| 11/17/2025 | Vestal Point Capital LP | 305,000 | $2.45M | 0.1% | -95.0% | 9.591% |  |
| 11/17/2025 | Citadel Advisors LLC | 19,091 | $0.15M | 0.0% | -92.7% | 0.600% |  |
| 11/14/2025 | Orbimed Advisors LLC | 59,046 | $0.47M | 0.0% | -99.0% | 1.857% |  |
| 11/14/2025 | Fiduciary Trust Co | 10,750 | $86K | 0.0% | -95.0% | 0.338% |  |
| 11/14/2025 | Bridgeway Capital Management LLC | 20,803 | $0.17M | 0.0% | -95.0% | 0.654% |  |
| 11/14/2025 | Squarepoint Ops LLC | 23,500 | $0.19M | 0.0% | N/A | 0.739% |  |
| 11/13/2025 | Lynx1 Capital Management LP | 623,704 | $5.01M | 1.0% | -93.3% | 19.613% |  |
| 11/12/2025 | Erste Asset Management GmbH | 122,790 | $1M | 0.0% | -95.0% | 3.861% |  |
| 8/15/2025 | Bridgeway Capital Management LLC | 416,042 | $0.17M | 0.0% | -17.8% | 13.083% |  |
| 8/14/2025 | Orbimed Advisors LLC | 6,055,300 | $2.42M | 0.1% | -13.9% | 194.080% |  |
| 8/8/2025 | Geode Capital Management LLC | 538,578 | $0.22M | 0.0% | -1.4% | 17.262% |  |
| 5/12/2025 | Simplex Trading LLC | 82,346 | $29K | 0.0% | +9,311.0% | 0.132% |  |
| 2/17/2025 | Squarepoint Ops LLC | 64,099 | $36K | 0.0% | +129.5% | 0.104% |  |
| 2/17/2025 | Two Sigma Investments LP | 49,364 | $28K | 0.0% | -49.6% | 0.080% |  |
| 2/17/2025 | Shay Capital LLC | 225,261 | $0.13M | 0.0% | +144.2% | 0.365% |  |
| 2/17/2025 | Orbimed Advisors LLC | 7,404,869 | $4.20M | 0.1% | -24.6% | 11.988% |  |
| 2/14/2025 | Jane Street Group LLC | 78,190 | $44K | 0.0% | +537.2% | 0.127% |  |
| 2/14/2025 | Northern Trust Corp | 62,476 | $35K | 0.0% | +55.1% | 0.101% |  |
| 2/14/2025 | Lynx1 Capital Management LP | 9,256,953 | $5.25M | 2.0% | +9.8% | 14.986% |  |
| 2/14/2025 | Tower Research Capital LLC TRC | 54,479 | $31K | 0.0% | +983.1% | 0.088% |  |
| 2/12/2025 | Geode Capital Management LLC | 531,565 | $0.30M | 0.0% | +4.3% | 0.861% |  |
| 11/16/2024 | Geode Capital Management LLC | 509,516 | $0.36M | 0.0% | +18.2% | 0.825% |  |
| 11/15/2024 | Erste Asset Management GmbH | 2,455,800 | $1.72M | 0.0% | N/A | 3.976% |  |
| 11/14/2024 | Vestal Point Capital LP | 6,100,000 | $4.27M | 0.3% | +0.8% | 9.876% |  |
| 11/9/2024 | Landscape Capital Management L.L.C. | 53,915 | $38K | 0.0% | N/A | 0.087% |  |
| 8/15/2024 | Lynx1 Capital Management LP | 5,057,629 | $4.02M | 1.5% | +4.4% | 8.188% |  |
| 8/9/2024 | Renaissance Technologies LLC | 1,125,574 | $0.89M | 0.0% | -6.6% | 1.826% |  |
| 8/8/2024 | Versant Venture Management LLC | 4,026,417 | $3.20M | 4.1% | -18.8% | 6.532% |  |
| 5/30/2024 | Lynx1 Capital Management LP | 4,845,871 | $6.54M | 1.7% | +1,178.1% | 7.862% |  |
| 5/20/2024 | Virtu Financial LLC | 25,425 | $34K | 0.0% | -62.4% | 0.041% |  |
| 5/15/2024 | Affinity Asset Advisors LLC | 264,266 | $0.36M | 0.0% | N/A | 0.429% |  |
| 5/10/2024 | Acadian Asset Management LLC | 961,271 | $1.30M | 0.0% | +59.0% | 1.560% |  |
| 5/10/2024 | Vanguard Group Inc. | 2,071,538 | $2.80M | 0.0% | +2.6% | 3.362% |  |
| 2/14/2024 | Pale Fire Capital SE | 581,257 | $0.59M | 0.1% | +489.1% | 1.060% |  |
| 11/14/2023 | Lynx1 Capital Management LP | 190,124 | $0.13M | 0.1% | -83.7% | 0.347% |  |
| 11/13/2023 | Acadian Asset Management LLC | 604,678 | $0.40M | 0.0% | +4.5% | 1.103% |  |
| 8/11/2023 | Pale Fire Capital SE | 98,662 | $93K | 0.0% | N/A | 0.180% |  |
| 7/24/2023 | BML Capital Management LLC | 2,058,767 | $1.94M | 1.7% | +510.1% | 3.768% |  |
| 5/1/2023 | Marquette Asset Management LLC | 86,050 | $82K | 0.0% | +28.2% | 0.158% |  |
| 4/12/2023 | Vontobel Holding Ltd. | 80,000 | $77K | 0.0% | +128.6% | 0.146% |  |
| 2/13/2023 | BML Capital Management LLC | 337,467 | $0.47M | 0.4% | N/A | 0.619% |  |
| 2/10/2023 | New York Life Investment Management LLC | 182,978 | $0.25M | 0.0% | +12.7% | 0.335% |  |
| 2/2/2023 | Bailard Inc. | 156,900 | $0.22M | 0.0% | N/A | 0.288% |  |
| 2/1/2023 | Bank of Montreal Can | 49,114 | $70K | 0.0% | N/A | 0.090% |  |
| 1/12/2023 | Marquette Asset Management LLC | 67,101 | $93K | 0.0% | N/A | 0.123% |  |
| 11/14/2022 | Annandale Capital LLC | 40,000 | $50K | 0.0% | N/A | 0.073% |  |
| 11/14/2022 | Lynx1 Capital Management LP | 2,752,422 | $3.44M | 3.1% | +553.1% | 5.054% |  |
| 11/14/2022 | Ergoteles LLC | 76,061 | $95K | 0.0% | -54.8% | 0.140% |  |
| 11/10/2022 | Connor Clark & Lunn Investment Management Ltd. | 87,832 | $0.11M | 0.0% | +117.8% | 0.161% |  |
| 11/4/2022 | Russell Investments Group Ltd. | 40,679 | $50K | 0.0% | -53.0% | 0.075% |  |
| 8/16/2022 | Woodline Partners LP | 1,788,059 | $4.22M | 0.1% | -6.6% | 3.283% |  |
| 8/11/2022 | Healthcare of Ontario Pension Plan Trust Fund | 200,300 | $0.47M | 0.0% | -43.7% | 0.368% |  |
| 8/5/2022 | Connor Clark & Lunn Investment Management Ltd. | 40,321 | $95K | 0.0% | -12.9% | 0.074% |  |
| 7/29/2022 | Russell Investments Group Ltd. | 86,515 | $0.20M | 0.0% | +269.7% | 0.159% |  |
| 5/17/2022 | Great Point Partners LLC | 113,900 | $0.35M | 0.1% | -92.5% | 0.210% |  |
| 5/16/2022 | Deep Track Capital LP | 3,375,000 | $10.46M | 0.7% | +4.9% | 6.215% |  |
| 5/16/2022 | Frazier Life Sciences Management L.P. | 5,009,219 | $15.53M | 1.3% | N/A | 9.224% |  |
| 5/12/2022 | Connor Clark & Lunn Investment Management Ltd. | 46,303 | $0.14M | 0.0% | +98.6% | 0.085% |  |
| 5/11/2022 | GSA Capital Partners LLP | 68,039 | $0.21M | 0.0% | +194.7% | 0.125% |  |
| 5/6/2022 | Los Angeles Capital Management LLC | 87,070 | $0.27M | 0.0% | N/A | 0.160% |  |
| 5/6/2022 | IndexIQ Advisors LLC | 129,561 | $0.40M | 0.0% | N/A | 0.239% |  |
| 5/5/2022 | Russell Investments Group Ltd. | 23,400 | $72K | 0.0% | N/A | 0.043% |  |
| 5/2/2022 | Allspring Global Investments Holdings LLC | 59,521 | $0.18M | 0.0% | N/A | 0.110% |  |
| 4/29/2022 | SG Americas Securities LLC | 10,752 | $33K | 0.0% | -33.0% | 0.020% |  |
| 4/21/2022 | Zurcher Kantonalbank Zurich Cantonalbank | 17,886 | $55K | 0.0% | +847.4% | 0.033% |  |
| 4/21/2022 | Virginia Retirement Systems ET AL | 16,200 | $50K | 0.0% | N/A | 0.030% |  |
| 2/19/2022 | Woodline Partners LP | 1,915,023 | $12.16M | 0.2% | +495.1% | 3.539% |  |
| 2/14/2022 | Virtus ETF Advisers LLC | 24,701 | $0.16M | 0.1% | +68.2% | 0.046% |  |
| 2/14/2022 | Deep Track Capital LP | 3,216,997 | $20.43M | 1.4% | N/A | 5.946% |  |
| 2/11/2022 | Renaissance Technologies LLC | 475,600 | $3.02M | 0.0% | +257.1% | 0.879% |  |
| 2/11/2022 | Ensign Peak Advisors Inc | 13,270 | $84K | 0.0% | N/A | 0.025% |  |
| 2/10/2022 | HighTower Advisors LLC | 28,170 | $0.19M | 0.0% | +30.0% | 0.052% |  |
| 2/10/2022 | Connor Clark & Lunn Investment Management Ltd. | 23,313 | $0.15M | 0.0% | N/A | 0.043% |  |
| 2/8/2022 | Swiss National Bank | 59,500 | $0.38M | 0.0% | +10.8% | 0.110% |  |
| 2/8/2022 | Northern Trust Corp | 340,863 | $2.16M | 0.0% | +3.9% | 0.630% |  |
| 2/7/2022 | SG Americas Securities LLC | 16,053 | $0.10M | 0.0% | -56.4% | 0.030% |  |
| 1/21/2022 | Denali Advisors LLC | 8,800 | $56K | 0.0% | N/A | 0.016% |  |
| 11/16/2021 | Squarepoint Ops LLC | 23,561 | $0.24M | 0.0% | -22.0% | 0.044% |  |
| 11/16/2021 | Two Sigma Advisers LP | 158,500 | $1.58M | 0.0% | +400.0% | 0.293% |  |
| 11/16/2021 | Two Sigma Investments LP | 205,640 | $2.05M | 0.0% | +130.3% | 0.380% |  |
| 11/16/2021 | Wellington Management Group LLP | 421,178 | $4.20M | 0.0% | +9.0% | 0.778% |  |
| 11/16/2021 | Metropolitan Life Insurance Co NY | 6,276 | $63K | 0.0% | -45.9% | 0.012% |  |
| 11/16/2021 | Millennium Management LLC | 344,178 | $3.43M | 0.0% | +76.3% | 0.636% |  |
| 11/15/2021 | California State Teachers Retirement System | 39,810 | $0.40M | 0.0% | -22.1% | 0.074% |  |
| 11/15/2021 | Marshall Wace LLP | 70,923 | $0.71M | 0.0% | -63.2% | 0.131% |  |
| 11/15/2021 | Morgan Stanley | 1,143,442 | $11.39M | 0.0% | -0.3% | 2.113% |  |
| 11/15/2021 | Dynamic Technology Lab Private Ltd | 17,771 | $0.18M | 0.0% | N/A | 0.033% |  |
| 11/15/2021 | GSA Capital Partners LLP | 21,979 | $0.22M | 0.0% | N/A | 0.041% |  |
| 11/15/2021 | HighTower Advisors LLC | 21,669 | $0.21M | 0.0% | +61.7% | 0.040% |  |
| 11/12/2021 | Trexquant Investment LP | 51,474 | $0.51M | 0.0% | +104.4% | 0.095% |  |
| 11/12/2021 | Renaissance Technologies LLC | 133,200 | $1.33M | 0.0% | +107.2% | 0.246% |  |
| 11/12/2021 | Jump Financial LLC | 32,700 | $0.33M | 0.0% | +145.9% | 0.060% |  |
| 11/12/2021 | Geode Capital Management LLC | 473,328 | $4.71M | 0.0% | -10.5% | 0.875% |  |
| 11/10/2021 | Goldman Sachs Group Inc. | 120,270 | $1.20M | 0.0% | +26.2% | 0.222% |  |
| 11/10/2021 | Citigroup Inc. | 55,101 | $0.55M | 0.0% | -66.2% | 0.102% |  |
| 11/10/2021 | Alliancebernstein L.P. | 15,500 | $0.15M | 0.0% | -14.4% | 0.029% |  |
| 11/9/2021 | BlackRock Inc. | 3,118,023 | $31.06M | 0.0% | +0.5% | 5.762% |  |
| 11/9/2021 | Principal Financial Group Inc. | 10,512 | $0.11M | 0.0% | -13.9% | 0.019% |  |
| 11/2/2021 | New York State Common Retirement Fund | 25,785 | $0.26M | 0.0% | -19.5% | 0.048% |  |
| 11/1/2021 | SG Americas Securities LLC | 36,828 | $0.37M | 0.0% | +372.5% | 0.068% |  |