| 11/17/2025 | Velan Capital Investment Management LP | 79,977 | $2.06M | 1.9% | N/A | 0.289% |  |
| 11/17/2025 | Susquehanna International Group LLP | 45,382 | $1.17M | 0.0% | +173.4% | 0.164% |  |
| 11/17/2025 | Nantahala Capital Management LLC | 623,282 | $16.07M | 0.6% | -34.5% | 2.249% |  |
| 11/17/2025 | Millennium Management LLC | 39,278 | $1.01M | 0.0% | +75.2% | 0.142% |  |
| 11/17/2025 | Fcpm Iii Services B.V. | 344,237 | $8.88M | 1.8% | -21.8% | 1.242% |  |
| 11/17/2025 | Column Group LLC | 166,075 | $4.28M | 5.3% | -87.5% | 0.599% |  |
| 11/17/2025 | Bank of America Corp DE | 3,971 | $0.10M | 0.0% | -42.6% | 0.014% |  |
| 11/17/2025 | Boone Capital Management LLC | 782,461 | $20.18M | 6.6% | N/A | 2.824% |  |
| 11/17/2025 | Ameriprise Financial Inc. | 51,406 | $1.33M | 0.0% | N/A | 0.186% |  |
| 11/14/2025 | SummitTX Capital L.P. | 91,912 | $2.37M | 0.1% | N/A | 0.556% |  |
| 11/14/2025 | Orbimed Advisors LLC | 1,086,618 | $28.02M | 0.7% | -33.8% | 6.570% |  |
| 11/14/2025 | ADAR1 Capital Management LLC | 507,771 | $13.10M | 1.2% | -35.2% | 3.070% |  |
| 11/14/2025 | Two Sigma Investments LP | 34,818 | $0.90M | 0.0% | -20.2% | 0.211% |  |
| 11/14/2025 | Bridgeway Capital Management LLC | 20,625 | $0.53M | 0.0% | +32.0% | 0.125% |  |
| 11/13/2025 | Invesco Ltd. | 140,544 | $3.63M | 0.0% | N/A | 0.850% |  |
| 11/13/2025 | UBS Group AG | 28,808 | $0.74M | 0.0% | +680.3% | 0.174% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 8,934 | $0.23M | 0.0% | N/A | 0.054% |  |
| 11/7/2025 | GSA Capital Partners LLP | 10,558 | $0.27M | 0.0% | -13.1% | 0.064% |  |
| 11/7/2025 | Vanguard Group Inc. | 696,188 | $17.96M | 0.0% | -20.9% | 4.209% |  |
| 8/15/2025 | Perceptive Advisors LLC | 183,890 | $1.47M | 0.1% | -95.8% | 1.112% |  |
| 8/15/2025 | Bridgeway Capital Management LLC | 15,625 | $0.13M | 0.0% | -84.4% | 0.094% |  |
| 8/15/2025 | BVF Inc. IL | 1,154,692 | $9.24M | 0.3% | -87.5% | 6.981% |  |
| 8/15/2025 | Bank of America Corp DE | 6,913 | $55K | 0.0% | -97.1% | 0.042% |  |
| 8/14/2025 | Nantahala Capital Management LLC | 951,613 | $7.61M | 0.3% | -81.0% | 5.753% |  |
| 8/14/2025 | Orbimed Advisors LLC | 1,641,906 | $13.14M | 0.4% | -87.5% | 9.927% |  |
| 8/14/2025 | TCG Crossover Management LLC | 1,636,275 | $13.09M | 1.5% | -87.5% | 9.893% |  |
| 8/14/2025 | Redmile Group LLC | 630,686 | $5.05M | 0.5% | -90.3% | 3.813% |  |
| 8/12/2025 | Foresite Capital Management VI LLC | 1,562,500 | $12.50M | 7.0% | -87.5% | 9.447% |  |
| 8/8/2025 | Geode Capital Management LLC | 140,059 | $1.12M | 0.0% | -89.3% | 0.847% |  |
| 7/10/2025 | AJU IB Investment Co. Ltd. | 12,437 | $99K | 0.1% | -87.5% | 0.075% |  |
| 7/8/2025 | Medicxi Ventures Management Jersey Ltd | 2,794,000 | $22.35M | 5.2% | -87.5% | 16.892% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 342,190 | $0.42M | 0.0% | -29.7% | 2.069% |  |
| 5/21/2025 | Acadian Asset Management LLC | 649,357 | $0.79M | 0.0% | -24.7% | 0.491% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 342,190 | $0.42M | 0.0% | -29.7% | 0.259% |  |
| 5/16/2025 | Checkpoint Capital L.P. | 109,830 | $0.13M | 0.1% | N/A | 0.083% |  |
| 5/16/2025 | AQR Capital Management LLC | 154,327 | $0.19M | 0.0% | N/A | 0.117% |  |
| 5/16/2025 | ADAR1 Capital Management LLC | 5,970,768 | $7.28M | 1.4% | +408.4% | 4.513% |  |
| 5/15/2025 | Nantahala Capital Management LLC | 5,012,927 | $6.12M | 0.2% | +303.1% | 3.789% |  |
| 5/14/2025 | Comerica Bank | 89,327 | $0.11M | 0.0% | +53.9% | 0.068% |  |
| 5/13/2025 | Callan Family Office LLC | 89,327 | $0.11M | 0.0% | +53.9% | 0.068% |  |
| 5/12/2025 | Nuveen LLC | 116,925 | $0.14M | 0.0% | N/A | 0.089% |  |
| 5/12/2025 | Invesco Ltd. | 58,901 | $72K | 0.0% | +411.7% | 0.045% |  |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 150,946 | $0.18M | 0.0% | +112.7% | 0.114% |  |
| 5/8/2025 | Federated Hermes Inc. | 201,372 | $0.25M | 0.0% | -74.9% | 0.153% |  |
| 4/17/2025 | Exchange Traded Concepts LLC | 113,738 | $0.14M | 0.0% | +27.7% | 0.086% |  |
| 4/15/2025 | Simplicity Wealth LLC | 20,285 | $25K | 0.0% | N/A | 0.015% |  |
| 2/17/2025 | Two Sigma Investments LP | 180,465 | $0.29M | 0.0% | -65.3% | 0.516% |  |
| 2/17/2025 | Two Sigma Advisers LP | 503,700 | $0.80M | 0.0% | -28.6% | 1.441% |  |
| 2/17/2025 | Trustees of Columbia University in the City of New York | 73,383 | $0.12M | 0.0% | N/A | 0.210% |  |
| 2/17/2025 | Shay Capital LLC | 51,300 | $81K | 0.0% | N/A | 0.147% |  |
| 2/17/2025 | RTW Investments LP | 11,764,000 | $18.59M | 0.3% | N/A | 33.650% |  |
| 2/17/2025 | Redmile Group LLC | 6,475,317 | $10.23M | 0.7% | +1,183.4% | 18.522% |  |
| 2/17/2025 | Nuveen Asset Management LLC | 116,925 | $0.19M | 0.0% | +50.5% | 0.334% |  |
| 2/17/2025 | OCONNOR A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS LLC | 40,000 | $63K | 0.0% | N/A | 0.114% |  |
| 2/17/2025 | Orbimed Advisors LLC | 13,135,260 | $20.75M | 0.5% | N/A | 37.572% |  |
| 2/17/2025 | Millennium Management LLC | 737,704 | $1.17M | 0.0% | -23.2% | 2.110% |  |
| 2/17/2025 | Deutsche Bank AG | 276,170 | $0.44M | 0.0% | -3.3% | 0.790% |  |
| 2/17/2025 | D. E. Shaw & Co. Inc. | 770,013 | $1.22M | 0.0% | -26.5% | 2.203% |  |
| 2/17/2025 | Deep Track Capital LP | 6,011,380 | $9.50M | 0.4% | N/A | 17.195% |  |
| 2/17/2025 | Column Group LLC | 1,328,613 | $2.10M | 3.8% | -50.4% | 3.800% |  |
| 2/17/2025 | Bridgeway Capital Management LLC | 125,000 | $0.20M | 0.0% | +66.7% | 0.358% |  |
| 2/17/2025 | BVF Inc. IL | 9,237,556 | $14.60M | 0.5% | N/A | 26.423% |  |
| 2/14/2025 | Jane Street Group LLC | 36,694 | $58K | 0.0% | -44.8% | 0.105% |  |
| 2/14/2025 | Comerica Bank | 58,040 | $92K | 0.0% | N/A | 0.166% |  |
| 2/14/2025 | TCG Crossover Management LLC | 13,135,260 | $19.75M | 1.9% | N/A | 37.572% |  |
| 2/14/2025 | Nantahala Capital Management LLC | 1,243,513 | $1.97M | 0.1% | N/A | 3.557% |  |
| 2/14/2025 | Foresite Capital Management VI LLC | 12,500,000 | $19.75M | 8.8% | N/A | 35.755% |  |
| 2/14/2025 | Dimensional Fund Advisors LP | 148,823 | $0.24M | 0.0% | -41.4% | 0.426% |  |
| 2/13/2025 | Affinity Asset Advisors LLC | 1,000,000 | $1.58M | 0.2% | N/A | 2.860% |  |
| 2/13/2025 | Renaissance Technologies LLC | 369,736 | $0.58M | 0.0% | +25.5% | 1.058% |  |
| 2/13/2025 | ADAR1 Capital Management LLC | 1,174,313 | $1.86M | 0.4% | +15,557.5% | 3.359% |  |
| 2/12/2025 | Geode Capital Management LLC | 716,937 | $1.13M | 0.0% | +4.9% | 2.051% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 205,164 | $0.32M | 0.0% | +1,128.3% | 0.587% |  |
| 2/11/2025 | Sei Investments Co. | 40,218 | $64K | 0.0% | N/A | 0.115% |  |
| 2/10/2025 | Picton Mahoney Asset Management | 16,175 | $26K | 0.0% | +994.4% | 0.046% |  |
| 2/7/2025 | Callan Family Office LLC | 58,040 | $92K | 0.0% | N/A | 0.166% |  |
| 2/4/2025 | Los Angeles Capital Management LLC | 219,997 | $0.35M | 0.0% | +9.2% | 0.629% |  |
| 1/23/2025 | Medicxi Ventures Management Jersey Ltd | 22,352,000 | $35.32M | 6.7% | N/A | 63.936% |  |
| 1/17/2025 | SG Americas Securities LLC | 53,244 | $84K | 0.0% | +401.9% | 0.152% |  |
| 12/26/2024 | JPMorgan Chase & Co. | 16,703 | $34K | 0.0% | -298.2% | 0.048% |  |
| 11/19/2024 | Barclays PLC | 39,729 | $79K | 0.0% | +277.2% | 0.114% |  |
| 11/15/2024 | Barclays PLC | 39,729 | $79K | 0.0% | +277.2% | 0.114% |  |
| 11/15/2024 | Jane Street Group LLC | 66,515 | $0.13M | 0.0% | -66.9% | 0.191% |  |
| 11/15/2024 | Readystate Asset Management LP | 18,074 | $36K | 0.0% | N/A | 0.052% |  |
| 11/15/2024 | Redmile Group LLC | 504,532 | $1.01M | 0.1% | -6.0% | 1.446% |  |
| 11/15/2024 | Point72 Asset Management L.P. | 525,221 | $1.06M | 0.0% | -25.7% | 1.505% |  |
| 11/14/2024 | PDT Partners LLC | 36,998 | $74K | 0.0% | -62.2% | 0.106% |  |
| 11/14/2024 | Walleye Capital LLC | 101,163 | $0.20M | 0.0% | -12.6% | 0.290% |  |
| 11/12/2024 | Charles Schwab Investment Management Inc. | 70,946 | $0.14M | 0.0% | -65.9% | 0.203% |  |
| 11/4/2024 | Los Angeles Capital Management LLC | 201,439 | $0.41M | 0.0% | +138.1% | 0.577% |  |
| 10/10/2024 | Exchange Traded Concepts LLC | 89,076 | $0.18M | 0.0% | +244.7% | 0.255% |  |
| 9/16/2024 | Point72 DIFC Ltd | 8,697 | $27K | 0.0% | -83.1% | 0.025% |  |
| 8/19/2024 | Point72 Asset Management L.P. | 707,300 | $2.16M | 0.0% | +176,725.0% | 2.027% |  |
| 8/16/2024 | Algert Global LLC | 47,483 | $0.15M | 0.0% | -11.9% | 0.136% |  |
| 8/15/2024 | The Manufacturers Life Insurance Company | 25,325 | $77K | 0.0% | -30.0% | 0.073% |  |
| 8/15/2024 | AQR Capital Management LLC | 88,373 | $0.27M | 0.0% | N/A | 0.253% |  |
| 8/14/2024 | Squarepoint Ops LLC | 107,994 | $0.33M | 0.0% | N/A | 0.309% |  |
| 8/14/2024 | Cubist Systematic Strategies LLC | 295,241 | $0.90M | 0.0% | +826.4% | 0.846% |  |
| 8/14/2024 | Point72 DIFC Ltd | 8,697 | $27K | 0.0% | -83.1% | 0.025% |  |
| 8/12/2024 | XTX Topco Ltd | 35,480 | $0.11M | 0.0% | N/A | 0.102% |  |