| 11/17/2025 | Jacobs Levy Equity Management Inc. | 17,708 | $0.14M | 0.0% | N/A | 0.442% |  |
| 11/17/2025 | NewEdge Advisors LLC | 12,960 | $0.11M | 0.0% | N/A | 0.323% |  |
| 11/17/2025 | Citadel Advisors LLC | 122,247 | $1M | 0.0% | N/A | 3.052% |  |
| 11/14/2025 | Deep Track Capital LP | 878,516 | $7.16M | 0.2% | N/A | 21.935% |  |
| 11/14/2025 | Bridgeway Capital Management LLC | 12,774 | $0.10M | 0.0% | N/A | 0.319% |  |
| 11/14/2025 | Squarepoint Ops LLC | 24,170 | $0.20M | 0.0% | N/A | 0.603% |  |
| 11/14/2025 | Atlas Venture Life Science Advisors LLC | 377,814 | $3.08M | 0.4% | N/A | 9.434% |  |
| 11/13/2025 | Blue Owl Capital Holdings LP | 540,924 | $4.41M | 1.4% | N/A | 13.489% |  |
| 11/10/2025 | Aldebaran Capital LLC | 19,562 | $0.16M | 0.1% | N/A | 0.488% |  |
| 11/10/2025 | BML Capital Management LLC | 182,509 | $1.49M | 1.1% | N/A | 4.551% |  |
| 11/7/2025 | Vanguard Group Inc. | 233,358 | $1.90M | 0.0% | N/A | 5.819% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 76,464 | $98K | 0.0% | +62.4% | 0.158% |  |
| 5/21/2025 | Acadian Asset Management LLC | 209,568 | $0.27M | 0.0% | -27.3% | 0.434% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 76,464 | $98K | 0.0% | +62.4% | 0.158% |  |
| 5/16/2025 | Jacobs Levy Equity Management Inc. | 245,485 | $0.31M | 0.0% | -25.0% | 0.509% |  |
| 5/13/2025 | Gilead Sciences Inc. | 1,159,145 | $1.48M | 0.1% | -42.3% | 2.402% |  |
| 5/13/2025 | Aldebaran Capital LLC | 247,795 | $0.32M | 0.3% | N/A | 0.513% |  |
| 5/8/2025 | XTX Topco Ltd | 56,452 | $72K | 0.0% | +350.6% | 0.117% |  |
| 5/7/2025 | BML Capital Management LLC | 3,710,803 | $4.75M | 3.7% | +3.5% | 7.690% |  |
| 4/30/2025 | Peapod Lane Capital LLC | 296,437 | $0.38M | 0.4% | -41.6% | 0.614% |  |
| 2/17/2025 | Squarepoint Ops LLC | 43,640 | $72K | 0.0% | N/A | 0.090% |  |
| 2/17/2025 | Two Sigma Investments LP | 100,778 | $0.17M | 0.0% | -35.7% | 0.209% |  |
| 2/17/2025 | Two Sigma Advisers LP | 157,400 | $0.26M | 0.0% | -22.1% | 0.326% |  |
| 2/17/2025 | Millennium Management LLC | 199,684 | $0.33M | 0.0% | -19.9% | 0.414% |  |
| 2/17/2025 | Jacobs Levy Equity Management Inc. | 327,410 | $0.54M | 0.0% | -15.8% | 0.678% |  |
| 2/17/2025 | Citadel Advisors LLC | 80,368 | $0.13M | 0.0% | -51.3% | 0.167% |  |
| 2/17/2025 | BVF Inc. IL | 4,006,564 | $6.57M | 0.2% | -16.0% | 8.302% |  |
| 2/17/2025 | BNP Paribas Financial Markets | 44,040 | $72K | 0.0% | N/A | 0.091% |  |
| 2/14/2025 | Northern Trust Corp | 57,565 | $94K | 0.0% | +19.7% | 0.119% |  |
| 2/14/2025 | Vazirani Asset Management LLC | 25,000 | $41K | 0.1% | -78.4% | 0.052% |  |
| 2/14/2025 | Adage Capital Partners GP L.L.C. | 800,000 | $1.31M | 0.0% | -19.0% | 1.658% |  |
| 2/14/2025 | Gilead Sciences Inc. | 2,008,338 | $3.29M | 0.2% | N/A | 4.161% |  |
| 2/13/2025 | Renaissance Technologies LLC | 330,200 | $0.54M | 0.0% | -17.6% | 0.684% |  |
| 2/12/2025 | Geode Capital Management LLC | 327,962 | $0.54M | 0.0% | +21.0% | 0.680% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 155,741 | $0.26M | 0.0% | +18,244.1% | 0.323% |  |
| 2/11/2025 | Prudential Financial Inc. | 18,200 | $30K | 0.0% | -38.9% | 0.038% |  |
| 2/7/2025 | BBR Partners LLC | 70,000 | $0.12M | 0.0% | -46.2% | 0.145% |  |
| 2/7/2025 | BML Capital Management LLC | 3,585,866 | $5.88M | 3.7% | +395.8% | 7.430% |  |
| 1/29/2025 | Peapod Lane Capital LLC | 507,868 | $0.83M | 0.8% | N/A | 1.052% |  |
| 11/16/2024 | Geode Capital Management LLC | 271,026 | $0.47M | 0.0% | +5.6% | 0.562% |  |
| 11/15/2024 | Jane Street Group LLC | 37,270 | $64K | 0.0% | -33.3% | 0.077% |  |
| 11/15/2024 | Jacobs Levy Equity Management Inc. | 388,748 | $0.67M | 0.0% | -8.4% | 0.806% |  |
| 11/15/2024 | Point72 Asia Singapore Pte. Ltd. | 22,146 | $38K | 0.0% | -51.3% | 0.046% |  |
| 11/14/2024 | NEA Management Company LLC | 600,063 | $1.04M | 0.1% | +5.3% | 1.243% |  |
| 11/14/2024 | BBR Partners LLC | 130,000 | $0.23M | 0.0% | +550.0% | 0.269% |  |
| 11/13/2024 | FMR LLC | 38,374 | $66K | 0.0% | +94.1% | 0.080% |  |
| 11/5/2024 | BML Capital Management LLC | 723,288 | $1.25M | 0.7% | +23.6% | 1.499% |  |
| 9/16/2024 | Point72 Asia Singapore Pte. Ltd. | 45,520 | $75K | 0.0% | N/A | 0.094% |  |
| 8/15/2024 | Blue Owl Capital Holdings LP | 4,091,118 | $6.75M | 1.9% | +5.1% | 8.478% |  |
| 8/15/2024 | AQR Capital Management LLC | 21,861 | $36K | 0.0% | N/A | 0.045% |  |
| 8/15/2024 | Point72 Asia Singapore Pte. Ltd. | 45,520 | $75K | 0.0% | N/A | 0.094% |  |
| 8/14/2024 | Marshall Wace LLP | 44,933 | $74K | 0.0% | -49.3% | 0.093% |  |
| 8/12/2024 | XTX Topco Ltd | 16,607 | $27K | 0.0% | -52.9% | 0.034% |  |
| 8/12/2024 | Vanguard Personalized Indexing Management LLC | 18,310 | $30K | 0.0% | N/A | 0.038% |  |
| 8/10/2024 | Sofinnova Investments Inc. | 382,616 | $0.63M | 0.0% | +230.7% | 0.793% |  |
| 8/9/2024 | Renaissance Technologies LLC | 476,400 | $0.79M | 0.0% | -38.7% | 0.987% |  |
| 8/8/2024 | JBF Capital Inc. | 72,647 | $0.12M | 0.0% | N/A | 0.151% |  |
| 8/6/2024 | Acadian Asset Management LLC | 325,713 | $0.54M | 0.0% | +15.2% | 0.675% |  |
| 8/5/2024 | BBR Partners LLC | 20,000 | $33K | 0.0% | N/A | 0.041% |  |
| 7/30/2024 | Deuterium Capital Management LLC | 80,578 | $0.13M | 0.2% | N/A | 0.167% |  |
| 5/16/2024 | Jacobs Levy Equity Management Inc. | 513,440 | $0.73M | 0.0% | +813.7% | 1.064% |  |
| 5/10/2024 | Acadian Asset Management LLC | 282,782 | $0.40M | 0.0% | +1,201.8% | 0.586% |  |
| 5/7/2024 | Marquette Asset Management LLC | 72,890 | $0.10M | 0.0% | N/A | 0.151% |  |
| 2/15/2024 | BVF Inc. IL | 4,769,164 | $9.40M | 0.2% | +50.5% | 9.883% |  |
| 2/14/2024 | Vestal Point Capital LP | 322,671 | $0.64M | 0.1% | N/A | 0.669% |  |
| 1/12/2024 | SG Americas Securities LLC | 20,222 | $40K | 0.0% | +88.5% | 0.042% |  |
| 11/15/2023 | Laurion Capital Management LP | 534,657 | $2.32M | 0.0% | +3.3% | 1.264% |  |
| 11/15/2023 | Adage Capital Partners GP L.L.C. | 407,900 | $1.77M | 0.0% | +5.2% | 0.964% |  |
| 11/13/2023 | CHI Advisors LLC | 2,180,934 | $9.44M | 2.8% | +2.8% | 5.156% |  |
| 11/13/2023 | FMR LLC | 4,458,134 | $19.30M | 0.0% | -12.1% | 10.539% |  |
| 11/9/2023 | OUP Management Co. LLC | 26,833 | $0.12M | 0.3% | N/A | 0.063% |  |
| 11/7/2023 | Barclays PLC | 206,545 | $0.89M | 0.0% | +2.1% | 0.488% |  |
| 10/24/2023 | Bank of New York Mellon Corp | 69,239 | $0.30M | 0.0% | +11.1% | 0.164% |  |
| 10/13/2023 | SG Americas Securities LLC | 10,727 | $46K | 0.0% | N/A | 0.025% |  |
| 10/3/2023 | Vida Ventures Advisors LLC | 225,192 | $0.98M | 1.5% | N/A | 0.532% |  |
| 8/22/2023 | CHI Advisors LLC | 2,122,040 | $13.92M | 4.2% | +27.8% | 5.851% |  |
| 8/11/2023 | Artal Group S.A. | 1,849,513 | $12.13M | 0.4% | +19.4% | 5.099% |  |
| 8/4/2023 | American International Group Inc. | 10,232 | $67K | 0.0% | N/A | 0.028% |  |
| 5/16/2023 | BVF Inc. IL | 3,169,164 | $10.93M | 0.4% | +26.6% | 8.741% |  |
| 5/11/2023 | CHI Advisors LLC | 1,660,872 | $5.73M | 1.5% | +1.4% | 4.580% |  |
| 5/11/2023 | Cornercap Investment Counsel Inc. | 39,461 | $0.14M | 0.0% | +33.9% | 0.109% |  |
| 2/14/2023 | Verition Fund Management LLC | 1,580,375 | $4.20M | 0.1% | +21.6% | 4.358% |  |
| 11/14/2022 | Point72 Asset Management L.P. | 1,343,496 | $4.77M | 0.0% | +95.1% | 3.705% |  |
| 11/14/2022 | Verition Fund Management LLC | 1,299,255 | $4.61M | 0.1% | +27.1% | 3.583% |  |
| 11/14/2022 | Ergoteles LLC | 100,640 | $0.36M | 0.0% | -13.3% | 0.278% |  |
| 8/30/2022 | Verition Fund Management LLC | 1,021,890 | $4.53M | 0.1% | N/A | 2.818% |  |
| 8/15/2022 | Point72 Asset Management L.P. | 688,696 | $3.05M | 0.0% | +97.5% | 1.904% |  |
| 8/15/2022 | Laurion Capital Management LP | 529,000 | $2.34M | 0.0% | N/A | 1.463% |  |
| 8/12/2022 | Ensign Peak Advisors Inc | 90,310 | $0.40M | 0.0% | -29.3% | 0.250% |  |
| 5/9/2022 | Qube Research & Technologies Ltd | 28,933 | $0.18M | 0.0% | -32.4% | 0.081% |  |
| 5/5/2022 | New York State Common Retirement Fund | 22,066 | $0.14M | 0.0% | +61.3% | 0.061% |  |
| 4/29/2022 | Nisa Investment Advisors LLC | 8,000 | $49K | 0.0% | N/A | 0.022% |  |
| 2/11/2022 | Ensign Peak Advisors Inc | 127,810 | $1.60M | 0.0% | +27.8% | 0.356% |  |
| 2/10/2022 | Qube Research & Technologies Ltd | 42,788 | $0.54M | 0.0% | N/A | 0.119% |  |
| 2/8/2022 | ProShare Advisors LLC | 11,111 | $0.14M | 0.0% | N/A | 0.031% |  |
| 2/8/2022 | Northern Trust Corp | 208,065 | $2.61M | 0.0% | +126.8% | 0.579% |  |
| 2/7/2022 | Victory Capital Management Inc. | 112,330 | $1.41M | 0.0% | +22.7% | 0.313% |  |
| 2/7/2022 | SG Americas Securities LLC | 9,353 | $0.12M | 0.0% | N/A | 0.026% |  |
| 2/2/2022 | New York State Common Retirement Fund | 13,684 | $0.17M | 0.0% | +75.7% | 0.038% |  |
| 2/1/2022 | Qube Research & Technologies Ltd | 42,788 | $0.54M | 0.0% | N/A | 0.119% |  |