| 11/17/2025 | Millennium Management LLC | 247,864 | $4.30M | 0.0% | -19.5% | 1.737% |  |
| 11/17/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,625 | $80K | 0.0% | -14.1% | 0.032% |  |
| 11/17/2025 | Brevan Howard Capital Management LP | 12,878 | $0.22M | 0.0% | N/A | 0.090% |  |
| 11/17/2025 | Bank of America Corp DE | 40,553 | $0.70M | 0.0% | -57.5% | 0.284% |  |
| 11/17/2025 | ArrowMark Colorado Holdings LLC | 595,839 | $10.33M | 0.2% | +1.8% | 4.175% |  |
| 11/14/2025 | ADAR1 Capital Management LLC | 30,633 | $0.53M | 0.0% | +3.4% | 0.215% |  |
| 11/14/2025 | Balyasny Asset Management L.P. | 699,002 | $12.11M | 0.0% | N/A | 4.898% |  |
| 11/14/2025 | Bridgeway Capital Management LLC | 10,781 | $0.19M | 0.0% | N/A | 0.076% |  |
| 11/13/2025 | UBS Group AG | 227,716 | $3.95M | 0.0% | -5.2% | 1.596% |  |
| 11/13/2025 | BNP Paribas Financial Markets | 2,067 | $36K | 0.0% | +89.8% | 0.014% |  |
| 11/13/2025 | Blair William & Co. IL | 141,820 | $2.46M | 0.0% | +6.4% | 0.994% |  |
| 11/10/2025 | Raiffeisen Bank International AG | 34,000 | $0.60M | 0.0% | +13.3% | 0.238% |  |
| 11/7/2025 | Vanguard Group Inc. | 604,611 | $10.48M | 0.0% | -0.9% | 4.236% |  |
| 11/7/2025 | JPMorgan Chase & Co. | 5,563 | $96K | 0.0% | -12.2% | 0.039% |  |
| 11/7/2025 | PNC Financial Services Group Inc. | 5,055 | $88K | 0.0% | +24.7% | 0.035% |  |
| 11/3/2025 | AlphaQuest LLC | 16,454 | $0.29M | 0.0% | +221.4% | 0.115% |  |
| 8/15/2025 | Bank of America Corp DE | 95,401 | $1.43M | 0.0% | +81.6% | 0.669% |  |
| 8/14/2025 | Commodore Capital LP | 427,866 | $6.40M | 0.5% | -53.7% | 2.998% |  |
| 8/14/2025 | Redmile Group LLC | 1,276,676 | $19.09M | 2.0% | -2.4% | 8.945% |  |
| 8/14/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5,384 | $80K | 0.0% | -22.9% | 0.038% |  |
| 8/14/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 34,761 | $0.52M | 0.0% | -37.9% | 0.244% |  |
| 8/13/2025 | Schroder Investment Management Group | 30,177 | $0.45M | 0.0% | N/A | 0.212% |  |
| 8/13/2025 | Virtus Investment Advisers LLC | 4,609 | $69K | 0.0% | -37.3% | 0.032% |  |
| 8/12/2025 | JPMorgan Chase & Co. | 6,335 | $95K | 0.0% | -92.7% | 0.044% |  |
| 8/8/2025 | Geode Capital Management LLC | 247,775 | $3.71M | 0.0% | -4.5% | 1.737% |  |
| 8/8/2025 | PNC Financial Services Group Inc. | 4,055 | $61K | 0.0% | +43.6% | 0.028% |  |
| 8/1/2025 | Jennison Associates LLC | 167,563 | $2.51M | 0.0% | +55.0% | 1.175% |  |
| 7/31/2025 | AlphaQuest LLC | 5,119 | $77K | 0.0% | -22.5% | 0.036% |  |
| 7/24/2025 | Blair William & Co. IL | 133,236 | $1.99M | 0.0% | -11.9% | 0.934% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 21,176 | $0.25M | 0.0% | -44.4% | 0.148% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 21,176 | $0.25M | 0.0% | -44.4% | 0.148% |  |
| 5/16/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 6,983 | $82K | 0.0% | +17.9% | 0.049% |  |
| 5/16/2025 | ADAR1 Capital Management LLC | 27,925 | $0.33M | 0.1% | N/A | 0.196% |  |
| 5/15/2025 | Redmile Group LLC | 1,308,063 | $15.32M | 1.4% | -0.9% | 9.172% |  |
| 5/15/2025 | Baker BROS. Advisors LP | 1,486,200 | $17.40M | 0.2% | +120.4% | 10.421% |  |
| 5/14/2025 | Corebridge Financial Inc. | 5,826 | $68K | 0.0% | +13.8% | 0.041% |  |
| 5/14/2025 | Walleye Capital LLC | 94,083 | $1.10M | 0.0% | +25.7% | 0.660% |  |
| 5/14/2025 | AlphaQuest LLC | 6,609 | $77K | 0.0% | N/A | 0.046% |  |
| 5/14/2025 | EntryPoint Capital LLC | 12,666 | $0.15M | 0.1% | N/A | 0.089% |  |
| 5/14/2025 | Wellington Management Group LLP | 34,421 | $0.40M | 0.0% | +58.5% | 0.241% |  |
| 5/12/2025 | Nuveen LLC | 27,482 | $0.32M | 0.0% | N/A | 0.193% |  |
| 5/12/2025 | Mitsubishi UFJ Asset Management Co. Ltd. | 11,231 | $0.13M | 0.0% | +9.1% | 0.079% |  |
| 5/9/2025 | Deutsche Bank AG | 150,862 | $1.77M | 0.0% | -1.0% | 1.058% |  |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 33,969 | $0.40M | 0.0% | +12.0% | 0.238% |  |
| 5/9/2025 | Raiffeisen Bank International AG | 30,000 | $0.35M | 0.0% | +87.5% | 0.210% |  |
| 5/9/2025 | Blair William & Co. IL | 151,180 | $1.77M | 0.0% | +141.3% | 1.060% |  |
| 5/5/2025 | Jennison Associates LLC | 108,084 | $1.27M | 0.0% | +48.9% | 0.758% |  |
| 4/29/2025 | Bank of New York Mellon Corp | 24,445 | $0.29M | 0.0% | +8.2% | 0.164% |  |
| 4/7/2025 | GAMMA Investing LLC | 4,134 | $48K | 0.0% | +2,985.1% | 0.028% |  |
| 3/24/2025 | Wellington Management Group LLP | 21,717 | $0.50M | 0.0% | +18.7% | 0.146% |  |
| 2/17/2025 | Vestal Point Capital LP | 80,000 | $1.83M | 0.1% | N/A | 0.539% |  |
| 2/17/2025 | Squarepoint Ops LLC | 17,431 | $0.40M | 0.0% | +250.0% | 0.117% |  |
| 2/17/2025 | Two Sigma Investments LP | 20,629 | $0.47M | 0.0% | N/A | 0.139% |  |
| 2/17/2025 | RTW Investments LP | 1,350,256 | $30.87M | 0.5% | +18.9% | 9.090% |  |
| 2/17/2025 | Raiffeisen Bank International AG | 16,000 | $0.36M | 0.0% | N/A | 0.108% |  |
| 2/17/2025 | Redmile Group LLC | 1,319,763 | $30.17M | 2.1% | +36.9% | 8.884% |  |
| 2/17/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 32,734 | $0.75M | 0.1% | +270.8% | 0.220% |  |
| 2/17/2025 | Octagon Capital Advisors LP | 303,000 | $6.93M | 1.1% | +1,920.0% | 2.040% |  |
| 2/17/2025 | Deutsche Bank AG | 152,371 | $3.48M | 0.0% | -54.4% | 1.026% |  |
| 2/17/2025 | DAFNA Capital Management LLC | 51,500 | $1.18M | 0.3% | +562.4% | 0.347% |  |
| 2/17/2025 | Deerfield Management Company L.P. Series C | 448,145 | $10.25M | 0.2% | N/A | 3.018% |  |
| 2/17/2025 | Driehaus Capital Management LLC | 32,765 | $0.75M | 0.0% | -67.9% | 0.221% |  |
| 2/17/2025 | Casdin Capital LLC | 1,295,361 | $29.61M | 2.0% | +146.9% | 8.723% |  |
| 2/17/2025 | Baker BROS. Advisors LP | 674,450 | $15.42M | 0.2% | +47.9% | 4.542% |  |
| 2/17/2025 | BNP Paribas Financial Markets | 1,380 | $32K | 0.0% | -36.4% | 0.009% |  |
| 2/17/2025 | ArrowMark Colorado Holdings LLC | 448,601 | $10.26M | 0.1% | +16.1% | 3.021% |  |
| 2/14/2025 | Samsara BioCapital LLC | 1,717,127 | $39.25M | 5.3% | +35.4% | 11.563% |  |
| 2/14/2025 | Schonfeld Strategic Advisors LLC | 9,189 | $0.21M | 0.0% | -71.9% | 0.062% |  |
| 2/14/2025 | Northern Trust Corp | 100,566 | $2.30M | 0.0% | +6.2% | 0.677% |  |
| 2/14/2025 | The Manufacturers Life Insurance Company | 14,079 | $0.32M | 0.0% | N/A | 0.095% |  |
| 2/14/2025 | Virtus ETF Advisers LLC | 3,183 | $73K | 0.0% | +45.1% | 0.021% |  |
| 2/14/2025 | Price T Rowe Associates Inc. MD | 123,291 | $2.82M | 0.0% | N/A | 0.830% |  |
| 2/14/2025 | Rock Springs Capital Management LP | 95,407 | $2.18M | 0.1% | N/A | 0.642% |  |
| 2/13/2025 | Walleye Capital LLC | 74,836 | $1.71M | 0.0% | +68.2% | 0.504% |  |
| 2/13/2025 | XTX Topco Ltd | 15,256 | $0.35M | 0.0% | N/A | 0.103% |  |
| 2/13/2025 | Mariner LLC | 10,475 | $0.24M | 0.0% | N/A | 0.071% |  |
| 2/13/2025 | Barclays PLC | 17,533 | $0.40M | 0.0% | +18.0% | 0.118% |  |
| 2/13/2025 | Wells Fargo & Company MN | 5,444 | $0.12M | 0.0% | +34.5% | 0.037% |  |
| 2/12/2025 | Geode Capital Management LLC | 234,625 | $5.37M | 0.0% | +6.4% | 1.580% |  |
| 2/12/2025 | Wellington Management Group LLP | 21,717 | $0.50M | 0.0% | +18.7% | 0.146% |  |
| 2/12/2025 | Blair William & Co. IL | 62,640 | $1.43M | 0.0% | N/A | 0.422% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 481,001 | $11M | 0.0% | +10,395.3% | 3.239% |  |
| 2/12/2025 | Mitsubishi UFJ Asset Management Co. Ltd. | 10,290 | $0.24M | 0.0% | +72.8% | 0.069% |  |
| 2/7/2025 | PNC Financial Services Group Inc. | 3,126 | $71K | 0.0% | N/A | 0.021% |  |
| 2/6/2025 | M&T Bank Corp | 14,138 | $0.32M | 0.0% | N/A | 0.095% |  |
| 1/30/2025 | Rhumbline Advisers | 15,704 | $0.36M | 0.0% | +9.2% | 0.106% |  |
| 1/24/2025 | Jennison Associates LLC | 72,596 | $1.66M | 0.0% | -7.7% | 0.489% |  |
| 1/24/2025 | China Universal Asset Management Co. Ltd. | 3,150 | $72K | 0.0% | N/A | 0.021% |  |
| 11/27/2024 | Franklin Resources Inc. | 7,050 | $0.30M | 0.0% | N/A | 0.047% |  |
| 11/19/2024 | Barclays PLC | 14,859 | $0.62M | 0.0% | +319.4% | 0.100% |  |
| 11/16/2024 | Geode Capital Management LLC | 220,599 | $9.26M | 0.0% | -0.7% | 1.698% |  |
| 11/15/2024 | Barclays PLC | 14,859 | $0.62M | 0.0% | +319.4% | 0.114% |  |
| 11/15/2024 | Jane Street Group LLC | 7,717 | $0.32M | 0.0% | N/A | 0.059% |  |
| 11/15/2024 | Wellington Management Group LLP | 18,290 | $0.77M | 0.0% | N/A | 0.141% |  |
| 11/15/2024 | State Street Corp | 246,540 | $10.35M | 0.0% | +17.5% | 1.898% |  |
| 11/15/2024 | RTW Investments LP | 1,135,256 | $47.64M | 0.7% | +6.0% | 8.739% |  |
| 11/15/2024 | Redmile Group LLC | 964,347 | $40.46M | 2.4% | -4.9% | 7.424% |  |
| 11/15/2024 | Janus Henderson Group PLC | 709,469 | $29.78M | 0.0% | -15.0% | 5.462% |  |
| 11/14/2024 | Walleye Capital LLC | 44,500 | $1.87M | 0.0% | -51.9% | 0.343% |  |
| 11/14/2024 | MetLife Investment Management LLC | 6,054 | $0.25M | 0.0% | N/A | 0.047% |  |