| 11/17/2025 | Laurion Capital Management LP | 1,882,162 | $1.66M | 0.0% | -1.2% | 1.908% |  |
| 11/17/2025 | Qube Research & Technologies Ltd | 32,669 | $29K | 0.0% | N/A | 0.033% |  |
| 11/17/2025 | Millennium Management LLC | 530,470 | $0.47M | 0.0% | +414.5% | 0.538% |  |
| 11/17/2025 | Focus Partners Wealth | 2,581,587 | $2.28M | 0.0% | +1.5% | 2.617% |  |
| 11/14/2025 | Virtu Financial LLC | 112,287 | $99K | 0.0% | N/A | 0.114% |  |
| 11/14/2025 | Two Sigma Investments LP | 58,681 | $52K | 0.0% | N/A | 0.059% |  |
| 11/14/2025 | Squarepoint Ops LLC | 271,574 | $0.24M | 0.0% | N/A | 0.275% |  |
| 11/7/2025 | GSA Capital Partners LLP | 192,923 | $0.17M | 0.0% | N/A | 0.196% |  |
| 11/7/2025 | Vanguard Group Inc. | 4,345,105 | $3.83M | 0.0% | +5.3% | 4.405% |  |
| 10/23/2025 | HB Wealth Management LLC | 91,450 | $81K | 0.0% | N/A | 0.093% |  |
| 8/15/2025 | Boothbay Fund Management LLC | 240,873 | $0.17M | 0.0% | -43.3% | 0.244% |  |
| 8/15/2025 | BVF Inc. IL | 7,652,972 | $5.34M | 0.2% | -14.0% | 7.758% |  |
| 8/15/2025 | 683 Capital Management LLC | 62,458 | $44K | 0.0% | -93.1% | 0.063% |  |
| 8/13/2025 | Marshall Wace LLP | 49,991 | $35K | 0.0% | -91.1% | 0.051% |  |
| 7/24/2025 | Aberdeen Group plc | 8,243,941 | $5.75M | 0.0% | +678.1% | 8.604% |  |
| 5/20/2025 | Focus Partners Wealth | 2,583,457 | $2.82M | 0.0% | +19.1% | 2.696% |  |
| 5/19/2025 | Jane Street Group LLC | 207,401 | $0.23M | 0.0% | +279.3% | 0.216% |  |
| 5/16/2025 | 683 Capital Management LLC | 900,000 | $0.98M | 0.1% | +28.6% | 0.939% |  |
| 5/13/2025 | Aberdeen Group plc | 1,059,484 | $1.16M | 0.0% | N/A | 1.106% |  |
| 5/12/2025 | Connor Clark & Lunn Investment Management Ltd. | 120,027 | $0.13M | 0.0% | -24.6% | 0.125% |  |
| 5/7/2025 | HB Wealth Management LLC | 52,400 | $57K | 0.0% | -33.2% | 0.055% |  |
| 2/17/2025 | Two Sigma Investments LP | 157,204 | $0.16M | 0.0% | -40.2% | 0.175% |  |
| 2/17/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 204,579 | $0.21M | 0.0% | +90.0% | 0.227% |  |
| 2/17/2025 | Millennium Management LLC | 579,683 | $0.58M | 0.0% | +480.6% | 0.644% |  |
| 2/17/2025 | Janus Henderson Group PLC | 2,689,082 | $2.69M | 0.0% | -47.3% | 2.985% |  |
| 2/17/2025 | Focus Partners Wealth | 2,168,353 | $2.17M | 0.0% | +1.1% | 2.407% |  |
| 2/17/2025 | Bridgeway Capital Management LLC | 215,000 | $0.22M | 0.0% | +11.5% | 0.239% |  |
| 2/17/2025 | 683 Capital Management LLC | 700,000 | $0.70M | 0.0% | +2.2% | 0.777% |  |
| 2/14/2025 | Jane Street Group LLC | 54,675 | $55K | 0.0% | -22.2% | 0.061% |  |
| 2/14/2025 | Adage Capital Partners GP L.L.C. | 1,398,600 | $1.40M | 0.0% | -75.0% | 1.553% |  |
| 2/13/2025 | Marshall Wace LLP | 417,883 | $0.42M | 0.0% | -10.4% | 0.464% |  |
| 2/13/2025 | Barclays PLC | 84,299 | $84K | 0.0% | N/A | 0.094% |  |
| 2/13/2025 | Renaissance Technologies LLC | 566,623 | $0.57M | 0.0% | +45.6% | 0.629% |  |
| 2/13/2025 | Invesco Ltd. | 36,811 | $37K | 0.0% | N/A | 0.041% |  |
| 1/15/2025 | HB Wealth Management LLC | 78,400 | $81K | 0.0% | N/A | 0.087% |  |
| 11/20/2024 | Virtu Financial LLC | 30,359 | $50K | 0.0% | N/A | 0.034% |  |
| 11/15/2024 | XTX Topco Ltd | 28,957 | $48K | 0.0% | -53.4% | 0.032% |  |
| 11/15/2024 | Jane Street Group LLC | 70,299 | $0.12M | 0.0% | +121.4% | 0.078% |  |
| 11/15/2024 | State Street Corp | 167,145 | $0.28M | 0.0% | +7.5% | 0.186% |  |
| 11/15/2024 | Janus Henderson Group PLC | 5,099,278 | $8.44M | 0.0% | -27.9% | 5.661% |  |
| 11/8/2024 | Connor Clark & Lunn Investment Management Ltd. | 102,257 | $0.17M | 0.0% | +70.8% | 0.114% |  |
| 11/5/2024 | GSA Capital Partners LLP | 32,766 | $54K | 0.0% | -71.9% | 0.036% |  |
| 8/14/2024 | Marshall Wace LLP | 39,621 | $44K | 0.0% | -20.0% | 0.044% |  |
| 8/9/2024 | Renaissance Technologies LLC | 291,087 | $0.32M | 0.0% | -61.0% | 0.323% |  |
| 5/20/2024 | Virtu Financial LLC | 19,088 | $25K | 0.0% | N/A | 0.021% |  |
| 5/17/2024 | Ikarian Capital LLC | 1,612,378 | $2.13M | 0.2% | +258.3% | 1.790% |  |
| 5/16/2024 | Janus Henderson Group PLC | 6,993,007 | $9.27M | 0.0% | N/A | 7.763% |  |
| 5/16/2024 | BVF Inc. IL | 8,902,972 | $11.75M | 0.3% | N/A | 9.884% |  |
| 5/10/2024 | Acadian Asset Management LLC | 239,962 | $0.32M | 0.0% | -57.1% | 0.266% |  |
| 5/10/2024 | Vanguard Group Inc. | 3,394,047 | $4.48M | 0.0% | +100.7% | 3.768% |  |
| 4/23/2024 | Summit Trail Advisors LLC | 18,600 | $25K | 0.0% | N/A | 0.021% |  |
| 2/22/2024 | Sierra Summit Advisors LLC | 324,829 | $0.49M | 0.1% | N/A | 0.719% |  |
| 2/7/2024 | Gratus Capital LLC | 1,941,454 | $2.91M | 0.2% | +15.1% | 4.300% |  |
| 1/12/2024 | Sweet Financial Partners LLC | 29,829 | $45K | 0.0% | N/A | 0.066% |  |
| 11/15/2023 | RTW Investments LP | 4,335,255 | $6.37M | 0.1% | +0.9% | 9.720% |  |
| 11/13/2023 | Connor Clark & Lunn Investment Management Ltd. | 24,773 | $36K | 0.0% | -77.0% | 0.056% |  |
| 11/13/2023 | Acadian Asset Management LLC | 757,250 | $1.11M | 0.0% | +26.8% | 1.698% |  |
| 11/9/2023 | Cowen AND Company LLC | 317,059 | $0.47M | 0.0% | -11.4% | 0.711% |  |
| 11/9/2023 | Innovis Asset Management LLC | 272,457 | $0.40M | 0.2% | +46.3% | 0.611% |  |
| 8/14/2023 | Deep Track Capital LP | 308,314 | $0.77M | 0.0% | -87.8% | 0.691% |  |
| 8/8/2023 | Balboa Wealth Partners | 12,000 | $30K | 0.0% | N/A | 0.027% |  |
| 8/7/2023 | Acadian Asset Management LLC | 597,277 | $1.50M | 0.0% | +439.2% | 1.339% |  |
| 8/3/2023 | Innovis Asset Management LLC | 186,240 | $0.47M | 0.2% | +130.6% | 0.419% |  |
| 8/3/2023 | Gratus Capital LLC | 1,678,793 | $4.21M | 0.3% | +1.4% | 3.781% |  |
| 7/27/2023 | Virtu Financial LLC | 67,424 | $0.17M | 0.0% | N/A | 0.152% |  |
| 7/24/2023 | Vontobel Holding Ltd. | 10,000 | $25K | 0.0% | N/A | 0.023% |  |
| 5/15/2023 | Logos Global Management LP | 421,184 | $0.63M | 0.1% | N/A | 0.949% |  |
| 5/15/2023 | RTW Investments LP | 4,294,459 | $6.40M | 0.1% | +11.2% | 9.671% |  |
| 5/10/2023 | Innovis Asset Management LLC | 80,773 | $0.12M | 0.0% | N/A | 0.182% |  |
| 5/10/2023 | Connor Clark & Lunn Investment Management Ltd. | 86,907 | $0.13M | 0.0% | N/A | 0.196% |  |
| 5/9/2023 | Cowen AND Company LLC | 357,855 | $0.53M | 0.1% | -54.8% | 0.806% |  |
| 4/20/2023 | Gratus Capital LLC | 1,655,405 | $2.47M | 0.2% | -0.8% | 3.728% |  |
| 2/14/2023 | RA Capital Management L.P. | 632,184 | $0.89M | 0.0% | N/A | 1.425% |  |
| 2/13/2023 | Vivo Capital LLC | 632,184 | $0.83M | 0.1% | N/A | 1.425% |  |
| 2/13/2023 | Artal Group S.A. | 1,274,713 | $1.79M | 0.1% | +82.1% | 2.874% |  |
| 2/9/2023 | Cowen AND Company LLC | 791,024 | $1.11M | 0.1% | -34.1% | 1.783% |  |
| 1/27/2023 | Gratus Capital LLC | 1,668,294 | $2.34M | 0.2% | +121.5% | 3.761% |  |
| 11/15/2022 | Parkman Healthcare Partners LLC | 657,643 | $2.08M | 0.6% | +1.2% | 1.675% |  |
| 11/14/2022 | Lynx1 Capital Management LP | 1,072,288 | $3.39M | 3.1% | -2.9% | 2.731% |  |
| 11/14/2022 | Verition Fund Management LLC | 698,934 | $2.21M | 0.0% | +14.6% | 1.780% |  |
| 11/14/2022 | Ergoteles LLC | 24,725 | $78K | 0.0% | -72.6% | 0.063% |  |
| 11/14/2022 | UBS Oconnor LLC | 197,988 | $0.63M | 0.0% | -14.9% | 0.504% |  |
| 11/4/2022 | Gratus Capital LLC | 753,190 | $2.38M | 0.3% | N/A | 2.464% |  |
| 10/25/2022 | Denali Advisors LLC | 17,000 | $54K | 0.0% | N/A | 0.056% |  |
| 8/30/2022 | Verition Fund Management LLC | 609,765 | $2.12M | 0.0% | +331.5% | 1.995% |  |
| 8/16/2022 | Corton Capital Inc. | 12,142 | $42K | 0.0% | N/A | 0.040% |  |
| 8/16/2022 | Delphia USA Inc. | 13,181 | $46K | 0.0% | N/A | 0.043% |  |
| 8/15/2022 | Point72 Asset Management L.P. | 1,325,000 | $4.60M | 0.0% | +82.8% | 4.335% |  |
| 8/5/2022 | Cowen AND Company LLC | 1,200,691 | $4.17M | 0.4% | -6.3% | 3.932% |  |
| 6/2/2022 | Verition Fund Management LLC | 141,319 | $1.60M | 0.0% | -26.2% | 0.463% |  |
| 5/17/2022 | RTW Investments LP | 2,705,513 | $30.57M | 0.6% | +57.7% | 8.859% |  |
| 5/17/2022 | Endurant Capital Management LP | 130,567 | $1.48M | 0.4% | -29.2% | 0.428% |  |
| 5/13/2022 | Parkman Healthcare Partners LLC | 1,089,251 | $12.31M | 3.6% | +11.8% | 3.567% |  |
| 5/13/2022 | DLD Asset Management LP | 50,000 | $0.57M | 0.0% | N/A | 0.164% |  |
| 4/21/2022 | Zurcher Kantonalbank Zurich Cantonalbank | 3,031 | $34K | 0.0% | N/A | 0.011% |  |
| 4/18/2022 | Golden Green Inc. | 32,649 | $0.37M | 0.3% | -49.7% | 0.117% |  |
| 2/16/2022 | Ghost Tree Capital LLC | 165,000 | $1.58M | 0.6% | -37.7% | 0.629% |  |
| 2/14/2022 | Altium Capital Management LP | 317,000 | $3.03M | 0.8% | +890.0% | 1.208% |  |
| 2/14/2022 | Point72 Asset Management L.P. | 725,000 | $6.94M | 0.0% | +16.0% | 2.762% |  |
| 2/14/2022 | Soleus Capital Management L.P. | 175,000 | $1.68M | 0.2% | N/A | 0.667% |  |