| 6/27/2025 | Goldman Sachs Group Inc. | 130,339 | $0.23M | 0.0% | -38.6% | 0.188% |  |
| 6/18/2025 | Voya Investment Management LLC | 21,368 | $37K | 0.0% | -7.4% | 0.031% |  |
| 5/29/2025 | Rhumbline Advisers | 57,744 | $0.10M | 0.0% | -3.0% | 0.083% |  |
| 5/16/2025 | Octagon Capital Advisors LP | 4,637,076 | $8.12M | 0.9% | -4.4% | 6.698% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 130,339 | $0.23M | 0.0% | -38.6% | 0.188% |  |
| 5/16/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 38,345 | $67K | 0.0% | +4.5% | 0.055% |  |
| 5/16/2025 | AQR Capital Management LLC | 68,580 | $0.12M | 0.0% | N/A | 0.099% |  |
| 5/16/2025 | Alyeska Investment Group L.P. | 937,500 | $1.64M | 0.0% | -9.6% | 1.354% |  |
| 5/15/2025 | Baker BROS. Advisors LP | 2,694,044 | $4.72M | 0.1% | N/A | 4.067% |  |
| 5/15/2025 | DAFNA Capital Management LLC | 847,176 | $1.48M | 0.4% | -3.2% | 1.279% |  |
| 5/15/2025 | Velan Capital Investment Management LP | 80,000 | $0.14M | 0.1% | +14.3% | 0.121% |  |
| 5/15/2025 | Driehaus Capital Management LLC | 958,345 | $1.68M | 0.0% | N/A | 1.447% |  |
| 5/12/2025 | Nuveen LLC | 85,602 | $0.15M | 0.0% | N/A | 0.129% |  |
| 5/12/2025 | Vivo Capital LLC | 2,696,426 | $4.72M | 0.6% | -46.1% | 4.071% |  |
| 5/8/2025 | Federated Hermes Inc. | 15,819,863 | $27.69M | 0.1% | +23.1% | 23.882% |  |
| 5/2/2025 | Victory Capital Management Inc. | 386,666 | $0.68M | 0.0% | -0.8% | 0.584% |  |
| 4/23/2025 | Tyche Wealth Partners LLC | 121,589 | $0.21M | 0.0% | +14.6% | 0.184% |  |
| 4/23/2025 | Oppenheimer & Co. Inc. | 55,000 | $96K | 0.0% | N/A | 0.083% |  |
| 2/17/2025 | Velan Capital Investment Management LP | 70,000 | $0.11M | 0.1% | N/A | 0.107% |  |
| 2/17/2025 | Octagon Capital Advisors LP | 4,848,802 | $7.66M | 1.3% | +13.7% | 7.403% |  |
| 2/17/2025 | Millennium Management LLC | 2,192,158 | $3.46M | 0.0% | +69.7% | 3.347% |  |
| 2/17/2025 | DAFNA Capital Management LLC | 875,200 | $1.38M | 0.4% | -2.2% | 1.336% |  |
| 2/14/2025 | RA Capital Management L.P. | 336,843 | $0.53M | 0.0% | -56.1% | 0.514% |  |
| 2/14/2025 | Northern Trust Corp | 457,233 | $0.72M | 0.0% | -8.1% | 0.698% |  |
| 2/14/2025 | Price T Rowe Associates Inc. MD | 29,597 | $47K | 0.0% | -98.6% | 0.045% |  |
| 2/13/2025 | PEAK6 LLC | 60,000 | $95K | 0.0% | N/A | 0.092% |  |
| 2/13/2025 | Barclays PLC | 96,247 | $0.15M | 0.0% | +13.9% | 0.147% |  |
| 2/13/2025 | Renaissance Technologies LLC | 117,100 | $0.19M | 0.0% | +20.5% | 0.179% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 190,457 | $0.30M | 0.0% | +141.2% | 0.291% |  |
| 2/6/2025 | Victory Capital Management Inc. | 389,886 | $0.62M | 0.0% | -2.3% | 0.595% |  |
| 1/30/2025 | Rhumbline Advisers | 59,531 | $94K | 0.0% | -20.1% | 0.091% |  |
| 12/26/2024 | JPMorgan Chase & Co. | 78,972 | $0.12M | 0.0% | +193.4% | 0.121% |  |
| 11/19/2024 | Barclays PLC | 84,477 | $0.13M | 0.0% | +285.2% | 0.129% |  |
| 11/16/2024 | Geode Capital Management LLC | 1,280,567 | $2.01M | 0.0% | -4.0% | 1.955% |  |
| 11/15/2024 | Barclays PLC | 84,477 | $0.13M | 0.0% | +285.2% | 0.129% |  |
| 11/15/2024 | Jane Street Group LLC | 29,580 | $46K | 0.0% | N/A | 0.045% |  |
| 11/15/2024 | State Street Corp | 1,000,998 | $1.57M | 0.0% | +3.5% | 1.528% |  |
| 11/15/2024 | RA Capital Management L.P. | 766,834 | $1.20M | 0.0% | -87.7% | 1.171% |  |
| 11/15/2024 | Point72 Asset Management L.P. | 893,762 | $1.40M | 0.0% | N/A | 1.365% |  |
| 11/14/2024 | NEA Management Company LLC | 6,467,802 | $10.15M | 0.6% | N/A | 9.875% |  |
| 11/13/2024 | FMR LLC | 328,157 | $0.52M | 0.0% | -83.8% | 0.501% |  |
| 11/13/2024 | The Manufacturers Life Insurance Company | 129,700 | $0.20M | 0.0% | N/A | 0.198% |  |
| 11/5/2024 | Victory Capital Management Inc. | 398,866 | $0.63M | 0.0% | +10.4% | 0.609% |  |
| 10/25/2024 | Tyche Wealth Partners LLC | 106,089 | $0.17M | 0.0% | +920.6% | 0.162% |  |
| 10/11/2024 | Creative Planning | 16,466 | $26K | 0.0% | N/A | 0.025% |  |
| 10/3/2024 | SG Americas Securities LLC | 20,800 | $33K | 0.0% | N/A | 0.032% |  |
| 8/15/2024 | CVI Holdings LLC | 401,012 | $0.72M | 0.6% | -71.5% | 0.613% |  |
| 8/9/2024 | Renaissance Technologies LLC | 118,100 | $0.21M | 0.0% | +56.4% | 0.180% |  |
| 8/5/2024 | Victory Capital Management Inc. | 361,386 | $0.65M | 0.0% | -1.8% | 0.552% |  |
| 8/1/2024 | Rhumbline Advisers | 76,472 | $0.14M | 0.0% | N/A | 0.117% |  |
| 7/26/2024 | Bank of New York Mellon Corp | 197,193 | $0.35M | 0.0% | N/A | 0.301% |  |
| 5/29/2024 | Opaleye Management Inc. | 170,308 | $0.49M | 0.1% | N/A | 0.260% |  |
| 5/17/2024 | RA Capital Management L.P. | 6,250,000 | $18M | 0.2% | N/A | 9.547% |  |
| 5/15/2024 | NEA Management Company LLC | 6,467,802 | $18.63M | 1.1% | N/A | 9.879% |  |
| 5/10/2024 | Vanguard Group Inc. | 740,215 | $2.13M | 0.0% | +158.4% | 1.131% |  |
| 5/7/2024 | CVI Holdings LLC | 1,406,250 | $4.05M | 3.9% | N/A | 2.148% |  |
| 4/22/2024 | Vivo Capital LLC | 5,000,000 | $14.40M | 1.1% | N/A | 7.638% |  |
| 2/5/2024 | Victory Capital Management Inc. | 271,736 | $0.35M | 0.0% | +16.5% | 1.344% |  |
| 11/13/2023 | FMR LLC | 2,922,600 | $4.03M | 0.0% | +32.4% | 14.454% |  |
| 11/6/2023 | Victory Capital Management Inc. | 233,207 | $0.32M | 0.0% | +5.3% | 1.197% |  |
| 8/14/2023 | Prelude Capital Management LLC | 40,660 | $60K | 0.0% | N/A | 0.209% |  |
| 9/16/2022 | Federated Hermes Inc. | 2,904,826 | $6.01M | 0.0% | -90.0% | 19.850% |  |
| 8/16/2022 | DAFNA Capital Management LLC | 555,555 | $1.15M | 0.3% | -90.0% | 3.797% |  |
| 8/12/2022 | Ikarian Capital LLC | 105,341 | $0.22M | 0.0% | -91.8% | 0.722% |  |
| 8/1/2022 | Victory Capital Management Inc. | 221,506 | $0.46M | 0.0% | -90.1% | 1.517% |  |
| 7/19/2022 | Commonwealth Equity Services LLC | 22,000 | $45K | 0.0% | -83.2% | 0.151% |  |
| 2/14/2022 | DAFNA Capital Management LLC | 5,555,555 | $1.75M | 0.4% | N/A | 6.382% |  |
| 1/19/2022 | Asymmetry Capital Management L.P. | 2,731,044 | $0.86M | 0.5% | +94.9% | 3.137% |  |
| 11/15/2021 | GSA Capital Partners LLP | 64,708 | $45K | 0.0% | -68.6% | 0.074% |  |
| 11/4/2021 | Asymmetry Capital Management L.P. | 1,401,491 | $0.97M | 0.6% | -3.4% | 1.610% |  |
| 10/29/2021 | Commonwealth Equity Services LLC | 111,000 | $76K | 0.0% | +38.8% | 0.128% |  |
| 8/16/2021 | State Street Corp | 176,494 | $0.14M | 0.0% | N/A | 0.203% |  |