| 2/19/2026 | Invesco Ltd. | 167,030 | $5.66M | 0.0% | +18.8% | 0.603% |  |
| 2/18/2026 | ADAR1 Capital Management LLC | 509,679 | $17.26M | 1.3% | +0.4% | 1.839% |  |
| 2/18/2026 | XTX Topco Ltd | 18,195 | $0.62M | 0.0% | N/A | 0.066% |  |
| 2/18/2026 | Voloridge Investment Management LLC | 6,893 | $0.23M | 0.0% | N/A | 0.025% |  |
| 2/18/2026 | Virtus Investment Advisers LLC | 7,229 | $0.25M | 0.1% | N/A | 0.026% |  |
| 2/18/2026 | Quadrature Capital Ltd | 57,590 | $1.95M | 0.0% | N/A | 0.208% |  |
| 2/18/2026 | RTW Investments LP | 1,637,165 | $55.45M | 0.6% | +11.3% | 5.908% |  |
| 2/18/2026 | Orbimed Advisors LLC | 1,642,891 | $55.65M | 1.2% | +51.2% | 5.929% |  |
| 2/18/2026 | Opaleye Management Inc. | 150,000 | $5.08M | 0.7% | N/A | 0.541% |  |
| 2/18/2026 | Perceptive Advisors LLC | 825,890 | $27.97M | 0.5% | +349.1% | 2.980% |  |
| 2/18/2026 | Millennium Management LLC | 106,671 | $3.61M | 0.0% | +171.6% | 0.385% |  |
| 2/18/2026 | Man Group plc | 18,802 | $0.64M | 0.0% | N/A | 0.068% |  |
| 2/18/2026 | Engineers Gate Manager LP | 9,784 | $0.33M | 0.0% | N/A | 0.035% |  |
| 2/18/2026 | Commodore Capital LP | 250,000 | $8.47M | 0.6% | N/A | 0.902% |  |
| 2/18/2026 | Boone Capital Management LLC | 470,456 | $15.93M | 5.3% | -39.9% | 1.698% |  |
| 2/18/2026 | Bridgeway Capital Management LLC | 14,375 | $0.49M | 0.0% | -30.3% | 0.052% |  |
| 2/17/2026 | Caligan Partners LP | 644,400 | $21.83M | 1.8% | N/A | 2.326% |  |
| 2/17/2026 | ADAR1 Capital Management LLC | 509,679 | $17.26M | 1.2% | +0.4% | 1.839% |  |
| 2/17/2026 | Burkehill Global Management LP | 50,000 | $1.69M | 0.1% | N/A | 0.180% |  |
| 2/17/2026 | Braidwell LP | 929,694 | $31.49M | 1.0% | N/A | 3.355% |  |
| 2/17/2026 | MPM Bioimpact LLC | 397,906 | $13.48M | 1.5% | N/A | 1.436% |  |
| 2/17/2026 | Jain Global LLC | 7,420 | $0.25M | 0.0% | N/A | 0.027% |  |
| 2/17/2026 | Trexquant Investment LP | 54,016 | $1.83M | 0.0% | N/A | 0.195% |  |
| 2/17/2026 | Jump Financial LLC | 9,845 | $0.33M | 0.0% | N/A | 0.036% |  |
| 2/17/2026 | Rock Springs Capital Management LP | 213,731 | $7.24M | 0.4% | N/A | 0.771% |  |
| 2/17/2026 | Adage Capital Partners GP L.L.C. | 275,000 | $9.31M | 0.0% | N/A | 0.992% |  |
| 2/17/2026 | Fcpm Iii Services B.V. | 1,833,333 | $62.10M | 8.2% | +432.6% | 6.616% |  |
| 2/16/2026 | Squarepoint Ops LLC | 24,572 | $0.83M | 0.0% | N/A | 0.089% |  |
| 2/16/2026 | OMERS ADMINISTRATION Corp | 11,600 | $0.39M | 0.0% | N/A | 0.042% |  |
| 2/16/2026 | Frazier Life Sciences Management L.P. | 983,333 | $33.31M | 0.9% | N/A | 3.549% |  |
| 2/16/2026 | Landscape Capital Management L.L.C. | 22,859 | $0.77M | 0.1% | N/A | 0.082% |  |
| 2/16/2026 | Barclays PLC | 76,659 | $2.60M | 0.0% | +80,593.7% | 0.277% |  |
| 2/13/2026 | Nantahala Capital Management LLC | 754,153 | $25.54M | 0.8% | +21.0% | 2.722% |  |
| 2/13/2026 | Marshall Wace LLP | 84,596 | $2.87M | 0.0% | +402.2% | 0.305% |  |
| 2/13/2026 | AWM Investment Company Inc. | 162,560 | $5.51M | 0.5% | N/A | 0.587% |  |
| 2/13/2026 | Column Group LLC | 156,270 | $5.29M | 6.4% | -5.9% | 0.564% |  |
| 2/13/2026 | Hudson Bay Capital Management LP | 8,900 | $0.30M | 0.0% | N/A | 0.032% |  |
| 2/13/2026 | Bank of Nova Scotia | 6,700 | $0.23M | 0.0% | N/A | 0.024% |  |
| 2/13/2026 | Exome Asset Management LLC | 14,194 | $0.48M | 0.2% | N/A | 0.051% |  |
| 2/13/2026 | Rafferty Asset Management LLC | 32,984 | $1.12M | 0.0% | N/A | 0.119% |  |
| 2/13/2026 | Birchview Capital LP | 15,000 | $0.51M | 0.3% | N/A | 0.054% |  |
| 2/13/2026 | Velan Capital Investment Management LP | 108,000 | $3.66M | 2.1% | +35.0% | 0.390% |  |
| 2/13/2026 | Siren L.L.C. | 1,375,000 | $46.57M | 1.4% | +136.9% | 4.962% |  |
| 2/13/2026 | State Street Corp | 639,804 | $21.67M | 0.0% | +1,611.5% | 2.309% |  |
| 2/12/2026 | Renaissance Technologies LLC | 91,173 | $3.09M | 0.0% | +165.7% | 0.329% |  |
| 2/10/2026 | Goldman Sachs Group Inc. | 254,053 | $8.61M | 0.0% | +312.6% | 0.917% |  |
| 2/9/2026 | Geode Capital Management LLC | 239,790 | $8.13M | 0.0% | +97.4% | 0.865% |  |
| 1/30/2026 | Sigma Planning Corp | 19,000 | $0.64M | 0.0% | N/A | 0.069% |  |
| 1/29/2026 | UBS Group AG | 66,225 | $2.24M | 0.0% | +129.9% | 0.239% |  |
| 1/29/2026 | China Universal Asset Management Co. Ltd. | 4,515 | $0.15M | 0.0% | N/A | 0.016% |  |
| 1/26/2026 | Mirae Asset Global Investments Co. Ltd. | 1,347 | $46K | 0.0% | N/A | 0.005% |  |
| 11/17/2025 | Velan Capital Investment Management LP | 79,977 | $2.06M | 1.9% | N/A | 0.289% |  |
| 11/17/2025 | Susquehanna International Group LLP | 45,382 | $1.17M | 0.0% | +173.4% | 0.164% |  |
| 11/17/2025 | Nantahala Capital Management LLC | 623,282 | $16.07M | 0.6% | -34.5% | 2.249% |  |
| 11/17/2025 | Millennium Management LLC | 39,278 | $1.01M | 0.0% | +75.2% | 0.142% |  |
| 11/17/2025 | Fcpm Iii Services B.V. | 344,237 | $8.88M | 1.8% | -21.8% | 1.242% |  |
| 11/17/2025 | Column Group LLC | 166,075 | $4.28M | 5.3% | -87.5% | 0.599% |  |
| 11/17/2025 | Bank of America Corp DE | 3,971 | $0.10M | 0.0% | -42.6% | 0.014% |  |
| 11/17/2025 | Boone Capital Management LLC | 782,461 | $20.18M | 6.6% | N/A | 2.824% |  |
| 11/17/2025 | Ameriprise Financial Inc. | 51,406 | $1.33M | 0.0% | N/A | 0.186% |  |
| 11/14/2025 | SummitTX Capital L.P. | 91,912 | $2.37M | 0.1% | N/A | 0.556% |  |
| 11/14/2025 | Orbimed Advisors LLC | 1,086,618 | $28.02M | 0.7% | -33.8% | 6.570% |  |
| 11/14/2025 | ADAR1 Capital Management LLC | 507,771 | $13.10M | 1.2% | -35.2% | 3.070% |  |
| 11/14/2025 | Two Sigma Investments LP | 34,818 | $0.90M | 0.0% | -20.2% | 0.211% |  |
| 11/14/2025 | Bridgeway Capital Management LLC | 20,625 | $0.53M | 0.0% | +32.0% | 0.125% |  |
| 11/13/2025 | Invesco Ltd. | 140,544 | $3.63M | 0.0% | N/A | 0.850% |  |
| 11/13/2025 | UBS Group AG | 28,808 | $0.74M | 0.0% | +680.3% | 0.174% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 8,934 | $0.23M | 0.0% | N/A | 0.054% |  |
| 11/7/2025 | GSA Capital Partners LLP | 10,558 | $0.27M | 0.0% | -13.1% | 0.064% |  |
| 11/7/2025 | Vanguard Group Inc. | 696,188 | $17.96M | 0.0% | -20.9% | 4.209% |  |
| 8/15/2025 | Perceptive Advisors LLC | 183,890 | $1.47M | 0.1% | -95.8% | 1.112% |  |
| 8/15/2025 | Bridgeway Capital Management LLC | 15,625 | $0.13M | 0.0% | -84.4% | 0.094% |  |
| 8/15/2025 | BVF Inc. IL | 1,154,692 | $9.24M | 0.3% | -87.5% | 6.981% |  |
| 8/15/2025 | Bank of America Corp DE | 6,913 | $55K | 0.0% | -97.1% | 0.042% |  |
| 8/14/2025 | Nantahala Capital Management LLC | 951,613 | $7.61M | 0.3% | -81.0% | 5.753% |  |
| 8/14/2025 | Orbimed Advisors LLC | 1,641,906 | $13.14M | 0.4% | -87.5% | 9.927% |  |
| 8/14/2025 | TCG Crossover Management LLC | 1,636,275 | $13.09M | 1.5% | -87.5% | 9.893% |  |
| 8/14/2025 | Redmile Group LLC | 630,686 | $5.05M | 0.5% | -90.3% | 3.813% |  |
| 8/12/2025 | Foresite Capital Management VI LLC | 1,562,500 | $12.50M | 7.0% | -87.5% | 9.447% |  |
| 8/8/2025 | Geode Capital Management LLC | 140,059 | $1.12M | 0.0% | -89.3% | 0.847% |  |
| 7/10/2025 | AJU IB Investment Co. Ltd. | 12,437 | $99K | 0.1% | -87.5% | 0.075% |  |
| 7/8/2025 | Medicxi Ventures Management Jersey Ltd | 2,794,000 | $22.35M | 5.2% | -87.5% | 16.892% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 342,190 | $0.42M | 0.0% | -29.7% | 2.069% |  |
| 5/21/2025 | Acadian Asset Management LLC | 649,357 | $0.79M | 0.0% | -24.7% | 0.491% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 342,190 | $0.42M | 0.0% | -29.7% | 0.259% |  |
| 5/16/2025 | Checkpoint Capital L.P. | 109,830 | $0.13M | 0.1% | N/A | 0.083% |  |
| 5/16/2025 | AQR Capital Management LLC | 154,327 | $0.19M | 0.0% | N/A | 0.117% |  |
| 5/16/2025 | ADAR1 Capital Management LLC | 5,970,768 | $7.28M | 1.4% | +408.4% | 4.513% |  |
| 5/15/2025 | Nantahala Capital Management LLC | 5,012,927 | $6.12M | 0.2% | +303.1% | 3.789% |  |
| 5/14/2025 | Comerica Bank | 89,327 | $0.11M | 0.0% | +53.9% | 0.068% |  |
| 5/13/2025 | Callan Family Office LLC | 89,327 | $0.11M | 0.0% | +53.9% | 0.068% |  |
| 5/12/2025 | Nuveen LLC | 116,925 | $0.14M | 0.0% | N/A | 0.089% |  |
| 5/12/2025 | Invesco Ltd. | 58,901 | $72K | 0.0% | +411.7% | 0.045% |  |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 150,946 | $0.18M | 0.0% | +112.7% | 0.114% |  |
| 5/8/2025 | Federated Hermes Inc. | 201,372 | $0.25M | 0.0% | -74.9% | 0.153% |  |
| 4/17/2025 | Exchange Traded Concepts LLC | 113,738 | $0.14M | 0.0% | +27.7% | 0.086% |  |
| 4/15/2025 | Simplicity Wealth LLC | 20,285 | $25K | 0.0% | N/A | 0.015% |  |
| 2/17/2025 | Two Sigma Investments LP | 180,465 | $0.29M | 0.0% | -65.3% | 0.516% |  |
| 2/17/2025 | Two Sigma Advisers LP | 503,700 | $0.80M | 0.0% | -28.6% | 1.441% |  |
| 2/17/2025 | Trustees of Columbia University in the City of New York | 73,383 | $0.12M | 0.0% | N/A | 0.210% |  |