| 2/18/2026 | Ikarian Capital LLC | 102,211 | $0.64M | 0.0% | -4.4% | 1.396% |  |
| 2/18/2026 | Vazirani Asset Management LLC | 48,428 | $0.31M | 1.9% | N/A | 0.661% |  |
| 2/18/2026 | Tang Capital Management LLC | 664,314 | $4.18M | 0.2% | -7.7% | 9.072% |  |
| 2/18/2026 | Torno Capital LLC | 20,000 | $0.13M | 0.0% | N/A | 0.273% |  |
| 2/18/2026 | Boothbay Fund Management LLC | 16,210 | $0.10M | 0.0% | -22.4% | 0.221% |  |
| 2/18/2026 | Bridgeway Capital Management LLC | 51,638 | $0.33M | 0.0% | +25.9% | 0.705% |  |
| 2/17/2026 | ADAR1 Capital Management LLC | 117,440 | $0.74M | 0.1% | -6.0% | 1.604% |  |
| 2/13/2026 | Nantahala Capital Management LLC | 276,754 | $1.74M | 0.1% | N/A | 3.781% |  |
| 2/13/2026 | Affinity Asset Advisors LLC | 229,076 | $1.44M | 0.1% | N/A | 3.129% |  |
| 2/13/2026 | State Street Corp | 27,093 | $0.17M | 0.0% | +28.4% | 0.370% |  |
| 2/12/2026 | Aldebaran Capital LLC | 80,630 | $0.51M | 0.5% | N/A | 1.101% |  |
| 2/12/2026 | Renaissance Technologies LLC | 131,285 | $0.83M | 0.0% | +13.3% | 1.793% |  |
| 2/12/2026 | Dimensional Fund Advisors LP | 26,543 | $0.17M | 0.0% | +14.3% | 0.362% |  |
| 2/9/2026 | Geode Capital Management LLC | 68,167 | $0.43M | 0.0% | +4.1% | 0.931% |  |
| 2/6/2026 | Nano Cap New Millennium Growth Fund L P | 25,000 | $0.16M | 0.1% | N/A | 0.342% |  |
| 1/16/2026 | FNY Investment Advisers LLC | 50,000 | $0.31M | 0.1% | N/A | 0.683% |  |
| 11/14/2025 | ADAR1 Capital Management LLC | 124,967 | $0.49M | 0.0% | -15.2% | 1.707% |  |
| 11/13/2025 | Landscape Capital Management L.L.C. | 13,042 | $51K | 0.0% | N/A | 0.178% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 23,231 | $91K | 0.0% | -22.5% | 0.317% |  |
| 11/10/2025 | Peapod Lane Capital LLC | 125,773 | $0.49M | 0.4% | +9.3% | 1.718% |  |
| 11/10/2025 | BML Capital Management LLC | 720,787 | $2.81M | 2.2% | +13.5% | 9.847% |  |
| 8/13/2025 | Stonepine Capital Management LLC | 169,859 | $0.78M | 0.8% | +69.9% | 2.325% |  |
| 8/11/2025 | BML Capital Management LLC | 635,183 | $2.91M | 2.2% | +55.6% | 8.689% |  |
| 7/31/2025 | Peapod Lane Capital LLC | 115,123 | $0.53M | 0.5% | -7.5% | 1.575% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 28,178 | $0.14M | 0.0% | -46.1% | 0.385% |  |
| 5/21/2025 | Acadian Asset Management LLC | 133,525 | $0.65M | 0.0% | -8.3% | 1.828% |  |
| 5/16/2025 | Woodline Partners LP | 25,555 | $0.13M | 0.0% | N/A | 0.350% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 28,178 | $0.14M | 0.0% | -46.1% | 0.386% |  |
| 5/14/2025 | Stonepine Capital Management LLC | 100,000 | $0.49M | 0.5% | -9.1% | 1.369% |  |
| 5/7/2025 | BML Capital Management LLC | 408,138 | $1.99M | 1.5% | +738.6% | 5.586% |  |
| 2/17/2025 | Two Sigma Investments LP | 61,983 | $0.42M | 0.0% | -93.1% | 0.849% |  |
| 2/17/2025 | Two Sigma Advisers LP | 100,141 | $0.67M | 0.0% | -92.9% | 1.372% |  |
| 2/17/2025 | Stonepine Capital Management LLC | 110,000 | $0.74M | 0.6% | -92.6% | 1.507% |  |
| 2/17/2025 | Tang Capital Management LLC | 720,000 | $4.84M | 0.3% | -80.2% | 9.863% |  |
| 2/17/2025 | Suvretta Capital Management LLC | 716,759 | $4.82M | 0.2% | -90.0% | 9.819% |  |
| 2/17/2025 | Shay Capital LLC | 59,158 | $0.40M | 0.1% | N/A | 0.810% |  |
| 2/17/2025 | Sphera Funds Management LTD. | 108,473 | $0.73M | 0.1% | -47.1% | 1.486% |  |
| 2/17/2025 | Orbimed Advisors LLC | 192,700 | $1.30M | 0.0% | -90.0% | 2.640% |  |
| 2/17/2025 | Millennium Management LLC | 43,337 | $0.29M | 0.0% | -91.2% | 0.594% |  |
| 2/14/2025 | Northern Trust Corp | 13,940 | $94K | 0.0% | -84.6% | 0.191% |  |
| 2/14/2025 | Boothbay Fund Management LLC | 20,900 | $0.14M | 0.0% | -90.0% | 0.286% |  |
| 2/14/2025 | RBF Capital LLC | 28,253 | $0.19M | 0.0% | -90.0% | 0.387% |  |
| 2/14/2025 | Dimensional Fund Advisors LP | 32,310 | $0.22M | 0.0% | N/A | 0.443% |  |
| 2/13/2025 | Affinity Asset Advisors LLC | 142,316 | $0.96M | 0.1% | -94.3% | 1.950% |  |
| 2/13/2025 | Renaissance Technologies LLC | 87,685 | $0.59M | 0.0% | -93.2% | 1.201% |  |
| 2/13/2025 | ADAR1 Capital Management LLC | 147,404 | $0.99M | 0.2% | -89.0% | 2.019% |  |
| 2/13/2025 | Wells Fargo & Company MN | 6,177 | $42K | 0.0% | -92.1% | 0.085% |  |
| 2/12/2025 | Geode Capital Management LLC | 66,570 | $0.45M | 0.0% | -89.4% | 0.912% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 11,884 | $80K | 0.0% | +613.8% | 0.163% |  |
| 2/7/2025 | Amundi | 8,224 | $54K | 0.0% | -90.0% | 0.113% |  |
| 2/7/2025 | BML Capital Management LLC | 48,668 | $0.33M | 0.2% | N/A | 0.667% |  |
| 1/29/2025 | Peapod Lane Capital LLC | 123,994 | $0.83M | 0.8% | N/A | 1.699% |  |
| 1/28/2025 | Qiming U.S. Ventures Management LLC | 82,871 | $0.56M | 1.1% | -90.0% | 1.135% |  |
| 1/14/2025 | Marquette Asset Management LLC | 17,805 | $0.12M | 0.0% | -90.0% | 0.244% |  |
| 11/16/2024 | Geode Capital Management LLC | 626,912 | $0.49M | 0.0% | +15.0% | 8.588% |  |
| 11/15/2024 | XTX Topco Ltd | 52,148 | $40K | 0.0% | +256.1% | 0.714% |  |
| 11/15/2024 | Jane Street Group LLC | 59,541 | $46K | 0.0% | -89.2% | 0.816% |  |
| 11/15/2024 | Sphera Funds Management LTD. | 205,168 | $0.16M | 0.0% | -90.0% | 2.811% |  |
| 11/15/2024 | Ikarian Capital LLC | 1,068,992 | $0.83M | 0.1% | +23.0% | 14.644% |  |
| 11/14/2024 | Stonepine Capital Management LLC | 1,491,305 | $1.15M | 0.7% | +42.0% | 20.429% |  |
| 9/16/2024 | Point72 Asia Singapore Pte. Ltd. | 105,105 | $63K | 0.0% | N/A | 0.144% |  |
| 8/21/2024 | Stonepine Capital Management LLC | 1,050,452 | $0.63M | 0.6% | N/A | 1.443% |  |
| 8/15/2024 | Mackenzie Financial Corp | 58,709 | $35K | 0.0% | N/A | 0.081% |  |
| 8/15/2024 | Point72 Asia Singapore Pte. Ltd. | 105,105 | $63K | 0.0% | N/A | 0.144% |  |
| 8/9/2024 | Renaissance Technologies LLC | 778,474 | $0.47M | 0.0% | -41.8% | 1.069% |  |
| 8/6/2024 | Acadian Asset Management LLC | 1,855,194 | $1.11M | 0.0% | +3.6% | 2.548% |  |
| 8/5/2024 | Acuitas Investments LLC | 986,785 | $0.59M | 0.3% | +42.8% | 1.355% |  |
| 5/17/2024 | Ikarian Capital LLC | 868,992 | $0.78M | 0.1% | +1.8% | 1.194% |  |
| 5/16/2024 | Jacobs Levy Equity Management Inc. | 53,216 | $48K | 0.0% | -94.5% | 0.073% |  |
| 5/15/2024 | Affinity Asset Advisors LLC | 1,761,778 | $1.59M | 0.2% | N/A | 2.420% |  |
| 5/10/2024 | Acadian Asset Management LLC | 1,790,838 | $1.61M | 0.0% | +42.5% | 2.460% |  |
| 5/10/2024 | Vanguard Group Inc. | 3,094,224 | $2.79M | 0.0% | +1.0% | 4.250% |  |
| 5/7/2024 | Marquette Asset Management LLC | 126,095 | $0.11M | 0.0% | N/A | 0.173% |  |
| 5/2/2024 | Fidelis Capital Partners LLC | 27,266 | $25K | 0.0% | N/A | 0.037% |  |
| 5/1/2024 | BNP Paribas Financial Markets | 273,430 | $0.25M | 0.0% | +35.4% | 0.376% |  |
| 2/14/2024 | Avidity Partners Management LP | 5,025,454 | $4.76M | 0.2% | -16.4% | 6.914% |  |
| 2/8/2024 | Panagora Asset Management Inc. | 84,087 | $80K | 0.0% | N/A | 0.116% |  |
| 1/12/2024 | SG Americas Securities LLC | 43,950 | $42K | 0.0% | +33.8% | 0.060% |  |
| 11/14/2023 | Avidity Partners Management LP | 6,011,100 | $7.15M | 0.3% | -1.1% | 8.270% |  |
| 11/14/2023 | Pale Fire Capital SE | 68,851 | $82K | 0.0% | N/A | 0.095% |  |
| 11/13/2023 | Acadian Asset Management LLC | 831,693 | $0.99M | 0.0% | +179.2% | 1.144% |  |
| 10/13/2023 | SG Americas Securities LLC | 32,841 | $39K | 0.0% | N/A | 0.045% |  |
| 10/12/2023 | RVW Wealth LLC | 23,765 | $28K | 0.0% | N/A | 0.033% |  |
| 9/21/2023 | Barclays PLC | 14,225 | $35K | 0.0% | -98.3% | 0.020% |  |
| 8/15/2023 | Sphera Funds Management LTD. | 1,988,228 | $4.87M | 0.8% | +5.3% | 2.735% |  |
| 8/15/2023 | Suvretta Capital Management LLC | 7,167,591 | $17.56M | 0.9% | +4.1% | 9.860% |  |
| 8/14/2023 | Prosight Management LP | 4,651,920 | $11.40M | 3.5% | +36.8% | 6.400% |  |
| 8/14/2023 | Granahan Investment Management LLC | 1,899,019 | $4.65M | 0.1% | +69.4% | 2.612% |  |
| 8/14/2023 | Prelude Capital Management LLC | 36,200 | $89K | 0.0% | +121.7% | 0.050% |  |
| 8/11/2023 | Franklin Resources Inc. | 1,388,157 | $3.40M | 0.0% | +1.7% | 1.917% |  |
| 8/7/2023 | Principal Financial Group Inc. | 26,635 | $65K | 0.0% | +57.8% | 0.037% |  |
| 8/7/2023 | Acadian Asset Management LLC | 297,933 | $0.73M | 0.0% | +1,952.4% | 0.411% |  |
| 8/4/2023 | American International Group Inc. | 34,350 | $84K | 0.0% | +35.2% | 0.047% |  |
| 6/1/2023 | Prelude Capital Management LLC | 16,330 | $51K | 0.0% | N/A | 0.023% |  |
| 5/15/2023 | Suvretta Capital Management LLC | 6,887,591 | $21.56M | 0.9% | +96.5% | 9.517% |  |
| 5/15/2023 | Hood River Capital Management LLC | 1,430,654 | $4.48M | 0.1% | +2.7% | 1.977% |  |
| 5/15/2023 | Granahan Investment Management LLC | 1,121,336 | $3.51M | 0.1% | +62.4% | 1.549% |  |
| 5/15/2023 | Ghost Tree Capital LLC | 175,000 | $0.55M | 0.2% | -48.5% | 0.242% |  |
| 5/12/2023 | Martingale Asset Management L P | 22,220 | $70K | 0.0% | -60.3% | 0.031% |  |
| 5/11/2023 | CHI Advisors LLC | 689,451 | $2.16M | 0.6% | -63.5% | 0.953% |  |