| 11/17/2025 | Armistice Capital LLC | 348,000 | $0.83M | 0.0% | N/A | 2.141% |  |
| 11/17/2025 | Acorn Capital Advisors LLC | 1,382,640 | $3.29M | 1.7% | N/A | 8.507% |  |
| 11/17/2025 | Woodline Partners LP | 1,039,751 | $2.48M | 0.0% | N/A | 6.397% |  |
| 11/17/2025 | Voleon Capital Management LP | 20,950 | $50K | 0.0% | N/A | 0.129% |  |
| 11/17/2025 | Velan Capital Investment Management LP | 2,668,395 | $6.21M | 5.8% | +86.1% | 16.418% |  |
| 11/17/2025 | Millennium Management LLC | 364,939 | $0.87M | 0.0% | +151.3% | 2.245% |  |
| 11/17/2025 | Kingdon Capital Management L.L.C. | 1,324,845 | $3.15M | 0.4% | +93.5% | 8.151% |  |
| 11/17/2025 | Boothbay Fund Management LLC | 442,642 | $1.05M | 0.0% | N/A | 2.723% |  |
| 11/14/2025 | Two Sigma Investments LP | 40,427 | $96K | 0.0% | N/A | 0.249% |  |
| 11/14/2025 | Squarepoint Ops LLC | 13,960 | $33K | 0.0% | -45.0% | 0.086% |  |
| 11/13/2025 | Knott David M Jr | 171,389 | $0.41M | 0.2% | N/A | 1.055% |  |
| 11/12/2025 | Propel Bio Management LLC | 1,028,806 | $2.45M | 2.5% | N/A | 6.331% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 38,963 | $93K | 0.0% | -12.8% | 0.240% |  |
| 11/7/2025 | Readystate Asset Management LP | 98,439 | $0.23M | 0.0% | N/A | 0.606% |  |
| 11/7/2025 | Vanguard Group Inc. | 1,032,842 | $2.46M | 0.0% | +65.4% | 6.356% |  |
| 10/20/2025 | Simplify Asset Management Inc. | 609,053 | $1.45M | 0.0% | N/A | 3.748% |  |
| 10/17/2025 | Sowell Financial Services LLC | 10,400 | $25K | 0.0% | -39.9% | 0.064% |  |
| 8/19/2025 | Marex Group plc | 13,300 | $74K | 0.0% | N/A | 0.089% |  |
| 8/15/2025 | Engineers Gate Manager LP | 13,972 | $78K | 0.0% | N/A | 0.093% |  |
| 8/15/2025 | Bank of America Corp DE | 293,460 | $1.63M | 0.0% | -18.6% | 1.954% |  |
| 8/14/2025 | Jane Street Group LLC | 132,905 | $0.74M | 0.0% | N/A | 0.885% |  |
| 8/13/2025 | Marshall Wace LLP | 50,686 | $0.28M | 0.0% | N/A | 0.337% |  |
| 8/12/2025 | XTX Topco Ltd | 27,348 | $0.15M | 0.0% | N/A | 0.182% |  |
| 8/12/2025 | JPMorgan Chase & Co. | 65,088 | $0.36M | 0.0% | +1,074.7% | 0.433% |  |
| 8/8/2025 | Geode Capital Management LLC | 131,130 | $0.73M | 0.0% | -50.3% | 0.873% |  |
| 8/5/2025 | Corton Capital Inc. | 10,004 | $56K | 0.1% | -62.1% | 0.067% |  |
| 8/5/2025 | Bank of Montreal Can | 158,133 | $0.88M | 0.0% | +120.4% | 1.053% |  |
| 7/14/2025 | Sowell Financial Services LLC | 17,303 | $96K | 0.0% | -16.9% | 0.115% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 233,758 | $1.01M | 0.0% | +11.2% | 1.556% |  |
| 5/21/2025 | Acadian Asset Management LLC | 10,708 | $46K | 0.0% | N/A | 0.071% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 233,758 | $1.01M | 0.0% | +11.2% | 1.556% |  |
| 5/15/2025 | Kingdon Capital Management L.L.C. | 490,000 | $2.11M | 0.2% | +9.6% | 3.262% |  |
| 5/14/2025 | T. Rowe Price Investment Management Inc. | 702,757 | $3.02M | 0.0% | +755.3% | 4.678% |  |
| 5/12/2025 | Nuveen LLC | 102,268 | $0.44M | 0.0% | N/A | 0.681% |  |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 26,648 | $0.12M | 0.0% | -17.6% | 0.177% |  |
| 5/7/2025 | Corton Capital Inc. | 26,382 | $0.11M | 0.4% | N/A | 0.176% |  |
| 4/17/2025 | Sowell Financial Services LLC | 20,825 | $90K | 0.0% | -25.7% | 0.139% |  |
| 3/24/2025 | Wellington Management Group LLP | 27,069 | $0.58M | 0.0% | +13.9% | 0.180% |  |
| 2/27/2025 | Jefferies Financial Group Inc. | 31,250 | $0.67M | 0.0% | N/A | 0.208% |  |
| 2/17/2025 | Woodline Partners LP | 245,676 | $5.25M | 0.0% | -50.4% | 1.638% |  |
| 2/17/2025 | Soleus Capital Management L.P. | 1,494,420 | $31.95M | 2.0% | +11.2% | 9.962% |  |
| 2/17/2025 | Tema Etfs LLC | 12,435 | $0.27M | 0.1% | N/A | 0.083% |  |
| 2/17/2025 | Stempoint Capital LP | 135,244 | $2.89M | 0.7% | N/A | 0.902% |  |
| 2/17/2025 | Integral Health Asset Management LLC | 650,000 | $13.90M | 1.2% | +85.7% | 4.333% |  |
| 2/17/2025 | Jefferies Financial Group Inc. | 31,250 | $0.67M | 0.0% | N/A | 0.208% |  |
| 2/17/2025 | Deutsche Bank AG | 170,695 | $3.65M | 0.0% | +30.0% | 1.138% |  |
| 2/17/2025 | Braidwell LP | 714,658 | $15.28M | 0.5% | +47.9% | 4.764% |  |
| 2/17/2025 | Bank of America Corp DE | 287,204 | $6.14M | 0.0% | -11.9% | 1.915% |  |
| 2/17/2025 | Allostery Investments LP | 22,000 | $0.47M | 0.5% | N/A | 0.147% |  |
| 2/17/2025 | Ally Bridge Group NY LLC | 122,424 | $2.62M | 2.2% | -69.4% | 0.816% |  |
| 2/14/2025 | Boxer Capital Management LLC | 350,000 | $7.48M | 0.6% | N/A | 2.333% |  |
| 2/14/2025 | Jane Street Group LLC | 10,852 | $0.23M | 0.0% | -18.7% | 0.072% |  |
| 2/14/2025 | Northern Trust Corp | 104,367 | $2.23M | 0.0% | -2.4% | 0.696% |  |
| 2/14/2025 | Propel Bio Management LLC | 20,000 | $0.43M | 0.4% | N/A | 0.133% |  |
| 2/14/2025 | T. Rowe Price Investment Management Inc. | 82,165 | $1.76M | 0.0% | N/A | 0.548% |  |
| 2/14/2025 | Rock Springs Capital Management LP | 463,088 | $9.90M | 0.4% | +0.9% | 3.087% |  |
| 2/13/2025 | Marshall Wace LLP | 77,722 | $1.66M | 0.0% | +17.2% | 0.518% |  |
| 2/13/2025 | Mariner LLC | 36,794 | $0.79M | 0.0% | -12.8% | 0.245% |  |
| 2/13/2025 | Barclays PLC | 18,334 | $0.39M | 0.0% | +13.6% | 0.122% |  |
| 2/13/2025 | Russell Investments Group Ltd. | 247,272 | $5.29M | 0.0% | +16.9% | 1.648% |  |
| 2/13/2025 | Wells Fargo & Company MN | 7,415 | $0.16M | 0.0% | +106.7% | 0.049% |  |
| 2/12/2025 | Wellington Management Group LLP | 27,069 | $0.58M | 0.0% | +13.9% | 0.180% |  |
| 2/12/2025 | Schroder Investment Management Group | 59,034 | $1.24M | 0.0% | N/A | 0.394% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 5,165 | $0.11M | 0.0% | -68.5% | 0.034% |  |
| 2/11/2025 | EntryPoint Capital LLC | 10,431 | $0.22M | 0.1% | N/A | 0.070% |  |
| 2/11/2025 | Simplify Asset Management Inc. | 20,000 | $0.43M | 0.0% | N/A | 0.133% |  |
| 1/30/2025 | Rhumbline Advisers | 14,761 | $0.32M | 0.0% | +12.6% | 0.098% |  |
| 12/26/2024 | JPMorgan Chase & Co. | 16,391 | $0.31M | 0.0% | +239.8% | 0.109% |  |
| 11/27/2024 | Franklin Resources Inc. | 579,636 | $10.90M | 0.0% | -17.0% | 3.864% |  |
| 11/19/2024 | Barclays PLC | 16,146 | $0.30M | 0.0% | +320.7% | 0.108% |  |
| 11/16/2024 | Geode Capital Management LLC | 257,416 | $4.84M | 0.0% | -0.9% | 1.704% |  |
| 11/15/2024 | Barclays PLC | 16,146 | $0.30M | 0.0% | +320.7% | 0.107% |  |
| 11/15/2024 | Jane Street Group LLC | 13,354 | $0.25M | 0.0% | N/A | 0.088% |  |
| 11/15/2024 | Wellington Management Group LLP | 23,759 | $0.45M | 0.0% | N/A | 0.157% |  |
| 11/15/2024 | State Street Corp | 214,883 | $4.04M | 0.0% | +12.3% | 1.423% |  |
| 11/15/2024 | Samsara BioCapital LLC | 584,642 | $11M | 2.1% | +11.4% | 3.872% |  |
| 11/15/2024 | Ikarian Capital LLC | 55,175 | $1.04M | 0.1% | -47.5% | 0.365% |  |
| 11/14/2024 | Braidwell LP | 483,300 | $9.09M | 0.3% | N/A | 3.201% |  |
| 11/14/2024 | Verition Fund Management LLC | 25,353 | $0.48M | 0.0% | N/A | 0.168% |  |
| 11/14/2024 | Ally Bridge Group NY LLC | 399,466 | $7.51M | 4.0% | +82.7% | 2.645% |  |
| 11/14/2024 | MetLife Investment Management LLC | 6,874 | $0.13M | 0.0% | +129.1% | 0.046% |  |
| 11/13/2024 | Great Point Partners LLC | 322,380 | $6.06M | 1.8% | -19.8% | 2.135% |  |
| 11/13/2024 | BNP Paribas Financial Markets | 2,512 | $47K | 0.0% | +208.6% | 0.017% |  |
| 11/13/2024 | FMR LLC | 38,361 | $0.72M | 0.0% | N/A | 0.254% |  |
| 10/30/2024 | AlphaCentric Advisors LLC | 17,500 | $0.33M | 0.2% | N/A | 0.116% |  |
| 10/29/2024 | Fernwood Investment Management LLC | 52,897 | $1M | 0.3% | +6.9% | 0.351% |  |
| 10/16/2024 | Wolff Wiese Magana LLC | 3,146 | $59K | 0.0% | N/A | 0.021% |  |
| 8/14/2024 | Great Point Partners LLC | 402,015 | $9.13M | 1.7% | -1.4% | 2.669% |  |
| 8/14/2024 | Ally Bridge Group NY LLC | 218,614 | $4.96M | 3.0% | -24.6% | 1.451% |  |
| 8/8/2024 | American Century Companies Inc. | 14,204 | $0.32M | 0.0% | +27.1% | 0.094% |  |
| 8/1/2024 | Rhumbline Advisers | 13,231 | $0.30M | 0.0% | N/A | 0.088% |  |
| 7/26/2024 | Bank of New York Mellon Corp | 32,579 | $0.74M | 0.0% | N/A | 0.216% |  |
| 5/29/2024 | Opaleye Management Inc. | 435,573 | $12.79M | 2.8% | -89.1% | 2.892% |  |
| 5/20/2024 | Virtu Financial LLC | 10,410 | $0.31M | 0.0% | N/A | 0.069% |  |
| 5/17/2024 | Ikarian Capital LLC | 105,175 | $3.09M | 0.3% | N/A | 0.698% |  |
| 5/16/2024 | Kingdon Capital Management L.L.C. | 497,000 | $14.59M | 1.6% | -86.0% | 3.300% |  |
| 5/14/2024 | Qiming U.S. Ventures Management LLC | 928,964 | $27.27M | 30.4% | -89.1% | 6.168% |  |
| 5/14/2024 | StemPoint Capital LP | 129,211 | $3.79M | 1.0% | N/A | 0.858% |  |
| 5/10/2024 | Vanguard Group Inc. | 612,745 | $17.99M | 0.0% | -85.0% | 4.069% |  |
| 5/8/2024 | Russell Investments Group Ltd. | 79,811 | $2.34M | 0.0% | N/A | 0.530% |  |