| 11/17/2025 | Qube Research & Technologies Ltd | 25,277 | $33K | 0.0% | -65.3% | 0.035% |  |
| 11/17/2025 | Parkman Healthcare Partners LLC | 202,978 | $0.26M | 0.0% | N/A | 0.285% |  |
| 11/17/2025 | Millennium Management LLC | 986,293 | $1.28M | 0.0% | -6.3% | 1.385% |  |
| 11/17/2025 | Integrated Wealth Concepts LLC | 52,900 | $69K | 0.0% | N/A | 0.074% |  |
| 11/17/2025 | Bank of America Corp DE | 362,707 | $0.47M | 0.0% | +2,333.0% | 0.509% |  |
| 11/17/2025 | Boothbay Fund Management LLC | 486,877 | $0.63M | 0.0% | N/A | 0.684% |  |
| 11/14/2025 | Schonfeld Strategic Advisors LLC | 883,154 | $1.15M | 0.0% | N/A | 1.240% |  |
| 11/14/2025 | Two Sigma Investments LP | 341,134 | $0.44M | 0.0% | N/A | 0.480% |  |
| 11/14/2025 | Squarepoint Ops LLC | 114,923 | $0.15M | 0.0% | -48.0% | 0.162% |  |
| 11/13/2025 | Kennedy Capital Management LLC | 1,106,638 | $1.44M | 0.0% | -26.3% | 1.556% |  |
| 11/13/2025 | Private Advisor Group LLC | 25,600 | $33K | 0.0% | N/A | 0.036% |  |
| 11/10/2025 | Persistent Asset Partners Ltd | 46,040 | $60K | 0.0% | N/A | 0.065% |  |
| 11/7/2025 | GSA Capital Partners LLP | 265,993 | $0.35M | 0.0% | -64.2% | 0.374% |  |
| 11/7/2025 | Vanguard Group Inc. | 2,820,813 | $3.67M | 0.0% | +7.0% | 3.967% |  |
| 11/4/2025 | TLS Advisors LLC | 18,858 | $26K | 0.1% | -97.2% | 0.027% |  |
| 10/17/2025 | Apollon Wealth Management LLC | 27,500 | $36K | 0.0% | N/A | 0.039% |  |
| 10/7/2025 | Assenagon Asset Management S.A. | 924,576 | $1.20M | 0.0% | +112.2% | 1.300% |  |
| 8/15/2025 | Rosalind Advisors Inc. | 500,000 | $0.17M | 0.1% | N/A | 0.703% |  |
| 8/15/2025 | Rubric Capital Management LP | 478,533 | $0.16M | 0.0% | -91.0% | 0.673% |  |
| 8/14/2025 | Jane Street Group LLC | 142,597 | $47K | 0.0% | N/A | 0.201% |  |
| 8/14/2025 | Velan Capital Investment Management LP | 160,000 | $53K | 0.1% | +64.9% | 0.225% |  |
| 8/13/2025 | Marshall Wace LLP | 164,721 | $54K | 0.0% | N/A | 0.232% |  |
| 8/13/2025 | Kennedy Capital Management LLC | 1,502,329 | $0.50M | 0.0% | -13.3% | 2.113% |  |
| 8/8/2025 | Geode Capital Management LLC | 643,335 | $0.21M | 0.0% | -51.7% | 0.905% |  |
| 8/1/2025 | Y Intercept Hong Kong Ltd | 160,306 | $53K | 0.0% | N/A | 0.225% |  |
| 7/11/2025 | Assenagon Asset Management S.A. | 435,620 | $0.14M | 0.0% | -22.3% | 0.613% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 104,435 | $33K | 0.0% | -47.3% | 0.147% |  |
| 5/21/2025 | Acadian Asset Management LLC | 2,088,046 | $0.65M | 0.0% | +12.8% | 2.936% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 104,435 | $33K | 0.0% | -47.3% | 0.147% |  |
| 5/16/2025 | Jacobs Levy Equity Management Inc. | 200,593 | $63K | 0.0% | -31.2% | 0.282% |  |
| 5/16/2025 | Adage Capital Partners GP L.L.C. | 1,150,000 | $0.36M | 0.0% | +15.0% | 1.617% |  |
| 5/14/2025 | Affinity Asset Advisors LLC | 667,516 | $0.21M | 0.0% | N/A | 0.939% |  |
| 5/12/2025 | Nuveen LLC | 119,113 | $37K | 0.0% | N/A | 0.168% |  |
| 5/8/2025 | XTX Topco Ltd | 93,154 | $29K | 0.0% | N/A | 0.131% |  |
| 4/15/2025 | Assenagon Asset Management S.A. | 560,830 | $0.18M | 0.0% | +699.9% | 0.789% |  |
| 2/17/2025 | Velan Capital Investment Management LP | 70,000 | $65K | 0.1% | N/A | 0.099% |  |
| 2/17/2025 | Madison Avenue Partners LP | 3,722,627 | $3.48M | 0.4% | -9.6% | 5.242% |  |
| 2/17/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 943,416 | $0.88M | 0.1% | +50.2% | 1.329% |  |
| 2/17/2025 | Jacobs Levy Equity Management Inc. | 291,701 | $0.27M | 0.0% | N/A | 0.411% |  |
| 2/17/2025 | Bridgeway Capital Management LLC | 229,115 | $0.21M | 0.0% | -26.0% | 0.323% |  |
| 2/17/2025 | Bank of America Corp DE | 56,733 | $53K | 0.0% | +49.7% | 0.080% |  |
| 2/17/2025 | BNP Paribas Financial Markets | 104,712 | $98K | 0.0% | -52.5% | 0.147% |  |
| 2/14/2025 | Adage Capital Partners GP L.L.C. | 1,000,000 | $0.93M | 0.0% | N/A | 1.408% |  |
| 2/13/2025 | Kennedy Capital Management LLC | 1,545,387 | $1.44M | 0.0% | +1.1% | 2.176% |  |
| 2/13/2025 | Renaissance Technologies LLC | 107,700 | $0.10M | 0.0% | +142.0% | 0.152% |  |
| 2/13/2025 | ADAR1 Capital Management LLC | 130,532 | $0.12M | 0.0% | +245.8% | 0.184% |  |
| 2/12/2025 | TLS Advisors LLC | 680,967 | $0.64M | 1.5% | -11.7% | 0.959% |  |
| 2/12/2025 | Takeda Pharmaceutical Co. Ltd. | 7,531,996 | $7.01M | 26.4% | N/A | 10.607% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 1,418,306 | $1.32M | 0.0% | -3.1% | 1.997% |  |
| 2/10/2025 | Monimus Capital Management LP | 138,266 | $0.13M | 0.1% | N/A | 0.195% |  |
| 1/30/2025 | Rhumbline Advisers | 84,078 | $79K | 0.0% | +22.3% | 0.118% |  |
| 1/17/2025 | SG Americas Securities LLC | 37,636 | $35K | 0.0% | +83.9% | 0.053% |  |
| 1/14/2025 | Assenagon Asset Management S.A. | 70,114 | $65K | 0.0% | -18.7% | 0.099% |  |
| 11/19/2024 | Barclays PLC | 84,175 | $98K | 0.0% | +311.2% | 0.119% |  |
| 11/16/2024 | Geode Capital Management LLC | 1,317,330 | $1.56M | 0.0% | +1.1% | 1.855% |  |
| 11/15/2024 | Barclays PLC | 84,175 | $98K | 0.0% | +311.2% | 0.119% |  |
| 11/15/2024 | XTX Topco Ltd | 38,230 | $45K | 0.0% | +46.2% | 0.054% |  |
| 11/15/2024 | Jane Street Group LLC | 38,399 | $45K | 0.0% | -61.1% | 0.054% |  |
| 11/14/2024 | Verition Fund Management LLC | 74,875 | $88K | 0.0% | N/A | 0.105% |  |
| 11/13/2024 | BNP Paribas Financial Markets | 220,401 | $0.26M | 0.0% | +4,128.7% | 0.311% |  |
| 11/13/2024 | FMR LLC | 50,225 | $59K | 0.0% | +1,907.4% | 0.071% |  |
| 11/5/2024 | GSA Capital Partners LLP | 260,509 | $0.31M | 0.0% | +118.0% | 0.367% |  |
| 10/23/2024 | Assenagon Asset Management S.A. | 86,289 | $0.10M | 0.0% | N/A | 0.122% |  |
| 8/16/2024 | Driehaus Capital Management LLC | 1,400,191 | $1.08M | 0.0% | N/A | 1.974% |  |
| 8/13/2024 | DCF Advisers LLC | 41,750 | $32K | 0.0% | +111.6% | 0.059% |  |
| 8/9/2024 | Renaissance Technologies LLC | 141,200 | $0.11M | 0.0% | -9.9% | 0.199% |  |
| 8/9/2024 | Dimensional Fund Advisors LP | 274,982 | $0.21M | 0.0% | -19.6% | 0.388% |  |
| 8/1/2024 | Rhumbline Advisers | 69,733 | $54K | 0.0% | -15.6% | 0.098% |  |
| 8/1/2024 | FFT Wealth Management LLC | 489,552 | $0.38M | 0.0% | +18.2% | 0.690% |  |
| 7/26/2024 | Bank of New York Mellon Corp | 218,163 | $0.17M | 0.0% | -5.0% | 0.308% |  |
| 5/16/2024 | BVF Inc. IL | 3,853,818 | $11.75M | 0.3% | -43.7% | 5.442% |  |
| 5/15/2024 | Price T Rowe Associates Inc. MD | 17,396 | $54K | 0.0% | +22.1% | 0.025% |  |
| 5/10/2024 | Vanguard Group Inc. | 2,976,308 | $9.08M | 0.0% | -0.5% | 4.203% |  |
| 5/7/2024 | SG Americas Securities LLC | 35,938 | $0.11M | 0.0% | -9.7% | 0.051% |  |
| 5/7/2024 | Empowered Funds LLC | 128,070 | $0.39M | 0.0% | +8.1% | 0.181% |  |
| 5/1/2024 | BNP Paribas Financial Markets | 32,162 | $98K | 0.0% | +74.7% | 0.045% |  |
| 4/29/2024 | China Universal Asset Management Co. Ltd. | 13,579 | $41K | 0.0% | +66.0% | 0.019% |  |
| 4/24/2024 | Assenagon Asset Management S.A. | 114,265 | $0.35M | 0.0% | +45.6% | 0.162% |  |
| 2/14/2024 | Rubric Capital Management LP | 5,315,969 | $17.12M | 0.4% | -2.4% | 7.521% |  |
| 2/14/2024 | Vestal Point Capital LP | 85,429 | $0.28M | 0.0% | N/A | 0.121% |  |
| 2/13/2024 | DCF Advisers LLC | 18,730 | $60K | 0.0% | -38.4% | 0.026% |  |
| 2/6/2024 | FFT Wealth Management LLC | 395,774 | $1.27M | 0.1% | N/A | 0.560% |  |
| 1/24/2024 | China Universal Asset Management Co. Ltd. | 8,178 | $26K | 0.0% | N/A | 0.012% |  |
| 1/17/2024 | Assenagon Asset Management S.A. | 78,479 | $0.25M | 0.0% | N/A | 0.111% |  |
| 1/12/2024 | SG Americas Securities LLC | 39,792 | $0.13M | 0.0% | +52.7% | 0.056% |  |
| 11/13/2023 | Connor Clark & Lunn Investment Management Ltd. | 81,173 | $0.31M | 0.0% | +17.2% | 0.115% |  |
| 11/13/2023 | Acadian Asset Management LLC | 1,701,228 | $6.53M | 0.0% | -4.5% | 2.407% |  |
| 11/7/2023 | New York State Common Retirement Fund | 19,110 | $73K | 0.0% | -28.7% | 0.027% |  |
| 11/7/2023 | Jump Financial LLC | 15,811 | $61K | 0.0% | N/A | 0.022% |  |
| 10/13/2023 | SG Americas Securities LLC | 26,064 | $100K | 0.0% | N/A | 0.037% |  |
| 9/21/2023 | Barclays PLC | 11,955 | $40K | 0.0% | N/A | 0.017% |  |
| 8/11/2023 | Rubric Capital Management LP | 5,445,910 | $17.86M | 0.8% | -22.2% | 7.714% |  |
| 8/11/2023 | Tejara Capital Ltd | 112,591 | $0.37M | 0.2% | -5.2% | 0.159% |  |
| 8/9/2023 | DCF Advisers LLC | 64,764 | $0.21M | 0.1% | -5.1% | 0.092% |  |
| 8/4/2023 | American International Group Inc. | 28,701 | $94K | 0.0% | N/A | 0.041% |  |
| 7/27/2023 | EA Series Trust | 98,952 | $0.33M | 0.0% | N/A | 0.140% |  |
| 7/25/2023 | Raymond James & Associates | 25,000 | $82K | 0.0% | N/A | 0.035% |  |
| 5/15/2023 | Madison Avenue Partners LP | 3,104,603 | $8.01M | 1.7% | +14.1% | 4.402% |  |
| 5/15/2023 | Rubric Capital Management LP | 7,001,124 | $18.06M | 0.5% | +2.5% | 9.928% |  |
| 5/12/2023 | Tejara Capital Ltd | 118,791 | $0.31M | 0.2% | +10.5% | 0.168% |  |