| 11/15/2023 | Redmile Group LLC | 582,443 | $2.30M | 0.1% | -80.0% | 6.619% |  |
| 11/15/2023 | Kynam Capital Management LP | 24,037 | $95K | 0.0% | -80.0% | 0.273% |  |
| 11/15/2023 | Adage Capital Partners GP L.L.C. | 310,000 | $1.22M | 0.0% | N/A | 3.523% |  |
| 10/23/2023 | BML Capital Management LLC | 98,664 | $0.39M | 0.4% | +315.4% | 1.121% |  |
| 7/26/2023 | Privium Fund Management B.V. | 117,200 | $95K | 0.0% | N/A | 0.274% |  |
| 5/15/2023 | MYDA Advisors LLC | 40,000 | $28K | 0.0% | N/A | 0.093% |  |
| 5/9/2023 | US Bancorp DE | 44,346 | $31K | 0.0% | +111.2% | 0.104% |  |
| 11/14/2022 | Point72 Asset Management L.P. | 2,064,222 | $1.32M | 0.0% | +43.6% | 4.848% |  |
| 11/1/2022 | Privium Fund Management UK Ltd | 117,200 | $75K | 0.1% | N/A | 0.275% |  |
| 8/15/2022 | Opaleye Management Inc. | 610,000 | $0.63M | 0.3% | -22.8% | 1.433% |  |
| 8/9/2022 | Pictet Asset Management SA | 781,551 | $0.81M | 0.0% | -69.6% | 1.839% |  |
| 8/8/2022 | Simon Quick Advisors LLC | 46,856 | $49K | 0.0% | N/A | 0.110% |  |
| 7/27/2022 | Bailard Inc. | 90,100 | $93K | 0.0% | N/A | 0.212% |  |
| 7/14/2022 | Adviser Investments LLC | 65,404 | $67K | 0.0% | +39.7% | 0.154% |  |
| 5/12/2022 | Gyon Technologies Capital Management LP | 36,803 | $69K | 0.0% | N/A | 0.087% |  |
| 5/11/2022 | ACT Capital Management LLC | 199,000 | $0.37M | 0.4% | -6.4% | 0.468% |  |
| 5/4/2022 | Adviser Investments LLC | 46,817 | $88K | 0.0% | +347.6% | 0.110% |  |
| 5/2/2022 | Allspring Global Investments Holdings LLC | 45,709 | $85K | 0.0% | N/A | 0.108% |  |
| 2/14/2022 | PDT Partners LLC | 39,462 | $0.19M | 0.0% | +90.0% | 0.093% |  |
| 2/14/2022 | Redmile Group LLC | 3,490,835 | $16.83M | 0.4% | -0.5% | 8.228% |  |
| 2/14/2022 | Point72 Asset Management L.P. | 1,010,790 | $4.87M | 0.0% | +1.1% | 2.382% |  |
| 2/14/2022 | GSA Capital Partners LLP | 130,899 | $0.63M | 0.1% | +73.6% | 0.309% |  |
| 2/11/2022 | Renaissance Technologies LLC | 843,612 | $4.07M | 0.0% | +11.5% | 1.988% |  |
| 2/10/2022 | Pictet Asset Management SA | 2,574,289 | $12.41M | 0.0% | -3.4% | 6.067% |  |
| 2/10/2022 | Acadian Asset Management LLC | 23,405 | $0.11M | 0.0% | N/A | 0.055% |  |
| 2/8/2022 | Northern Trust Corp | 326,497 | $1.57M | 0.0% | -7.1% | 0.770% |  |
| 2/3/2022 | Los Angeles Capital Management LLC | 51,453 | $0.25M | 0.0% | +20.7% | 0.121% |  |
| 2/3/2022 | ACT Capital Management LLC | 212,500 | $1.02M | 0.7% | -11.1% | 0.501% |  |
| 2/2/2022 | New York State Common Retirement Fund | 14,396 | $69K | 0.0% | -57.2% | 0.034% |  |
| 1/31/2022 | Adviser Investments LLC | 10,460 | $50K | 0.0% | N/A | 0.025% |  |
| 1/21/2022 | Kestra Private Wealth Services LLC | 12,000 | $58K | 0.0% | N/A | 0.028% |  |
| 1/21/2022 | Pinnacle Wealth Planning Services Inc. | 14,303 | $69K | 0.0% | N/A | 0.034% |  |
| 11/22/2021 | EcoR1 Capital LLC | 860,619 | $6.22M | 0.2% | -63.5% | 2.028% |  |
| 11/16/2021 | Opaleye Management Inc. | 1,047,300 | $7.57M | 1.4% | -9.4% | 2.468% |  |
| 11/16/2021 | Two Sigma Advisers LP | 174,600 | $1.26M | 0.0% | +192.5% | 0.412% |  |
| 11/16/2021 | Two Sigma Investments LP | 120,212 | $0.87M | 0.0% | +207.5% | 0.283% |  |
| 11/16/2021 | Metropolitan Life Insurance Co NY | 4,698 | $34K | 0.0% | -52.4% | 0.011% |  |
| 11/15/2021 | Point72 Asset Management L.P. | 1,000,000 | $7.23M | 0.0% | +13.2% | 2.357% |  |
| 11/15/2021 | Marshall Wace LLP | 19,421 | $0.14M | 0.0% | N/A | 0.046% |  |
| 11/15/2021 | Granahan Investment Management Inc. MA | 125,331 | $0.91M | 0.0% | -35.8% | 0.295% |  |
| 11/15/2021 | GSA Capital Partners LLP | 75,419 | $0.55M | 0.1% | N/A | 0.178% |  |
| 11/12/2021 | Trexquant Investment LP | 34,300 | $0.25M | 0.0% | +141.4% | 0.081% |  |
| 11/12/2021 | Renaissance Technologies LLC | 756,892 | $5.47M | 0.0% | +31.4% | 1.784% |  |
| 11/12/2021 | Macquarie Group Ltd. | 11,960 | $86K | 0.0% | +2,208.9% | 0.028% |  |
| 11/12/2021 | The Manufacturers Life Insurance Company | 11,580 | $84K | 0.0% | -45.8% | 0.027% |  |
| 11/12/2021 | Geode Capital Management LLC | 617,827 | $4.47M | 0.0% | +6.0% | 1.456% |  |
| 11/10/2021 | Goldman Sachs Group Inc. | 117,656 | $0.85M | 0.0% | -43.6% | 0.277% |  |
| 11/10/2021 | Citigroup Inc. | 6,773 | $49K | 0.0% | -88.6% | 0.016% |  |
| 11/9/2021 | BlackRock Inc. | 2,669,276 | $19.30M | 0.0% | +1.2% | 6.291% |  |
| 11/9/2021 | Candriam Luxembourg S.C.A. | 858,173 | $6.20M | 0.0% | +67.6% | 2.023% |  |
| 11/8/2021 | Los Angeles Capital Management LLC | 42,633 | $0.31M | 0.0% | -8.0% | 0.100% |  |
| 11/2/2021 | New York State Common Retirement Fund | 33,672 | $0.24M | 0.0% | -27.9% | 0.079% |  |
| 11/1/2021 | SG Americas Securities LLC | 22,340 | $0.16M | 0.0% | N/A | 0.053% |  |
| 8/17/2021 | Millennium Management LLC | 157,971 | $1.46M | 0.0% | +7.9% | 0.372% |  |
| 8/16/2021 | Bank of America Corp DE | 184,214 | $1.70M | 0.0% | +481.9% | 0.434% |  |
| 8/16/2021 | Morgan Stanley | 631,008 | $5.82M | 0.0% | +82.5% | 1.487% |  |