| 5/16/2024 | BVF Inc. IL | 522,238 | $1.17M | 0.0% | -1.8% | 7.937% |  |
| 2/12/2024 | Monashee Investment Management LLC | 121,841 | $0.45M | 0.1% | -14.1% | 2.269% |  |
| 11/15/2023 | Adage Capital Partners GP L.L.C. | 292,764 | $1.85M | 0.0% | -75.6% | 5.442% |  |
| 11/14/2023 | Monashee Investment Management LLC | 141,841 | $0.90M | 0.4% | N/A | 2.636% |  |
| 11/13/2023 | Acadian Asset Management LLC | 10,937 | $67K | 0.0% | -93.3% | 0.203% |  |
| 11/13/2023 | Silverarc Capital Management LLC | 354,608 | $2.24M | 0.7% | N/A | 6.591% |  |
| 11/3/2023 | Carlyle Group Inc. | 13,333 | $84K | 0.0% | -93.3% | 0.248% |  |
| 8/7/2023 | Acadian Asset Management LLC | 164,085 | $78K | 0.0% | -30.0% | 0.291% |  |
| 5/5/2023 | Carlyle Group Inc. | 200,000 | $75K | 0.0% | N/A | 0.355% |  |
| 11/10/2022 | Kingsbury Capital Investment Advisors LLC | 298,638 | $0.22M | 0.3% | +732.5% | 0.530% |  |
| 8/9/2022 | Pictet Asset Management SA | 2,903,180 | $2.65M | 0.0% | -9.5% | 5.153% |  |
| 8/9/2022 | Kingsbury Capital Investment Advisors LLC | 35,873 | $33K | 0.0% | +58.5% | 0.064% |  |
| 5/17/2022 | Endurant Capital Management LP | 314,238 | $1.08M | 0.3% | +17.1% | 0.558% |  |
| 5/16/2022 | Frazier Life Sciences Management L.P. | 1,374,047 | $4.74M | 0.4% | N/A | 2.440% |  |
| 5/12/2022 | Connor Clark & Lunn Investment Management Ltd. | 20,560 | $71K | 0.0% | N/A | 0.037% |  |
| 5/5/2022 | Russell Investments Group Ltd. | 458,138 | $1.58M | 0.0% | +61.6% | 0.814% |  |
| 5/4/2022 | ClariVest Asset Management LLC | 158,900 | $0.55M | 0.0% | +20.7% | 0.282% |  |
| 3/3/2022 | Walleye Capital LLC | 155,449 | $0.61M | 0.0% | N/A | 0.276% |  |
| 2/15/2022 | Adage Capital Partners GP L.L.C. | 1,200,000 | $4.70M | 0.0% | +18.2% | 2.131% |  |
| 2/14/2022 | ClariVest Asset Management LLC | 131,679 | $0.52M | 0.0% | +45.2% | 0.234% |  |
| 2/14/2022 | GSA Capital Partners LLP | 145,329 | $0.57M | 0.1% | +274.3% | 0.258% |  |
| 2/11/2022 | Ensign Peak Advisors Inc | 140,767 | $0.55M | 0.0% | +33.7% | 0.250% |  |
| 2/10/2022 | Pictet Asset Management SA | 3,301,019 | $12.94M | 0.0% | -2.5% | 5.863% |  |
| 2/10/2022 | Acadian Asset Management LLC | 18,889 | $74K | 0.0% | N/A | 0.034% |  |
| 2/9/2022 | Dimensional Fund Advisors LP | 344,162 | $1.35M | 0.0% | +2.6% | 0.611% |  |
| 2/8/2022 | ProShare Advisors LLC | 16,009 | $63K | 0.0% | N/A | 0.028% |  |
| 2/8/2022 | Northern Trust Corp | 385,420 | $1.51M | 0.0% | -4.3% | 0.685% |  |
| 2/7/2022 | SG Americas Securities LLC | 12,046 | $47K | 0.0% | -36.7% | 0.021% |  |
| 1/21/2022 | Russell Investments Group Ltd. | 283,563 | $1.11M | 0.0% | +7.0% | 0.504% |  |
| 11/16/2021 | Two Sigma Advisers LP | 382,029 | $2.56M | 0.0% | +19.4% | 0.680% |  |
| 11/16/2021 | Two Sigma Investments LP | 308,964 | $2.07M | 0.0% | +175.4% | 0.550% |  |
| 11/15/2021 | Man Group plc | 106,684 | $0.72M | 0.0% | +27.9% | 0.190% |  |
| 11/15/2021 | California State Teachers Retirement System | 48,422 | $0.33M | 0.0% | -5.2% | 0.086% |  |
| 11/15/2021 | Kingdon Capital Management L.L.C. | 1,021,317 | $6.85M | 0.8% | +1.0% | 1.819% |  |
| 11/15/2021 | Dimensional Fund Advisors LP | 335,427 | $2.25M | 0.0% | -5.9% | 0.597% |  |
| 11/15/2021 | Ensign Peak Advisors Inc | 105,288 | $0.71M | 0.0% | N/A | 0.188% |  |
| 11/12/2021 | Renaissance Technologies LLC | 210,569 | $1.41M | 0.0% | N/A | 0.375% |  |
| 11/12/2021 | Hsbc Holdings PLC | 11,549 | $78K | 0.0% | N/A | 0.021% |  |
| 11/12/2021 | Element Capital Management LLC | 26,434 | $0.18M | 0.1% | N/A | 0.047% |  |
| 11/12/2021 | The Manufacturers Life Insurance Company | 15,235 | $0.10M | 0.0% | -34.6% | 0.027% |  |
| 11/12/2021 | Geode Capital Management LLC | 656,908 | $4.41M | 0.0% | -4.2% | 1.170% |  |
| 11/12/2021 | Bellevue Group AG | 10,878,003 | $72.99M | 0.7% | +13.0% | 19.376% |  |
| 11/10/2021 | Goldman Sachs Group Inc. | 85,026 | $0.57M | 0.0% | +63.9% | 0.151% |  |
| 11/10/2021 | Panagora Asset Management Inc. | 195,619 | $1.31M | 0.0% | -2.5% | 0.348% |  |
| 11/10/2021 | IndexIQ Advisors LLC | 35,626 | $0.24M | 0.0% | +11.1% | 0.063% |  |
| 11/10/2021 | Citigroup Inc. | 4,765 | $32K | 0.0% | +100.4% | 0.008% |  |
| 11/9/2021 | BlackRock Inc. | 2,622,580 | $17.60M | 0.0% | -1.2% | 4.671% |  |
| 11/8/2021 | Russell Investments Group Ltd. | 265,010 | $1.78M | 0.0% | -5.4% | 0.472% |  |
| 11/5/2021 | Advisor Group Holdings Inc. | 4,349 | $29K | 0.0% | +764.6% | 0.008% |  |
| 11/2/2021 | New York State Common Retirement Fund | 19,067 | $0.13M | 0.0% | -40.1% | 0.034% |  |
| 11/1/2021 | SG Americas Securities LLC | 19,043 | $0.13M | 0.0% | N/A | 0.034% |  |
| 8/17/2021 | Millennium Management LLC | 136,907 | $1.07M | 0.0% | -80.9% | 0.244% |  |
| 8/16/2021 | Goldman Sachs Group Inc. | 51,880 | $0.41M | 0.0% | +38.1% | 0.092% |  |