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PYXS Insider Trading

Insider Ownership Percentage: 10.60%
Insider Buying (Last 12 Months): $0.00
Insider Selling (Last 12 Months): $0.00

Pyxis Oncology Insider Trading History Chart

This chart shows the insider buying and selling history at Pyxis Oncology by year and by quarter.

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Pyxis Oncology Share Price & Price History

Current Price: $4.32
Price Change: ▼ Price Decrease of -0.28 (-6.09%)
As of 12/4/2025 05:00 PM ET

This chart shows the closing price history over time for PYXS up to the past year.

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Days: 30 | 90 | 365

Pyxis Oncology Insider Trading History

Transaction DateInsider NameTitleBuy/SellNumber of SharesAverage Share PriceTotal TransactionShares Held After TransactionDetails
11/26/2024Pamela Ann ConnealyCFOBuy88,850$1.96$174,146.001,199,143View SEC Filing Icon  
9/27/2023Jitendra WadhaneCAOBuy2,500$1.87$4,675.00226,937View SEC Filing Icon  
9/27/2023Pamela Ann ConnealyCFOBuy6,426$1.85$11,888.10810,532View SEC Filing Icon  
9/25/2023Jitendra WadhaneCAOBuy5,000$1.77$8,850.00224,437View SEC Filing Icon  
9/25/2023Pamela Ann ConnealyCFOBuy12,000$1.67$20,040.00804,106View SEC Filing Icon  
9/22/2023Jitendra WadhaneCAOBuy2,500$1.74$4,350.00219,437View SEC Filing Icon  
9/22/2023Pamela Ann ConnealyCFOBuy5,000$1.74$8,700.00792,106View SEC Filing Icon  
9/18/2023Lara SullivanCEOSell8,541$2.10$17,936.102,403,882View SEC Filing Icon  
9/13/2023Lara SullivanCEOSell3,000$2.27$6,810.002,597,265View SEC Filing Icon  
9/11/2023Lara SullivanCEOSell20,000$2.27$45,400.002,605,182View SEC Filing Icon  
3/17/2023Pfizer IncMajor ShareholderBuy1,811,594$2.76$4,999,999.445,952,263View SEC Filing Icon  
See Full Table

SEC Filings (Institutional Ownership Changes) for Pyxis Oncology (NASDAQ:PYXS)

39.09% of Pyxis Oncology stock is owned by institutions. Institutional ownership can be a sign of analyst confidence in the fundamentals of the stock.

Institutional Buying and Selling by Quarter

This chart shows the instiutional buying and selling at PYXS by year and by quarter.

Skip Institutional Buying and Selling Chart and Table DataRead Chart Data in Institutional Trading History Table

Pyxis Oncology Institutional Trading History

Reporting DateHedge FundShares HeldMarket Value% of PortfolioQuarterly Change in SharesOwnership in CompanyDetails
11/17/2025Jacobs Levy Equity Management Inc.60,333$0.13M0.0%N/A0.097%Search for SEC Filing on Google Icon
11/17/2025Velan Capital Investment Management LP55,000$0.12M0.1%+37.5%0.088%Search for SEC Filing on Google Icon
11/17/2025Qube Research & Technologies Ltd30,808$68K0.0%-70.1%0.049%Search for SEC Filing on Google Icon
11/17/2025Millennium Management LLC815,331$1.81M0.0%-77.0%1.309%Search for SEC Filing on Google Icon
11/17/2025Citadel Advisors LLC337,359$0.75M0.0%N/A0.542%Search for SEC Filing on Google Icon
11/17/2025Bank of America Corp DE615,922$1.37M0.0%+2,690.9%0.989%Search for SEC Filing on Google Icon
11/14/2025Longaeva Partners L.P.503,214$1.12M0.2%N/A0.808%Search for SEC Filing on Google Icon
11/14/2025Two Sigma Investments LP46,501$0.10M0.0%N/A0.075%Search for SEC Filing on Google Icon
11/14/2025Bridgeway Capital Management LLC76,700$0.17M0.0%-46.1%0.123%Search for SEC Filing on Google Icon
11/13/2025UBS Group AG373,727$0.83M0.0%-5.6%0.600%Search for SEC Filing on Google Icon
11/10/2025Persistent Asset Partners Ltd34,632$77K0.1%N/A0.056%Search for SEC Filing on Google Icon
11/7/2025Vanguard Group Inc.2,163,962$4.80M0.0%+0.7%3.476%Search for SEC Filing on Google Icon
10/31/2025Pier 88 Investment Partners LLC151,730$0.34M0.1%-58.7%0.245%Search for SEC Filing on Google Icon
8/15/2025Bridgeway Capital Management LLC142,295$0.16M0.0%+76.1%0.230%Search for SEC Filing on Google Icon
8/14/2025Jane Street Group LLC336,084$0.37M0.0%N/A0.543%Search for SEC Filing on Google Icon
8/14/2025Velan Capital Investment Management LP40,000$44K0.0%N/A0.065%Search for SEC Filing on Google Icon
8/14/2025Qube Research & Technologies Ltd103,063$0.11M0.0%+128.4%0.166%Search for SEC Filing on Google Icon
8/13/2025Marshall Wace LLP147,771$0.16M0.0%N/A0.239%Search for SEC Filing on Google Icon
8/12/2025XTX Topco Ltd36,380$40K0.0%N/A0.059%Search for SEC Filing on Google Icon
8/12/2025Catalyst Funds Management Pty Ltd23,200$26K0.0%N/A0.037%Search for SEC Filing on Google Icon
8/8/2025Geode Capital Management LLC510,963$0.56M0.0%-53.9%0.825%Search for SEC Filing on Google Icon
8/7/2025Pier 88 Investment Partners LLC367,170$0.40M0.1%-6.1%0.593%Search for SEC Filing on Google Icon
8/1/2025Y Intercept Hong Kong Ltd133,047$0.15M0.0%N/A0.215%Search for SEC Filing on Google Icon
7/30/2025Schulhoff & Co. Inc.275,000$0.30M0.1%+125.4%0.444%Search for SEC Filing on Google Icon
7/11/2025Kingstone Capital Partners Texas LLC33,600$37K0.0%N/A0.054%Search for SEC Filing on Google Icon
6/27/2025Goldman Sachs Group Inc.160,830$0.16M0.0%-12.9%0.260%Search for SEC Filing on Google Icon
5/21/2025Acadian Asset Management LLC84,122$81K0.0%N/A0.136%Search for SEC Filing on Google Icon
5/16/2025Goldman Sachs Group Inc.160,830$0.16M0.0%-12.9%0.260%Search for SEC Filing on Google Icon
5/16/2025AQR Capital Management LLC40,270$39K0.0%-19.6%0.065%Search for SEC Filing on Google Icon
5/16/2025683 Capital Management LLC550,000$0.54M0.0%+32.5%0.888%Search for SEC Filing on Google Icon
5/13/2025American Century Companies Inc.26,353$26K0.0%-91.2%0.043%Search for SEC Filing on Google Icon
5/12/2025Nuveen LLC127,304$0.13M0.0%N/A0.206%Search for SEC Filing on Google Icon
5/9/2025Charles Schwab Investment Management Inc.115,237$0.11M0.0%-11.2%0.186%Search for SEC Filing on Google Icon
5/6/2025Pier 88 Investment Partners LLC390,960$0.38M0.1%+296.6%0.631%Search for SEC Filing on Google Icon
2/17/2025Ridgeback Capital Investments L.P.359,231$0.56M100.0%N/A0.604%Search for SEC Filing on Google Icon
2/17/2025ProShare Advisors LLC16,568$26K0.0%N/A0.028%Search for SEC Filing on Google Icon
2/17/2025Nuveen Asset Management LLC127,304$0.20M0.0%-14.6%0.214%Search for SEC Filing on Google Icon
2/17/2025OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC146,400$0.23M0.0%N/A0.246%Search for SEC Filing on Google Icon
2/17/2025Millennium Management LLC2,980,906$4.65M0.0%+53.8%5.012%Search for SEC Filing on Google Icon
2/17/2025Jacobs Levy Equity Management Inc.601,940$0.94M0.0%+57.2%1.012%Search for SEC Filing on Google Icon
2/17/2025Graham Capital Management L.P.30,287$47K0.0%N/A0.051%Search for SEC Filing on Google Icon
2/17/2025Deutsche Bank AG30,300$47K0.0%-87.3%0.051%Search for SEC Filing on Google Icon
2/17/2025Caption Management LLC22,306$35K0.0%N/A0.038%Search for SEC Filing on Google Icon
2/17/2025Bank of America Corp DE53,745$84K0.0%+20.3%0.090%Search for SEC Filing on Google Icon
2/17/2025Ameriprise Financial Inc.22,251$35K0.0%N/A0.037%Search for SEC Filing on Google Icon
2/14/2025Jane Street Group LLC67,686$0.11M0.0%+36.6%0.114%Search for SEC Filing on Google Icon
2/14/2025Northern Trust Corp378,586$0.59M0.0%-3.9%0.637%Search for SEC Filing on Google Icon
2/14/2025Boothbay Fund Management LLC181,042$0.28M0.0%-52.7%0.304%Search for SEC Filing on Google Icon
2/14/2025Dimensional Fund Advisors LP111,051$0.17M0.0%+35.5%0.187%Search for SEC Filing on Google Icon
2/13/2025Marshall Wace LLP157,953$0.25M0.0%+35.7%0.266%Search for SEC Filing on Google Icon
2/13/2025XTX Topco Ltd22,492$35K0.0%-73.5%0.038%Search for SEC Filing on Google Icon
2/13/2025Barclays PLC77,013$0.12M0.0%+20.2%0.129%Search for SEC Filing on Google Icon
2/13/2025Renaissance Technologies LLC293,354$0.46M0.0%+83.0%0.493%Search for SEC Filing on Google Icon
2/13/2025Aristides Capital LLC124,000$0.19M0.0%N/A0.209%Search for SEC Filing on Google Icon
2/12/2025Pier 88 Investment Partners LLC98,590$0.15M0.0%-18.9%0.166%Search for SEC Filing on Google Icon
2/11/2025Sei Investments Co.61,140$95K0.0%N/A0.103%Search for SEC Filing on Google Icon
2/11/2025American Century Companies Inc.299,937$0.47M0.0%+88.1%0.504%Search for SEC Filing on Google Icon
2/10/2025Commonwealth Equity Services LLC26,250$41K0.0%+61.5%0.044%Search for SEC Filing on Google Icon
11/19/2024Barclays PLC64,089$0.24M0.0%+275.0%0.108%Search for SEC Filing on Google Icon
11/16/2024Geode Capital Management LLC1,084,727$3.98M0.0%+5.5%1.824%Search for SEC Filing on Google Icon
11/15/2024Barclays PLC64,089$0.24M0.0%+275.0%0.108%Search for SEC Filing on Google Icon
11/15/2024Public Employees Retirement System of Ohio29,100$0.11M0.0%N/A0.049%Search for SEC Filing on Google Icon
11/15/2024XTX Topco Ltd84,771$0.31M0.0%+133.6%0.143%Search for SEC Filing on Google Icon
11/15/2024Jane Street Group LLC49,558$0.18M0.0%+40.8%0.083%Search for SEC Filing on Google Icon
11/15/2024State Street Corp951,251$3.49M0.0%+28.0%1.600%Search for SEC Filing on Google Icon
11/15/2024Jacobs Levy Equity Management Inc.382,840$1.41M0.0%N/A0.644%Search for SEC Filing on Google Icon
11/14/2024MetLife Investment Management LLC18,818$69K0.0%+41.1%0.032%Search for SEC Filing on Google Icon
11/9/2024Intech Investment Management LLC14,897$55K0.0%N/A0.025%Search for SEC Filing on Google Icon
11/7/2024LMR Partners LLP80,000$0.29M0.0%N/A0.135%Search for SEC Filing on Google Icon
11/6/2024Schulhoff & Co. Inc.122,000$0.45M0.2%+190.5%0.205%Search for SEC Filing on Google Icon
11/6/2024Pier 88 Investment Partners LLC121,610$0.45M0.1%+7.0%0.205%Search for SEC Filing on Google Icon
10/25/2024abrdn plc913,045$3.35M0.0%+28.9%1.537%Search for SEC Filing on Google Icon
10/3/2024SG Americas Securities LLC15,800$58K0.0%N/A0.027%Search for SEC Filing on Google Icon
8/15/2024Susquehanna Fundamental Investments LLC57,025$0.19M0.0%-30.8%0.097%Search for SEC Filing on Google Icon
8/15/2024Blue Owl Capital Holdings LP1,046,025$3.46M1.0%N/A1.776%Search for SEC Filing on Google Icon
8/15/2024The Manufacturers Life Insurance Company19,730$65K0.0%N/A0.034%Search for SEC Filing on Google Icon
8/15/2024Millennium Management LLC1,336,908$4.43M0.0%+125.3%2.270%Search for SEC Filing on Google Icon
8/14/2024Marshall Wace LLP10,000$33K0.0%-92.5%0.017%Search for SEC Filing on Google Icon
8/12/2024XTX Topco Ltd36,290$0.12M0.0%-44.9%0.062%Search for SEC Filing on Google Icon
8/12/2024Marathon Trading Investment Management LLC16,380$54K0.0%-71.3%0.028%Search for SEC Filing on Google Icon
8/9/2024Renaissance Technologies LLC96,936$0.32M0.0%-34.5%0.165%Search for SEC Filing on Google Icon
8/9/2024Dimensional Fund Advisors LP81,934$0.27M0.0%-19.5%0.139%Search for SEC Filing on Google Icon
8/8/2024Schulhoff & Co. Inc.42,000$0.14M0.1%+90.9%0.071%Search for SEC Filing on Google Icon
8/8/2024American Century Companies Inc.58,252$0.19M0.0%+56.0%0.099%Search for SEC Filing on Google Icon
8/6/2024Pier 88 Investment Partners LLC113,700$0.38M0.1%+121.4%0.193%Search for SEC Filing on Google Icon
8/1/2024Rhumbline Advisers65,287$0.22M0.0%N/A0.111%Search for SEC Filing on Google Icon
7/26/2024Bank of New York Mellon Corp311,630$1.03M0.0%+92.2%0.529%Search for SEC Filing on Google Icon
7/25/2024Fullcircle Wealth LLC12,000$40K0.0%N/A0.020%Search for SEC Filing on Google Icon
5/24/2024Cetera Advisors LLC23,500$100K0.0%N/A0.040%Search for SEC Filing on Google Icon
5/17/2024Ikarian Capital LLC1,662,408$7.08M0.8%N/A2.823%Search for SEC Filing on Google Icon
5/14/2024StemPoint Capital LP1,794,195$7.64M2.0%N/A3.047%Search for SEC Filing on Google Icon
5/10/2024Vanguard Group Inc.1,401,425$5.97M0.0%+7.3%2.380%Search for SEC Filing on Google Icon
5/7/2024Susquehanna Fundamental Investments LLC82,447$0.35M0.0%N/A0.140%Search for SEC Filing on Google Icon
5/7/2024SG Americas Securities LLC13,809$59K0.0%N/A0.023%Search for SEC Filing on Google Icon
2/20/2024Cable Car Capital LLC61,606$0.11M0.1%N/A0.139%Search for SEC Filing on Google Icon
2/14/2024Vestal Point Capital LP440,000$0.79M0.1%N/A0.993%Search for SEC Filing on Google Icon
2/12/2024Decheng Capital LLC326,810$0.59M0.2%N/A0.737%Search for SEC Filing on Google Icon
1/31/2024abrdn plc708,303$1.28M0.0%N/A1.598%Search for SEC Filing on Google Icon
11/29/2023Decheng Capital Management III Cayman LLC326,810$0.65M0.2%N/A0.737%Search for SEC Filing on Google Icon
11/15/2023Radcliffe Capital Management L.P.53,288$0.11M0.0%N/A0.120%Search for SEC Filing on Google Icon
Data available starting January 2016

See Full Table
Pyxis Oncology logo
Pyxis Oncology, Inc., a clinical stage company, engages in the development of therapeutics to treat cancers. Its lead antibody-drug conjugates (ADC) product candidate is PYX-201, an investigational novel ADC consisting of human immunoglobulin G1 (IgG1), which is in Phase 1 clinical trial to treat patients with relapsed or refractory solid tumors; and lead immuno-oncology (IO) product candidate is PYX-106, an investigational fully human IgG1 Siglec-15-targeting antibody that is in Phase 1 clinical trial to treat patients with advanced solid tumors. The company is also developing PYX-107, a CD40 agonist with demonstrated anti-cancer activity in patients who previously progressed on PD-(L)1 inhibitors, which is in Phase 2 clinical trial for the treatment of solid tumors, such as soft tissue sarcomas, esophageal and gastroesophageal junction, cancers, and melanoma in combination with chemotherapy, radiation therapy, and immunotherapy. It has in-license agreement with Pfizer Inc. to develop and commercialize ADC product candidates directed to certain licensed targets, including PYX-201 and PYX-203, and products containing the ADC product candidates; and Biosion USA, Inc. for development, manufacture, and commercialization of PYX-106, an IO product candidate. Pyxis Oncology, Inc. was incorporated in 2018 and is headquartered in Boston, Massachusetts.
Read More on Pyxis Oncology

Today's Range

Now: $4.32
Low: $4.25
High: $4.59

50 Day Range

MA: $3.79
Low: $2.14
High: $5.34

52 Week Range

Now: $4.32
Low: $0.83
High: $5.55

Volume

850,202 shs

Average Volume

755,551 shs

Market Capitalization

$268.96 million

P/E Ratio

N/A

Dividend Yield

N/A

Beta

1.37

Who are the company insiders with the largest holdings of Pyxis Oncology?

Pyxis Oncology's top insider investors include:
  1. Pamela Ann Connealy (CFO)
Learn More about top insider investors at Pyxis Oncology.

Who are the major institutional investors of Pyxis Oncology?

Pyxis Oncology's top institutional shareholders include:
  1. Vanguard Group Inc. — 3.48%
  2. Millennium Management LLC — 1.31%
  3. Bank of America Corp DE — 0.99%
  4. Longaeva Partners L.P. — 0.81%
  5. UBS Group AG — 0.60%
  6. Citadel Advisors LLC — 0.54%
Learn More about top institutional investors of Pyxis Oncology stock.

Which institutional investors are selling Pyxis Oncology stock?

During the previous quarter, PYXS stock was sold by these institutional investors:
  1. Millennium Management LLC
  2. Pier 88 Investment Partners LLC
  3. Qube Research & Technologies Ltd
  4. Bridgeway Capital Management LLC
  5. UBS Group AG
  6. Group One Trading LLC

Which institutional investors are buying Pyxis Oncology stock?

In the last quarter, PYXS stock was bought by institutional investors including:
  1. Bank of America Corp DE
  2. Longaeva Partners L.P.
  3. Citadel Advisors LLC
  4. Jacobs Levy Equity Management Inc.
  5. Two Sigma Investments LP
  6. Persistent Asset Partners Ltd
  7. Velan Capital Investment Management LP
  8. Vanguard Group Inc.