| 11/17/2025 | Woodline Partners LP | 345,749 | $21.68M | 0.1% | -22.4% | 2.921% |  |
| 11/17/2025 | Summit Partners Public Asset Management LLC | 34,895 | $2.19M | 0.0% | N/A | 0.295% |  |
| 11/17/2025 | Mariner LLC | 20,722 | $1.30M | 0.0% | N/A | 0.175% |  |
| 11/17/2025 | Millennium Management LLC | 26,874 | $1.69M | 0.0% | -91.5% | 0.227% |  |
| 11/17/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 3,174 | $0.20M | 0.0% | -15.4% | 0.027% |  |
| 11/17/2025 | Fred Alger Management LLC | 186,751 | $11.71M | 0.0% | +1,279.1% | 1.578% |  |
| 11/17/2025 | First Light Asset Management LLC | 541,544 | $33.95M | 3.2% | N/A | 4.575% |  |
| 11/17/2025 | Bank of America Corp DE | 4,689 | $0.29M | 0.0% | +12.3% | 0.040% |  |
| 11/17/2025 | Boothbay Fund Management LLC | 25,532 | $1.60M | 0.0% | N/A | 0.216% |  |
| 11/17/2025 | Apis Capital Advisors LLC | 10,000 | $0.63M | 0.1% | N/A | 0.084% |  |
| 11/14/2025 | Raymond James Financial Inc. | 23,838 | $1.49M | 0.0% | +476,660.0% | 0.216% |  |
| 11/14/2025 | Balyasny Asset Management L.P. | 166,535 | $10.44M | 0.0% | N/A | 1.506% |  |
| 11/14/2025 | Two Sigma Investments LP | 4,090 | $0.26M | 0.0% | N/A | 0.037% |  |
| 11/14/2025 | Suvretta Capital Management LLC | 822,400 | $51.56M | 1.3% | +15.1% | 7.436% |  |
| 11/13/2025 | Invesco Ltd. | 48,610 | $3.05M | 0.0% | N/A | 0.440% |  |
| 11/13/2025 | UBS Group AG | 20,439 | $1.28M | 0.0% | -52.6% | 0.185% |  |
| 11/13/2025 | BNP Paribas Financial Markets | 1,404 | $88K | 0.0% | -69.7% | 0.013% |  |
| 11/13/2025 | Franklin Resources Inc. | 4,650 | $0.29M | 0.0% | N/A | 0.042% |  |
| 11/13/2025 | Russell Investments Group Ltd. | 568 | $36K | 0.0% | N/A | 0.005% |  |
| 11/13/2025 | Blue Owl Capital Holdings LP | 95,259 | $5.97M | 1.8% | -24.0% | 0.861% |  |
| 11/12/2025 | Cresset Asset Management LLC | 17,424 | $1.09M | 0.0% | -16.7% | 0.158% |  |
| 11/12/2025 | Royce & Associates LP | 49,509 | $3.10M | 0.0% | -33.6% | 0.448% |  |
| 11/12/2025 | Intech Investment Management LLC | 4,128 | $0.26M | 0.0% | N/A | 0.037% |  |
| 11/7/2025 | Vanguard Group Inc. | 494,656 | $31.01M | 0.0% | +202.0% | 4.472% |  |
| 11/7/2025 | JPMorgan Chase & Co. | 4,338 | $0.27M | 0.0% | +33.7% | 0.039% |  |
| 11/7/2025 | Aberdeen Group plc | 51,243 | $3.21M | 0.0% | N/A | 0.463% |  |
| 11/5/2025 | Alps Advisors Inc. | 5,486 | $0.34M | 0.0% | N/A | 0.050% |  |
| 11/3/2025 | AlphaQuest LLC | 2,617 | $0.16M | 0.0% | N/A | 0.024% |  |
| 11/3/2025 | Archer Investment Corp | 449 | $28K | 0.0% | N/A | 0.004% |  |
| 11/3/2025 | New York State Common Retirement Fund | 2,800 | $0.18M | 0.0% | -42.9% | 0.025% |  |
| 11/3/2025 | Federated Hermes Inc. | 339,047 | $21.26M | 0.0% | N/A | 3.066% |  |
| 10/24/2025 | Aspiriant LLC | 5,852 | $0.37M | 0.0% | N/A | 0.053% |  |
| 10/23/2025 | Spire Wealth Management | 1,016 | $64K | 0.0% | -59.6% | 0.009% |  |
| 8/15/2025 | Frazier Life Sciences Management L.P. | 722,400 | $16.28M | 0.7% | +4.7% | 6.532% |  |
| 8/15/2025 | BNP Paribas Financial Markets | 4,630 | $0.10M | 0.0% | N/A | 0.042% |  |
| 8/15/2025 | Bank of America Corp DE | 4,174 | $94K | 0.0% | -45.1% | 0.038% |  |
| 8/14/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 3,750 | $85K | 0.0% | N/A | 0.034% |  |
| 8/14/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 43,994 | $0.99M | 0.1% | -9.6% | 0.398% |  |
| 8/13/2025 | Marshall Wace LLP | 49,077 | $1.11M | 0.0% | +61.7% | 0.444% |  |
| 8/13/2025 | New York State Common Retirement Fund | 4,900 | $0.11M | 0.0% | N/A | 0.044% |  |
| 8/13/2025 | Adams Street Partners LLC | 298,986 | $6.74M | 4.7% | -27.0% | 2.703% |  |
| 8/12/2025 | XTX Topco Ltd | 17,701 | $0.40M | 0.0% | N/A | 0.160% |  |
| 8/12/2025 | Rhumbline Advisers | 9,956 | $0.22M | 0.0% | N/A | 0.090% |  |
| 8/12/2025 | JPMorgan Chase & Co. | 3,245 | $73K | 0.0% | +108,066.7% | 0.029% |  |
| 8/8/2025 | Police & Firemen s Retirement System of New Jersey | 1,639 | $37K | 0.0% | N/A | 0.015% |  |
| 8/8/2025 | Geode Capital Management LLC | 173,986 | $3.92M | 0.0% | +84.7% | 1.574% |  |
| 7/22/2025 | Strid Group LLC | 18,166 | $0.41M | 0.1% | -37.8% | 0.164% |  |
| 7/14/2025 | Clio Asset Management LLC | 91,508 | $2.06M | 1.6% | N/A | 0.828% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 19,053 | $0.53M | 0.0% | N/A | 0.172% |  |
| 5/16/2025 | Woodline Partners LP | 194,167 | $5.44M | 0.0% | N/A | 1.758% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 19,053 | $0.53M | 0.0% | N/A | 0.173% |  |
| 5/16/2025 | Millennium Management LLC | 269,837 | $7.55M | 0.0% | N/A | 2.444% |  |
| 5/16/2025 | AWM Investment Company Inc. | 69,416 | $1.94M | 0.3% | N/A | 0.629% |  |
| 5/15/2025 | Frazier Life Sciences Management L.P. | 690,012 | $19.31M | 0.9% | +5.5% | 6.248% |  |
| 5/15/2025 | DAFNA Capital Management LLC | 43,348 | $1.21M | 0.3% | -39.3% | 0.393% |  |
| 5/6/2025 | Royce & Associates LP | 71,514 | $2M | 0.0% | N/A | 0.648% |  |
| 4/25/2025 | Strid Group LLC | 29,219 | $0.82M | 0.1% | N/A | 0.265% |  |
| 4/23/2025 | Spire Wealth Management | 2,516 | $70K | 0.0% | N/A | 0.023% |  |
| 2/19/2025 | Toronto Dominion Bank | 13,211 | $0.16M | 0.0% | N/A | 0.118% |  |
| 2/18/2025 | Frazier Life Sciences Management L.P. | 653,892 | $7.85M | 0.3% | N/A | 5.828% |  |
| 2/17/2025 | Toronto Dominion Bank | 13,211 | $0.16M | 0.0% | N/A | 0.118% |  |
| 2/17/2025 | Suvretta Capital Management LLC | 714,463 | $8.57M | 0.3% | N/A | 6.367% |  |
| 2/17/2025 | DAFNA Capital Management LLC | 71,452 | $0.86M | 0.2% | N/A | 0.637% |  |
| 2/17/2025 | Cresset Asset Management LLC | 20,911 | $0.25M | 0.0% | N/A | 0.186% |  |
| 2/17/2025 | Citadel Advisors LLC | 10,408 | $0.13M | 0.0% | N/A | 0.093% |  |
| 2/17/2025 | BVF Inc. IL | 696,555 | $8.36M | 0.3% | N/A | 6.208% |  |
| 2/17/2025 | Adams Street Partners LLC | 409,666 | $4.92M | 4.4% | N/A | 3.651% |  |
| 2/14/2025 | Samsara BioCapital LLC | 679,486 | $8.15M | 1.1% | N/A | 6.056% |  |
| 2/14/2025 | Nantahala Capital Management LLC | 250,062 | $3M | 0.1% | N/A | 2.229% |  |
| 2/14/2025 | Blue Owl Capital Holdings LP | 250,062 | $3M | 0.7% | N/A | 2.229% |  |
| 2/13/2025 | Renaissance Technologies LLC | 21,371 | $0.26M | 0.0% | N/A | 0.190% |  |
| 2/13/2025 | ADAR1 Capital Management LLC | 144,641 | $1.74M | 0.3% | N/A | 1.289% |  |
| 2/12/2025 | Geode Capital Management LLC | 14,270 | $0.17M | 0.0% | N/A | 0.127% |  |
| 2/7/2025 | BML Capital Management LLC | 42,130 | $0.51M | 0.3% | N/A | 0.375% |  |