | 1.308% |  |
| 5/21/2025 | Acadian Asset Management LLC | 165,770 | $0.24M | 0.0% | -59.6% | 0.331% |  |
| 5/19/2025 | Jane Street Group LLC | 56,563 | $82K | 0.0% | +26.9% | 0.113% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 655,711 | $0.95M | 0.0% | -6.2% | 1.308% |  |
| 5/16/2025 | AQR Capital Management LLC | 33,495 | $49K | 0.0% | +38.0% | 0.067% |  |
| 5/14/2025 | Stonepine Capital Management LLC | 238,950 | $0.35M | 0.3% | +80.5% | 0.477% |  |
| 5/13/2025 | Callan Family Office LLC | 19,327 | $28K | 0.0% | N/A | 0.039% |  |
| 5/9/2025 | Deutsche Bank AG | 324,484 | $0.47M | 0.0% | -22.8% | 0.647% |  |
| 5/8/2025 | XTX Topco Ltd | 24,491 | $36K | 0.0% | N/A | 0.049% |  |
| 5/8/2025 | Federated Hermes Inc. | 24,429 | $35K | 0.0% | +128.3% | 0.049% |  |
| 4/30/2025 | Trium Capital LLP | 378,205 | $0.55M | 0.1% | N/A | 0.754% |  |
| 2/17/2025 | Two Sigma Advisers LP | 41,200 | $85K | 0.0% | +76.8% | 0.083% |  |
| 2/17/2025 | Two Sigma Investments LP | 55,535 | $0.12M | 0.0% | +76.3% | 0.112% |  |
| 2/17/2025 | Stonepine Capital Management LLC | 132,347 | $0.27M | 0.2% | N/A | 0.266% |  |
| 2/17/2025 | Millennium Management LLC | 411,820 | $0.85M | 0.0% | +59.6% | 0.827% |  |
| 2/17/2025 | Lightspeed Management Company L.L.C. | 2,341,376 | $4.85M | 1.4% | N/A | 4.701% |  |
| 2/17/2025 | Deutsche Bank AG | 420,550 | $0.87M | 0.0% | +32.9% | 0.844% |  |
| 2/17/2025 | Citadel Advisors LLC | 118,400 | $0.25M | 0.0% | -32.5% | 0.238% |  |
| 2/17/2025 | Balyasny Asset Management L.P. | 1,002,787 | $2.08M | 0.0% | -1.2% | 2.013% |  |
| 2/17/2025 | Bank of America Corp DE | 231,930 | $0.48M | 0.0% | +51.4% | 0.466% |  |
| 2/14/2025 | Jane Street Group LLC | 44,572 | $92K | 0.0% | -43.6% | 0.089% |  |
| 2/14/2025 | Samsara BioCapital LLC | 399,637 | $0.83M | 0.1% | -50.0% | 0.802% |  |
| 2/14/2025 | Northern Trust Corp | 249,610 | $0.52M | 0.0% | +2.8% | 0.501% |  |
| 2/14/2025 | Voya Investment Management LLC | 61,141 | $0.13M | 0.0% | -27.6% | 0.123% |  |
| 2/14/2025 | Dimensional Fund Advisors LP | 61,947 | $0.13M | 0.0% | -14.7% | 0.124% |  |
| 2/13/2025 | Barclays PLC | 47,946 | $100K | 0.0% | +14.1% | 0.096% |  |
| 2/13/2025 | Bank of Montreal Can | 35,763 | $74K | 0.0% | +47.1% | 0.072% |  |
| 2/13/2025 | Russell Investments Group Ltd. | 38,236 | $79K | 0.0% | +328.0% | 0.077% |  |
| 2/12/2025 | Landscape Capital Management L.L.C. | 43,188 | $89K | 0.0% | N/A | 0.087% |  |
| 2/12/2025 | Geode Capital Management LLC | 603,952 | $1.25M | 0.0% | -3.8% | 1.213% |  |
| 2/12/2025 | Takeda Pharmaceutical Co. Ltd. | 6,724,000 | $13.92M | 52.4% | N/A | 13.499% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 207,151 | $0.43M | 0.0% | +1,376.8% | 0.416% |  |
| 2/11/2025 | Intech Investment Management LLC | 12,647 | $26K | 0.0% | N/A | 0.025% |  |
| 2/3/2025 | Ieq Capital LLC | 22,495 | $47K | 0.0% | +71.1% | 0.045% |  |
| 1/28/2025 | Qiming U.S. Ventures Management LLC | 372,615 | $0.77M | 1.5% | -33.3% | 0.748% |  |
| 1/17/2025 | SG Americas Securities LLC | 18,145 | $38K | 0.0% | +61.6% | 0.036% |  |
| 12/26/2024 | JPMorgan Chase & Co. | 14,027 | $25K | 0.0% | -58.0% | 0.028% |  |
| 11/27/2024 | Franklin Resources Inc. | 1,957,619 | $3.49M | 0.0% | -1.5% | 3.930% |  |
| 11/19/2024 | Barclays PLC | 42,033 | $74K | 0.0% | +255.6% | 0.084% |  |
| 11/16/2024 | Geode Capital Management LLC | 627,669 | $1.11M | 0.0% | -11.4% | 1.260% |  |
| 11/15/2024 | Barclays PLC | 42,033 | $74K | 0.0% | +255.6% | 0.084% |  |
| 11/15/2024 | Zacks Investment Management | 92,803 | $0.16M | 0.0% | +411.9% | 0.186% |  |
| 11/15/2024 | Jane Street Group LLC | 79,039 | $0.14M | 0.0% | +81.7% | 0.159% |  |
| 11/15/2024 | State Street Corp | 585,795 | $1.03M | 0.0% | -1.6% | 1.176% |  |
| 11/14/2024 | Braidwell LP | 1,064,000 | $1.87M | 0.1% | N/A | 2.136% |  |
| 11/14/2024 | Verition Fund Management LLC | 188,035 | $0.33M | 0.0% | N/A | 0.378% |  |
| 11/12/2024 | Charles Schwab Investment Management Inc. | 75,596 | $0.13M | 0.0% | -66.4% | 0.152% |  |
| 11/5/2024 | BML Capital Management LLC | 19,760 | $35K | 0.0% | N/A | 0.040% |  |
| 11/5/2024 | GSA Capital Partners LLP | 71,463 | $0.13M | 0.0% | N/A | 0.144% |  |
| 10/8/2024 | Trium Capital LLP | 453,260 | $0.80M | 0.2% | N/A | 0.912% |  |
| 8/29/2024 | Maven Securities LTD | 15,000 | $0.22M | 0.0% | N/A | 0.030% |  |
| 8/19/2024 | Point72 Asset Management L.P. | 481,312 | $6.96M | 0.0% | N/A | 0.968% |  |
| 8/16/2024 | Algert Global LLC | 35,884 | $0.52M | 0.0% | N/A | 0.072% |  |
| 8/16/2024 | Frazier Life Sciences Management L.P. | 10,617,062 | $153.52M | 7.2% | +8.5% | 21.353% |  |
| 8/15/2024 | Millennium Management LLC | 489,975 | $7.09M | 0.0% | -27.6% | 0.985% |  |
| 8/15/2024 | Affinity Asset Advisors LLC | 265,859 | $3.84M | 0.4% | N/A | 0.535% |  |
| 8/14/2024 | Fred Alger Management LLC | 136,166 | $1.97M | 0.0% | +9.7% | 0.274% |  |
| 8/13/2024 | Ensign Peak Advisors Inc | 311,784 | $4.51M | 0.0% | +164.8% | 0.627% |  |
| 8/9/2024 | Renaissance Technologies LLC | 56,700 | $0.82M | 0.0% | +119.8% | 0.114% |  |
| 8/9/2024 | Dimensional Fund Advisors LP | 152,602 | $2.20M | 0.0% | +31.7% | 0.307% |  |
| 8/3/2024 | TD Asset Management Inc | 54,236 | $0.78M | 0.0% | +53.9% | 0.109% |  |
| 8/1/2024 | Rhumbline Advisers | 42,658 | $0.62M | 0.0% | +27.0% | 0.086% |  |
| 7/26/2024 | Bank of New York Mellon Corp | 93,865 | $1.36M | 0.0% | +35.1% | 0.189% |  |
| 5/17/2024 | Tidal Investments LLC | 12,465 | $0.21M | 0.0% | N/A | 0.025% |  |
| 5/16/2024 | California State Teachers Retirement System | 20,032 | $0.33M | 0.0% | -7.0% | 0.040% |  |
| 5/14/2024 | EntryPoint Capital LLC | 4,802 | $80K | 0.1% | N/A | 0.010% |  |
| 5/10/2024 | Vanguard Group Inc. | 1,362,672 | $22.66M | 0.0% | -7.0% | 2.741% |  |
| 5/7/2024 | SG Americas Securities LLC | 7,621 | $0.13M | 0.0% | -12.3% | 0.015% |  |
| 2/14/2024 | Braidwell LP | 203,407 | $3.27M | 0.1% | -86.0% | 0.420% |  |
| 2/14/2024 | Catalys Pacific LLC | 1,308,974 | $21.01M | 19.7% | N/A | 2.702% |  |
| 2/9/2024 | Franklin Resources Inc. | 1,846,396 | $29.64M | 0.0% | +4.1% | 3.812% |  |
| 2/6/2024 | Swiss National Bank | 38,200 | $0.61M | 0.0% | +22.4% | 0.079% |  |
| 1/31/2024 | abrdn plc | 27,000 | $0.43M | 0.0% | N/A | 0.056% |  |
| 1/12/2024 | SG Americas Securities LLC | 8,686 | $0.14M | 0.0% | N/A | 0.018% |  |
| 11/15/2023 | Acuta Capital Partners LLC | 270,319 | $3.64M | 2.4% | +328.5% | 0.558% |  |
| 11/15/2023 | Adage Capital Partners GP L.L.C. | 176,512 | $2.37M | 0.0% | N/A | 0.364% |  |
| 11/14/2023 | 683 Capital Management LLC | 121,200 | $1.63M | 0.1% | N/A | 0.250% |  |
| 11/14/2023 | Braidwell LP | 1,449,246 | $19.49M | 0.6% | +16.0% | 2.993% |  |
| 11/14/2023 | Seven Grand Managers LLC | 14,845 | $0.20M | 0.3% | N/A | 0.031% |  |
| 11/14/2023 | Fred Alger Management LLC | 120,634 | $1.62M | 0.0% | +38.6% | 0.249% |  |
| 11/14/2023 | Deerfield Management Company L.P. Series C | 4,004,231 | $53.86M | 1.2% | +20.3% | 8.270% |  |
| 11/14/2023 | Monashee Investment Management LLC | 110,000 | $1.48M | 0.6% | N/A | 0.227% |  |
| 11/13/2023 | Federated Hermes Inc. | 2,113 | $28K | 0.0% | +80.6% | 0.004% |  |
| 11/13/2023 | Maven Securities LTD | 35,544 | $0.48M | 0.0% | N/A | 0.073% |  |
| 11/13/2023 | StepStone Group LP | 826,567 | $11.12M | 2.4% | +22.2% | 1.707% |  |