| 3/16/2026 | Avoro Capital Advisors LLC | 3,300,000 | $32.77M | 0.3% | N/A | 4.521% |  |
| 3/3/2026 | Caitong International Asset Management Co. Ltd | 3,714 | $37K | 0.0% | N/A | 0.005% |  |
| 2/19/2026 | Invesco Ltd. | 463,029 | $4.60M | 0.0% | N/A | 0.634% |  |
| 2/18/2026 | ADAR1 Capital Management LLC | 1,393,161 | $13.83M | 1.0% | -9.1% | 1.909% |  |
| 2/18/2026 | XTX Topco Ltd | 11,144 | $0.11M | 0.0% | -58.3% | 0.015% |  |
| 2/18/2026 | Ikarian Capital LLC | 513,011 | $5.09M | 0.4% | -9.6% | 0.703% |  |
| 2/18/2026 | Vestal Point Capital LP | 4,475,000 | $44.44M | 1.5% | +37.7% | 6.131% |  |
| 2/18/2026 | Virtus Investment Advisers LLC | 27,230 | $0.27M | 0.1% | N/A | 0.037% |  |
| 2/18/2026 | Wellington Management Group LLP | 83,230 | $0.83M | 0.0% | N/A | 0.114% |  |
| 2/18/2026 | Susquehanna Portfolio Strategies LLC | 26,205 | $0.26M | 0.0% | +14.4% | 0.036% |  |
| 2/18/2026 | Suvretta Capital Management LLC | 1,250,000 | $12.41M | 0.3% | N/A | 1.713% |  |
| 2/18/2026 | Orbimed Advisors LLC | 2,125,000 | $21.10M | 0.4% | N/A | 2.911% |  |
| 2/18/2026 | Millennium Management LLC | 908,024 | $9.02M | 0.0% | -60.8% | 1.244% |  |
| 2/18/2026 | Janus Henderson Group PLC | 5,509,635 | $54.67M | 0.0% | -9.8% | 7.549% |  |
| 2/18/2026 | Balyasny Asset Management L.P. | 1,635,026 | $16.24M | 0.0% | -58.2% | 2.240% |  |
| 2/18/2026 | Bridgeway Capital Management LLC | 13,400 | $0.13M | 0.0% | -72.3% | 0.018% |  |
| 2/18/2026 | Boothbay Fund Management LLC | 136,377 | $1.35M | 0.0% | -24.5% | 0.187% |  |
| 2/18/2026 | 683 Capital Management LLC | 1,120,000 | $11.12M | 0.5% | +21.4% | 1.534% |  |
| 2/17/2026 | ADAR1 Capital Management LLC | 1,393,161 | $13.83M | 1.0% | -9.1% | 1.909% |  |
| 2/17/2026 | Burkehill Global Management LP | 125,000 | $1.24M | 0.1% | N/A | 0.171% |  |
| 2/17/2026 | AQR Capital Management LLC | 337,386 | $3.35M | 0.0% | -3.0% | 0.462% |  |
| 2/17/2026 | RA Capital Management L.P. | 5,000,000 | $49.65M | 0.5% | N/A | 6.850% |  |
| 2/17/2026 | Paradigm Biocapital Advisors LP | 4,763,198 | $47.30M | 1.2% | N/A | 6.526% |  |
| 2/17/2026 | Price T Rowe Associates Inc. MD | 33,872 | $0.34M | 0.0% | +183.1% | 0.046% |  |
| 2/17/2026 | California State Teachers Retirement System | 3,884 | $39K | 0.0% | +123.7% | 0.005% |  |
| 2/17/2026 | Russell Investments Group Ltd. | 5,872 | $58K | 0.0% | +160.2% | 0.008% |  |
| 2/17/2026 | Atom Investors LP | 68,491 | $0.68M | 0.1% | N/A | 0.094% |  |
| 2/17/2026 | Avoro Capital Advisors LLC | 3,300,000 | $32.77M | 0.3% | N/A | 4.521% |  |
| 2/17/2026 | Graham Capital Management L.P. | 32,898 | $0.33M | 0.0% | N/A | 0.045% |  |
| 2/17/2026 | Persistent Asset Partners Ltd | 16,025 | $0.16M | 0.1% | N/A | 0.022% |  |
| 2/16/2026 | OMERS ADMINISTRATION Corp | 20,900 | $0.21M | 0.0% | N/A | 0.029% |  |
| 2/16/2026 | Squarepoint Ops LLC | 92,608 | $0.92M | 0.0% | N/A | 0.127% |  |
| 2/16/2026 | Spruce Street Capital LP | 175,000 | $1.74M | 0.6% | N/A | 0.240% |  |
| 2/16/2026 | Verition Fund Management LLC | 428,458 | $4.26M | 0.0% | +3.3% | 0.587% |  |
| 2/16/2026 | Barclays PLC | 188,754 | $1.87M | 0.0% | +69.2% | 0.259% |  |
| 2/13/2026 | Nantahala Capital Management LLC | 1,000,000 | $9.93M | 0.3% | N/A | 1.370% |  |
| 2/13/2026 | The Manufacturers Life Insurance Company | 19,147 | $0.19M | 0.0% | N/A | 0.026% |  |
| 2/13/2026 | Affinity Asset Advisors LLC | 3,200,000 | $31.78M | 1.8% | -17.3% | 4.384% |  |
| 2/13/2026 | Rafferty Asset Management LLC | 102,159 | $1.01M | 0.0% | N/A | 0.140% |  |
| 2/13/2026 | Siren L.L.C. | 720,622 | $7.16M | 0.2% | +19.4% | 0.987% |  |
| 2/13/2026 | Charles Schwab Investment Management Inc. | 192,210 | $1.91M | 0.0% | +81.7% | 0.263% |  |
| 2/13/2026 | Police & Firemen s Retirement System of New Jersey | 16,373 | $0.16M | 0.0% | +171.1% | 0.022% |  |
| 2/13/2026 | State Street Corp | 3,187,722 | $31.65M | 0.0% | +485.1% | 4.367% |  |
| 2/13/2026 | Ieq Capital LLC | 24,692 | $0.25M | 0.0% | -26.5% | 0.034% |  |
| 2/13/2026 | Wells Fargo & Company MN | 70,736 | $0.70M | 0.0% | +267.2% | 0.097% |  |
| 2/12/2026 | Jane Street Group LLC | 140,096 | $1.39M | 0.0% | +8.2% | 0.192% |  |
| 2/12/2026 | MetLife Investment Management LLC | 35,721 | $0.36M | 0.0% | N/A | 0.049% |  |
| 2/12/2026 | Renaissance Technologies LLC | 217,772 | $2.16M | 0.0% | +45.9% | 0.298% |  |
| 2/12/2026 | Dimensional Fund Advisors LP | 862,892 | $8.57M | 0.0% | -5.4% | 1.182% |  |
| 2/12/2026 | New York State Common Retirement Fund | 19,887 | $0.20M | 0.0% | +375.0% | 0.027% |  |
| 2/12/2026 | Nuveen LLC | 211,529 | $2.10M | 0.0% | +539.0% | 0.290% |  |
| 2/11/2026 | Deutsche Bank AG | 57,166 | $0.57M | 0.0% | +135.0% | 0.078% |  |
| 2/11/2026 | WINTON GROUP Ltd | 26,900 | $0.27M | 0.0% | N/A | 0.037% |  |
| 2/10/2026 | Goldman Sachs Group Inc. | 781,855 | $7.76M | 0.0% | +449.0% | 1.071% |  |
| 2/10/2026 | Intech Investment Management LLC | 14,188 | $0.14M | 0.0% | +19.5% | 0.019% |  |
| 2/9/2026 | Geode Capital Management LLC | 1,445,887 | $14.36M | 0.0% | +100.3% | 1.981% |  |
| 2/6/2026 | ProShare Advisors LLC | 14,752 | $0.15M | 0.0% | N/A | 0.020% |  |
| 2/5/2026 | Allworth Financial LP | 3,386 | $34K | 0.0% | +1,002.9% | 0.005% |  |
| 2/3/2026 | Mitsubishi UFJ Asset Management Co. Ltd. | 26,209 | $0.25M | 0.0% | N/A | 0.036% |  |
| 1/29/2026 | UBS Group AG | 281,083 | $2.79M | 0.0% | +12.5% | 0.385% |  |
| 1/29/2026 | China Universal Asset Management Co. Ltd. | 11,893 | $0.12M | 0.0% | +25.6% | 0.016% |  |
| 1/26/2026 | Mirae Asset Global Investments Co. Ltd. | 3,547 | $35K | 0.0% | +69.9% | 0.005% |  |
| 1/9/2026 | SG Americas Securities LLC | 18,640 | $0.19M | 0.0% | N/A | 0.026% |  |
| 11/17/2025 | Vestal Point Capital LP | 3,250,000 | $21.58M | 1.0% | +0.7% | 4.453% |  |
| 11/17/2025 | Scientech Research LLC | 13,502 | $90K | 0.0% | N/A | 0.018% |  |
| 11/17/2025 | Millennium Management LLC | 2,313,642 | $15.36M | 0.0% | -18.4% | 3.170% |  |
| 11/17/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,453 | $76K | 0.0% | -15.0% | 0.016% |  |
| 11/17/2025 | Brevan Howard Capital Management LP | 18,400 | $0.12M | 0.0% | N/A | 0.025% |  |
| 11/17/2025 | Citadel Advisors LLC | 3,719,043 | $24.69M | 0.0% | +3.1% | 5.095% |  |
| 11/17/2025 | Bank of America Corp DE | 28,279 | $0.19M | 0.0% | +6.1% | 0.039% |  |
| 11/17/2025 | Boothbay Fund Management LLC | 180,744 | $1.20M | 0.0% | +10.8% | 0.248% |  |
| 11/17/2025 | Ameriprise Financial Inc. | 166,538 | $1.11M | 0.0% | N/A | 0.228% |  |
| 11/14/2025 | Virtu Financial LLC | 43,269 | $0.29M | 0.0% | N/A | 0.080% |  |
| 11/14/2025 | ADAR1 Capital Management LLC | 1,531,953 | $10.17M | 1.0% | +955.7% | 2.837% |  |
| 11/14/2025 | Balyasny Asset Management L.P. | 3,913,788 | $25.99M | 0.0% | -2.4% | 7.248% |  |
| 11/14/2025 | Two Sigma Investments LP | 84,763 | $0.56M | 0.0% | +22.4% | 0.157% |  |
| 11/14/2025 | Bridgeway Capital Management LLC | 48,400 | $0.32M | 0.0% | -9.4% | 0.090% |  |
| 11/13/2025 | UBS Group AG | 249,909 | $1.66M | 0.0% | -8.1% | 0.463% |  |
| 11/13/2025 | BNP Paribas Financial Markets | 30,727 | $0.20M | 0.0% | -36.6% | 0.057% |  |
| 11/12/2025 | Barclays PLC | 111,579 | $0.74M | 0.0% | -3.9% | 0.207% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 912,533 | $6.06M | 0.0% | +1,840.6% | 1.690% |  |
| 11/12/2025 | Intech Investment Management LLC | 11,871 | $79K | 0.0% | -13.2% | 0.022% |  |
| 11/10/2025 | Palumbo Wealth Management LLC | 61,276 | $0.41M | 0.1% | +8.8% | 0.113% |  |
| 11/10/2025 | AXQ Capital LP | 14,921 | $99K | 0.0% | +19.6% | 0.028% |  |
| 11/10/2025 | China Universal Asset Management Co. Ltd. | 9,466 | $63K | 0.0% | +42.0% | 0.018% |  |
| 11/7/2025 | Vanguard Group Inc. | 2,226,290 | $14.78M | 0.0% | +11.2% | 4.123% |  |
| 11/5/2025 | Savant Capital LLC | 34,914 | $0.23M | 0.0% | +17.7% | 0.065% |  |
| 11/4/2025 | Privium Fund Management B.V. | 192,356 | $1.28M | 0.2% | +7.8% | 0.356% |  |
| 10/31/2025 | Vanguard Personalized Indexing Management LLC | 16,595 | $0.11M | 0.0% | +10.6% | 0.031% |  |
| 10/29/2025 | Wealth Enhancement Advisory Services LLC | 14,244 | $95K | 0.0% | N/A | 0.026% |  |
| 10/15/2025 | CWM LLC | 18,864 | $0.13M | 0.0% | +82.2% | 0.035% |  |
| 8/15/2025 | Vestal Point Capital LP | 3,228,161 | $12.98M | 0.7% | +184.1% | 9.723% |  |
| 8/15/2025 | Frazier Life Sciences Management L.P. | 4,424,725 | $17.79M | 0.7% | +363.1% | 13.327% |  |
| 8/15/2025 | BNP Paribas Financial Markets | 48,434 | $0.20M | 0.0% | +20.4% | 0.146% |  |
| 8/15/2025 | Bridgeway Capital Management LLC | 53,400 | $0.22M | 0.0% | +39.1% | 0.161% |  |
| 8/15/2025 | Balyasny Asset Management L.P. | 4,009,137 | $16.12M | 0.0% | N/A | 12.076% |  |
| 8/15/2025 | Bank of America Corp DE | 26,653 | $0.11M | 0.0% | +22.4% | 0.080% |  |
| 8/14/2025 | Pale Fire Capital SE | 27,650 | $0.11M | 0.0% | +46.3% | 0.083% |  |
| 8/14/2025 | Cerity Partners LLC | 12,447 | $50K | 0.0% | N/A | 0.037% |  |
| 8/13/2025 | Affinity Asset Advisors LLC | 3,589,355 | $14.43M | 2.0% | +142.4% | 10.812% |  |