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PRME Insider Trading

Insider Ownership Percentage: 22.74%
Insider Buying (Last 12 Months): $10,110,240.00
Insider Selling (Last 12 Months): $0.00

Prime Medicine Insider Trading History Chart

This chart shows the insider buying and selling history at Prime Medicine by year and by quarter.

Skip ChartChart Data in Insider Trading History Table

Prime Medicine Share Price & Price History

Current Price: $3.83
Price Change: ▲ Price Increase of +0.49 (14.67%)
As of 02/24/2026 05:00 PM ET

This chart shows the closing price history over time for PRME up to the past year.

Skip Chart and Table DataPrice Data in Insider Trading History Table
Days: 30 | 90 | 365

Prime Medicine Insider Trading History

Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionShares Held After TransactionDetails
8/1/2025Arch Venture Partners Xii, LlcMajor ShareholderBuy3,030,300$3.30$9,999,990.006,230,300View SEC Filing Icon  
6/23/2025David R LiuMajor ShareholderBuy21,000$2.16$45,360.0020,219,945View SEC Filing Icon  
6/16/2025David R LiuMajor ShareholderBuy21,000$1.49$31,290.0020,198,945View SEC Filing Icon  
6/11/2025David R LiuMajor ShareholderBuy21,000$1.60$33,600.0020,177,945View SEC Filing Icon  
2/15/2024Robert NelsenDirectorBuy3,200,000$6.25$20,000,000.003,200,000View SEC Filing Icon  
6/20/20232019 Gp L.L.C. GvMajor ShareholderSell37,405$15.06$563,319.30View SEC Filing Icon  
6/16/20232019 Gp L.L.C. GvMajor ShareholderSell6,532$15.02$98,110.64View SEC Filing Icon  
6/14/20232019 Gp L.L.C. GvMajor ShareholderSell28,960$14.87$430,635.20View SEC Filing Icon  
6/12/20232019 Gp L.L.C. GvMajor ShareholderSell16,031$14.98$240,144.38View SEC Filing Icon  
6/9/20232019 Gp L.L.C. GvMajor ShareholderSell15,672$14.48$226,930.56View SEC Filing Icon  
6/5/20232019 Gp L.L.C. GvMajor ShareholderSell22,434$16.70$374,647.80View SEC Filing Icon  
5/31/20232019 Gp L.L.C. GvMajor ShareholderSell16,633$13.65$227,040.45View SEC Filing Icon  
5/26/20232019 Gp L.L.C. GvMajor ShareholderSell12,602$13.70$172,647.40View SEC Filing Icon  
5/24/20232019 Gp L.L.C. GvMajor ShareholderSell7,900$13.66$107,914.00View SEC Filing Icon  
5/22/20232019 Gp L.L.C. GvMajor ShareholderSell87,922$14.13$1,242,337.86View SEC Filing Icon  
See Full Table

SEC Filings (Institutional Ownership Changes) for Prime Medicine (NYSE:PRME)

70.37% of Prime Medicine stock is owned by institutions. Institutional ownership can be a sign of analyst confidence in the fundamentals of the stock.

Institutional Buying and Selling by Quarter

This chart shows the instiutional buying and selling at PRME by year and by quarter.

Skip Institutional Buying and Selling Chart and Table DataRead Chart Data in Institutional Trading History Table

Prime Medicine Institutional Trading History

Reporting DateHedge FundShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
2/24/2026Chelsea Counsel Co.227,000$0.79M0.3%+9.0%0.126%Search for SEC Filing on Google Icon
2/23/2026Virtu Financial LLC94,778$0.33M0.0%+701.2%0.053%Search for SEC Filing on Google Icon
2/19/2026T. Rowe Price Investment Management Inc.5,995,183$20.80M0.0%-35.0%3.321%Search for SEC Filing on Google Icon
2/19/2026Invesco Ltd.56,779$0.20M0.0%-92.5%0.031%Search for SEC Filing on Google Icon
2/18/2026XTX Topco Ltd72,935$0.25M0.0%+51.2%0.040%Search for SEC Filing on Google Icon
2/18/2026Voloridge Investment Management LLC23,121$80K0.0%-86.4%0.013%Search for SEC Filing on Google Icon
2/18/2026Virtus Investment Advisers LLC64,886$0.23M0.1%N/A0.036%Search for SEC Filing on Google Icon
2/18/2026Wellington Management Group LLP248,227$0.86M0.0%+20.9%0.138%Search for SEC Filing on Google Icon
2/18/2026Polymer Capital Management US LLC35,981$0.13M0.0%+73.1%0.020%Search for SEC Filing on Google Icon
2/18/2026Quadrature Capital Ltd52,866$0.18M0.0%+419.2%0.029%Search for SEC Filing on Google Icon
2/18/2026Millennium Management LLC51,335$0.18M0.0%-96.4%0.028%Search for SEC Filing on Google Icon
2/18/2026MWG Caph Ltd1,792,210$6.22M8.6%N/A0.993%Search for SEC Filing on Google Icon
2/18/2026Janus Henderson Group PLC60,900$0.21M0.0%N/A0.034%Search for SEC Filing on Google Icon
2/18/2026Engineers Gate Manager LP60,490$0.21M0.0%+8.8%0.034%Search for SEC Filing on Google Icon
2/18/2026Balyasny Asset Management L.P.3,124,362$10.84M0.0%+6,426.4%1.731%Search for SEC Filing on Google Icon
2/18/2026Bridgeway Capital Management LLC134,800$0.47M0.0%-18.2%0.075%Search for SEC Filing on Google Icon
2/17/2026Lazard Asset Management LLC10,844$38K0.0%N/A0.006%Search for SEC Filing on Google Icon
2/17/2026Jump Financial LLC171,931$0.60M0.0%N/A0.095%Search for SEC Filing on Google Icon
2/17/2026Farallon Capital Management LLC1,240,843$4.31M0.0%-73.9%0.687%Search for SEC Filing on Google Icon
2/17/2026Price T Rowe Associates Inc. MD104,553$0.36M0.0%+40.3%0.058%Search for SEC Filing on Google Icon
2/17/2026T. Rowe Price Investment Management Inc.1,094,316$3.80M0.0%-88.1%0.606%Search for SEC Filing on Google Icon
2/17/2026California State Teachers Retirement System86,929$0.30M0.0%+2,279.0%0.048%Search for SEC Filing on Google Icon
2/17/2026&PARTNERS60,352$0.21M0.0%+409.4%0.033%Search for SEC Filing on Google Icon
2/17/2026Graham Capital Management L.P.114,680$0.40M0.0%N/A0.064%Search for SEC Filing on Google Icon
2/16/2026Squarepoint Ops LLC218,042$0.76M0.0%+450.6%0.121%Search for SEC Filing on Google Icon
2/16/2026Verition Fund Management LLC290,983$1.01M0.0%N/A0.161%Search for SEC Filing on Google Icon
2/16/2026Mariner LLC36,290$0.13M0.0%+99.2%0.020%Search for SEC Filing on Google Icon
2/16/2026Glen Eagle Advisors LLC10,000$35K0.0%N/A0.006%Search for SEC Filing on Google Icon
2/16/2026Barclays PLC363,826$1.26M0.0%+213.9%0.202%Search for SEC Filing on Google Icon
2/13/2026The Manufacturers Life Insurance Company 31,602$0.11M0.0%+16.5%0.018%Search for SEC Filing on Google Icon
2/13/2026Walleye Capital LLC46,139$0.16M0.0%N/A0.026%Search for SEC Filing on Google Icon
2/13/2026Rafferty Asset Management LLC187,711$0.65M0.0%N/A0.104%Search for SEC Filing on Google Icon
2/13/2026Charles Schwab Investment Management Inc.936,815$3.25M0.0%+63.4%0.519%Search for SEC Filing on Google Icon
2/13/2026State Street Corp5,095,510$17.68M0.0%+293.0%2.823%Search for SEC Filing on Google Icon
2/13/2026Martingale Asset Management L P14,808$51K0.0%N/A0.008%Search for SEC Filing on Google Icon
2/13/2026Caitong International Asset Management Co. Ltd9,624$33K0.1%N/A0.005%Search for SEC Filing on Google Icon
2/13/2026UBS AM a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC99,100$0.34M0.0%N/A0.055%Search for SEC Filing on Google Icon
2/13/2026Wells Fargo & Company MN294,496$1.02M0.0%+49.5%0.163%Search for SEC Filing on Google Icon
2/12/2026Federation des caisses Desjardins du Quebec12,000$42K0.0%-24.5%0.007%Search for SEC Filing on Google Icon
2/12/2026HRT Financial LP655,351$2.27M0.0%+195.9%0.363%Search for SEC Filing on Google Icon
2/12/2026MetLife Investment Management LLC57,570$0.20M0.0%+33.9%0.032%Search for SEC Filing on Google Icon
2/12/2026Commonwealth Equity Services LLC34,399$0.12M0.0%-45.5%0.019%Search for SEC Filing on Google Icon
2/12/2026Renaissance Technologies LLC1,149,159$3.99M0.0%+1.3%0.637%Search for SEC Filing on Google Icon
2/12/2026Dimensional Fund Advisors LP84,054$0.29M0.0%N/A0.047%Search for SEC Filing on Google Icon
2/12/2026IQ EQ FUND MANAGEMENT IRELAND Ltd178,519$0.62M0.0%+47.8%0.099%Search for SEC Filing on Google Icon
2/12/2026Steward Partners Investment Advisory LLC118,406$0.41M0.0%-6.3%0.066%Search for SEC Filing on Google Icon
2/12/2026Swiss National Bank170,100$0.59M0.0%N/A0.094%Search for SEC Filing on Google Icon
2/12/2026Nuveen LLC251,636$0.87M0.0%+11.4%0.139%Search for SEC Filing on Google Icon
2/11/2026ARK Investment Management LLC5,368,526$18.63M0.1%-2.0%2.974%Search for SEC Filing on Google Icon
2/11/2026Deutsche Bank AG147,943$0.51M0.0%+11.4%0.082%Search for SEC Filing on Google Icon
2/11/2026Amova Asset Management Americas Inc.3,245,506$11.20M0.1%-10.6%1.798%Search for SEC Filing on Google Icon
2/10/2026TD Asset Management Inc94,148$0.33M0.0%-48.0%0.052%Search for SEC Filing on Google Icon
2/10/2026Goldman Sachs Group Inc.1,755,768$6.09M0.0%+327.5%0.973%Search for SEC Filing on Google Icon
2/10/2026Greenwich Wealth Management LLC740,001$2.57M0.1%+2.8%0.410%Search for SEC Filing on Google Icon
2/10/2026AXQ Capital LP33,405$0.12M0.0%-25.5%0.019%Search for SEC Filing on Google Icon
2/10/2026Intech Investment Management LLC35,036$0.12M0.0%+50.8%0.019%Search for SEC Filing on Google Icon
2/9/2026Kingsview Wealth Management LLC15,000$52K0.0%-39.4%0.008%Search for SEC Filing on Google Icon
2/9/2026Geode Capital Management LLC2,628,429$9.12M0.0%+48.8%1.456%Search for SEC Filing on Google Icon
2/9/2026Integrity Advisory Solutions LLC11,689$41K0.0%N/A0.006%Search for SEC Filing on Google Icon
2/9/2026Sterling Investment Advisors Ltd.13,400$46K0.0%+34.0%0.007%Search for SEC Filing on Google Icon
2/6/2026ProShare Advisors LLC26,158$91K0.0%+37.0%0.014%Search for SEC Filing on Google Icon
2/6/2026HighTower Advisors LLC400,110$1.39M0.0%+19.9%0.222%Search for SEC Filing on Google Icon
2/2/2026CENTRAL TRUST Co34,995$0.12M0.0%N/A0.019%Search for SEC Filing on Google Icon
2/2/2026Oppenheimer & Co. Inc.12,433$43K0.0%N/A0.007%Search for SEC Filing on Google Icon
1/29/2026UBS Group AG2,440,583$8.47M0.0%+700.8%1.352%Search for SEC Filing on Google Icon
1/28/2026Arizona State Retirement System24,085$84K0.0%N/A0.013%Search for SEC Filing on Google Icon
1/27/2026Zurcher Kantonalbank Zurich Cantonalbank 8,814$31K0.0%N/A0.005%Search for SEC Filing on Google Icon
1/26/2026Shelton Wealth Management LLC20,066$70K0.0%+15.8%0.011%Search for SEC Filing on Google Icon
1/23/2026Transcend Capital Advisors LLC26,500$92K0.0%N/A0.015%Search for SEC Filing on Google Icon
1/23/2026Sumitomo Mitsui Trust Group Inc.3,245,506$11.26M0.0%-10.6%1.798%Search for SEC Filing on Google Icon
1/23/2026Elevate Capital Advisors LLC42,666$0.15M0.1%N/A0.024%Search for SEC Filing on Google Icon
1/21/2026Palumbo Wealth Management LLC85,539$0.30M0.1%-7.6%0.047%Search for SEC Filing on Google Icon
1/12/2026Thompson Davis & CO. Inc.22,740$79K0.0%-17.5%0.013%Search for SEC Filing on Google Icon
1/9/2026SG Americas Securities LLC30,954$0.11M0.0%N/A0.017%Search for SEC Filing on Google Icon
1/1/2026JPMorgan Chase & Co.43,389$0.24M0.0%+31.3%0.024%Search for SEC Filing on Google Icon
1/1/2026Tudor Investment Corp ET AL62,981$0.35M0.0%N/A0.035%Search for SEC Filing on Google Icon
12/15/2025Hudson Bay Capital Management LP13,025$72K0.0%N/A0.007%Search for SEC Filing on Google Icon
12/9/2025Tudor Investment Corp ET AL62,981$0.35M0.0%N/A0.035%Search for SEC Filing on Google Icon
11/17/2025Keystone Financial Group70,855$0.39M0.0%N/A0.039%Search for SEC Filing on Google Icon
11/17/2025Woodline Partners LP3,002,482$16.63M0.1%N/A1.663%Search for SEC Filing on Google Icon
11/17/2025Polymer Capital Management US LLC20,791$0.12M0.0%N/A0.012%Search for SEC Filing on Google Icon
11/17/2025RA Capital Management L.P.3,000,000$16.62M0.2%N/A1.662%Search for SEC Filing on Google Icon
11/17/2025Prelude Capital Management LLC22,483$0.13M0.0%-45.5%0.012%Search for SEC Filing on Google Icon
11/17/2025Nomura Holdings Inc.24,915$0.14M0.0%N/A0.014%Search for SEC Filing on Google Icon
11/17/2025Millennium Management LLC1,418,463$7.86M0.0%+858.4%0.786%Search for SEC Filing on Google Icon
11/17/2025Jain Global LLC44,849$0.25M0.0%N/A0.025%Search for SEC Filing on Google Icon
11/17/2025Farallon Capital Management LLC4,750,000$26.32M0.1%+533.3%2.631%Search for SEC Filing on Google Icon
11/17/2025Fred Alger Management LLC122,654$0.68M0.0%-68.0%0.068%Search for SEC Filing on Google Icon
11/17/2025Brevan Howard Capital Management LP62,242$0.35M0.0%N/A0.046%Search for SEC Filing on Google Icon
11/17/2025Casdin Capital LLC3,167,175$17.55M1.5%+102.1%2.353%Search for SEC Filing on Google Icon
11/17/2025Bank of America Corp DE110,842$0.61M0.0%-23.3%0.082%Search for SEC Filing on Google Icon
11/17/2025Bank of Nova Scotia25,500$0.14M0.0%N/A0.019%Search for SEC Filing on Google Icon
11/17/2025Alliancebernstein L.P.108,690$0.60M0.0%-35.1%0.081%Search for SEC Filing on Google Icon
11/17/2025Ameriprise Financial Inc.61,572$0.34M0.0%N/A0.046%Search for SEC Filing on Google Icon
11/14/2025Schonfeld Strategic Advisors LLC593,039$3.29M0.0%-27.5%0.441%Search for SEC Filing on Google Icon
11/14/2025Raymond James Financial Inc.31,807$0.18M0.0%+1,933.7%0.024%Search for SEC Filing on Google Icon
11/14/2025Man Group plc189,588$1.05M0.0%N/A0.141%Search for SEC Filing on Google Icon
11/14/2025Two Sigma Investments LP447,667$2.48M0.0%+73.2%0.333%Search for SEC Filing on Google Icon
11/14/2025Bridgeway Capital Management LLC164,800$0.91M0.0%-23.3%0.122%Search for SEC Filing on Google Icon
11/14/2025Squarepoint Ops LLC39,601$0.22M0.0%+10.5%0.029%Search for SEC Filing on Google Icon
Data available starting January 2016

See Full Table
Prime Medicine logo
Prime Medicine, Inc., a biotechnology company, delivers genetic therapies to address the spectrum of diseases by deploying gene editing technology. The company offers Prime Editors with a Prime Editor protein, comprising a fusion between a Cas protein and a reverse transcriptase enzyme; and a pegRNA, which targets the Prime Editor to a specific genomic location and provides a template for making the desired edit to the target DNA sequence. It has a research collaboration with Cimeio Therapeutics to develop Prime Edited Shielded-Cell & Immunotherapy Pairs for genetic diseases, acute myeloid leukemia, and myelodysplastic syndrome. The company was incorporated in 2019 and is based in Cambridge, Massachusetts.
Read More on Prime Medicine

Today's Range

Now: $3.83
Low: $3.35
High: $3.86

50 Day Range

MA: $3.73
Low: $3.24
High: $4.68

52 Week Range

Now: $3.83
Low: $1.11
High: $6.94

Volume

3,411,981 shs

Average Volume

2,880,292 shs

Market Capitalization

$691.36 million

P/E Ratio

N/A

Dividend Yield

N/A

Beta

2.7

Who are the company insiders with the largest holdings of Prime Medicine?

Prime Medicine's top insider shareholders include:
  1. David R Liu (Major Shareholder)
  2. Arch Venture Partners Xii, Llc (Major Shareholder)
Learn More about top insider investors at Prime Medicine.

Who are the major institutional investors of Prime Medicine?

Prime Medicine's top institutional shareholders include:
  1. T. Rowe Price Investment Management Inc. — 3.32%
  2. ARK Investment Management LLC — 2.97%
  3. State Street Corp — 2.82%
  4. Sumitomo Mitsui Trust Group Inc. — 1.80%
  5. Amova Asset Management Americas Inc. — 1.80%
  6. Balyasny Asset Management L.P. — 1.73%
Learn More about top institutional investors of Prime Medicine stock.

Which major investors are selling Prime Medicine stock?

Within the previous quarter, PRME stock was sold by these institutional investors:
  1. T. Rowe Price Investment Management Inc.
  2. Farallon Capital Management LLC
  3. T. Rowe Price Investment Management Inc.
  4. Millennium Management LLC
  5. Invesco Ltd.
  6. Amova Asset Management Americas Inc.
  7. Sumitomo Mitsui Trust Group Inc.
  8. Ikarian Capital LLC

Which major investors are buying Prime Medicine stock?

Within the previous quarter, PRME stock was bought by institutional investors including:
  1. State Street Corp
  2. Balyasny Asset Management L.P.
  3. UBS Group AG
  4. MWG Caph Ltd
  5. Goldman Sachs Group Inc.
  6. Geode Capital Management LLC
  7. HRT Financial LP
  8. Charles Schwab Investment Management Inc.
Within the previous year, these company insiders have bought Prime Medicine stock:
  1. David R Liu (Major Shareholder)
  2. Arch Venture Partners Xii, Llc (Major Shareholder)
Learn More investors buying Prime Medicine stock.