| 11/17/2025 | Woodline Partners LP | 1,274,729 | $14.93M | 0.1% | -23.1% | 1.390% |  |
| 11/17/2025 | XTX Topco Ltd | 70,514 | $0.83M | 0.0% | N/A | 0.077% |  |
| 11/17/2025 | Velan Capital Investment Management LP | 10,000 | $0.12M | 0.1% | N/A | 0.011% |  |
| 11/17/2025 | Polar Capital Holdings Plc | 1,058,776 | $12.40M | 0.1% | +5.9% | 1.154% |  |
| 11/17/2025 | Quarry LP | 10,000 | $0.12M | 0.0% | N/A | 0.011% |  |
| 11/17/2025 | Qube Research & Technologies Ltd | 25,217 | $0.30M | 0.0% | N/A | 0.027% |  |
| 11/17/2025 | Parkman Healthcare Partners LLC | 351,131 | $4.11M | 0.4% | N/A | 0.383% |  |
| 11/17/2025 | Millennium Management LLC | 41,884 | $0.49M | 0.0% | -63.1% | 0.046% |  |
| 11/17/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,299 | $0.47M | 0.0% | -8.6% | 0.044% |  |
| 11/17/2025 | Granahan Investment Management LLC | 426,219 | $4.99M | 0.2% | +8.5% | 0.465% |  |
| 11/17/2025 | Bank of America Corp DE | 92,155 | $1.08M | 0.0% | -7.5% | 0.100% |  |
| 11/14/2025 | Schonfeld Strategic Advisors LLC | 73,058 | $0.86M | 0.0% | N/A | 0.080% |  |
| 11/14/2025 | Creative Planning | 18,664 | $0.22M | 0.0% | +4.0% | 0.020% |  |
| 11/14/2025 | Raymond James Financial Inc. | 10,300 | $0.12M | 0.0% | +168.2% | 0.011% |  |
| 11/14/2025 | California State Teachers Retirement System | 65,845 | $0.77M | 0.0% | +72.2% | 0.072% |  |
| 11/14/2025 | UBS AM A Distinct Business Unit of UBS Asset Management Americas LLC | 112,298 | $1.32M | 0.0% | -39.9% | 0.122% |  |
| 11/14/2025 | Pivotal bioVenture Partners Investment Advisor LLC | 502,512 | $5.88M | 3.4% | N/A | 0.548% |  |
| 11/13/2025 | Marshall Wace LLP | 692,179 | $8.11M | 0.0% | -46.7% | 0.755% |  |
| 11/13/2025 | Kennedy Capital Management LLC | 257,426 | $3.01M | 0.1% | +135.4% | 0.281% |  |
| 11/13/2025 | UBS Group AG | 583,942 | $6.84M | 0.0% | +37.1% | 0.637% |  |
| 11/13/2025 | BNP Paribas Financial Markets | 15,129 | $0.18M | 0.0% | +134.1% | 0.016% |  |
| 11/13/2025 | Legal & General Group Plc | 81,073 | $0.95M | 0.0% | +28.6% | 0.088% |  |
| 11/13/2025 | Russell Investments Group Ltd. | 6,482 | $76K | 0.0% | N/A | 0.007% |  |
| 11/12/2025 | Barclays PLC | 208,513 | $2.44M | 0.0% | -9.3% | 0.227% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 338,355 | $3.96M | 0.0% | +222.9% | 0.369% |  |
| 11/12/2025 | Rafferty Asset Management LLC | 86,490 | $1.01M | 0.0% | +13.2% | 0.094% |  |
| 11/12/2025 | Handelsbanken Fonder AB | 180,000 | $2.11M | 0.0% | -10.0% | 0.196% |  |
| 11/12/2025 | Private Capital Advisors Inc. | 118,046 | $1.38M | 0.2% | -37.8% | 0.129% |  |
| 11/12/2025 | Primecap Management Co. CA | 3,018,009 | $35.34M | 0.0% | -0.1% | 3.291% |  |
| 11/12/2025 | Intech Investment Management LLC | 22,704 | $0.27M | 0.0% | -44.0% | 0.025% |  |
| 11/10/2025 | TD Asset Management Inc | 701,280 | $8.21M | 0.0% | +15.8% | 0.806% |  |
| 11/10/2025 | Palumbo Wealth Management LLC | 21,844 | $0.26M | 0.1% | N/A | 0.025% |  |
| 11/10/2025 | ANTIPODES PARTNERS Ltd | 10,892 | $0.13M | 0.0% | +6.1% | 0.013% |  |
| 11/10/2025 | BIT Capital GmbH | 5,927 | $69K | 0.0% | N/A | 0.007% |  |
| 11/7/2025 | Readystate Asset Management LP | 1,318,290 | $15.44M | 0.7% | -2.6% | 1.515% |  |
| 11/7/2025 | NEOS Investment Management LLC | 162,186 | $1.90M | 0.0% | +40.5% | 0.186% |  |
| 11/7/2025 | GSA Capital Partners LLP | 66,420 | $0.78M | 0.1% | -12.7% | 0.076% |  |
| 11/7/2025 | Vanguard Group Inc. | 4,893,626 | $57.30M | 0.0% | +8.1% | 5.622% |  |
| 11/7/2025 | JPMorgan Chase & Co. | 32,603 | $0.38M | 0.0% | -94.3% | 0.037% |  |
| 11/6/2025 | Assetmark Inc. | 3,364 | $39K | 0.0% | N/A | 0.004% |  |
| 11/6/2025 | Profund Advisors LLC | 19,260 | $0.23M | 0.0% | +16.5% | 0.022% |  |
| 11/6/2025 | ProShare Advisors LLC | 13,194 | $0.16M | 0.0% | -12.7% | 0.015% |  |
| 11/6/2025 | Candriam S.C.A. | 859,527 | $10.07M | 0.1% | +170.2% | 0.988% |  |
| 11/5/2025 | Alps Advisors Inc. | 39,261 | $0.46M | 0.0% | -16.4% | 0.045% |  |
| 11/4/2025 | Principal Financial Group Inc. | 1,104,938 | $12.94M | 0.0% | +222.3% | 1.269% |  |
| 11/4/2025 | Nan Fung Trinity HK Ltd. | 592,103 | $6.93M | 0.7% | +7.9% | 0.680% |  |
| 11/3/2025 | AlphaQuest LLC | 45,060 | $0.53M | 0.0% | -11.9% | 0.052% |  |
| 11/3/2025 | New York State Common Retirement Fund | 23,500 | $0.28M | 0.0% | +85.0% | 0.027% |  |
| 10/31/2025 | Stoneridge Investment Partners LLC | 12,174 | $0.14M | 0.1% | +5.4% | 0.014% |  |
| 10/29/2025 | Wealth Enhancement Advisory Services LLC | 17,660 | $0.21M | 0.0% | -66.8% | 0.020% |  |
| 10/24/2025 | Tema Etfs LLC | 162,186 | $1.90M | 0.2% | +40.5% | 0.186% |  |
| 10/23/2025 | Nisa Investment Advisors LLC | 80,426 | $0.94M | 0.0% | +3,513.0% | 0.092% |  |
| 10/23/2025 | SG Americas Securities LLC | 8,769 | $0.10M | 0.0% | N/A | 0.010% |  |
| 10/20/2025 | VIRGINIA RETIREMENT SYSTEMS ET Al | 58,400 | $0.68M | 0.0% | +27.0% | 0.067% |  |
| 10/9/2025 | Voya Investment Management LLC | 13,747 | $0.16M | 0.0% | -32.0% | 0.016% |  |
| 8/15/2025 | Tower Research Capital LLC TRC | 6,938 | $65K | 0.0% | +121.2% | 0.008% |  |
| 8/15/2025 | Sofinnova Investments Inc. | 778,476 | $7.24M | 0.4% | -1.3% | 0.894% |  |
| 8/15/2025 | Rafferty Asset Management LLC | 76,402 | $0.71M | 0.0% | -25.4% | 0.088% |  |
| 8/15/2025 | Opaleye Management Inc. | 3,529,581 | $32.83M | 6.6% | -0.6% | 4.055% |  |
| 8/15/2025 | Man Group plc | 20,614 | $0.19M | 0.0% | -8.6% | 0.024% |  |
| 8/15/2025 | BNP Paribas Financial Markets | 6,464 | $60K | 0.0% | +81.8% | 0.007% |  |
| 8/15/2025 | Birchview Capital LP | 60,000 | $0.56M | 0.6% | N/A | 0.069% |  |
| 8/15/2025 | Balyasny Asset Management L.P. | 109,754 | $1.02M | 0.0% | N/A | 0.126% |  |
| 8/15/2025 | Bank of America Corp DE | 99,676 | $0.93M | 0.0% | -71.1% | 0.115% |  |
| 8/14/2025 | Raymond James Financial Inc. | 3,841 | $36K | 0.0% | -68.1% | 0.004% |  |
| 8/14/2025 | Redmile Group LLC | 4,872,225 | $45.31M | 4.8% | -9.1% | 5.598% |  |
| 8/14/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 44,093 | $0.41M | 0.0% | -5.8% | 0.051% |  |
| 8/14/2025 | The Manufacturers Life Insurance Company | 280,816 | $2.61M | 0.0% | +3.6% | 0.323% |  |
| 8/14/2025 | Natixis | 229,305 | $2.13M | 0.0% | N/A | 0.263% |  |
| 8/14/2025 | Cerity Partners LLC | 46,532 | $0.43M | 0.0% | -10.6% | 0.053% |  |
| 8/13/2025 | Tema Etfs LLC | 115,431 | $1.07M | 0.3% | N/A | 0.133% |  |
| 8/13/2025 | Marshall Wace LLP | 1,297,752 | $12.07M | 0.0% | -19.4% | 1.491% |  |
| 8/13/2025 | Kennedy Capital Management LLC | 109,352 | $1.02M | 0.0% | +642.6% | 0.126% |  |
| 8/13/2025 | Lido Advisors LLC | 59,085 | $0.55M | 0.0% | +11.5% | 0.068% |  |
| 8/13/2025 | Virtus Investment Advisers LLC | 9,605 | $89K | 0.0% | -23.5% | 0.011% |  |
| 8/12/2025 | Rhumbline Advisers | 108,414 | $1.01M | 0.0% | +22.0% | 0.125% |  |
| 8/12/2025 | JPMorgan Chase & Co. | 576,130 | $5.36M | 0.0% | -7.0% | 0.662% |  |
| 8/12/2025 | Swiss National Bank | 132,800 | $1.24M | 0.0% | +3.8% | 0.153% |  |
| 8/12/2025 | Main Management ETF Advisors LLC | 76,944 | $0.72M | 0.0% | +1.6% | 0.088% |  |
| 8/11/2025 | Primecap Management Co. CA | 3,020,210 | $28.09M | 0.0% | -11.5% | 3.470% |  |
| 8/8/2025 | Intech Investment Management LLC | 40,565 | $0.38M | 0.0% | +17.8% | 0.047% |  |
| 8/8/2025 | Creative Planning | 17,954 | $0.17M | 0.0% | N/A | 0.021% |  |
| 8/8/2025 | Candriam S.C.A. | 318,086 | $2.96M | 0.0% | N/A | 0.366% |  |
| 8/8/2025 | Geode Capital Management LLC | 1,860,580 | $17.31M | 0.0% | +6.7% | 2.138% |  |
| 8/8/2025 | Nan Fung Trinity HK Ltd. | 548,850 | $5.10M | 0.6% | N/A | 0.631% |  |
| 8/7/2025 | Profund Advisors LLC | 16,537 | $0.15M | 0.0% | -23.4% | 0.019% |  |
| 8/7/2025 | Los Angeles Capital Management LLC | 41,857 | $0.39M | 0.0% | +16.8% | 0.048% |  |
| 8/5/2025 | ANTIPODES PARTNERS Ltd | 10,261 | $95K | 0.0% | -27.6% | 0.012% |  |
| 8/4/2025 | Whalen Wealth Management Inc. | 13,722 | $0.13M | 0.1% | N/A | 0.016% |  |
| 8/1/2025 | Teacher Retirement System of Texas | 18,548 | $0.17M | 0.0% | +6.8% | 0.021% |  |
| 8/1/2025 | Y Intercept Hong Kong Ltd | 85,227 | $0.79M | 0.0% | N/A | 0.098% |  |
| 7/31/2025 | Brighton Jones LLC | 10,491 | $98K | 0.0% | N/A | 0.012% |  |
| 7/31/2025 | AlphaQuest LLC | 51,139 | $0.48M | 0.0% | -4.9% | 0.059% |  |
| 7/30/2025 | Private Capital Advisors Inc. | 189,844 | $1.77M | 0.2% | +393.1% | 0.218% |  |
| 7/29/2025 | VIRGINIA RETIREMENT SYSTEMS ET Al | 46,000 | $0.43M | 0.0% | N/A | 0.053% |  |
| 7/28/2025 | TD Asset Management Inc | 605,530 | $5.63M | 0.0% | -0.2% | 0.696% |  |
| 7/23/2025 | KLP Kapitalforvaltning AS | 13,200 | $0.12M | 0.0% | -22.8% | 0.015% |  |
| 7/10/2025 | Wealth Enhancement Advisory Services LLC | 53,187 | $0.47M | 0.0% | +3.2% | 0.061% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 193,302 | $1.30M | 0.0% | -29.4% | 0.222% |  |
| 6/18/2025 | Voya Investment Management LLC | 18,905 | $0.13M | 0.0% | +21.2% | 0.022% |  |