| 11/17/2025 | Woodline Partners LP | 2,217,893 | $21.71M | 0.1% | -36.7% | 3.230% |  |
| 11/17/2025 | Susquehanna Fundamental Investments LLC | 94,883 | $0.93M | 0.0% | -16.4% | 0.138% |  |
| 11/17/2025 | Susquehanna International Group LLP | 112,277 | $1.10M | 0.0% | +20.6% | 0.164% |  |
| 11/17/2025 | Quarry LP | 18,751 | $0.18M | 0.0% | N/A | 0.027% |  |
| 11/17/2025 | Paradigm Biocapital Advisors LP | 6,794,172 | $66.52M | 1.9% | +0.4% | 9.895% |  |
| 11/17/2025 | Millennium Management LLC | 331,454 | $3.25M | 0.0% | -73.9% | 0.483% |  |
| 11/17/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 27,334 | $0.27M | 0.0% | N/A | 0.040% |  |
| 11/17/2025 | Kingdon Capital Management L.L.C. | 854,000 | $8.36M | 1.0% | N/A | 1.244% |  |
| 11/17/2025 | HighVista Strategies LLC | 437,179 | $4.28M | 1.0% | +57.0% | 0.637% |  |
| 11/17/2025 | Bank of America Corp DE | 802,304 | $7.86M | 0.0% | +0.4% | 1.169% |  |
| 11/17/2025 | Ameriprise Financial Inc. | 1,147,068 | $11.23M | 0.0% | -2.2% | 1.671% |  |
| 11/14/2025 | Creative Planning | 55,310 | $0.54M | 0.0% | +183.3% | 0.081% |  |
| 11/14/2025 | Zacks Investment Management | 30,803 | $0.30M | 0.0% | +138.0% | 0.045% |  |
| 11/14/2025 | Deep Track Capital LP | 3,470,172 | $33.97M | 0.9% | +0.8% | 5.054% |  |
| 11/14/2025 | Two Sigma Investments LP | 109,526 | $1.07M | 0.0% | +18.4% | 0.160% |  |
| 11/14/2025 | Bridgeway Capital Management LLC | 70,000 | $0.69M | 0.0% | +40.0% | 0.102% |  |
| 11/14/2025 | Squarepoint Ops LLC | 14,091 | $0.14M | 0.0% | -67.7% | 0.021% |  |
| 11/13/2025 | Pier Capital LLC | 524,249 | $5.13M | 0.8% | -32.0% | 0.764% |  |
| 11/13/2025 | UBS Group AG | 1,190,654 | $11.66M | 0.0% | -15.7% | 1.735% |  |
| 11/13/2025 | BNP Paribas Financial Markets | 299,619 | $2.93M | 0.0% | +4,450.0% | 0.437% |  |
| 11/13/2025 | Russell Investments Group Ltd. | 5,399 | $53K | 0.0% | N/A | 0.008% |  |
| 11/12/2025 | Barclays PLC | 104,624 | $1.02M | 0.0% | -32.9% | 0.152% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 1,064,549 | $10.42M | 0.0% | -11.8% | 1.551% |  |
| 11/12/2025 | Intech Investment Management LLC | 13,567 | $0.13M | 0.0% | -64.9% | 0.020% |  |
| 11/10/2025 | China Universal Asset Management Co. Ltd. | 12,031 | $0.12M | 0.0% | -12.5% | 0.018% |  |
| 11/7/2025 | Vanguard Group Inc. | 3,197,320 | $31.30M | 0.0% | -2.1% | 4.659% |  |
| 11/7/2025 | JPMorgan Chase & Co. | 30,131 | $0.30M | 0.0% | -7.2% | 0.044% |  |
| 11/6/2025 | Rhumbline Advisers | 84,289 | $0.83M | 0.0% | -2.0% | 0.123% |  |
| 11/6/2025 | ProShare Advisors LLC | 12,627 | $0.12M | 0.0% | -14.5% | 0.018% |  |
| 11/6/2025 | Candriam S.C.A. | 1,249,727 | $12.24M | 0.1% | +46.9% | 1.821% |  |
| 11/5/2025 | Alps Advisors Inc. | 32,510 | $0.32M | 0.0% | -11.9% | 0.047% |  |
| 10/28/2025 | Campbell & CO Investment Adviser LLC | 29,048 | $0.28M | 0.0% | N/A | 0.042% |  |
| 10/22/2025 | Hennion & Walsh Asset Management Inc. | 244,076 | $2.39M | 0.1% | -1.8% | 0.356% |  |
| 10/9/2025 | Voya Investment Management LLC | 11,082 | $0.11M | 0.0% | -33.2% | 0.016% |  |
| 8/26/2025 | Thrivent Financial for Lutherans | 72,455 | $0.31M | 0.0% | N/A | 0.106% |  |
| 8/15/2025 | BNP Paribas Financial Markets | 6,585 | $28K | 0.0% | -98.2% | 0.010% |  |
| 8/15/2025 | Bridgeway Capital Management LLC | 50,000 | $0.21M | 0.0% | N/A | 0.073% |  |
| 8/15/2025 | Birchview Capital LP | 134,000 | $0.57M | 0.6% | N/A | 0.195% |  |
| 8/15/2025 | Bank of America Corp DE | 799,502 | $3.41M | 0.0% | -12.0% | 1.165% |  |
| 8/15/2025 | Ameriprise Financial Inc. | 1,172,863 | $5M | 0.0% | +193.4% | 1.709% |  |
| 8/14/2025 | MPM Bioimpact LLC | 2,378,762 | $10.13M | 1.8% | -18.8% | 3.466% |  |
| 8/14/2025 | PDT Partners LLC | 28,337 | $0.12M | 0.0% | -61.9% | 0.041% |  |
| 8/14/2025 | The Manufacturers Life Insurance Company | 22,442 | $96K | 0.0% | +46.7% | 0.033% |  |
| 8/14/2025 | HighVista Strategies LLC | 278,430 | $1.19M | 0.4% | +31.2% | 0.407% |  |
| 8/14/2025 | Diadema Partners LP | 253,657 | $1.08M | 0.3% | +153.7% | 0.371% |  |
| 8/13/2025 | Affinity Asset Advisors LLC | 250,000 | $1.07M | 0.1% | -23.1% | 0.365% |  |
| 8/13/2025 | Marshall Wace LLP | 12,800 | $55K | 0.0% | -96.0% | 0.019% |  |
| 8/13/2025 | Invesco Ltd. | 79,929 | $0.34M | 0.0% | +57.3% | 0.117% |  |
| 8/13/2025 | Schroder Investment Management Group | 618,184 | $2.63M | 0.0% | +16.0% | 0.904% |  |
| 8/12/2025 | XTX Topco Ltd | 80,414 | $0.34M | 0.0% | N/A | 0.118% |  |
| 8/12/2025 | Ameritas Investment Partners Inc. | 6,080 | $26K | 0.0% | +55.4% | 0.009% |  |
| 8/12/2025 | Titleist Asset Management LLC | 15,000 | $64K | 0.0% | N/A | 0.022% |  |
| 8/12/2025 | American Century Companies Inc. | 12,756 | $54K | 0.0% | N/A | 0.019% |  |
| 8/12/2025 | Rhumbline Advisers | 86,027 | $0.37M | 0.0% | +48.2% | 0.126% |  |
| 8/12/2025 | JPMorgan Chase & Co. | 32,479 | $0.14M | 0.0% | -88.7% | 0.047% |  |
| 8/11/2025 | Persistent Asset Partners Ltd | 58,333 | $0.25M | 0.2% | +153.8% | 0.085% |  |
| 8/8/2025 | Intech Investment Management LLC | 38,609 | $0.16M | 0.0% | +58.8% | 0.056% |  |
| 8/8/2025 | Creative Planning | 19,521 | $83K | 0.0% | N/A | 0.029% |  |
| 8/8/2025 | Police & Firemen s Retirement System of New Jersey | 14,195 | $60K | 0.0% | +76.2% | 0.021% |  |
| 8/8/2025 | Geode Capital Management LLC | 1,326,123 | $5.65M | 0.0% | +22.4% | 1.938% |  |
| 8/7/2025 | ProShare Advisors LLC | 14,766 | $63K | 0.0% | +21.1% | 0.022% |  |
| 8/5/2025 | Pier Capital LLC | 771,072 | $3.29M | 0.5% | -5.7% | 1.127% |  |
| 7/30/2025 | FNY Investment Advisers LLC | 10,000 | $42K | 0.0% | +100.0% | 0.015% |  |
| 7/11/2025 | Farther Finance Advisors LLC | 6,839 | $29K | 0.0% | +602.9% | 0.010% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 741,329 | $2.79M | 0.0% | +93.6% | 1.083% |  |
| 5/19/2025 | Jane Street Group LLC | 138,552 | $0.52M | 0.0% | +216.8% | 0.203% |  |
| 5/16/2025 | Woodline Partners LP | 1,477,907 | $5.56M | 0.0% | +8.9% | 2.162% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 741,329 | $2.79M | 0.0% | +93.6% | 1.084% |  |
| 5/16/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 23,932 | $90K | 0.0% | -8.7% | 0.035% |  |
| 5/16/2025 | BVF Inc. IL | 5,295,893 | $19.91M | 0.8% | -7.3% | 7.747% |  |
| 5/16/2025 | Bain Capital Life Sciences Investors LLC | 6,843,954 | $25.73M | 3.8% | -8.4% | 10.011% |  |
| 5/16/2025 | AQR Capital Management LLC | 45,661 | $0.17M | 0.0% | N/A | 0.067% |  |
| 5/15/2025 | MPM Bioimpact LLC | 2,930,446 | $11.02M | 1.9% | +0.6% | 4.287% |  |
| 5/15/2025 | PDT Partners LLC | 74,299 | $0.28M | 0.0% | N/A | 0.109% |  |
| 5/15/2025 | Cubist Systematic Strategies LLC | 93,669 | $0.35M | 0.0% | +260.4% | 0.137% |  |
| 5/15/2025 | Alpine Global Management LLC | 13,874 | $52K | 0.0% | N/A | 0.020% |  |
| 5/15/2025 | Quarry LP | 12,000 | $45K | 0.0% | N/A | 0.018% |  |
| 5/15/2025 | Paradigm Biocapital Advisors LP | 6,741,172 | $25.35M | 1.2% | -7.7% | 9.861% |  |
| 5/14/2025 | Affinity Asset Advisors LLC | 325,000 | $1.22M | 0.1% | N/A | 0.475% |  |
| 5/14/2025 | MetLife Investment Management LLC | 17,675 | $66K | 0.0% | -25.4% | 0.026% |  |
| 5/14/2025 | Walleye Capital LLC | 87,705 | $0.33M | 0.0% | +30.9% | 0.128% |  |
| 5/14/2025 | Portland Investment Counsel Inc. | 50,000 | $0.19M | 0.1% | +100.0% | 0.073% |  |
| 5/14/2025 | Candriam S.C.A. | 850,517 | $3.20M | 0.0% | -45.2% | 1.244% |  |
| 5/14/2025 | Hsbc Holdings PLC | 15,698 | $58K | 0.0% | +56.9% | 0.023% |  |
| 5/14/2025 | Wellington Management Group LLP | 1,473,679 | $5.54M | 0.0% | -3.4% | 2.156% |  |
| 5/13/2025 | Brooklyn Investment Group | 18,915 | $71K | 0.0% | N/A | 0.028% |  |
| 5/13/2025 | Persistent Asset Partners Ltd | 22,988 | $86K | 0.1% | N/A | 0.034% |  |
| 5/12/2025 | Nuveen LLC | 344,296 | $1.30M | 0.0% | N/A | 0.504% |  |
| 5/12/2025 | Invesco Ltd. | 50,810 | $0.19M | 0.0% | +208.9% | 0.074% |  |
| 5/9/2025 | Deutsche Bank AG | 54,329 | $0.20M | 0.0% | +38.1% | 0.079% |  |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 349,023 | $1.31M | 0.0% | +4.8% | 0.511% |  |
| 5/7/2025 | Corton Capital Inc. | 21,741 | $82K | 0.3% | +25.6% | 0.032% |  |
| 5/6/2025 | Y Intercept Hong Kong Ltd | 10,882 | $41K | 0.0% | -42.7% | 0.016% |  |
| 4/30/2025 | Alps Advisors Inc. | 50,484 | $0.19M | 0.0% | +9.0% | 0.074% |  |
| 4/30/2025 | China Universal Asset Management Co. Ltd. | 14,892 | $56K | 0.0% | +22.6% | 0.022% |  |
| 4/29/2025 | Bank of New York Mellon Corp | 131,994 | $0.50M | 0.0% | +2.6% | 0.193% |  |
| 4/10/2025 | Hennion & Walsh Asset Management Inc. | 242,486 | $0.91M | 0.0% | +14.2% | 0.355% |  |
| 3/24/2025 | Wellington Management Group LLP | 1,525,484 | $8.84M | 0.0% | +52.1% | 2.662% |  |
| 2/25/2025 | Polar Asset Management Partners Inc. | 20,400 | $0.12M | 0.0% | N/A | 0.036% |  |
| 2/17/2025 | UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 93,979 | $0.55M | 0.0% | +23.7% | 0.164% |  |