| 11/17/2025 | Jacobs Levy Equity Management Inc. | 30,001 | $0.31M | 0.0% | -27.4% | 0.115% |  |
| 11/17/2025 | Millennium Management LLC | 25,357 | $0.26M | 0.0% | N/A | 0.098% |  |
| 11/14/2025 | Bridgeway Capital Management LLC | 25,000 | $0.26M | 0.0% | N/A | 0.096% |  |
| 11/7/2025 | GSA Capital Partners LLP | 86,095 | $0.88M | 0.1% | +106.9% | 0.331% |  |
| 11/7/2025 | Vanguard Group Inc. | 520,722 | $5.32M | 0.0% | +4.9% | 2.003% |  |
| 11/3/2025 | AlphaQuest LLC | 6,924 | $71K | 0.0% | +64.6% | 0.027% |  |
| 8/15/2025 | Bank of America Corp DE | 13,933 | $0.15M | 0.0% | +133.0% | 0.054% |  |
| 8/15/2025 | 683 Capital Management LLC | 219,000 | $2.28M | 0.1% | +46.0% | 0.842% |  |
| 8/14/2025 | MPM Bioimpact LLC | 686,007 | $7.13M | 1.2% | -13.2% | 2.638% |  |
| 8/14/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5,056 | $53K | 0.0% | -16.0% | 0.019% |  |
| 8/13/2025 | Marshall Wace LLP | 82,630 | $0.86M | 0.0% | +114.0% | 0.318% |  |
| 8/13/2025 | Virtus Investment Advisers LLC | 9,183 | $95K | 0.0% | +12.5% | 0.035% |  |
| 8/12/2025 | JPMorgan Chase & Co. | 6,080 | $63K | 0.0% | -96.9% | 0.023% |  |
| 8/12/2025 | Miller Financial Services LLC | 11,643 | $0.12M | 0.2% | N/A | 0.045% |  |
| 8/8/2025 | Geode Capital Management LLC | 218,927 | $2.28M | 0.0% | -2.9% | 0.844% |  |
| 7/31/2025 | AlphaQuest LLC | 4,207 | $44K | 0.0% | -41.5% | 0.016% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 15,775 | $0.21M | 0.0% | -42.7% | 0.061% |  |
| 5/29/2025 | Rhumbline Advisers | 13,006 | $0.17M | 0.0% | +27.5% | 0.050% |  |
| 5/23/2025 | Siren L.L.C. | 563,272 | $7.42M | 0.4% | -1.6% | 2.170% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 15,775 | $0.21M | 0.0% | -42.7% | 0.061% |  |
| 5/16/2025 | 683 Capital Management LLC | 150,000 | $1.98M | 0.1% | +20.0% | 0.578% |  |
| 5/15/2025 | MPM Bioimpact LLC | 790,779 | $10.42M | 1.8% | +9.7% | 3.049% |  |
| 5/15/2025 | Siren L.L.C. | 563,272 | $7.42M | 0.4% | -1.6% | 2.172% |  |
| 5/14/2025 | AlphaQuest LLC | 7,191 | $95K | 0.0% | N/A | 0.028% |  |
| 5/14/2025 | Erste Asset Management GmbH | 260,011 | $3.43M | 0.0% | +49.8% | 1.002% |  |
| 5/13/2025 | Twin Focus Capital Partners LLC | 15,000 | $0.20M | 0.0% | +25.0% | 0.058% |  |
| 5/12/2025 | Nuveen LLC | 27,869 | $0.37M | 0.0% | N/A | 0.107% |  |
| 5/9/2025 | Deutsche Bank AG | 7,424 | $98K | 0.0% | +104.1% | 0.029% |  |
| 5/9/2025 | Charles Schwab Investment Management Inc. | 29,303 | $0.39M | 0.0% | +9.3% | 0.113% |  |
| 4/30/2025 | Alps Advisors Inc. | 19,392 | $0.26M | 0.0% | -5.6% | 0.075% |  |
| 4/29/2025 | Bank of New York Mellon Corp | 20,937 | $0.28M | 0.0% | +7.9% | 0.081% |  |
| 4/8/2025 | Rhumbline Advisers | 13,006 | $0.17M | 0.0% | +27.5% | 0.050% |  |
| 2/17/2025 | Two Sigma Investments LP | 11,812 | $0.21M | 0.0% | -8.5% | 0.046% |  |
| 2/17/2025 | MPM Bioimpact LLC | 721,139 | $12.92M | 1.8% | +14.6% | 2.837% |  |
| 2/17/2025 | Nuveen Asset Management LLC | 72,099 | $1.29M | 0.0% | +197.8% | 0.284% |  |
| 2/17/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5,786 | $0.10M | 0.0% | +44.8% | 0.023% |  |
| 2/17/2025 | Citadel Advisors LLC | 315,000 | $5.64M | 0.0% | -16.2% | 1.239% |  |
| 2/17/2025 | Bank of America Corp DE | 11,690 | $0.21M | 0.0% | +54.4% | 0.046% |  |
| 2/17/2025 | 683 Capital Management LLC | 125,000 | $2.24M | 0.1% | +65.7% | 0.492% |  |
| 2/14/2025 | Northern Trust Corp | 95,030 | $1.70M | 0.0% | +50.6% | 0.374% |  |
| 2/14/2025 | Virtus ETF Advisers LLC | 3,533 | $63K | 0.0% | N/A | 0.014% |  |
| 2/14/2025 | MetLife Investment Management LLC | 6,667 | $0.12M | 0.0% | N/A | 0.026% |  |
| 2/13/2025 | Barclays PLC | 19,099 | $0.34M | 0.0% | +64.5% | 0.075% |  |
| 2/13/2025 | Renaissance Technologies LLC | 13,800 | $0.25M | 0.0% | N/A | 0.054% |  |
| 2/13/2025 | Wells Fargo & Company MN | 4,847 | $87K | 0.0% | +112.7% | 0.019% |  |
| 2/12/2025 | Geode Capital Management LLC | 221,257 | $3.96M | 0.0% | +63.0% | 0.870% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 274,740 | $4.92M | 0.0% | -11.1% | 1.081% |  |
| 2/11/2025 | Corebridge Financial Inc. | 5,122 | $92K | 0.0% | +32.6% | 0.020% |  |
| 2/10/2025 | Erste Asset Management GmbH | 173,566 | $3.26M | 0.0% | -93.6% | 0.683% |  |
| 2/6/2025 | Charles Schwab Investment Management Inc. | 26,803 | $0.48M | 0.0% | +40.7% | 0.105% |  |
| 2/4/2025 | Bank of New York Mellon Corp | 19,407 | $0.35M | 0.0% | +28.5% | 0.076% |  |
| 1/31/2025 | New York State Common Retirement Fund | 3,902 | $70K | 0.0% | -23.5% | 0.015% |  |
| 1/30/2025 | Rhumbline Advisers | 10,201 | $0.18M | 0.0% | +10.0% | 0.040% |  |
| 1/27/2025 | Mirae Asset Global Investments Co. Ltd. | 4,562 | $82K | 0.0% | +22.8% | 0.018% |  |
| 1/24/2025 | China Universal Asset Management Co. Ltd. | 5,389 | $97K | 0.0% | N/A | 0.021% |  |
| 12/26/2024 | JPMorgan Chase & Co. | 309,018 | $4.98M | 0.0% | +0.9% | 1.216% |  |
| 11/19/2024 | Barclays PLC | 11,611 | $0.19M | 0.0% | +208.6% | 0.046% |  |
| 11/16/2024 | Geode Capital Management LLC | 135,700 | $2.19M | 0.0% | +2.1% | 0.534% |  |
| 11/15/2024 | Barclays PLC | 11,611 | $0.19M | 0.0% | +208.6% | 0.046% |  |
| 11/15/2024 | State Street Corp | 157,495 | $2.54M | 0.0% | +2.5% | 0.620% |  |
| 11/15/2024 | Ikarian Capital LLC | 52,193 | $0.84M | 0.1% | -78.5% | 0.205% |  |
| 11/13/2024 | Great Point Partners LLC | 200,000 | $3.22M | 0.9% | N/A | 0.787% |  |
| 11/13/2024 | BNP Paribas Financial Markets | 1,651 | $27K | 0.0% | +122.5% | 0.006% |  |
| 11/13/2024 | FMR LLC | 2,851,830 | $45.97M | 0.0% | +458.3% | 11.219% |  |
| 10/23/2024 | Lake Street Advisors Group LLC | 15,822 | $0.26M | 0.0% | -50.0% | 0.074% |  |
| 9/16/2024 | Point72 DIFC Ltd | 1,725 | $47K | 0.0% | N/A | 0.008% |  |
| 9/16/2024 | Cubist Systematic Strategies LLC | 13,010 | $0.35M | 0.0% | N/A | 0.061% |  |
| 9/16/2024 | Point72 Asia Singapore Pte. Ltd. | 1,824 | $49K | 0.0% | N/A | 0.009% |  |
| 8/27/2024 | Logos Global Management LP | 90,000 | $2.43M | 0.2% | N/A | 0.506% |  |
| 8/15/2024 | Point72 Asia Singapore Pte. Ltd. | 1,824 | $49K | 0.0% | N/A | 0.009% |  |
| 8/14/2024 | Cubist Systematic Strategies LLC | 13,010 | $0.35M | 0.0% | N/A | 0.061% |  |
| 8/14/2024 | Point72 DIFC Ltd | 1,725 | $47K | 0.0% | N/A | 0.008% |  |
| 8/14/2024 | Marshall Wace LLP | 30,038 | $0.81M | 0.0% | N/A | 0.140% |  |
| 8/14/2024 | Logos Global Management LP | 90,000 | $2.43M | 0.2% | N/A | 0.421% |  |
| 8/9/2024 | Renaissance Technologies LLC | 17,052 | $0.46M | 0.0% | -96.9% | 0.096% |  |
| 8/6/2024 | Lake Street Advisors Group LLC | 31,644 | $0.86M | 0.0% | N/A | 0.178% |  |
| 8/1/2024 | Rhumbline Advisers | 8,487 | $0.23M | 0.0% | -93.5% | 0.048% |  |
| 7/26/2024 | Bank of New York Mellon Corp | 19,916 | $0.54M | 0.0% | -93.7% | 0.112% |  |
| 7/22/2024 | Hall Laurie J Trustee | 1,759 | $48K | 0.0% | -96.7% | 0.010% |  |
| 5/17/2024 | Artal Group S.A. | 9,136,635 | $5.94M | 0.2% | N/A | 171.098% |  |
| 5/14/2024 | American International Group Inc. | 56,202 | $37K | 0.0% | N/A | 1.052% |  |
| 5/10/2024 | Vanguard Group Inc. | 6,315,113 | $4.11M | 0.0% | N/A | 118.172% |  |
| 5/7/2024 | SG Americas Securities LLC | 47,134 | $31K | 0.0% | N/A | 0.883% |  |
| 5/3/2024 | Delphi Financial Group Inc. | 660,852 | $0.43M | 0.3% | N/A | 12.261% |  |
| 5/1/2024 | BNP Paribas Financial Markets | 59,125 | $38K | 0.0% | N/A | 1.097% |  |
| 4/23/2024 | Hall Laurie J Trustee | 52,775 | $34K | 0.0% | N/A | 0.979% |  |