| 8/15/2023 | Black Maple Capital Management LP | 266,736 | $0.23M | 0.1% | N/A | 0.439% |  |
| 8/7/2023 | Acadian Asset Management LLC | 868,620 | $0.75M | 0.0% | -17.4% | 1.428% |  |
| 7/10/2023 | ARK Investment Management LLC | 1,412,077 | $1.23M | 0.0% | -74.3% | 2.326% |  |
| 5/15/2023 | EcoR1 Capital LLC | 3,082,959 | $2.15M | 0.1% | -21.4% | 5.078% |  |
| 5/11/2023 | Acadian Asset Management LLC | 1,051,718 | $0.73M | 0.0% | -3.7% | 1.732% |  |
| 5/3/2023 | Nikko Asset Management Americas Inc. | 999,026 | $0.65M | 0.0% | -6.8% | 1.645% |  |
| 5/1/2023 | Arete Wealth Advisors LLC | 53,965 | $37.71B | 0.0% | N/A | 0.089% |  |
| 4/27/2023 | Sumitomo Mitsui Trust Holdings Inc. | 999,026 | $0.70M | 0.0% | -6.8% | 1.645% |  |
| 4/17/2023 | ARK Investment Management LLC | 5,496,146 | $3.84M | 0.0% | -1.3% | 9.052% |  |
| 2/15/2023 | Tang Capital Management LLC | 429,647 | $0.35M | 0.1% | N/A | 0.710% |  |
| 2/14/2023 | Susquehanna International Group LLP | 49,815 | $41K | 0.0% | +108.3% | 0.082% |  |
| 2/13/2023 | Nikko Asset Management Americas Inc. | 1,072,013 | $0.86M | 0.0% | -2.9% | 1.771% |  |
| 1/30/2023 | Sumitomo Mitsui Trust Holdings Inc. | 1,072,013 | $0.88M | 0.0% | -2.9% | 1.771% |  |
| 1/30/2023 | International Assets Investment Management LLC | 48,830 | $40K | 0.0% | +28.7% | 0.081% |  |
| 1/25/2023 | Eagle Rock Investment Company LLC | 42,000 | $41K | 0.0% | +90.9% | 0.069% |  |
| 1/24/2023 | International Assets Investment Management LLC | 76,830 | $50K | 0.0% | +102.5% | 0.127% |  |
| 1/24/2023 | ARK Investment Management LLC | 5,567,224 | $4.57M | 0.0% | -7.8% | 9.196% |  |
| 11/15/2022 | EcoR1 Capital LLC | 3,924,713 | $4.08M | 0.1% | -15.7% | 6.483% |  |
| 11/14/2022 | Forefront Analytics LLC | 66,838 | $70K | 0.0% | +60.3% | 0.110% |  |
| 11/10/2022 | Kingsbury Capital Investment Advisors LLC | 144,217 | $0.15M | 0.2% | +69.3% | 0.238% |  |
| 11/10/2022 | Connor Clark & Lunn Investment Management Ltd. | 98,062 | $0.10M | 0.0% | N/A | 0.162% |  |
| 11/3/2022 | Barclays PLC | 417,765 | $0.43M | 0.0% | -3.0% | 0.720% |  |
| 10/21/2022 | Sumitomo Mitsui Trust Holdings Inc. | 1,104,230 | $1.15M | 0.0% | N/A | 1.903% |  |
| 10/17/2022 | ARK Investment Management LLC | 6,035,691 | $6.28M | 0.0% | +8.6% | 10.400% |  |
| 8/16/2022 | DAFNA Capital Management LLC | 1,100,000 | $1.80M | 0.5% | +61.8% | 1.896% |  |
| 8/15/2022 | Laurion Capital Management LP | 665,400 | $1.09M | 0.0% | N/A | 1.147% |  |
| 8/10/2022 | Forefront Analytics LLC | 41,688 | $71K | 0.0% | +111.5% | 0.072% |  |
| 8/9/2022 | Kingsbury Capital Investment Advisors LLC | 85,166 | $0.14M | 0.2% | +171.3% | 0.147% |  |
| 8/8/2022 | Keybank National Association OH | 26,455 | $43K | 0.0% | N/A | 0.048% |  |
| 8/5/2022 | Los Angeles Capital Management LLC | 32,663 | $54K | 0.0% | -83.7% | 0.060% |  |
| 7/11/2022 | ARK Investment Management LLC | 5,557,382 | $10.28M | 0.1% | +4.0% | 10.176% |  |
| 5/13/2022 | Parkman Healthcare Partners LLC | 209,148 | $0.62M | 0.2% | -19.2% | 0.383% |  |
| 5/11/2022 | GSA Capital Partners LLP | 27,568 | $81K | 0.0% | N/A | 0.050% |  |
| 5/9/2022 | Forefront Analytics LLC | 19,713 | $62K | 0.0% | N/A | 0.036% |  |
| 5/6/2022 | Los Angeles Capital Management LLC | 199,825 | $0.59M | 0.0% | +104.0% | 0.366% |  |
| 5/6/2022 | Princeton Global Asset Management LLC | 53,442 | $0.16M | 0.0% | N/A | 0.098% |  |
| 5/5/2022 | Russell Investments Group Ltd. | 9,240 | $27K | 0.0% | N/A | 0.017% |  |
| 5/4/2022 | SummerHaven Investment Management LLC | 134,167 | $0.39M | 0.2% | +4.8% | 0.246% |  |
| 5/4/2022 | Formidable Asset Management LLC | 11,150 | $33K | 0.0% | N/A | 0.020% |  |
| 4/29/2022 | SG Americas Securities LLC | 10,043 | $30K | 0.0% | -33.4% | 0.021% |  |
| 4/29/2022 | C M Bidwell & Associates Ltd. | 50,655 | $0.15M | 0.1% | +51.1% | 0.108% |  |
| 4/25/2022 | Assenagon Asset Management S.A. | 45,821 | $0.14M | 0.0% | N/A | 0.098% |  |
| 4/19/2022 | ARK Investment Management LLC | 5,343,116 | $15.71M | 0.1% | +0.3% | 11.378% |  |
| 4/12/2022 | Connective Portfolio Management LLC | 25,000 | $71K | 0.2% | -58.3% | 0.053% |  |
| 2/17/2022 | Eagle Rock Investment Company LLC | 22,000 | $0.11M | 0.0% | N/A | 0.048% |  |
| 2/14/2022 | PDT Partners LLC | 104,365 | $0.50M | 0.0% | N/A | 0.226% |  |
| 2/14/2022 | DAFNA Capital Management LLC | 315,000 | $1.51M | 0.4% | N/A | 0.683% |  |
| 2/10/2022 | Qube Research & Technologies Ltd | 25,371 | $0.12M | 0.0% | N/A | 0.055% |  |
| 2/10/2022 | Acadian Asset Management LLC | 163,214 | $0.78M | 0.0% | N/A | 0.354% |  |
| 2/10/2022 | Connor Clark & Lunn Investment Management Ltd. | 11,966 | $57K | 0.0% | -72.4% | 0.026% |  |
| 2/9/2022 | Principal Financial Group Inc. | 64,157 | $0.31M | 0.0% | -59.7% | 0.139% |  |
| 2/9/2022 | Alps Advisors Inc. | 53,388 | $0.26M | 0.0% | N/A | 0.116% |  |
| 2/9/2022 | Dimensional Fund Advisors LP | 404,977 | $1.94M | 0.0% | +52.4% | 0.878% |  |
| 2/8/2022 | Raymond James & Associates | 18,393 | $88K | 0.0% | -75.4% | 0.040% |  |
| 2/8/2022 | Northern Trust Corp | 311,139 | $1.49M | 0.0% | +6.3% | 0.674% |  |
| 2/7/2022 | Victory Capital Management Inc. | 328,228 | $1.57M | 0.0% | -4.3% | 0.711% |  |
| 2/7/2022 | SG Americas Securities LLC | 15,073 | $72K | 0.0% | -48.1% | 0.033% |  |
| 2/7/2022 | Connective Portfolio Management LLC | 60,000 | $0.29M | 0.5% | N/A | 0.130% |  |
| 2/7/2022 | Arete Wealth Advisors LLC | 55,807 | $0.28M | 0.0% | N/A | 0.121% |  |
| 2/3/2022 | Advisor Group Holdings Inc. | 12,366 | $59K | 0.0% | -28.9% | 0.027% |  |
| 2/2/2022 | Oppenheimer & Co. Inc. | 11,049 | $53K | 0.0% | -65.9% | 0.024% |  |
| 2/1/2022 | Qube Research & Technologies Ltd | 25,371 | $0.12M | 0.0% | N/A | 0.055% |  |
| 1/28/2022 | Allspring Global Investments Holdings LLC | 141,261 | $0.68M | 0.0% | N/A | 0.306% |  |
| 1/28/2022 | ARK Investment Management LLC | 5,326,127 | $25.46M | 0.1% | +15.3% | 11.545% |  |
| 1/24/2022 | Strs Ohio | 133,500 | $0.64M | 0.0% | +9.8% | 0.289% |  |
| 1/14/2022 | Spire Wealth Management | 11,000 | $53K | 0.0% | N/A | 0.024% |  |
| 11/16/2021 | Schonfeld Strategic Advisors LLC | 14,700 | $0.11M | 0.0% | N/A | 0.032% |  |
| 11/15/2021 | Marshall Wace LLP | 232,162 | $1.76M | 0.0% | N/A | 0.503% |  |
| 11/15/2021 | HighVista Strategies LLC | 13,932 | $0.11M | 0.1% | N/A | 0.030% |  |
| 11/15/2021 | Dimensional Fund Advisors LP | 265,667 | $2.01M | 0.0% | -57.6% | 0.576% |  |
| 11/12/2021 | Parkman Healthcare Partners LLC | 248,267 | $1.88M | 0.5% | +8.8% | 0.538% |  |
| 11/12/2021 | The Manufacturers Life Insurance Company | 21,704 | $0.16M | 0.0% | N/A | 0.047% |  |
| 11/12/2021 | Oppenheimer & Co. Inc. | 32,397 | $0.25M | 0.0% | -7.0% | 0.070% |  |
| 11/12/2021 | Geode Capital Management LLC | 609,257 | $4.61M | 0.0% | +23.6% | 1.321% |  |
| 11/12/2021 | Connor Clark & Lunn Investment Management Ltd. | 43,300 | $0.33M | 0.0% | N/A | 0.094% |  |
| 11/10/2021 | NinePointTwo Capital LLC | 16,206 | $0.12M | 0.0% | N/A | 0.036% |  |
| 11/10/2021 | Goldman Sachs Group Inc. | 1,199,889 | $9.08M | 0.0% | +56.4% | 2.640% |  |
| 11/10/2021 | Citigroup Inc. | 6,482 | $49K | 0.0% | -86.2% | 0.014% |  |
| 11/9/2021 | Barclays PLC | 24,838 | $0.19M | 0.0% | -58.3% | 0.054% |  |
| 11/9/2021 | BlackRock Inc. | 2,424,943 | $18.36M | 0.0% | -4.7% | 5.257% |  |
| 11/9/2021 | Principal Financial Group Inc. | 159,042 | $1.20M | 0.0% | -1.5% | 0.345% |  |
| 11/8/2021 | Summit Global Investments | 56,549 | $0.43M | 0.0% | N/A | 0.124% |  |
| 11/8/2021 | Los Angeles Capital Management LLC | 97,930 | $0.74M | 0.0% | N/A | 0.215% |  |
| 11/5/2021 | Advisor Group Holdings Inc. | 17,396 | $0.13M | 0.0% | +9.9% | 0.038% |  |
| 11/2/2021 | Raymond James & Associates | 74,898 | $0.57M | 0.0% | -29.5% | 0.165% |  |
| 11/2/2021 | New York State Common Retirement Fund | 14,753 | $0.11M | 0.0% | -48.2% | 0.032% |  |
| 11/2/2021 | Victory Capital Management Inc. | 343,108 | $2.60M | 0.0% | -0.9% | 0.755% |  |
| 11/1/2021 | SG Americas Securities LLC | 29,036 | $0.22M | 0.0% | N/A | 0.064% |  |
| 10/28/2021 | International Assets Investment Management LLC | 30,800 | $0.23M | 0.0% | +12.4% | 0.068% |  |
| 10/22/2021 | Strs Ohio | 121,600 | $0.92M | 0.0% | +12.6% | 0.268% |  |
| 8/16/2021 | Morgan Stanley | 733,295 | $5.47M | 0.0% | +252.6% | 1.613% |  |