| 8/15/2023 | Corsair Capital Management L.P. | 100,000 | $76K | 0.0% | +204.5% | 0.165% |  |
| 8/7/2023 | Acadian Asset Management LLC | 457,690 | $0.35M | 0.0% | -25.5% | 0.754% |  |
| 7/11/2023 | Harbor Capital Advisors Inc. | 167,454 | $0.13M | 0.0% | +10.1% | 0.276% |  |
| 5/16/2023 | Atlas Venture Life Science Advisors LLC | 3,791,698 | $3.01M | 0.4% | +9.1% | 6.252% |  |
| 5/12/2023 | Corsair Capital Management L.P. | 32,846 | $26K | 0.0% | N/A | 0.054% |  |
| 5/11/2023 | Acadian Asset Management LLC | 614,213 | $0.49M | 0.0% | +408.5% | 1.013% |  |
| 2/8/2023 | Thrivent Financial for Lutherans | 129,395 | $47K | 0.0% | N/A | 0.214% |  |
| 1/20/2023 | Hellman Jordan Management Co. Inc. MA | 441,125 | $0.17M | 0.3% | +142.4% | 0.728% |  |
| 11/16/2022 | Alphabet Inc. | 3,339,138 | $4.71M | 0.2% | N/A | 5.514% |  |
| 11/14/2022 | RA Capital Management L.P. | 3,588,081 | $5.06M | 0.1% | N/A | 5.925% |  |
| 11/14/2022 | Ergoteles LLC | 115,122 | $0.16M | 0.0% | -12.3% | 0.190% |  |
| 11/14/2022 | Integral Health Asset Management LLC | 377,000 | $0.53M | 0.1% | +14.8% | 0.623% |  |
| 11/10/2022 | Connor Clark & Lunn Investment Management Ltd. | 86,631 | $0.12M | 0.0% | +160.8% | 0.143% |  |
| 10/13/2022 | Hellman Jordan Management Co. Inc. MA | 181,964 | $0.26M | 0.4% | -38.3% | 0.309% |  |
| 9/27/2022 | Hellman Jordan Management Co. Inc. MA | 295,000 | $0.35M | 0.5% | N/A | 0.501% |  |
| 9/16/2022 | Federated Hermes Inc. | 189,312 | $0.23M | 0.0% | -51.1% | 0.321% |  |
| 8/16/2022 | Woodline Partners LP | 933,181 | $1.12M | 0.0% | +17.2% | 1.585% |  |
| 8/16/2022 | Casdin Capital LLC | 2,415,000 | $2.90M | 0.2% | -12.9% | 4.101% |  |
| 8/15/2022 | Laurion Capital Management LP | 582,300 | $0.70M | 0.0% | N/A | 0.989% |  |
| 8/13/2022 | Virtu Financial LLC | 77,069 | $92K | 0.0% | N/A | 0.131% |  |
| 8/5/2022 | Connor Clark & Lunn Investment Management Ltd. | 33,220 | $40K | 0.0% | N/A | 0.056% |  |
| 8/3/2022 | Integral Health Asset Management LLC | 328,269 | $0.39M | 0.1% | +63.3% | 0.558% |  |
| 7/26/2022 | Harbor Capital Advisors Inc. | 159,307 | $0.19M | 0.1% | +5.1% | 0.271% |  |
| 5/17/2022 | Gilder Gagnon Howe & Co. LLC | 3,383,850 | $9.81M | 0.1% | -7.9% | 5.755% |  |
| 5/16/2022 | Deep Track Capital LP | 5,359,000 | $15.54M | 1.0% | +10.0% | 9.114% |  |
| 5/12/2022 | Integral Health Asset Management LLC | 201,000 | $0.58M | 0.2% | +123.3% | 0.342% |  |
| 5/11/2022 | GSA Capital Partners LLP | 42,662 | $0.12M | 0.0% | +48.5% | 0.073% |  |
| 5/10/2022 | Cheyne Capital Management UK LLP | 47,170 | $0.14M | 0.1% | N/A | 0.080% |  |
| 4/28/2022 | Harbor Capital Advisors Inc. | 151,599 | $0.44M | 0.2% | -16.6% | 0.258% |  |
| 2/18/2022 | TCG Crossover Management LLC | 2,222,222 | $9.84M | 4.6% | N/A | 3.781% |  |
| 2/14/2022 | Deep Track Capital LP | 4,870,000 | $21.57M | 1.5% | N/A | 8.286% |  |
| 2/14/2022 | GSA Capital Partners LLP | 28,729 | $0.13M | 0.0% | N/A | 0.049% |  |
| 2/10/2022 | Bleichroeder LP | 484,400 | $2.15M | 0.3% | +11.5% | 0.824% |  |
| 2/10/2022 | Acadian Asset Management LLC | 6,637 | $29K | 0.0% | N/A | 0.011% |  |
| 2/9/2022 | Principal Financial Group Inc. | 596,678 | $2.64M | 0.0% | +23.7% | 1.015% |  |
| 2/9/2022 | Alps Advisors Inc. | 68,023 | $0.30M | 0.0% | -5.2% | 0.116% |  |
| 2/8/2022 | First Trust Advisors LP | 60,068 | $0.27M | 0.0% | +14.5% | 0.102% |  |
| 2/8/2022 | Northern Trust Corp | 309,276 | $1.37M | 0.0% | +2.3% | 0.526% |  |
| 2/4/2022 | Harbor Capital Advisors Inc. | 181,729 | $0.81M | 0.3% | N/A | 0.309% |  |
| 1/31/2022 | Dupont Capital Management Corp | 27,546 | $0.12M | 0.0% | -28.5% | 0.047% |  |
| 1/18/2022 | Aries Wealth Management | 42,000 | $0.19M | 0.0% | +133.3% | 0.071% |  |
| 12/14/2021 | UBS Asset Management Americas Inc. | 511,542 | $3.72M | 0.0% | -2.2% | 0.870% |  |
| 11/16/2021 | Janus Henderson Group PLC | 596,402 | $4.34M | 0.0% | +420.2% | 1.015% |  |
| 11/16/2021 | Two Sigma Advisers LP | 219,000 | $1.59M | 0.0% | +6.1% | 0.373% |  |
| 11/16/2021 | Two Sigma Investments LP | 142,365 | $1.04M | 0.0% | -16.8% | 0.242% |  |
| 11/16/2021 | Casdin Capital LLC | 3,901,589 | $28.40M | 0.7% | +16.6% | 6.638% |  |
| 11/15/2021 | Great Point Partners LLC | 1,170,000 | $8.52M | 2.0% | +5.3% | 1.991% |  |
| 11/15/2021 | Eversept Partners LP | 198,879 | $1.45M | 0.1% | N/A | 0.338% |  |
| 11/15/2021 | Dimensional Fund Advisors LP | 191,640 | $1.40M | 0.0% | -37.6% | 0.326% |  |
| 11/15/2021 | Hershey Trust Co. | 20,290 | $0.15M | 0.0% | N/A | 0.035% |  |
| 11/12/2021 | Rockefeller Capital Management L.P. | 3,600 | $26K | 0.0% | N/A | 0.006% |  |
| 11/12/2021 | Credit Suisse AG | 156,375 | $1.14M | 0.0% | +273.9% | 0.266% |  |
| 11/12/2021 | Geode Capital Management LLC | 528,274 | $3.85M | 0.0% | +5.0% | 0.899% |  |
| 11/12/2021 | Integral Health Asset Management LLC | 90,000 | $0.66M | 0.2% | +20.0% | 0.153% |  |
| 11/10/2021 | Goldman Sachs Group Inc. | 171,871 | $1.25M | 0.0% | +12.2% | 0.293% |  |
| 11/10/2021 | Citigroup Inc. | 6,418 | $47K | 0.0% | +29.6% | 0.011% |  |
| 11/10/2021 | Alliancebernstein L.P. | 35,800 | $0.26M | 0.0% | -6.5% | 0.061% |  |
| 11/9/2021 | Barclays PLC | 20,611 | $0.15M | 0.0% | -21.6% | 0.035% |  |
| 11/9/2021 | BlackRock Inc. | 2,215,655 | $16.13M | 0.0% | +4.2% | 3.783% |  |
| 11/9/2021 | Principal Financial Group Inc. | 482,401 | $3.51M | 0.0% | +1.6% | 0.824% |  |
| 11/5/2021 | TRV GP IV LLC | 6,758,204 | $49.20M | 11.2% | -15.6% | 11.539% |  |
| 11/5/2021 | Truist Financial Corp | 125,820 | $0.92M | 0.0% | +6.2% | 0.215% |  |
| 11/3/2021 | Dupont Capital Management Corp | 38,529 | $0.28M | 0.0% | +46.9% | 0.066% |  |
| 11/2/2021 | New York State Common Retirement Fund | 14,971 | $0.11M | 0.0% | -41.8% | 0.026% |  |
| 11/1/2021 | SG Americas Securities LLC | 14,639 | $0.11M | 0.0% | N/A | 0.025% |  |
| 10/29/2021 | Vontobel Holding Ltd. | 14,790 | $0.11M | 0.0% | N/A | 0.025% |  |
| 10/25/2021 | Cerity Partners LLC | 20,000 | $0.15M | 0.0% | -23.1% | 0.034% |  |
| 10/18/2021 | Nisa Investment Advisors LLC | 15,395 | $0.11M | 0.0% | N/A | 0.026% |  |
| 8/17/2021 | Price T Rowe Associates Inc. MD | 22,558 | $0.22M | 0.0% | N/A | 0.039% |  |
| 8/17/2021 | Citadel Advisors LLC | 138,267 | $1.35M | 0.0% | -82.2% | 0.236% |  |