| 2/14/2025 | Two Sigma Securities LLC | 107,742 | $25K | 0.0% | N/A | 0.402% |  |
| 12/13/2024 | Exome Asset Management LLC | 298,575 | $0.64M | 0.4% | +87.6% | 1.113% |  |
| 11/14/2024 | Walleye Capital LLC | 86,641 | $0.19M | 0.0% | -69.7% | 0.323% |  |
| 11/5/2024 | GSA Capital Partners LLP | 15,905 | $34K | 0.0% | N/A | 0.059% |  |
| 8/9/2024 | Renaissance Technologies LLC | 117,435 | $0.61M | 0.0% | -2.0% | 0.438% |  |
| 8/6/2024 | Certuity LLC | 21,202 | $0.11M | 0.0% | N/A | 0.079% |  |
| 8/6/2024 | Acadian Asset Management LLC | 34,578 | $0.18M | 0.0% | +101.5% | 0.129% |  |
| 7/18/2024 | Assenagon Asset Management S.A. | 15,873 | $82K | 0.0% | -90.7% | 0.059% |  |
| 5/29/2024 | Opaleye Management Inc. | 787,545 | $4.21M | 0.9% | +119.1% | 2.947% |  |
| 5/20/2024 | Virtu Financial LLC | 12,030 | $64K | 0.0% | N/A | 0.045% |  |
| 5/16/2024 | Kennedy Capital Management LLC | 404,914 | $2.17M | 0.0% | N/A | 1.515% |  |
| 5/10/2024 | Acadian Asset Management LLC | 17,162 | $91K | 0.0% | N/A | 0.064% |  |
| 5/10/2024 | Vanguard Group Inc. | 928,046 | $4.97M | 0.0% | +21.3% | 3.472% |  |
| 4/24/2024 | Assenagon Asset Management S.A. | 169,999 | $0.91M | 0.0% | +576.5% | 0.636% |  |
| 2/15/2024 | Opaleye Management Inc. | 359,370 | $2.80M | 0.7% | N/A | 1.706% |  |
| 2/15/2024 | Flagship Pioneering Inc. | 1,293,848 | $10.08M | 0.8% | +30.2% | 6.141% |  |
| 2/14/2024 | Avidity Partners Management LP | 1,673,538 | $13.04M | 0.5% | +5.8% | 7.943% |  |
| 2/13/2024 | Bain Capital Life Sciences Investors LLC | 2,749,808 | $21.42M | 2.1% | +29.4% | 13.051% |  |
| 11/14/2023 | Avidity Partners Management LP | 1,581,142 | $6.25M | 0.3% | +8.0% | 7.635% |  |
| 11/13/2023 | CHI Advisors LLC | 1,299,359 | $5.12M | 1.5% | +69.3% | 6.274% |  |
| 11/6/2023 | Assenagon Asset Management S.A. | 25,130 | $99K | 0.0% | +142.2% | 0.121% |  |
| 10/19/2023 | Clarius Group LLC | 18,620 | $74K | 0.0% | N/A | 0.090% |  |
| 8/14/2023 | Shay Capital LLC | 26,426 | $83K | 0.0% | +87.3% | 0.128% |  |
| 8/11/2023 | ExodusPoint Capital Management LP | 118,398 | $0.37M | 0.0% | -2.6% | 0.572% |  |
| 5/16/2023 | Ally Bridge Group NY LLC | 249,126 | $0.67M | 0.9% | -71.3% | 1.210% |  |
| 5/11/2023 | CHI Advisors LLC | 767,445 | $2.05M | 0.5% | N/A | 3.760% |  |
| 4/18/2023 | Assenagon Asset Management S.A. | 10,376 | $28K | 0.0% | N/A | 0.051% |  |
| 2/9/2023 | Denali Advisors LLC | 7,700 | $28K | 0.0% | N/A | 0.038% |  |
| 11/15/2022 | Flagship Pioneering Inc. | 993,848 | $6.40M | 0.3% | -66.2% | 15.775% |  |
| 11/15/2022 | Bain Capital Life Sciences Investors LLC | 1,082,404 | $6.97M | 0.8% | -82.7% | 17.181% |  |
| 11/9/2022 | Edmond DE Rothschild Holding S.A. | 4,382 | $28K | 0.0% | N/A | 0.070% |  |
| 10/24/2022 | Clarius Group LLC | 19,347 | $0.13M | 0.0% | -90.0% | 0.307% |  |
| 10/13/2022 | LGT Capital Partners LTD. | 55,000 | $0.35M | 0.0% | -90.0% | 0.873% |  |
| 8/11/2022 | Artal Group S.A. | 4,000,000 | $3.85M | 0.2% | +14.3% | 6.367% |  |
| 8/10/2022 | Clarius Group LLC | 193,483 | $0.19M | 0.0% | N/A | 0.308% |  |
| 7/19/2022 | Sawtooth Solutions LLC | 42,286 | $41K | 0.0% | +76.5% | 0.067% |  |
| 7/13/2022 | LGT Capital Partners LTD. | 550,000 | $0.53M | 0.0% | +10.0% | 0.876% |  |
| 7/13/2022 | Private Advisor Group LLC | 51,437 | $50K | 0.0% | +112.9% | 0.082% |  |
| 5/16/2022 | Ally Bridge Group NY LLC | 3,364,895 | $4M | 3.0% | -4.9% | 5.420% |  |
| 5/12/2022 | Artal Group S.A. | 3,500,000 | $4.17M | 0.2% | +16.7% | 5.638% |  |
| 5/12/2022 | Connor Clark & Lunn Investment Management Ltd. | 137,156 | $0.16M | 0.0% | +15.6% | 0.221% |  |
| 5/11/2022 | ACT Capital Management LLC | 35,000 | $42K | 0.0% | +62.8% | 0.056% |  |
| 5/11/2022 | GSA Capital Partners LLP | 372,208 | $0.44M | 0.1% | +53.7% | 0.600% |  |
| 2/15/2022 | Adage Capital Partners GP L.L.C. | 1,900,000 | $6.19M | 0.0% | +5.6% | 3.067% |  |
| 2/14/2022 | Altium Capital Management LP | 1,160,000 | $3.78M | 1.0% | -8.8% | 1.873% |  |
| 2/14/2022 | GSA Capital Partners LLP | 242,132 | $0.79M | 0.1% | +119.4% | 0.391% |  |
| 2/14/2022 | Ally Bridge Group NY LLC | 3,539,895 | $11.54M | 4.0% | +2.9% | 5.714% |  |
| 2/11/2022 | Ensign Peak Advisors Inc | 45,000 | $0.15M | 0.0% | -55.0% | 0.073% |  |
| 2/10/2022 | Connor Clark & Lunn Investment Management Ltd. | 118,632 | $0.39M | 0.0% | +14.8% | 0.192% |  |
| 2/7/2022 | SG Americas Securities LLC | 12,012 | $39K | 0.0% | -61.4% | 0.019% |  |
| 2/3/2022 | ACT Capital Management LLC | 21,500 | $70K | 0.1% | -59.0% | 0.035% |  |
| 1/14/2022 | LGT Capital Partners LTD. | 500,000 | $1.63M | 0.0% | +1,052.4% | 0.807% |  |
| 11/17/2021 | Altium Capital Management LP | 1,272,412 | $5.69M | 1.3% | +18.2% | 2.054% |  |
| 11/16/2021 | Two Sigma Advisers LP | 172,700 | $0.77M | 0.0% | -32.6% | 0.279% |  |
| 11/16/2021 | Two Sigma Investments LP | 91,278 | $0.41M | 0.0% | -24.2% | 0.147% |  |
| 11/16/2021 | Metropolitan Life Insurance Co NY | 16,415 | $73K | 0.0% | N/A | 0.026% |  |
| 11/15/2021 | Point72 Hong Kong Ltd | 7,062 | $32K | 0.0% | +168.8% | 0.011% |  |
| 11/15/2021 | Cubist Systematic Strategies LLC | 86,990 | $0.39M | 0.0% | -66.3% | 0.140% |  |
| 11/15/2021 | Marshall Wace LLP | 183,451 | $0.82M | 0.0% | -38.1% | 0.296% |  |
| 11/15/2021 | Franklin Resources Inc. | 64,000 | $0.29M | 0.0% | N/A | 0.103% |  |
| 11/15/2021 | GSA Capital Partners LLP | 110,337 | $0.49M | 0.1% | -21.7% | 0.178% |  |
| 11/12/2021 | Trexquant Investment LP | 30,162 | $0.14M | 0.0% | -10.4% | 0.049% |  |
| 11/12/2021 | Geode Capital Management LLC | 857,646 | $3.83M | 0.0% | -11.3% | 1.384% |  |
| 11/12/2021 | Artal Group S.A. | 2,000,000 | $8.94M | 0.2% | +17.6% | 3.229% |  |
| 11/12/2021 | Connor Clark & Lunn Investment Management Ltd. | 103,307 | $0.46M | 0.0% | +35.8% | 0.167% |  |
| 11/10/2021 | Goldman Sachs Group Inc. | 490,501 | $2.19M | 0.0% | -2.1% | 0.792% |  |
| 11/10/2021 | Citigroup Inc. | 9,702 | $43K | 0.0% | +49.5% | 0.016% |  |
| 11/9/2021 | Barclays PLC | 44,863 | $0.20M | 0.0% | -23.7% | 0.072% |  |
| 11/9/2021 | BlackRock Inc. | 4,353,672 | $19.46M | 0.0% | -2.5% | 7.030% |  |
| 11/9/2021 | Ieq Capital LLC | 27,800 | $0.12M | 0.0% | N/A | 0.045% |  |
| 11/8/2021 | Summit Global Investments | 31,800 | $0.14M | 0.0% | N/A | 0.051% |  |
| 11/8/2021 | State Board of Administration of Florida Retirement System | 78,535 | $0.35M | 0.0% | +233.0% | 0.127% |  |
| 11/8/2021 | Russell Investments Group Ltd. | 10,289 | $45K | 0.0% | -49.4% | 0.017% |  |
| 11/8/2021 | Los Angeles Capital Management LLC | 258,938 | $1.16M | 0.0% | -4.6% | 0.418% |  |
| 11/4/2021 | Deutsche Bank AG | 59,973 | $0.27M | 0.0% | +65.9% | 0.097% |  |
| 11/1/2021 | SG Americas Securities LLC | 31,096 | $0.14M | 0.0% | N/A | 0.050% |  |
| 10/19/2021 | Assenagon Asset Management S.A. | 87,073 | $0.39M | 0.0% | -24.8% | 0.141% |  |
| 9/3/2021 | Parametric Portfolio Associates LLC | 19,110 | $0.10M | 0.0% | N/A | 0.031% |  |