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PRME Insider Trading

Insider Ownership Percentage: 22.74%
Insider Buying (Last 12 Months): $10,110,240.00
Insider Selling (Last 12 Months): $0.00

Prime Medicine Insider Trading History Chart

This chart shows the insider buying and selling history at Prime Medicine by year and by quarter.

Skip ChartChart Data in Insider Trading History Table

Prime Medicine Share Price & Price History

Current Price: $3.85
Price Change: ▲ Price Increase of +0.24 (6.65%)
As of 12/4/2025 05:00 PM ET

This chart shows the closing price history over time for PRME up to the past year.

Skip Chart and Table DataPrice Data in Insider Trading History Table
Days: 30 | 90 | 365

Prime Medicine Insider Trading History

Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionShares Held After TransactionDetails
8/1/2025Arch Venture Partners Xii, LlcMajor ShareholderBuy3,030,300$3.30$9,999,990.006,230,300View SEC Filing Icon  
6/23/2025David R LiuMajor ShareholderBuy21,000$2.16$45,360.0020,219,945View SEC Filing Icon  
6/16/2025David R LiuMajor ShareholderBuy21,000$1.49$31,290.0020,198,945View SEC Filing Icon  
6/11/2025David R LiuMajor ShareholderBuy21,000$1.60$33,600.0020,177,945View SEC Filing Icon  
2/15/2024Robert NelsenDirectorBuy3,200,000$6.25$20,000,000.003,200,000View SEC Filing Icon  
6/20/20232019 Gp L.L.C. GvMajor ShareholderSell37,405$15.06$563,319.30View SEC Filing Icon  
6/16/20232019 Gp L.L.C. GvMajor ShareholderSell6,532$15.02$98,110.64View SEC Filing Icon  
6/14/20232019 Gp L.L.C. GvMajor ShareholderSell28,960$14.87$430,635.20View SEC Filing Icon  
6/12/20232019 Gp L.L.C. GvMajor ShareholderSell16,031$14.98$240,144.38View SEC Filing Icon  
6/9/20232019 Gp L.L.C. GvMajor ShareholderSell15,672$14.48$226,930.56View SEC Filing Icon  
6/5/20232019 Gp L.L.C. GvMajor ShareholderSell22,434$16.70$374,647.80View SEC Filing Icon  
5/31/20232019 Gp L.L.C. GvMajor ShareholderSell16,633$13.65$227,040.45View SEC Filing Icon  
5/26/20232019 Gp L.L.C. GvMajor ShareholderSell12,602$13.70$172,647.40View SEC Filing Icon  
5/24/20232019 Gp L.L.C. GvMajor ShareholderSell7,900$13.66$107,914.00View SEC Filing Icon  
5/22/20232019 Gp L.L.C. GvMajor ShareholderSell87,922$14.13$1,242,337.86View SEC Filing Icon  
See Full Table

SEC Filings (Institutional Ownership Changes) for Prime Medicine (NYSE:PRME)

70.37% of Prime Medicine stock is owned by institutions. Institutional ownership can be a sign of analyst confidence in the fundamentals of the stock.

Institutional Buying and Selling by Quarter

This chart shows the instiutional buying and selling at PRME by year and by quarter.

Skip Institutional Buying and Selling Chart and Table DataRead Chart Data in Institutional Trading History Table

Prime Medicine Institutional Trading History

Reporting DateHedge FundShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
11/17/2025Keystone Financial Group70,855$0.39M0.0%N/A0.039%Search for SEC Filing on Google Icon
11/17/2025Woodline Partners LP3,002,482$16.63M0.1%N/A1.663%Search for SEC Filing on Google Icon
11/17/2025Polymer Capital Management US LLC20,791$0.12M0.0%N/A0.012%Search for SEC Filing on Google Icon
11/17/2025RA Capital Management L.P.3,000,000$16.62M0.2%N/A1.662%Search for SEC Filing on Google Icon
11/17/2025Prelude Capital Management LLC22,483$0.13M0.0%-45.5%0.012%Search for SEC Filing on Google Icon
11/17/2025Nomura Holdings Inc.24,915$0.14M0.0%N/A0.014%Search for SEC Filing on Google Icon
11/17/2025Millennium Management LLC1,418,463$7.86M0.0%+858.4%0.786%Search for SEC Filing on Google Icon
11/17/2025Jain Global LLC44,849$0.25M0.0%N/A0.025%Search for SEC Filing on Google Icon
11/17/2025Farallon Capital Management LLC4,750,000$26.32M0.1%+533.3%2.631%Search for SEC Filing on Google Icon
11/17/2025Fred Alger Management LLC122,654$0.68M0.0%-68.0%0.068%Search for SEC Filing on Google Icon
11/17/2025Brevan Howard Capital Management LP62,242$0.35M0.0%N/A0.046%Search for SEC Filing on Google Icon
11/17/2025Casdin Capital LLC3,167,175$17.55M1.5%+102.1%2.353%Search for SEC Filing on Google Icon
11/17/2025Bank of America Corp DE110,842$0.61M0.0%-23.3%0.082%Search for SEC Filing on Google Icon
11/17/2025Bank of Nova Scotia25,500$0.14M0.0%N/A0.019%Search for SEC Filing on Google Icon
11/17/2025Alliancebernstein L.P.108,690$0.60M0.0%-35.1%0.081%Search for SEC Filing on Google Icon
11/17/2025Ameriprise Financial Inc.61,572$0.34M0.0%N/A0.046%Search for SEC Filing on Google Icon
11/14/2025Schonfeld Strategic Advisors LLC593,039$3.29M0.0%-27.5%0.441%Search for SEC Filing on Google Icon
11/14/2025Raymond James Financial Inc.31,807$0.18M0.0%+1,933.7%0.024%Search for SEC Filing on Google Icon
11/14/2025Man Group plc189,588$1.05M0.0%N/A0.141%Search for SEC Filing on Google Icon
11/14/2025Two Sigma Investments LP447,667$2.48M0.0%+73.2%0.333%Search for SEC Filing on Google Icon
11/14/2025Bridgeway Capital Management LLC164,800$0.91M0.0%-23.3%0.122%Search for SEC Filing on Google Icon
11/14/2025Squarepoint Ops LLC39,601$0.22M0.0%+10.5%0.029%Search for SEC Filing on Google Icon
11/13/2025Invesco Ltd.762,078$4.22M0.0%+5,478.1%0.566%Search for SEC Filing on Google Icon
11/13/2025UBS Group AG304,773$1.69M0.0%+56.0%0.226%Search for SEC Filing on Google Icon
11/13/2025BNP Paribas Financial Markets19,656$0.11M0.0%-26.5%0.015%Search for SEC Filing on Google Icon
11/13/2025Russell Investments Group Ltd.6,827$38K0.0%+1,316.4%0.005%Search for SEC Filing on Google Icon
11/12/2025Amova Asset Management Americas Inc.3,629,924$20.04M0.2%+128.4%2.697%Search for SEC Filing on Google Icon
11/12/2025ARK Investment Management LLC5,477,851$30.35M0.2%+135.8%4.071%Search for SEC Filing on Google Icon
11/12/2025Victory Capital Management Inc.10,190$56K0.0%N/A0.008%Search for SEC Filing on Google Icon
11/12/2025DNB Asset Management AS182,133$1.01M0.0%N/A0.135%Search for SEC Filing on Google Icon
11/12/2025IvyRock Asset Management HK Ltd41,800$0.23M0.1%N/A0.031%Search for SEC Filing on Google Icon
11/12/2025Intech Investment Management LLC23,228$0.13M0.0%-24.6%0.017%Search for SEC Filing on Google Icon
11/10/2025TD Asset Management Inc181,048$1M0.0%+690.3%0.135%Search for SEC Filing on Google Icon
11/10/2025Palumbo Wealth Management LLC92,535$0.51M0.1%-49.5%0.069%Search for SEC Filing on Google Icon
11/10/2025AXQ Capital LP44,818$0.25M0.1%+19.2%0.033%Search for SEC Filing on Google Icon
11/10/2025China Universal Asset Management Co. Ltd.30,650$0.17M0.0%+16.2%0.023%Search for SEC Filing on Google Icon
11/7/2025Levin Capital Strategies L.P.15,000$83K0.0%-89.3%0.011%Search for SEC Filing on Google Icon
11/7/2025Vanguard Group Inc.4,921,865$27.27M0.0%+35.7%3.657%Search for SEC Filing on Google Icon
11/7/2025JPMorgan Chase & Co.43,389$0.24M0.0%+31.3%0.032%Search for SEC Filing on Google Icon
11/7/2025HighTower Advisors LLC333,755$1.85M0.0%+1,463.0%0.248%Search for SEC Filing on Google Icon
11/7/2025Alphabet Inc.16,562,498$91.76M3.8%+10.0%12.307%Search for SEC Filing on Google Icon
11/6/2025Rhumbline Advisers109,787$0.61M0.0%+12.1%0.082%Search for SEC Filing on Google Icon
11/5/2025Thompson Davis & CO. Inc.27,573$0.15M0.1%N/A0.020%Search for SEC Filing on Google Icon
11/5/2025IQ EQ FUND MANAGEMENT IRELAND Ltd120,773$0.67M0.0%+258.8%0.090%Search for SEC Filing on Google Icon
11/4/2025Jones Financial Companies Lllp9,575$49K0.0%N/A0.007%Search for SEC Filing on Google Icon
10/31/2025Owen LaRue LLC19,032$0.11M0.0%N/A0.014%Search for SEC Filing on Google Icon
10/29/2025Turtle Creek Wealth Advisors LLC25,000$0.14M0.0%N/A0.019%Search for SEC Filing on Google Icon
10/28/2025Sterling Investment Advisors Ltd.10,000$55K0.0%N/A0.007%Search for SEC Filing on Google Icon
10/27/2025Sumitomo Mitsui Trust Group Inc.3,629,924$20.11M0.0%+127.7%2.697%Search for SEC Filing on Google Icon
10/23/2025Nisa Investment Advisors LLC60,446$0.34M0.0%+1,327.0%0.045%Search for SEC Filing on Google Icon
10/22/2025Abacus Planning Group Inc.25,188$0.14M0.0%N/A0.019%Search for SEC Filing on Google Icon
10/15/2025CWM LLC25,352$0.14M0.0%-29.1%0.019%Search for SEC Filing on Google Icon
10/15/2025Green Alpha Advisors LLC190,353$1.06M1.0%+141.0%0.141%Search for SEC Filing on Google Icon
10/9/2025Shelton Wealth Management LLC17,332$96K0.0%N/A0.013%Search for SEC Filing on Google Icon
10/9/2025Voya Investment Management LLC12,849$71K0.0%-25.4%0.010%Search for SEC Filing on Google Icon
8/16/2025Nikko Asset Management Americas Inc.1,589,117$3.89M0.0%-45.7%1.181%Search for SEC Filing on Google Icon
8/15/2025BNP Paribas Financial Markets26,735$66K0.0%-14.6%0.020%Search for SEC Filing on Google Icon
8/15/2025Bridgeway Capital Management LLC214,800$0.53M0.0%N/A0.160%Search for SEC Filing on Google Icon
8/15/2025Bank of America Corp DE144,511$0.36M0.0%+28.0%0.107%Search for SEC Filing on Google Icon
8/14/2025MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.119,856$0.30M0.0%+253.4%0.089%Search for SEC Filing on Google Icon
8/14/2025The Manufacturers Life Insurance Company 20,979$52K0.0%-15.8%0.016%Search for SEC Filing on Google Icon
8/13/2025Diametric Capital LP105,530$0.26M0.1%N/A0.078%Search for SEC Filing on Google Icon
8/13/2025Greenwich Wealth Management LLC846,201$2.09M0.1%+3.3%0.629%Search for SEC Filing on Google Icon
8/12/2025XTX Topco Ltd133,490$0.33M0.0%N/A0.099%Search for SEC Filing on Google Icon
8/12/2025Jaffetilchin Investment Partners LLC37,744$93K0.0%N/A0.028%Search for SEC Filing on Google Icon
8/12/2025Rhumbline Advisers97,972$0.24M0.0%+19.6%0.073%Search for SEC Filing on Google Icon
8/8/2025Kingsview Wealth Management LLC25,000$62K0.0%N/A0.019%Search for SEC Filing on Google Icon
8/8/2025Intech Investment Management LLC30,810$76K0.0%-43.9%0.023%Search for SEC Filing on Google Icon
8/8/2025Creative Planning10,145$25K0.0%N/A0.008%Search for SEC Filing on Google Icon
8/8/2025Geode Capital Management LLC1,510,749$3.73M0.0%-1.0%1.123%Search for SEC Filing on Google Icon
8/6/2025Savant Capital LLC15,166$37K0.0%N/A0.011%Search for SEC Filing on Google Icon
8/5/2025Levin Capital Strategies L.P.140,000$0.35M0.0%+300.0%0.104%Search for SEC Filing on Google Icon
8/1/2025IQ EQ FUND MANAGEMENT IRELAND Ltd33,660$83K0.0%-62.5%0.025%Search for SEC Filing on Google Icon
8/1/2025Green Alpha Advisors LLC78,994$0.20M0.2%-5.4%0.059%Search for SEC Filing on Google Icon
7/31/2025Sumitomo Mitsui Trust Group Inc.1,594,518$3.94M0.0%-45.5%1.186%Search for SEC Filing on Google Icon
7/31/2025R Squared Ltd12,519$31K0.0%N/A0.009%Search for SEC Filing on Google Icon
7/30/2025Freedom Investment Management Inc.10,432$26K0.0%N/A0.008%Search for SEC Filing on Google Icon
7/30/2025ARK Investment Management LLC2,322,669$5.74M0.0%-25.0%1.727%Search for SEC Filing on Google Icon
7/29/2025JTC Employer Solutions Trustee Ltd13,249$33K0.0%N/A0.010%Search for SEC Filing on Google Icon
7/28/2025Mutual Advisors LLC45,200$0.11M0.0%N/A0.034%Search for SEC Filing on Google Icon
7/28/2025TD Asset Management Inc22,910$57K0.0%-50.7%0.017%Search for SEC Filing on Google Icon
7/25/2025CWM LLC35,761$88K0.0%+74.7%0.027%Search for SEC Filing on Google Icon
7/25/2025Vanguard Personalized Indexing Management LLC23,191$57K0.0%+52.2%0.017%Search for SEC Filing on Google Icon
7/23/2025Prime Capital Investment Advisors LLC16,031$40K0.0%-33.9%0.012%Search for SEC Filing on Google Icon
7/15/2025Palumbo Wealth Management LLC183,358$0.45M0.1%+92.1%0.136%Search for SEC Filing on Google Icon
7/10/2025Wealth Enhancement Advisory Services LLC26,007$64K0.0%+112.6%0.020%Search for SEC Filing on Google Icon
6/27/2025Goldman Sachs Group Inc.251,399$0.50M0.0%-40.4%0.191%Search for SEC Filing on Google Icon
5/29/2025Rhumbline Advisers81,900$0.16M0.0%+13.8%0.062%Search for SEC Filing on Google Icon
5/22/2025Chelsea Counsel Co.208,210$0.41M0.2%+11.5%0.159%Search for SEC Filing on Google Icon
5/16/2025Goldman Sachs Group Inc.251,399$0.50M0.0%-40.4%0.191%Search for SEC Filing on Google Icon
5/16/2025Jacobs Levy Equity Management Inc.50,514$0.10M0.0%N/A0.039%Search for SEC Filing on Google Icon
5/16/2025AQR Capital Management LLC243,795$0.49M0.0%+1,419.4%0.186%Search for SEC Filing on Google Icon
5/14/2025Ieq Capital LLC34,882$69K0.0%N/A0.027%Search for SEC Filing on Google Icon
5/14/2025T. Rowe Price Investment Management Inc.4,143,096$8.25M0.0%+4.2%3.159%Search for SEC Filing on Google Icon
5/13/2025Brooklyn Investment Group39,967$80K0.0%+2,010.2%0.030%Search for SEC Filing on Google Icon
5/13/2025Vestmark Advisory Solutions Inc.78,599$0.16M0.0%-29.5%0.060%Search for SEC Filing on Google Icon
5/12/2025Nuveen LLC59,402$0.12M0.0%N/A0.045%Search for SEC Filing on Google Icon
5/9/2025Deutsche Bank AG126,846$0.25M0.0%+56.9%0.097%Search for SEC Filing on Google Icon
5/9/2025Charles Schwab Investment Management Inc.503,697$1M0.0%+3.9%0.384%Search for SEC Filing on Google Icon
5/9/2025Levin Capital Strategies L.P.35,000$70K0.0%-53.3%0.027%Search for SEC Filing on Google Icon
Data available starting January 2016

See Full Table
Prime Medicine logo
Prime Medicine, Inc., a biotechnology company, delivers genetic therapies to address the spectrum of diseases by deploying gene editing technology. The company offers Prime Editors with a Prime Editor protein, comprising a fusion between a Cas protein and a reverse transcriptase enzyme; and a pegRNA, which targets the Prime Editor to a specific genomic location and provides a template for making the desired edit to the target DNA sequence. It has a research collaboration with Cimeio Therapeutics to develop Prime Edited Shielded-Cell & Immunotherapy Pairs for genetic diseases, acute myeloid leukemia, and myelodysplastic syndrome. The company was incorporated in 2019 and is based in Cambridge, Massachusetts.
Read More on Prime Medicine

Today's Range

Now: $3.85
Low: $3.58
High: $4.08

50 Day Range

MA: $4.72
Low: $3.30
High: $6.67

52 Week Range

Now: $3.85
Low: $1.11
High: $6.94

Volume

6,216,133 shs

Average Volume

2,925,260 shs

Market Capitalization

$694.97 million

P/E Ratio

N/A

Dividend Yield

N/A

Beta

2.7

Who are the company insiders with the largest holdings of Prime Medicine?

Prime Medicine's top insider shareholders include:
  1. David R Liu (Major Shareholder)
  2. Arch Venture Partners Xii, Llc (Major Shareholder)
  3. Robert Nelsen (Director)
Learn More about top insider investors at Prime Medicine.

Who are the major institutional investors of Prime Medicine?

Prime Medicine's top institutional shareholders include:
  1. Alphabet Inc. — 12.31%
  2. ARK Investment Management LLC — 4.07%
  3. Vanguard Group Inc. — 3.66%
  4. Farallon Capital Management LLC — 2.63%
  5. Sumitomo Mitsui Trust Group Inc. — 2.70%
  6. Amova Asset Management Americas Inc. — 2.70%
Learn More about top institutional investors of Prime Medicine stock.

Which major investors are selling Prime Medicine stock?

Within the previous quarter, PRME stock was sold by these institutional investors:
  1. Fred Alger Management LLC
  2. Schonfeld Strategic Advisors LLC
  3. Levin Capital Strategies L.P.
  4. Palumbo Wealth Management LLC
  5. Alliancebernstein L.P.
  6. Bridgeway Capital Management LLC
  7. Bank of America Corp DE
  8. Prelude Capital Management LLC

Which major investors are buying Prime Medicine stock?

Within the previous quarter, PRME stock was bought by institutional investors including:
  1. Farallon Capital Management LLC
  2. ARK Investment Management LLC
  3. Woodline Partners LP
  4. RA Capital Management L.P.
  5. Amova Asset Management Americas Inc.
  6. Sumitomo Mitsui Trust Group Inc.
  7. Casdin Capital LLC
  8. Alphabet Inc.
Within the previous year, these company insiders have bought Prime Medicine stock:
  1. David R Liu (Major Shareholder)
  2. Arch Venture Partners Xii, Llc (Major Shareholder)
  3. Robert Nelsen (Director)
Learn More investors buying Prime Medicine stock.