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LYRA Insider Trading

Insider Ownership Percentage: 3.25%
Insider Buying (Last 12 Months): $0.00
Insider Selling (Last 12 Months): $546,822.64

Lyra Therapeutics Insider Trading History Chart

This chart shows the insider buying and selling history at Lyra Therapeutics by year and by quarter.

Skip ChartChart Data in Insider Trading History Table

Lyra Therapeutics Share Price & Price History

Current Price: $4.50
Price Change: ▲ Price Increase of +0.31 (7.40%)
As of 12/4/2025 05:00 PM ET

This chart shows the closing price history over time for LYRA up to the past year.

Skip Chart and Table DataPrice Data in Insider Trading History Table
Days: 30 | 90 | 365

Lyra Therapeutics Insider Trading History

Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionShares Held After TransactionDetails
11/13/2025Perceptive Advisors LlcMajor ShareholderSell31,810$3.90$124,059.0014,026View SEC Filing Icon  
11/12/2025Perceptive Advisors LlcMajor ShareholderSell8,745$4.06$35,504.7017,239View SEC Filing Icon  
11/11/2025Perceptive Advisors LlcMajor ShareholderSell5,320$4.31$22,929.2018,122View SEC Filing Icon  
11/10/2025Perceptive Advisors LlcMajor ShareholderSell18,502$4.54$83,999.0818,659View SEC Filing Icon  
11/7/2025Perceptive Advisors LlcMajor ShareholderSell19,739$4.75$93,760.2520,528View SEC Filing Icon  
11/6/2025Perceptive Advisors LlcMajor ShareholderSell32,149$5.18$166,531.8222,521View SEC Filing Icon  
7/10/2025Jason CavalierCFOSell684$8.91$6,094.44519,316View SEC Filing Icon  
7/10/2025Maria PalasisCEOSell1,565$8.91$13,944.151,098,435View SEC Filing Icon  
11/10/2023Harlan WaksalInsiderBuy500$148.00$74,000.005,239View SEC Filing Icon  
5/31/2023Nbvm Gp, LlcMajor ShareholderBuy36,108$121.50$4,387,122.0050,434View SEC Filing Icon  
5/31/2023Perceptive Advisors LlcDirectorBuy72,216$124.50$8,990,892.00229,382View SEC Filing Icon  
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SEC Filings (Institutional Ownership Changes) for Lyra Therapeutics (NASDAQ:LYRA)

95.62% of Lyra Therapeutics stock is owned by institutions. Institutional ownership can be a sign of analyst confidence in the fundamentals of the stock.

Institutional Buying and Selling by Quarter

This chart shows the instiutional buying and selling at LYRA by year and by quarter.

Skip Institutional Buying and Selling Chart and Table DataRead Chart Data in Institutional Trading History Table

Lyra Therapeutics Institutional Trading History

Reporting DateHedge FundShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
11/17/2025Citadel Advisors LLC19,484$0.13M0.0%N/A1.101%Search for SEC Filing on Google Icon
8/15/2025Perceptive Advisors LLC255,150$2.29M0.2%-98.0%15.558%Search for SEC Filing on Google Icon
8/15/2025Bank of America Corp DE28,542$0.26M0.0%+33.7%1.740%Search for SEC Filing on Google Icon
8/8/2025Geode Capital Management LLC10,986$98K0.0%-98.9%0.687%Search for SEC Filing on Google Icon
6/27/2025Goldman Sachs Group Inc.370,194$47K0.0%-33.4%27.834%Search for SEC Filing on Google Icon
5/16/2025Goldman Sachs Group Inc.370,194$47K0.0%-33.4%0.559%Search for SEC Filing on Google Icon
2/17/2025Two Sigma Investments LP209,997$43K0.0%-25.7%0.321%Search for SEC Filing on Google Icon
2/17/2025Two Sigma Advisers LP385,500$80K0.0%-16.3%0.589%Search for SEC Filing on Google Icon
2/17/2025BNP Paribas Financial Markets244,920$51K0.0%N/A0.374%Search for SEC Filing on Google Icon
2/14/2025Samsara BioCapital LLC1,965,689$0.41M0.1%-29.3%3.003%Search for SEC Filing on Google Icon
2/14/2025Northern Trust Corp286,310$59K0.0%+56.2%0.437%Search for SEC Filing on Google Icon
2/13/2025ADAR1 Capital Management LLC533,200$0.11M0.0%N/A0.815%Search for SEC Filing on Google Icon
2/12/2025Geode Capital Management LLC885,966$0.18M0.0%+15.3%1.353%Search for SEC Filing on Google Icon
2/12/2025JPMorgan Chase & Co.156,442$32K0.0%+161.8%0.239%Search for SEC Filing on Google Icon
11/15/2024State Street Corp488,720$0.13M0.0%+88.1%0.747%Search for SEC Filing on Google Icon
8/6/2024Acadian Asset Management LLC985,631$0.27M0.0%N/A1.617%Search for SEC Filing on Google Icon
7/12/2024Rosalind Advisors Inc.1,034,773$0.29M0.2%-9.6%1.697%Search for SEC Filing on Google Icon
5/17/2024Ikarian Capital LLC1,056,829$6.57M0.7%-15.7%1.733%Search for SEC Filing on Google Icon
5/10/2024Vanguard Group Inc.1,481,481$9.22M0.0%+38.3%2.430%Search for SEC Filing on Google Icon
4/25/2024Rosalind Advisors Inc.1,144,524$7.12M6.7%-39.4%1.916%Search for SEC Filing on Google Icon
2/15/2024Parkman Healthcare Partners LLC754,885$3.96M0.6%+20.8%1.436%Search for SEC Filing on Google Icon
2/14/2024Vestal Point Capital LP3,000,000$15.72M1.7%N/A5.708%Search for SEC Filing on Google Icon
2/13/2024Armistice Capital LLC1,088,000$5.70M0.1%-29.8%2.070%Search for SEC Filing on Google Icon
2/7/2024Jump Financial LLC16,737$88K0.0%N/A0.032%Search for SEC Filing on Google Icon
1/25/2024Heritage Wealth Management Inc. Texas10,000$52K0.0%N/A0.019%Search for SEC Filing on Google Icon
12/6/2023Citigroup Inc.67,677$0.27M0.0%N/A0.129%Search for SEC Filing on Google Icon
11/15/2023Armistice Capital LLC1,550,000$6.06M0.1%-61.4%2.949%Search for SEC Filing on Google Icon
11/14/2023Prescott Group Capital Management L.L.C.30,000$0.12M0.0%N/A0.057%Search for SEC Filing on Google Icon
10/24/2023Bank of New York Mellon Corp18,621$73K0.0%N/A0.038%Search for SEC Filing on Google Icon
8/24/2023Perceptive Advisors LLC12,757,562$52.43M1.5%+39.5%25.747%Search for SEC Filing on Google Icon
8/14/2023Samsara BioCapital LLC2,780,261$11.43M2.0%+56.4%8.733%Search for SEC Filing on Google Icon
8/14/2023Pura Vida Investments LLC1,413,242$5.72M0.8%-29.2%4.439%Search for SEC Filing on Google Icon
8/10/2023Letko Brosseau & Associates Inc.31,900$0.13M0.0%N/A0.100%Search for SEC Filing on Google Icon
2/15/2023Nantahala Capital Management LLC2,220,830$6.97M0.5%-1.1%6.977%Search for SEC Filing on Google Icon
2/14/2023Pura Vida Investments LLC2,157,298$6.77M0.3%-14.1%6.778%Search for SEC Filing on Google Icon
11/15/2022Pura Vida Investments LLC2,510,302$12.58M0.7%-2.6%7.888%Search for SEC Filing on Google Icon
11/14/2022Boothbay Fund Management LLC34,721$0.17M0.0%-9.5%0.109%Search for SEC Filing on Google Icon
11/10/2022Nantahala Capital Management LLC2,245,830$11.25M0.7%-5.2%17.262%Search for SEC Filing on Google Icon
8/16/2022Pura Vida Investments LLC2,576,196$14.56M0.8%+394.9%19.802%Search for SEC Filing on Google Icon
8/16/2022CVI Holdings LLC60,822$0.34M0.0%N/A0.468%Search for SEC Filing on Google Icon
8/15/2022Nantahala Capital Management LLC2,369,668$13.39M0.7%N/A18.214%Search for SEC Filing on Google Icon
8/12/2022Ensign Peak Advisors Inc56,229$0.32M0.0%+43.6%0.432%Search for SEC Filing on Google Icon
8/12/2022Ikarian Capital LLC347,338$1.96M0.4%-17.8%2.670%Search for SEC Filing on Google Icon
5/16/2022Clearline Capital LP119,924$0.48M0.1%+84.9%0.922%Search for SEC Filing on Google Icon
2/14/2022Clearline Capital LP64,862$0.28M0.0%N/A0.499%Search for SEC Filing on Google Icon
2/14/2022Soleus Capital Management L.P.10,000$44K0.0%-95.4%0.077%Search for SEC Filing on Google Icon
2/11/2022Pentwater Capital Management LP71,313$0.31M0.0%+122.8%0.548%Search for SEC Filing on Google Icon
11/16/2021Two Sigma Advisers LP58,000$0.53M0.0%+31.8%0.446%Search for SEC Filing on Google Icon
11/15/2021Pura Vida Investments LLC533,417$4.87M0.1%-1.7%4.103%Search for SEC Filing on Google Icon
11/15/2021Marshall Wace LLP12,457$0.11M0.0%-35.5%0.096%Search for SEC Filing on Google Icon
11/9/2021BlackRock Inc.17,818$0.16M0.0%-11.4%0.137%Search for SEC Filing on Google Icon
11/4/2021Close Asset Management Ltd7,000$64K0.0%N/A0.054%Search for SEC Filing on Google Icon
8/17/2021Millennium Management LLC155,135$1.25M0.0%N/A1.193%Search for SEC Filing on Google Icon
Data available starting January 2016

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Lyra Therapeutics logo
Lyra Therapeutics, Inc., a clinical-stage biotechnology company, focuses on the development and commercialization of novel integrated drug and delivery solutions for the localized treatment of patients with ear, nose, and throat diseases. It's XTreo technology platform is designed to deliver medicines directly to the affected tissue for sustained periods with a single administration. The company's product candidates include LYR-210, an anti-inflammatory implantable drug matrix for the treatment of chronic rhinosinusitis (CRS), which is in Phase III clinical trial; and LYR-220 for CRS patients with and without nasal polyps. It has a collaboration agreement with LianBio Inflammatory Limited to develop and commercialize LYR-210 in mainland China, Hong Kong, Taiwan, Macau, South Korea, Singapore, and Thailand. The company was formerly known as 480 Biomedical, Inc. and changed its name to Lyra Therapeutics, Inc. in July 2018. Lyra Therapeutics, Inc. was incorporated in 2005 and is headquartered in Watertown, Massachusetts.
Read More on Lyra Therapeutics

Today's Range

Now: $4.50
Low: $3.93
High: $4.56

50 Day Range

MA: $5.49
Low: $2.88
High: $8.09

52 Week Range

Now: $4.50
Low: $2.84
High: $37.50

Volume

46,688 shs

Average Volume

96,320 shs

Market Capitalization

$7.97 million

P/E Ratio

N/A

Dividend Yield

N/A

Beta

N/A

Who are the company insiders with the largest holdings of Lyra Therapeutics?

Lyra Therapeutics' top insider shareholders include:
  1. Maria Palasis (CEO)
  2. Jason Cavalier (CFO)
  3. Perceptive Advisors Llc (Major Shareholder)
Learn More about top insider investors at Lyra Therapeutics.

Who are the major institutional investors of Lyra Therapeutics?

Lyra Therapeutics' top institutional investors include:
  1. Citadel Advisors LLC — 1.10%
Learn More about top institutional investors of Lyra Therapeutics stock.

Which major investors are buying Lyra Therapeutics stock?

During the previous quarter, LYRA stock was acquired by institutional investors including:
  1. Citadel Advisors LLC