| 11/17/2025 | Susquehanna International Group LLP | 136,294 | $68K | 0.0% | +485.9% | 0.323% |  |
| 11/17/2025 | Citadel Advisors LLC | 438,705 | $0.22M | 0.0% | +576.1% | 1.039% |  |
| 11/17/2025 | Almitas Capital LLC | 1,538,727 | $0.77M | 0.2% | -15.3% | 3.642% |  |
| 10/23/2025 | Canaan Partners XI LLC | 450,000 | $0.23M | 0.2% | -52.2% | 1.077% |  |
| 7/24/2025 | Aberdeen Group plc | 1,595,262 | $0.54M | 0.0% | -7.6% | 3.834% |  |
| 7/17/2025 | Canaan Partners XI LLC | 940,984 | $0.32M | 0.2% | -38.6% | 2.261% |  |
| 5/16/2025 | Allostery Investments LP | 752,235 | $0.49M | 0.7% | -6.4% | 1.808% |  |
| 4/9/2025 | Canaan Partners XI LLC | 1,532,552 | $1M | 1.5% | -9.7% | 3.683% |  |
| 2/17/2025 | Northeast Financial Consultants Inc | 96,422 | $93K | 0.0% | +336.5% | 0.232% |  |
| 2/17/2025 | Allostery Investments LP | 803,398 | $0.77M | 0.8% | N/A | 1.936% |  |
| 2/17/2025 | Almitas Capital LLC | 1,298,119 | $1.25M | 0.3% | +48.3% | 3.129% |  |
| 2/13/2025 | Renaissance Technologies LLC | 441,318 | $0.42M | 0.0% | +9.3% | 1.064% |  |
| 1/21/2025 | Canaan Partners XI LLC | 1,697,684 | $1.63M | 2.1% | -11.2% | 4.092% |  |
| 11/16/2024 | Geode Capital Management LLC | 244,986 | $0.29M | 0.0% | +11.4% | 0.590% |  |
| 11/15/2024 | Jane Street Group LLC | 22,275 | $26K | 0.0% | -58.0% | 0.054% |  |
| 11/15/2024 | Point72 Asia Singapore Pte. Ltd. | 22,119 | $26K | 0.0% | -51.4% | 0.053% |  |
| 11/13/2024 | FMR LLC | 2,315,480 | $2.71M | 0.0% | +1.1% | 5.581% |  |
| 10/16/2024 | Canaan Partners XI LLC | 1,910,987 | $2.24M | 1.9% | -7.2% | 4.610% |  |
| 9/16/2024 | Point72 Asia Singapore Pte. Ltd. | 45,531 | $61K | 0.0% | N/A | 0.110% |  |
| 8/16/2024 | Almitas Capital LLC | 100,876 | $0.14M | 0.1% | N/A | 0.243% |  |
| 8/15/2024 | Point72 Asia Singapore Pte. Ltd. | 45,531 | $61K | 0.0% | N/A | 0.110% |  |
| 8/12/2024 | Hsbc Holdings PLC | 17,531 | $25K | 0.0% | N/A | 0.042% |  |
| 8/9/2024 | Renaissance Technologies LLC | 340,700 | $0.46M | 0.0% | -30.2% | 0.822% |  |
| 8/9/2024 | Johnson & Johnson | 3,636,363 | $4.87M | 1.2% | N/A | 8.773% |  |
| 8/6/2024 | Acadian Asset Management LLC | 67,695 | $89K | 0.0% | +116.3% | 0.163% |  |
| 5/10/2024 | Acadian Asset Management LLC | 31,294 | $57K | 0.0% | N/A | 0.083% |  |
| 5/10/2024 | Vanguard Group Inc. | 1,076,771 | $1.99M | 0.0% | +1.2% | 2.848% |  |
| 1/31/2024 | abrdn plc | 1,727,067 | $4.13M | 0.0% | N/A | 4.570% |  |
| 1/12/2024 | SG Americas Securities LLC | 16,813 | $40K | 0.0% | N/A | 0.044% |  |
| 11/13/2023 | CHI Advisors LLC | 390,734 | $1.32M | 0.4% | -28.0% | 1.034% |  |
| 11/13/2023 | Mariner LLC | 408,180 | $1.38M | 0.0% | -32.7% | 1.080% |  |
| 11/8/2023 | Financial Security Advisor Inc. | 50,278 | $0.17M | 0.1% | N/A | 0.133% |  |
| 9/21/2023 | Barclays PLC | 6,103 | $35K | 0.0% | -36.3% | 0.016% |  |
| 8/22/2023 | CHI Advisors LLC | 542,774 | $3.07M | 0.9% | -28.6% | 1.436% |  |
| 8/15/2023 | Caas Capital Management LP | 31,470 | $0.18M | 0.0% | -80.8% | 0.083% |  |
| 8/11/2023 | Sectoral Asset Management Inc. | 375,960 | $2.13M | 0.4% | -31.9% | 0.995% |  |
| 8/4/2023 | American International Group Inc. | 14,715 | $83K | 0.0% | +62.0% | 0.039% |  |
| 5/12/2023 | Sectoral Asset Management Inc. | 551,937 | $3.15M | 0.6% | -11.0% | 1.450% |  |
| 5/11/2023 | CHI Advisors LLC | 760,543 | $4.34M | 1.2% | +4.7% | 1.997% |  |
| 4/24/2023 | DekaBank Deutsche Girozentrale | 30,000 | $0.17M | 0.0% | N/A | 0.079% |  |
| 2/10/2023 | Sectoral Asset Management Inc. | 619,891 | $4.07M | 0.8% | +165.6% | 1.935% |  |
| 2/10/2023 | Tekla Capital Management LLC | 1,727,067 | $11.35M | 0.4% | -0.8% | 5.392% |  |
| 2/6/2023 | New Leaf Venture Partners L.L.C. | 3,301,603 | $21.69M | 15.7% | +43.4% | 10.308% |  |
| 2/1/2023 | Canaan Partners XI LLC | 2,059,712 | $13.53M | 10.6% | -14.5% | 6.431% |  |
| 11/15/2022 | Northeast Financial Consultants Inc | 13,066 | $0.19M | 0.0% | N/A | 0.041% |  |
| 11/14/2022 | MetLife Investment Management LLC | 10,279 | $0.15M | 0.0% | N/A | 0.032% |  |
| 11/8/2022 | New York State Common Retirement Fund | 10,337 | $0.15M | 0.0% | -19.8% | 0.032% |  |
| 11/1/2022 | Tekla Capital Management LLC | 1,740,931 | $25.19M | 1.0% | -9.8% | 5.418% |  |
| 8/15/2022 | Laurion Capital Management LP | 402,000 | $3.04M | 0.0% | +0.5% | 1.251% |  |
| 8/11/2022 | Alps Advisors Inc. | 19,060 | $0.14M | 0.0% | N/A | 0.059% |  |
| 7/29/2022 | Tekla Capital Management LLC | 1,931,120 | $14.58M | 0.6% | -12.0% | 6.010% |  |
| 5/27/2022 | Walleye Capital LLC | 59,543 | $0.42M | 0.0% | N/A | 0.185% |  |
| 5/13/2022 | Tekla Capital Management LLC | 2,195,010 | $15.32M | 0.5% | -4.9% | 6.832% |  |
| 5/10/2022 | Sectoral Asset Management Inc. | 385,069 | $2.69M | 0.5% | +27.8% | 1.198% |  |
| 2/9/2022 | AJU IB Investment Co. Ltd. | 754,678 | $7.20M | 10.0% | N/A | 2.349% |  |
| 2/8/2022 | Northern Trust Corp | 61,571 | $0.59M | 0.0% | +7.1% | 0.192% |  |
| 2/3/2022 | Canaan Partners XI LLC | 2,409,712 | $22.99M | 5.9% | N/A | 7.500% |  |
| 1/28/2022 | Allspring Global Investments Holdings LLC | 2,914 | $27K | 0.0% | N/A | 0.009% |  |
| 11/16/2021 | Laurion Capital Management LP | 400,000 | $7.03M | 0.0% | N/A | 1.245% |  |
| 11/15/2021 | Viking Global Investors LP | 4,194,777 | $73.74M | 0.2% | N/A | 13.056% |  |
| 11/15/2021 | Sectoral Asset Management Inc | 527,136 | $9.27M | 0.8% | N/A | 1.641% |  |
| 11/15/2021 | Caas Capital Management LP | 10,000 | $0.18M | 0.0% | N/A | 0.031% |  |
| 11/12/2021 | New Leaf Venture Partners L.L.C. | 2,301,603 | $40.46M | 11.7% | N/A | 7.163% |  |
| 11/12/2021 | Geode Capital Management LLC | 69,963 | $1.23M | 0.0% | N/A | 0.218% |  |
| 11/9/2021 | BlackRock Inc. | 292,204 | $5.14M | 0.0% | N/A | 0.909% |  |
| 11/4/2021 | Deutsche Bank AG | 4,139 | $73K | 0.0% | N/A | 0.013% |  |
| 11/2/2021 | New York State Common Retirement Fund | 4,396 | $77K | 0.0% | N/A | 0.014% |  |