| 5/30/2024 | Lynx1 Capital Management LP | 1,981,106 | $5.27M | 1.4% | -0.8% | 4.195% |  |
| 5/20/2024 | Virtu Financial LLC | 11,445 | $30K | 0.0% | N/A | 0.024% |  |
| 5/10/2024 | Acadian Asset Management LLC | 964,881 | $2.57M | 0.0% | +16.2% | 2.043% |  |
| 5/10/2024 | Vanguard Group Inc. | 1,076,789 | $2.86M | 0.0% | +3.2% | 2.280% |  |
| 5/9/2024 | State Board of Administration of Florida Retirement System | 14,254 | $38K | 0.0% | N/A | 0.030% |  |
| 5/7/2024 | SG Americas Securities LLC | 20,819 | $55K | 0.0% | N/A | 0.044% |  |
| 5/3/2024 | GSA Capital Partners LLP | 334,694 | $0.89M | 0.1% | -1.3% | 0.709% |  |
| 5/1/2024 | Mirae Asset Global Investments Co. Ltd. | 11,200 | $30K | 0.0% | N/A | 0.024% |  |
| 4/23/2024 | BML Capital Management LLC | 498,851 | $1.33M | 0.9% | +6.5% | 1.056% |  |
| 4/17/2024 | Deltec Asset Management LLC | 1,039,800 | $2.77M | 0.5% | N/A | 2.202% |  |
| 2/14/2024 | Pale Fire Capital SE | 220,555 | $0.52M | 0.1% | +214.3% | 0.468% |  |
| 2/9/2024 | Dynamic Technology Lab Private Ltd | 13,891 | $33K | 0.0% | N/A | 0.029% |  |
| 2/2/2024 | Marquette Asset Management LLC | 59,961 | $0.14M | 0.0% | N/A | 0.127% |  |
| 2/2/2024 | Acuitas Investments LLC | 289,766 | $0.69M | 0.3% | N/A | 0.615% |  |
| 2/2/2024 | BML Capital Management LLC | 468,210 | $1.11M | 0.8% | N/A | 0.994% |  |
| 1/30/2024 | BML Capital Management LLC | 446,874 | $1.06M | 0.8% | N/A | 0.949% |  |
| 12/6/2023 | Citigroup Inc. | 420,585 | $0.59M | 0.0% | +53,138.6% | 0.893% |  |
| 11/15/2023 | Rock Springs Capital Management LP | 405,811 | $0.57M | 0.0% | -45.7% | 0.861% |  |
| 11/14/2023 | Lynx1 Capital Management LP | 1,997,006 | $2.80M | 1.8% | -2.5% | 4.240% |  |
| 11/14/2023 | Pale Fire Capital SE | 70,174 | $98K | 0.0% | +196.3% | 0.149% |  |
| 11/13/2023 | Connor Clark & Lunn Investment Management Ltd. | 52,168 | $73K | 0.0% | N/A | 0.111% |  |
| 11/13/2023 | Acadian Asset Management LLC | 736,686 | $1.03M | 0.0% | +71.0% | 1.564% |  |
| 11/9/2023 | Citigroup Inc. | 420,585 | $0.59M | 0.0% | +53,138.6% | 0.893% |  |
| 9/21/2023 | Barclays PLC | 14,568 | $44K | 0.0% | -50.5% | 0.031% |  |
| 8/15/2023 | Boxer Capital LLC | 491,000 | $1.49M | 0.1% | -3.7% | 1.042% |  |
| 8/14/2023 | Prelude Capital Management LLC | 28,754 | $87K | 0.0% | N/A | 0.061% |  |
| 8/11/2023 | Pale Fire Capital SE | 23,682 | $72K | 0.0% | N/A | 0.050% |  |
| 8/11/2023 | Harvard Management Co. Inc. | 462,418 | $1.40M | 0.1% | -7.1% | 0.982% |  |
| 8/11/2023 | Foresite Capital Management V LLC | 3,525,957 | $10.68M | 7.8% | +78.5% | 7.486% |  |
| 8/7/2023 | Acadian Asset Management LLC | 430,802 | $1.30M | 0.0% | +1,389.9% | 0.925% |  |
| 7/27/2023 | Virtu Financial LLC | 20,585 | $62K | 0.0% | N/A | 0.044% |  |
| 7/21/2023 | Creative Planning | 12,257 | $37K | 0.0% | N/A | 0.026% |  |
| 5/16/2023 | Ally Bridge Group NY LLC | 109,393 | $0.68M | 0.9% | N/A | 0.235% |  |
| 5/12/2023 | Foresite Capital Management V LLC | 1,975,001 | $12.34M | 9.1% | +125.7% | 4.241% |  |
| 4/27/2023 | Simplex Trading LLC | 12,089 | $75K | 0.0% | +1,956.0% | 0.026% |  |
| 2/14/2023 | Boxer Capital LLC | 510,000 | $3.11M | 0.2% | -66.5% | 1.155% |  |
| 2/13/2023 | Martingale Asset Management L P | 22,522 | $0.14M | 0.0% | N/A | 0.051% |  |
| 2/13/2023 | GSA Capital Partners LLP | 70,174 | $0.43M | 0.1% | -4.2% | 0.159% |  |
| 2/9/2023 | Victory Capital Management Inc. | 71,020 | $0.43M | 0.0% | -38.5% | 0.161% |  |
| 2/7/2023 | State Board of Administration of Florida Retirement System | 14,254 | $87K | 0.0% | -26.2% | 0.032% |  |
| 2/2/2023 | SG Americas Securities LLC | 10,435 | $64K | 0.0% | -12.4% | 0.024% |  |
| 11/15/2022 | Boxer Capital LLC | 1,522,559 | $18.20M | 1.0% | -17.6% | 3.447% |  |
| 11/2/2022 | Victory Capital Management Inc. | 115,550 | $1.38M | 0.0% | -2.5% | 0.262% |  |
| 10/5/2022 | Vida Ventures Advisors LLC | 2,207,772 | $26.38M | 23.7% | -19.6% | 5.001% |  |
| 8/16/2022 | Western Standard LLC | 102,780 | $1.30M | 1.0% | N/A | 0.233% |  |
| 8/16/2022 | DAFNA Capital Management LLC | 224,451 | $2.83M | 0.8% | +51.5% | 0.508% |  |
| 8/16/2022 | Deerfield Management Company L.P. Series C | 250,000 | $3.15M | 0.1% | -74.6% | 0.566% |  |
| 8/11/2022 | Trexquant Investment LP | 13,420 | $0.17M | 0.0% | N/A | 0.031% |  |
| 8/5/2022 | State Board of Administration of Florida Retirement System | 19,304 | $0.24M | 0.0% | N/A | 0.044% |  |
| 8/1/2022 | Victory Capital Management Inc. | 118,530 | $1.50M | 0.0% | +37.8% | 0.270% |  |
| 7/29/2022 | SG Americas Securities LLC | 11,642 | $0.15M | 0.0% | N/A | 0.026% |  |
| 6/30/2022 | Amalgamated Bank | 3,172 | $36K | 0.0% | N/A | 0.007% |  |
| 5/17/2022 | RA Capital Management L.P. | 4,264,144 | $48.01M | 1.0% | +18.7% | 9.698% |  |
| 5/11/2022 | American Century Companies Inc. | 319,527 | $3.60M | 0.0% | +49.6% | 0.727% |  |
| 5/11/2022 | GSA Capital Partners LLP | 47,175 | $0.53M | 0.1% | N/A | 0.107% |  |
| 5/4/2022 | Victory Capital Management Inc. | 86,040 | $0.97M | 0.0% | -25.9% | 0.196% |  |
| 2/14/2022 | Citadel Advisors LLC | 1,121,704 | $19.88M | 0.0% | -2.8% | 2.567% |  |
| 2/14/2022 | Virtus ETF Advisers LLC | 9,725 | $0.17M | 0.1% | N/A | 0.022% |  |
| 2/14/2022 | Deerfield Management Company L.P. Series C | 985,568 | $17.46M | 0.4% | -4.2% | 2.256% |  |
| 2/14/2022 | Nextech Invest AG | 3,008,243 | $53.31M | 12.4% | N/A | 6.884% |  |
| 2/14/2022 | Novo Holdings A S | 553,128 | $9.80M | 0.5% | +11.0% | 1.266% |  |
| 2/11/2022 | Foresite Capital Opportunity Management V LLC | 291,667 | $5.17M | 3.5% | N/A | 0.667% |  |
| 2/8/2022 | ProShare Advisors LLC | 11,778 | $0.21M | 0.0% | N/A | 0.027% |  |
| 2/8/2022 | Northern Trust Corp | 213,537 | $3.78M | 0.0% | +1.0% | 0.489% |  |
| 2/7/2022 | Victory Capital Management Inc. | 116,140 | $2.06M | 0.0% | +21.9% | 0.266% |  |
| 2/7/2022 | SG Americas Securities LLC | 7,707 | $0.14M | 0.0% | -49.9% | 0.018% |  |
| 2/7/2022 | American Century Companies Inc. | 213,645 | $3.79M | 0.0% | +22.9% | 0.489% |  |
| 2/2/2022 | New York State Common Retirement Fund | 18,817 | $0.33M | 0.0% | +78.6% | 0.043% |  |
| 1/31/2022 | Dupont Capital Management Corp | 8,804 | $0.16M | 0.0% | -28.5% | 0.020% |  |
| 1/21/2022 | Russell Investments Group Ltd. | 55,568 | $0.98M | 0.0% | +147.5% | 0.127% |  |
| 11/22/2021 | EcoR1 Capital LLC | 175,000 | $4.03M | 0.1% | +600.0% | 0.400% |  |
| 11/16/2021 | Janus Henderson Group PLC | 127,027 | $2.92M | 0.0% | -78.9% | 0.291% |  |
| 11/16/2021 | Metropolitan Life Insurance Co NY | 7,510 | $0.17M | 0.0% | N/A | 0.017% |  |
| 11/16/2021 | Millennium Management LLC | 118,734 | $2.73M | 0.0% | N/A | 0.272% |  |
| 11/16/2021 | Boxer Capital LLC | 1,847,559 | $42.53M | 1.5% | +73.3% | 4.230% |  |
| 11/16/2021 | Citadel Advisors LLC | 1,154,273 | $26.57M | 0.0% | -11.3% | 2.643% |  |
| 11/15/2021 | Point72 Hong Kong Ltd | 1,862 | $43K | 0.0% | N/A | 0.004% |  |
| 11/15/2021 | Deerfield Management Company L.P. Series C | 1,028,508 | $23.68M | 0.5% | +0.8% | 2.355% |  |
| 11/15/2021 | California State Teachers Retirement System | 22,837 | $0.53M | 0.0% | +22.1% | 0.052% |  |
| 11/15/2021 | Rock Springs Capital Management LP | 332,986 | $7.67M | 0.2% | +0.4% | 0.762% |  |
| 11/15/2021 | HighVista Strategies LLC | 60,905 | $1.40M | 0.9% | +82.4% | 0.139% |  |
| 11/15/2021 | Voya Investment Management LLC | 9,198 | $0.21M | 0.0% | N/A | 0.021% |  |
| 11/12/2021 | Renaissance Technologies LLC | 23,358 | $0.54M | 0.0% | -34.9% | 0.053% |  |
| 11/12/2021 | The Manufacturers Life Insurance Company | 13,805 | $0.32M | 0.0% | N/A | 0.032% |  |
| 11/12/2021 | Geode Capital Management LLC | 337,222 | $7.76M | 0.0% | +42.1% | 0.772% |  |
| 11/10/2021 | Goldman Sachs Group Inc. | 94,561 | $2.18M | 0.0% | +521.6% | 0.217% |  |
| 11/10/2021 | Citigroup Inc. | 3,798 | $87K | 0.0% | +170.7% | 0.009% |  |
| 11/9/2021 | BlackRock Inc. | 1,874,361 | $43.15M | 0.0% | +47.2% | 4.291% |  |
| 11/8/2021 | Russell Investments Group Ltd. | 22,455 | $0.52M | 0.0% | N/A | 0.051% |  |
| 11/4/2021 | Deutsche Bank AG | 132,866 | $3.06M | 0.0% | +5.2% | 0.304% |  |
| 11/3/2021 | Dupont Capital Management Corp | 12,315 | $0.28M | 0.0% | N/A | 0.028% |  |
| 11/2/2021 | New York State Common Retirement Fund | 10,538 | $0.24M | 0.0% | -19.6% | 0.024% |  |
| 11/2/2021 | Victory Capital Management Inc. | 95,270 | $2.19M | 0.0% | -0.8% | 0.218% |  |
| 11/1/2021 | SG Americas Securities LLC | 15,385 | $0.35M | 0.0% | N/A | 0.035% |  |
| 10/19/2021 | JJJ Advisors Inc. | 990 | $35K | 0.0% | N/A | 0.002% |  |
| 8/16/2021 | Goldman Sachs Group Inc. | 15,212 | $0.35M | 0.0% | -14.4% | 0.035% |  |