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PRLD Insider Trading

Insider Ownership Percentage: 63.90%
Insider Buying (Last 12 Months): $781,961.25
Insider Selling (Last 12 Months): $0.00

Prelude Therapeutics Insider Trading History Chart

This chart shows the insider buying and selling history at Prelude Therapeutics by year and by quarter.

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Prelude Therapeutics Share Price & Price History

Current Price: $1.54
Price Change: ▲ Price Increase of +0.16 (11.59%)
As of 12/4/2025 05:00 PM ET

This chart shows the closing price history over time for PRLD up to the past year.

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Days: 30 | 90 | 365

Prelude Therapeutics Insider Trading History

Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionShares Held After TransactionDetails
3/25/2025Andrew CombsInsiderBuy100,000$0.69$69,000.00480,123View SEC Filing Icon  
3/25/2025Krishna VaddiCEOBuy675,000$0.69$465,750.001,999,296View SEC Filing Icon  
3/12/2025Krishna VaddiCEOBuy47,500$0.71$33,725.001,214,775View SEC Filing Icon  
12/30/2024Krishna VaddiCEOBuy10,000$1.20$12,000.00137,553View SEC Filing Icon  
12/23/2024Andrew CombsInsiderBuy60,000$1.37$82,200.00377,623View SEC Filing Icon  
12/20/2024Andrew CombsInsiderBuy3,075$1.15$3,536.25317,623View SEC Filing Icon  
12/19/2024Bryant David LimCFOBuy25,000$0.91$22,750.0027,400View SEC Filing Icon  
12/18/2024Krishna VaddiCEOBuy100,000$0.93$93,000.001,167,275View SEC Filing Icon  
5/24/2023Krishna VaddiCEOBuy1,000$5.01$5,010.001,066,375View SEC Filing Icon  
5/22/2023Orbimed Advisors LlcDirectorBuy869,565$5.75$4,999,998.7510,119,756View SEC Filing Icon  
4/6/2023Jane HuangCMOSell13,280$6.12$81,273.6024,220View SEC Filing Icon  
12/20/2022Krishna VaddiCEOBuy19,188$5.13$98,434.44120,665View SEC Filing Icon  
12/8/2022Laurent ChardonnetCFOBuy10,000$4.76$47,600.0035,873View SEC Filing Icon  
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SEC Filings (Institutional Ownership Changes) for Prelude Therapeutics (NASDAQ:PRLD)

79.72% of Prelude Therapeutics stock is owned by institutions. Institutional ownership can be a sign of analyst confidence in the fundamentals of the stock.

Institutional Buying and Selling by Quarter

This chart shows the instiutional buying and selling at PRLD by year and by quarter.

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Prelude Therapeutics Institutional Trading History

Reporting DateHedge FundShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
11/17/2025Millennium Management LLC1,147,044$1.65M0.0%+361.7%1.824%Search for SEC Filing on Google Icon
11/14/2025Shay Capital LLC100,000$0.14M0.0%+33.3%0.177%Search for SEC Filing on Google Icon
11/14/2025Bridgeway Capital Management LLC53,500$77K0.0%-39.5%0.095%Search for SEC Filing on Google Icon
11/7/2025Vanguard Group Inc.992,854$1.43M0.0%+6.5%1.754%Search for SEC Filing on Google Icon
8/15/2025Shay Capital LLC75,000$61K0.0%N/A0.133%Search for SEC Filing on Google Icon
8/14/2025Jane Street Group LLC91,753$74K0.0%N/A0.163%Search for SEC Filing on Google Icon
8/13/2025Marshall Wace LLP41,747$34K0.0%N/A0.074%Search for SEC Filing on Google Icon
8/12/2025XTX Topco Ltd42,573$34K0.0%+72.4%0.075%Search for SEC Filing on Google Icon
8/8/2025Geode Capital Management LLC217,568$0.18M0.0%-46.3%0.385%Search for SEC Filing on Google Icon
8/1/2025Y Intercept Hong Kong Ltd47,788$39K0.0%N/A0.085%Search for SEC Filing on Google Icon
5/21/2025Acadian Asset Management LLC529,327$0.41M0.0%+9.1%0.938%Search for SEC Filing on Google Icon
5/16/2025AQR Capital Management LLC33,823$26K0.0%+170.7%0.078%Search for SEC Filing on Google Icon
5/12/2025Simplex Trading LLC41,846$32K0.0%+121.2%0.096%Search for SEC Filing on Google Icon
5/9/2025Deutsche Bank AG80,723$62K0.0%-34.8%0.185%Search for SEC Filing on Google Icon
2/17/2025Two Sigma Investments LP231,839$0.30M0.0%+307.2%0.421%Search for SEC Filing on Google Icon
2/17/2025Two Sigma Advisers LP300,000$0.38M0.0%+526.3%0.545%Search for SEC Filing on Google Icon
2/17/2025Millennium Management LLC462,555$0.59M0.0%+188.2%0.841%Search for SEC Filing on Google Icon
2/17/2025Jacobs Levy Equity Management Inc.666,574$0.85M0.0%+280.9%1.211%Search for SEC Filing on Google Icon
2/17/2025Deutsche Bank AG123,899$0.16M0.0%+747.6%0.225%Search for SEC Filing on Google Icon
2/17/2025Bridgeway Capital Management LLC111,000$0.14M0.0%-37.0%0.202%Search for SEC Filing on Google Icon
2/17/2025BNP Paribas Financial Markets20,572$26K0.0%N/A0.037%Search for SEC Filing on Google Icon
2/14/2025Boxer Capital Management LLC1,708,187$2.18M0.2%N/A3.104%Search for SEC Filing on Google Icon
2/14/2025Northern Trust Corp83,387$0.11M0.0%-21.6%0.152%Search for SEC Filing on Google Icon
2/14/2025Price T Rowe Associates Inc. MD1,029,199$1.31M0.0%-6.2%1.870%Search for SEC Filing on Google Icon
2/13/2025Marshall Wace LLP392,155$0.50M0.0%+9.2%0.713%Search for SEC Filing on Google Icon
2/13/2025Renaissance Technologies LLC634,500$0.81M0.0%+222.2%1.153%Search for SEC Filing on Google Icon
2/12/2025Massachusetts Financial Services Co. MA494,497$0.63M0.0%-10.0%0.899%Search for SEC Filing on Google Icon
2/12/2025JPMorgan Chase & Co.61,149$78K0.0%+925.0%0.111%Search for SEC Filing on Google Icon
2/6/2025Charles Schwab Investment Management Inc.117,200$0.15M0.0%-12.0%0.213%Search for SEC Filing on Google Icon
1/30/2025Rhumbline Advisers166,830$0.21M0.0%+1,289.8%0.303%Search for SEC Filing on Google Icon
11/19/2024Barclays PLC27,165$57K0.0%+86.0%0.049%Search for SEC Filing on Google Icon
11/16/2024Geode Capital Management LLC391,716$0.81M0.0%+8.2%0.712%Search for SEC Filing on Google Icon
11/15/2024Barclays PLC27,165$57K0.0%+86.0%0.049%Search for SEC Filing on Google Icon
11/15/2024XTX Topco Ltd48,239$100K0.0%N/A0.088%Search for SEC Filing on Google Icon
11/15/2024State Street Corp286,046$0.59M0.0%+35.1%0.520%Search for SEC Filing on Google Icon
11/15/2024Jacobs Levy Equity Management Inc.174,979$0.36M0.0%+885.2%0.318%Search for SEC Filing on Google Icon
11/14/2024Walleye Capital LLC83,175$0.17M0.0%+446.2%0.151%Search for SEC Filing on Google Icon
11/12/2024Massachusetts Financial Services Co. MA549,530$1.14M0.0%+5.2%0.999%Search for SEC Filing on Google Icon
10/10/2024Exchange Traded Concepts LLC64,409$0.13M0.0%+32.2%0.153%Search for SEC Filing on Google Icon
8/15/2024The Manufacturers Life Insurance Company70,045$0.27M0.0%-3.1%0.166%Search for SEC Filing on Google Icon
8/9/2024Renaissance Technologies LLC206,600$0.79M0.0%-15.6%0.491%Search for SEC Filing on Google Icon
8/9/2024Dimensional Fund Advisors LP29,074$0.11M0.0%+103.2%0.069%Search for SEC Filing on Google Icon
8/9/2024Massachusetts Financial Services Co. MA522,375$1.99M0.0%+2.8%1.241%Search for SEC Filing on Google Icon
7/26/2024Bank of New York Mellon Corp36,276$0.14M0.0%-9.5%0.086%Search for SEC Filing on Google Icon
5/16/2024Kennedy Capital Management LLC25,035$0.12M0.0%N/A0.059%Search for SEC Filing on Google Icon
5/15/2024Price T Rowe Associates Inc. MD941,971$4.47M0.0%-9.7%2.239%Search for SEC Filing on Google Icon
5/10/2024Acadian Asset Management LLC22,110$0.10M0.0%+42.7%0.053%Search for SEC Filing on Google Icon
5/10/2024Vanguard Group Inc.1,016,999$4.82M0.0%+1.0%2.417%Search for SEC Filing on Google Icon
2/15/2024Boxer Capital LLC2,568,287$10.97M0.5%+2.9%4.684%Search for SEC Filing on Google Icon
2/14/2024Pale Fire Capital SE63,581$0.27M0.0%+106.6%0.116%Search for SEC Filing on Google Icon
1/12/2024SG Americas Securities LLC13,100$56K0.0%N/A0.024%Search for SEC Filing on Google Icon
1/5/2024Exchange Traded Concepts LLC44,087$0.19M0.0%+34.0%0.080%Search for SEC Filing on Google Icon
11/14/2023Pale Fire Capital SE30,781$95K0.0%N/A0.056%Search for SEC Filing on Google Icon
11/13/2023FMR LLC5,131,433$15.86M0.0%-13.6%9.359%Search for SEC Filing on Google Icon
11/7/2023Barclays PLC13,316$42K0.0%+120.0%0.024%Search for SEC Filing on Google Icon
10/27/2023TD Asset Management Inc160,652$0.50M0.0%+100.0%0.293%Search for SEC Filing on Google Icon
10/18/2023Exchange Traded Concepts LLC32,907$0.10M0.0%+29.4%0.060%Search for SEC Filing on Google Icon
9/21/2023Barclays PLC6,052$27K0.0%-41.4%0.011%Search for SEC Filing on Google Icon
8/15/2023Boxer Capital LLC2,495,018$11.23M0.5%+256.9%4.552%Search for SEC Filing on Google Icon
8/9/2023TD Asset Management Inc80,326$0.36M0.0%+182.4%0.147%Search for SEC Filing on Google Icon
7/20/2023Exchange Traded Concepts LLC25,428$0.11M0.0%N/A0.053%Search for SEC Filing on Google Icon
5/16/2023Boxer Capital LLC699,047$3.99M0.2%N/A1.458%Search for SEC Filing on Google Icon
5/1/2023Virtu Financial LLC11,201$64K0.0%N/A0.023%Search for SEC Filing on Google Icon
2/14/2023683 Capital Management LLC28,631$0.17M0.0%N/A0.060%Search for SEC Filing on Google Icon
2/13/2023GSA Capital Partners LLP47,801$0.29M0.0%-11.8%0.100%Search for SEC Filing on Google Icon
2/10/2023New York Life Investment Management LLC82,000$0.50M0.0%+11.7%0.171%Search for SEC Filing on Google Icon
2/9/2023Citigroup Inc.60,072$0.36M0.0%+604.1%0.126%Search for SEC Filing on Google Icon
2/7/2023Bleakley Financial Group LLC22,325$0.14M0.0%N/A0.047%Search for SEC Filing on Google Icon
11/15/2022Caxton Associates LP85,992$0.57M0.1%+2.5%0.180%Search for SEC Filing on Google Icon
11/14/2022PDT Partners LLC12,641$84K0.0%-71.1%0.026%Search for SEC Filing on Google Icon
11/9/2022Massachusetts Financial Services Co. MA513,293$3.39M0.0%+7.3%1.073%Search for SEC Filing on Google Icon
10/25/2022Denali Advisors LLC8,200$54K0.0%N/A0.017%Search for SEC Filing on Google Icon
8/16/2022Corton Capital Inc.15,586$81K0.1%+42.8%0.033%Search for SEC Filing on Google Icon
8/16/2022Delphia USA Inc.16,940$88K0.1%N/A0.035%Search for SEC Filing on Google Icon
8/13/2022Massachusetts Financial Services Co. MA478,525$2.50M0.0%-0.7%1.000%Search for SEC Filing on Google Icon
8/12/2022Virtus ETF Advisers LLC24,005$0.13M0.0%+84.0%0.050%Search for SEC Filing on Google Icon
7/19/2022Commonwealth Equity Services LLC16,617$86K0.0%-18.8%0.035%Search for SEC Filing on Google Icon
5/11/2022Massachusetts Financial Services Co. MA482,119$3.33M0.0%+2.8%1.012%Search for SEC Filing on Google Icon
5/11/2022GSA Capital Partners LLP23,201$0.16M0.0%N/A0.049%Search for SEC Filing on Google Icon
5/6/2022IndexIQ Advisors LLC56,750$0.39M0.0%N/A0.119%Search for SEC Filing on Google Icon
5/5/2022New York State Common Retirement Fund4,992$34K0.0%-45.1%0.010%Search for SEC Filing on Google Icon
5/4/2022Commonwealth Equity Services LLC20,467$0.14M0.0%-10.4%0.043%Search for SEC Filing on Google Icon
3/3/2022Walleye Capital LLC41,954$0.52M0.0%N/A0.089%Search for SEC Filing on Google Icon
2/14/2022PDT Partners LLC35,907$0.45M0.0%N/A0.076%Search for SEC Filing on Google Icon
2/14/2022Virtus ETF Advisers LLC13,815$0.17M0.1%+119.6%0.029%Search for SEC Filing on Google Icon
2/14/2022Point72 Hong Kong Ltd3,872$48K0.0%+141.7%0.008%Search for SEC Filing on Google Icon
2/11/2022Ensign Peak Advisors Inc8,080$0.10M0.0%N/A0.017%Search for SEC Filing on Google Icon
2/11/2022Parkwood LLC12,667$0.16M0.0%N/A0.027%Search for SEC Filing on Google Icon
2/10/2022Qube Research & Technologies Ltd23,384$0.29M0.0%N/A0.050%Search for SEC Filing on Google Icon
2/10/2022Massachusetts Financial Services Co. MA468,797$5.84M0.0%-0.7%0.993%Search for SEC Filing on Google Icon
2/8/2022Swiss National Bank27,500$0.34M0.0%+34.1%0.058%Search for SEC Filing on Google Icon
2/1/2022Qube Research & Technologies Ltd23,384$0.29M0.0%N/A0.050%Search for SEC Filing on Google Icon
1/31/2022Commonwealth Equity Services LLC22,832$0.28M0.0%+69.4%0.048%Search for SEC Filing on Google Icon
12/14/2021UBS Asset Management Americas Inc.1,483,319$46.35M0.0%+15.2%3.142%Search for SEC Filing on Google Icon
11/15/2021Point72 Hong Kong Ltd1,602$50K0.0%N/A0.003%Search for SEC Filing on Google Icon
11/15/2021Cubist Systematic Strategies LLC21,755$0.68M0.0%+26.5%0.046%Search for SEC Filing on Google Icon
11/15/2021California State Teachers Retirement System13,524$0.42M0.0%-9.5%0.029%Search for SEC Filing on Google Icon
11/15/2021Rock Springs Capital Management LP362,359$11.32M0.2%-5.2%0.769%Search for SEC Filing on Google Icon
11/15/2021Morgan Stanley756,787$23.65M0.0%+472.6%1.607%Search for SEC Filing on Google Icon
11/12/2021Credit Suisse AG6,950$0.22M0.0%N/A0.015%Search for SEC Filing on Google Icon
Data available starting January 2016

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Prelude Therapeutics logo
Prelude Therapeutics Incorporated, a clinical-stage biopharmaceutical company, focuses on the discovery and development of novel precision cancer medicines to underserved patients. It is developing PRT1419, a myeloid cell leukemia-1 inhibitor, which is in Phase 1 clinical trial for the treatment of selected relapsed/refractory myeloid or B-cell malignancies; PRT2527, a cyclin-dependent kinase, which is in Phase 1 clinical trial for the treatment of advanced solid tumors; PRT3645, a cyclin-dependent kinase 4/6 inhibitor, which is in Phase 1 clinical trial for the treatment of advanced and metastatic solid tumors; and PRT3879, a SMARCA2 selective protein degrader, which is in Phase 2/3 clinical trial for the treatment of advanced and metastatic solid tumors with loss of SMARCA4 due to truncating mutation and/or deletion. The company's CDK9 program is a regulator of cancer-promoting transcriptional programs, including MCL1, MYC and MYB. Prelude Therapeutics Incorporated was incorporated in 2016 and is based in Wilmington, Delaware.
Read More on Prelude Therapeutics

Today's Range

Now: $1.54
Low: $1.34
High: $1.55

50 Day Range

MA: $1.53
Low: $1.19
High: $3.98

52 Week Range

Now: $1.54
Low: $0.61
High: $4.22

Volume

292,091 shs

Average Volume

543,330 shs

Market Capitalization

$96.82 million

P/E Ratio

N/A

Dividend Yield

N/A

Beta

1.06

Who are the company insiders with the largest holdings of Prelude Therapeutics?

Prelude Therapeutics' top insider shareholders include:
  1. Krishna Vaddi (CEO)
  2. Andrew Combs (Insider)
  3. Bryant David Lim (CFO)
Learn More about top insider investors at Prelude Therapeutics.

Who are the major institutional investors of Prelude Therapeutics?

Prelude Therapeutics' top institutional investors include:
  1. Millennium Management LLC — 1.82%
  2. Vanguard Group Inc. — 1.75%
  3. Shay Capital LLC — 0.18%
  4. Bridgeway Capital Management LLC — 0.09%
Learn More about top institutional investors of Prelude Therapeutics stock.

Which major investors are selling Prelude Therapeutics stock?

During the last quarter, PRLD stock was sold by these institutional investors:
  1. Bridgeway Capital Management LLC

Which major investors are buying Prelude Therapeutics stock?

Within the last quarter, PRLD stock was acquired by institutional investors including:
  1. Millennium Management LLC
  2. Vanguard Group Inc.
  3. Shay Capital LLC
In the last year, these company insiders have bought Prelude Therapeutics stock:
  1. Krishna Vaddi (CEO)
  2. Andrew Combs (Insider)
  3. Bryant David Lim (CFO)
Learn More investors buying Prelude Therapeutics stock.