| 11/17/2025 | Woodline Partners LP | 48,193 | $0.62M | 0.0% | N/A | 0.562% |  |
| 11/17/2025 | Millennium Management LLC | 109,769 | $1.41M | 0.0% | N/A | 1.281% |  |
| 11/17/2025 | Citadel Advisors LLC | 13,875 | $0.18M | 0.0% | +32.8% | 0.162% |  |
| 11/14/2025 | Schonfeld Strategic Advisors LLC | 69,024 | $0.89M | 0.0% | N/A | 0.805% |  |
| 11/14/2025 | Acuta Capital Partners LLC | 178,415 | $2.30M | 2.4% | +5.0% | 2.082% |  |
| 11/7/2025 | Vanguard Group Inc. | 266,418 | $3.43M | 0.0% | +21.7% | 3.109% |  |
| 8/15/2025 | Braidwell LP | 140,000 | $1.25M | 0.0% | N/A | 1.636% |  |
| 8/14/2025 | Armistice Capital LLC | 60,000 | $0.54M | 0.0% | N/A | 0.701% |  |
| 8/14/2025 | Stempoint Capital LP | 686,539 | $6.14M | 2.0% | +185.1% | 8.018% |  |
| 8/13/2025 | Stonepine Capital Management LLC | 306,029 | $2.74M | 2.7% | +7.1% | 3.575% |  |
| 8/8/2025 | Geode Capital Management LLC | 30,963 | $0.28M | 0.0% | +22.6% | 0.362% |  |
| 5/16/2025 | 5AM Venture Management LLC | 310,000 | $3.62M | 1.4% | N/A | 9.448% |  |
| 5/16/2025 | Adage Capital Partners GP L.L.C. | 88,653 | $1.03M | 0.0% | +37.1% | 2.702% |  |
| 5/15/2025 | RA Capital Management L.P. | 679,130 | $7.92M | 0.1% | +140.3% | 20.699% |  |
| 5/15/2025 | Nantahala Capital Management LLC | 229,527 | $2.68M | 0.1% | +17.1% | 6.996% |  |
| 5/15/2025 | Driehaus Capital Management LLC | 204,934 | $2.39M | 0.0% | N/A | 6.246% |  |
| 5/15/2025 | Heights Capital Management Inc. | 44,978 | $0.52M | 0.3% | N/A | 1.371% |  |
| 5/14/2025 | Stonepine Capital Management LLC | 285,782 | $3.33M | 3.2% | +108.3% | 8.710% |  |
| 5/12/2025 | Vivo Capital LLC | 260,000 | $3.03M | 0.4% | N/A | 7.924% |  |
| 2/17/2025 | Trustees of Columbia University in the City of New York | 47,930 | $0.69M | 0.1% | N/A | 1.475% |  |
| 2/17/2025 | Stonepine Capital Management LLC | 137,200 | $1.97M | 1.6% | +24.7% | 4.222% |  |
| 2/17/2025 | Stempoint Capital LP | 350,573 | $5.03M | 1.3% | +91.7% | 10.787% |  |
| 2/17/2025 | Alyeska Investment Group L.P. | 10,188 | $0.15M | 0.0% | -50.0% | 0.313% |  |
| 2/14/2025 | Nantahala Capital Management LLC | 196,023 | $2.81M | 0.1% | +4.7% | 6.031% |  |
| 2/14/2025 | Adage Capital Partners GP L.L.C. | 64,653 | $0.93M | 0.0% | N/A | 1.989% |  |
| 2/12/2025 | Geode Capital Management LLC | 22,391 | $0.32M | 0.0% | +26.1% | 0.689% |  |
| 2/5/2025 | Regents of The University of California | 133,207 | $1.91M | 0.6% | N/A | 4.099% |  |
| 11/14/2024 | Stonepine Capital Management LLC | 110,000 | $1.32M | 0.8% | +66.5% | 3.427% |  |
| 8/21/2024 | Stonepine Capital Management LLC | 66,084 | $0.72M | 0.7% | N/A | 2.066% |  |
| 8/20/2024 | Nantahala Capital Management LLC | 187,206 | $2.05M | 0.1% | N/A | 5.852% |  |
| 8/15/2024 | CVI Holdings LLC | 64,905 | $0.71M | 0.6% | N/A | 2.029% |  |
| 8/15/2024 | Armistice Capital LLC | 190,000 | $2.08M | 0.0% | N/A | 5.939% |  |
| 2/15/2024 | Board of Trustees of The Leland Stanford Junior University | 52,131 | $0.49M | 0.0% | -93.3% | 2.557% |  |
| 2/9/2024 | Column Group LLC | 627,651 | $5.90M | 3.9% | -93.3% | 30.767% |  |
| 12/1/2023 | Euclidean Capital LLC | 1,315,463 | $0.65M | 0.1% | +63.8% | 64.483% |  |
| 10/23/2023 | BML Capital Management LLC | 89,271 | $44K | 0.0% | -93.9% | 0.292% |  |
| 7/24/2023 | Column Group LLC | 9,414,795 | $5.18M | 2.0% | +1.8% | 31.299% |  |
| 7/24/2023 | BML Capital Management LLC | 1,459,084 | $0.80M | 0.7% | -2.3% | 4.851% |  |
| 4/14/2023 | BML Capital Management LLC | 1,494,037 | $0.90M | 0.8% | N/A | 4.967% |  |
| 11/15/2022 | Empery Asset Management LP | 215,942 | $0.44M | 2.6% | -16.2% | 0.615% |  |
| 11/15/2022 | Board of Trustees of The Leland Stanford Junior University | 781,960 | $1.58M | 0.1% | +3,102.9% | 2.227% |  |
| 8/13/2022 | Column Group LLC | 9,248,129 | $27.75M | 5.9% | -1.8% | 26.328% |  |
| 8/12/2022 | Board of Trustees of The Leland Stanford Junior University | 24,414 | $73K | 0.0% | -97.0% | 0.070% |  |
| 5/17/2022 | Empery Asset Management LP | 333,965 | $1.01M | 4.7% | -42.5% | 0.951% |  |
| 2/15/2022 | Laurion Capital Management LP | 520,000 | $3.35M | 0.0% | +40.5% | 1.485% |  |
| 2/15/2022 | Consonance Capital Management LP | 3,497,500 | $22.36M | 14.6% | +249.8% | 9.987% |  |
| 2/14/2022 | Perceptive Advisors LLC | 413,446 | $2.66M | 0.0% | -17.3% | 1.181% |  |
| 2/11/2022 | Column Group LLC | 9,414,795 | $60.63M | 8.2% | +1.8% | 26.884% |  |
| 2/9/2022 | Wolverine Asset Management LLC | 9,172 | $59K | 0.0% | +466.5% | 0.026% |  |
| 2/7/2022 | Monashee Investment Management LLC | 350,000 | $2.25M | 0.6% | -30.0% | 0.999% |  |
| 12/29/2021 | Hudson Bay Capital Management LP | 300,000 | $2.11M | 0.0% | N/A | 2.514% |  |
| 12/3/2021 | Perceptive Advisors LLC | 500,000 | $3.54M | 0.1% | N/A | 4.190% |  |
| 11/16/2021 | Laurion Capital Management LP | 370,000 | $2.62M | 0.0% | N/A | 3.100% |  |
| 11/16/2021 | Bridger Management LLC | 700,001 | $4.19M | 0.5% | N/A | 5.866% |  |
| 11/16/2021 | Boxer Capital LLC | 200,000 | $1.42M | 0.0% | N/A | 1.676% |  |
| 11/15/2021 | Trustees of Columbia University in the City of New York | 718,950 | $5.09M | 7.8% | N/A | 6.024% |  |
| 11/15/2021 | Harvard Management Co. Inc. | 826,852 | $5.85M | 0.3% | N/A | 6.929% |  |
| 11/15/2021 | Highbridge Capital Management LLC | 11,701 | $83K | 0.0% | N/A | 0.098% |  |
| 11/15/2021 | Jasper Ridge Partners L.P. | 46,838 | $0.33M | 0.0% | N/A | 0.392% |  |
| 11/12/2021 | Board of Trustees of The Leland Stanford Junior University | 806,374 | $5.71M | 0.4% | N/A | 6.757% |  |
| 11/9/2021 | BlackRock Inc. | 34,959 | $0.25M | 0.0% | N/A | 0.293% |  |
| 11/9/2021 | Monashee Investment Management LLC | 500,000 | $3.54M | 0.7% | N/A | 4.191% |  |