| 11/18/2025 | Heights Capital Management Inc. | 10,000 | $46K | 0.0% | N/A | 0.030% |  |
| 11/17/2025 | Laurion Capital Management LP | 1,892,156 | $8.74M | 0.2% | +133.4% | 5.769% |  |
| 11/17/2025 | Woodline Partners LP | 1,311,021 | $6.06M | 0.0% | +89.6% | 3.997% |  |
| 11/17/2025 | TCG Crossover Management LLC | 1,200,000 | $5.54M | 0.3% | N/A | 3.659% |  |
| 11/17/2025 | Vivo Capital LLC | 2,325,000 | $10.74M | 0.9% | N/A | 7.088% |  |
| 11/17/2025 | RA Capital Management L.P. | 20,064,545 | $92.70M | 1.1% | +87.7% | 61.172% |  |
| 11/17/2025 | Militia Capital Partners LP | 15,500 | $72K | 0.0% | N/A | 0.047% |  |
| 11/17/2025 | Millennium Management LLC | 500,266 | $2.31M | 0.0% | -66.9% | 1.525% |  |
| 11/17/2025 | Boxer Capital Management LLC | 250,000 | $1.16M | 0.4% | N/A | 0.762% |  |
| 11/17/2025 | Commodore Capital LP | 2,357,319 | $10.89M | 0.5% | N/A | 7.187% |  |
| 11/17/2025 | Boothbay Fund Management LLC | 350,385 | $1.62M | 0.0% | +668.9% | 1.068% |  |
| 11/14/2025 | Viking Global Investors LP | 3,482,434 | $16.09M | 0.0% | +134.9% | 10.617% |  |
| 11/14/2025 | Deep Track Capital LP | 1,200,000 | $5.54M | 0.2% | N/A | 3.659% |  |
| 11/14/2025 | Burkehill Global Management LP | 10,000 | $46K | 0.0% | N/A | 0.030% |  |
| 11/14/2025 | ADAR1 Capital Management LLC | 36,842 | $0.17M | 0.0% | +81.0% | 0.112% |  |
| 11/14/2025 | Two Sigma Investments LP | 92,493 | $0.43M | 0.0% | +45.1% | 0.282% |  |
| 11/14/2025 | Bridgeway Capital Management LLC | 63,000 | $0.29M | 0.0% | -31.5% | 0.192% |  |
| 11/13/2025 | UBS Group AG | 242,451 | $1.12M | 0.0% | +1,714.5% | 0.739% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 33,006 | $0.15M | 0.0% | -16.9% | 0.101% |  |
| 11/12/2025 | Monashee Investment Management LLC | 300,000 | $1.39M | 0.7% | N/A | 0.915% |  |
| 11/12/2025 | Fifth Lane Capital LP | 70,000 | $0.32M | 0.3% | N/A | 0.213% |  |
| 11/7/2025 | GSA Capital Partners LLP | 46,158 | $0.21M | 0.0% | N/A | 0.141% |  |
| 11/7/2025 | Vanguard Group Inc. | 1,768,356 | $8.17M | 0.0% | +88.7% | 5.391% |  |
| 8/15/2025 | Rangeley Capital LLC | 35,000 | $39K | 0.0% | +133.3% | 0.107% |  |
| 8/15/2025 | Opaleye Management Inc. | 240,000 | $0.27M | 0.1% | -42.9% | 0.732% |  |
| 8/15/2025 | Bridgeway Capital Management LLC | 91,923 | $0.10M | 0.0% | +61.5% | 0.280% |  |
| 8/14/2025 | RBF Capital LLC | 100,000 | $0.11M | 0.0% | N/A | 0.305% |  |
| 8/14/2025 | Qube Research & Technologies Ltd | 73,004 | $81K | 0.0% | N/A | 0.223% |  |
| 8/13/2025 | Marshall Wace LLP | 39,209 | $44K | 0.0% | N/A | 0.120% |  |
| 8/8/2025 | Geode Capital Management LLC | 201,096 | $0.22M | 0.0% | -47.6% | 0.615% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 40,240 | $57K | 0.0% | -59.1% | 0.123% |  |
| 5/16/2025 | Woodline Partners LP | 780,897 | $1.10M | 0.0% | N/A | 2.387% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 40,240 | $57K | 0.0% | -59.1% | 0.123% |  |
| 5/16/2025 | AQR Capital Management LLC | 87,003 | $0.12M | 0.0% | N/A | 0.266% |  |
| 5/16/2025 | Adage Capital Partners GP L.L.C. | 1,350,000 | $1.90M | 0.0% | +68.8% | 4.126% |  |
| 5/16/2025 | ADAR1 Capital Management LLC | 20,352 | $29K | 0.0% | N/A | 0.062% |  |
| 5/12/2025 | Nuveen LLC | 98,701 | $0.14M | 0.0% | N/A | 0.302% |  |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 40,070 | $56K | 0.0% | -17.1% | 0.122% |  |
| 5/8/2025 | XTX Topco Ltd | 18,139 | $25K | 0.0% | N/A | 0.055% |  |
| 3/24/2025 | Wellington Management Group LLP | 47,506 | $0.18M | 0.0% | +17.2% | 0.145% |  |
| 2/17/2025 | Suvretta Capital Management LLC | 1,174,321 | $4.45M | 0.2% | -29.3% | 3.603% |  |
| 2/17/2025 | RTW Investments LP | 3,193,097 | $12.10M | 0.2% | N/A | 9.796% |  |
| 2/17/2025 | Orbimed Advisors LLC | 653,016 | $2.48M | 0.1% | -18.1% | 2.003% |  |
| 2/17/2025 | Millennium Management LLC | 156,636 | $0.59M | 0.0% | +1,033.2% | 0.481% |  |
| 2/17/2025 | Jacobs Levy Equity Management Inc. | 136,262 | $0.52M | 0.0% | N/A | 0.418% |  |
| 2/17/2025 | Janus Henderson Group PLC | 522,256 | $1.98M | 0.0% | -77.6% | 1.602% |  |
| 2/17/2025 | Deutsche Bank AG | 44,735 | $0.17M | 0.0% | +442.5% | 0.137% |  |
| 2/17/2025 | Corton Capital Inc. | 17,833 | $68K | 0.0% | N/A | 0.055% |  |
| 2/17/2025 | Bridgeway Capital Management LLC | 98,900 | $0.38M | 0.0% | +103.1% | 0.303% |  |
| 2/17/2025 | Bank of America Corp DE | 53,868 | $0.20M | 0.0% | +54.7% | 0.165% |  |
| 2/14/2025 | Northern Trust Corp | 157,038 | $0.60M | 0.0% | +5.4% | 0.482% |  |
| 2/14/2025 | Adage Capital Partners GP L.L.C. | 800,000 | $3.03M | 0.0% | -29.0% | 2.454% |  |
| 2/14/2025 | Dimensional Fund Advisors LP | 57,102 | $0.22M | 0.0% | +26.2% | 0.175% |  |
| 2/13/2025 | Walleye Capital LLC | 14,418 | $55K | 0.0% | -76.2% | 0.044% |  |
| 1/24/2025 | China Universal Asset Management Co. Ltd. | 6,911 | $26K | 0.0% | N/A | 0.021% |  |
| 12/26/2024 | JPMorgan Chase & Co. | 26,611 | $0.23M | 0.0% | +289.9% | 0.082% |  |
| 11/19/2024 | Barclays PLC | 21,971 | $0.19M | 0.0% | +318.7% | 0.067% |  |
| 11/16/2024 | Geode Capital Management LLC | 375,325 | $3.21M | 0.0% | -1.0% | 1.151% |  |
| 11/15/2024 | Frazier Life Sciences Management L.P. | 702,694 | $6.01M | 0.2% | -53.2% | 2.156% |  |
| 11/15/2024 | Barclays PLC | 21,971 | $0.19M | 0.0% | +318.7% | 0.067% |  |
| 11/15/2024 | XTX Topco Ltd | 15,241 | $0.13M | 0.0% | N/A | 0.047% |  |
| 11/15/2024 | Jane Street Group LLC | 27,748 | $0.24M | 0.0% | +29.1% | 0.085% |  |
| 11/15/2024 | Wellington Management Group LLP | 40,517 | $0.35M | 0.0% | +76.9% | 0.124% |  |
| 11/15/2024 | Janus Henderson Group PLC | 2,336,516 | $20.01M | 0.0% | +331.2% | 7.167% |  |
| 11/14/2024 | Walleye Capital LLC | 60,654 | $0.52M | 0.0% | N/A | 0.186% |  |
| 11/14/2024 | Suvretta Capital Management LLC | 1,660,932 | $14.20M | 0.5% | +9.2% | 5.095% |  |
| 11/13/2024 | FMR LLC | 61,607 | $0.53M | 0.0% | -84.2% | 0.189% |  |
| 10/19/2024 | Allspring Global Investments Holdings LLC | 11,103 | $95K | 0.0% | N/A | 0.034% |  |
| 9/16/2024 | Point72 DIFC Ltd | 2,621 | $42K | 0.0% | N/A | 0.008% |  |
| 8/19/2024 | Point72 Asset Management L.P. | 145,174 | $2.32M | 0.0% | -24.5% | 0.448% |  |
| 8/14/2024 | Point72 DIFC Ltd | 2,621 | $42K | 0.0% | N/A | 0.008% |  |
| 8/14/2024 | Marshall Wace LLP | 12,251 | $0.20M | 0.0% | N/A | 0.038% |  |
| 8/10/2024 | Sofinnova Investments Inc. | 561,128 | $8.96M | 0.5% | +11.4% | 1.731% |  |
| 8/9/2024 | Renaissance Technologies LLC | 12,000 | $0.19M | 0.0% | N/A | 0.037% |  |
| 8/8/2024 | American Century Companies Inc. | 20,028 | $0.32M | 0.0% | +19.9% | 0.062% |  |
| 8/1/2024 | Rhumbline Advisers | 18,853 | $0.30M | 0.0% | +36.1% | 0.058% |  |
| 7/26/2024 | Bank of New York Mellon Corp | 44,157 | $0.71M | 0.0% | +43.6% | 0.136% |  |
| 5/17/2024 | RA Capital Management L.P. | 10,689,545 | $157.14M | 2.0% | +31.5% | 32.972% |  |
| 5/17/2024 | Artal Group S.A. | 200,000 | $2.94M | 0.1% | N/A | 0.617% |  |
| 5/16/2024 | Janus Henderson Group PLC | 1,166,642 | $17.23M | 0.0% | +18.1% | 3.602% |  |
| 5/10/2024 | Acadian Asset Management LLC | 2,052 | $30K | 0.0% | N/A | 0.006% |  |
| 5/10/2024 | Vanguard Group Inc. | 850,445 | $12.50M | 0.0% | +68.0% | 2.626% |  |
| 11/15/2023 | Adage Capital Partners GP L.L.C. | 680,000 | $3.45M | 0.0% | +18.3% | 2.856% |  |
| 11/13/2023 | Rathbones Group PLC | 62,003 | $0.32M | 0.0% | N/A | 0.260% |  |
| 11/13/2023 | FMR LLC | 2,365,965 | $12.02M | 0.0% | -13.8% | 9.937% |  |
| 10/27/2023 | Allspring Global Investments Holdings LLC | 6,564 | $33K | 0.0% | N/A | 0.028% |  |
| 10/24/2023 | Bank of New York Mellon Corp | 31,398 | $0.16M | 0.0% | -15.0% | 0.132% |  |
| 8/15/2023 | Suvretta Capital Management LLC | 486,611 | $4.35M | 0.2% | -41.2% | 2.044% |  |
| 8/4/2023 | American International Group Inc. | 4,837 | $43K | 0.0% | -33.3% | 0.020% |  |
| 8/2/2023 | Bank of Montreal Can | 199,532 | $2.66M | 0.0% | N/A | 0.839% |  |
| 3/23/2023 | MetLife Investment Management LLC | 8,647 | $0.12M | 0.0% | N/A | 0.037% |  |
| 11/15/2022 | Parkman Healthcare Partners LLC | 100,000 | $0.91M | 0.3% | N/A | 0.423% |  |
| 11/14/2022 | Tudor Investment Corp Et Al | 220,530 | $1.57M | 0.0% | -24.2% | 0.933% |  |
| 11/14/2022 | Altium Capital Management LP | 40,000 | $0.36M | 0.1% | -50.0% | 0.169% |  |
| 8/16/2022 | Deerfield Management Company L.P. Series C | 953,626 | $9.47M | 0.2% | N/A | 4.036% |  |
| 8/15/2022 | Laurion Capital Management LP | 664,516 | $6.60M | 0.1% | N/A | 2.812% |  |