| 2/15/2024 | Frazier Life Sciences Management L.P. | 2,118,051 | $8.58M | 0.5% | -5.8% | 4.789% |  |
| 2/15/2024 | Beryl Capital Management LLC | 288,887 | $1.17M | 0.6% | N/A | 0.653% |  |
| 2/14/2024 | ADAR1 Capital Management LLC | 174,715 | $0.71M | 0.3% | N/A | 0.395% |  |
| 2/13/2024 | Tower Research Capital LLC TRC | 9,302 | $38K | 0.0% | +62.2% | 0.021% |  |
| 2/12/2024 | MMCAP International Inc. SPC | 277,303 | $1.12M | 0.2% | N/A | 0.627% |  |
| 2/12/2024 | Highbridge Capital Management LLC | 616,860 | $2.50M | 0.1% | N/A | 1.395% |  |
| 2/6/2024 | AJOVista LLC | 9,520 | $39K | 0.0% | N/A | 0.022% |  |
| 2/2/2024 | BML Capital Management LLC | 1,108,320 | $4.49M | 3.4% | N/A | 2.506% |  |
| 1/30/2024 | BML Capital Management LLC | 1,108,317 | $4.49M | 3.5% | N/A | 2.506% |  |
| 1/30/2024 | Strs Ohio | 46,300 | $0.19M | 0.0% | +1,614.8% | 0.105% |  |
| 1/19/2024 | Denali Advisors LLC | 103,800 | $0.42M | 0.1% | -18.8% | 0.235% |  |
| 1/12/2024 | SG Americas Securities LLC | 13,212 | $54K | 0.0% | N/A | 0.030% |  |
| 1/5/2024 | Exchange Traded Concepts LLC | 48,510 | $0.20M | 0.0% | +34.0% | 0.110% |  |
| 11/15/2023 | Laurion Capital Management LP | 171,157 | $0.46M | 0.0% | -4.7% | 0.393% |  |
| 11/15/2023 | Affinity Asset Advisors LLC | 400,726 | $1.08M | 0.3% | +66.8% | 0.919% |  |
| 11/14/2023 | Lynx1 Capital Management LP | 702,415 | $1.89M | 1.2% | -7.2% | 1.611% |  |
| 11/13/2023 | Foresite Capital Management V LLC | 4,108,796 | $11.05M | 17.6% | +14.6% | 9.424% |  |
| 11/13/2023 | Acadian Asset Management LLC | 259,470 | $0.70M | 0.0% | N/A | 0.595% |  |
| 11/8/2023 | Forefront Analytics LLC | 17,672 | $48K | 0.0% | N/A | 0.041% |  |
| 10/27/2023 | TD Asset Management Inc | 213,896 | $0.58M | 0.0% | +100.0% | 0.491% |  |
| 10/20/2023 | Denali Advisors LLC | 127,900 | $0.34M | 0.1% | +675.2% | 0.293% |  |
| 10/18/2023 | Exchange Traded Concepts LLC | 36,210 | $97K | 0.0% | +144.8% | 0.083% |  |
| 8/21/2023 | Affinity Asset Advisors LLC | 240,244 | $2.24M | 0.8% | +144.6% | 0.551% |  |
| 8/15/2023 | HighVista Strategies LLC | 136,719 | $1.28M | 0.6% | N/A | 0.314% |  |
| 8/14/2023 | Driehaus Capital Management LLC | 232,693 | $2.17M | 0.0% | +2.9% | 0.534% |  |
| 8/8/2023 | Candriam S.C.A. | 270,015 | $2.52M | 0.0% | -16.6% | 0.620% |  |
| 8/7/2023 | Principal Financial Group Inc. | 10,679 | $100K | 0.0% | N/A | 0.025% |  |
| 8/2/2023 | Bank of Montreal Can | 277,074 | $2.80M | 0.0% | N/A | 0.636% |  |
| 7/20/2023 | Exchange Traded Concepts LLC | 14,791 | $0.14M | 0.0% | N/A | 0.034% |  |
| 7/18/2023 | Denali Advisors LLC | 16,500 | $0.15M | 0.1% | N/A | 0.038% |  |
| 5/16/2023 | Fairmount Funds Management LLC | 1,865,671 | $16.57M | 2.8% | N/A | 4.281% |  |
| 5/16/2023 | Altium Capital Management LP | 112,614 | $1M | 0.6% | N/A | 0.258% |  |
| 5/16/2023 | Boxer Capital LLC | 350,000 | $3.11M | 0.2% | -15.7% | 0.803% |  |
| 5/15/2023 | Affinity Asset Advisors LLC | 98,221 | $0.87M | 0.3% | N/A | 0.225% |  |
| 5/10/2023 | Tekla Capital Management LLC | 75,000 | $0.67M | 0.0% | -25.0% | 0.172% |  |
| 5/3/2023 | Jump Financial LLC | 15,859 | $0.14M | 0.0% | N/A | 0.036% |  |
| 2/14/2023 | Boxer Capital LLC | 415,000 | $2.07M | 0.1% | -53.5% | 1.072% |  |
| 2/13/2023 | Foresite Capital Management V LLC | 3,585,346 | $17.86M | 13.9% | +7.5% | 9.262% |  |
| 2/10/2023 | Opaleye Management Inc. | 535,000 | $2.66M | 0.9% | +142.5% | 1.382% |  |
| 2/3/2023 | Frazier Life Sciences Management L.P. | 1,398,194 | $6.96M | 0.4% | N/A | 3.612% |  |
| 11/15/2022 | Farallon Capital Management LLC | 223,149 | $1.29M | 0.0% | -45.5% | 0.576% |  |
| 11/14/2022 | Forefront Analytics LLC | 13,065 | $74K | 0.0% | N/A | 0.034% |  |
| 8/16/2022 | Woodline Partners LP | 211,684 | $1.17M | 0.0% | -15.3% | 0.547% |  |
| 8/16/2022 | DAFNA Capital Management LLC | 81,899 | $0.45M | 0.1% | +2.2% | 0.212% |  |
| 8/15/2022 | Opaleye Management Inc. | 32,300 | $0.18M | 0.1% | N/A | 0.083% |  |
| 8/12/2022 | Ensign Peak Advisors Inc | 142,598 | $0.79M | 0.0% | -43.0% | 0.368% |  |
| 8/8/2022 | Walleye Capital LLC | 31,719 | $0.18M | 0.0% | N/A | 0.082% |  |
| 8/4/2022 | TD Asset Management Inc. | 106,948 | $0.59M | 0.0% | +59.3% | 0.276% |  |
| 5/10/2022 | TD Asset Management Inc. | 67,133 | $0.77M | 0.0% | +19.4% | 0.173% |  |
| 5/5/2022 | New York State Common Retirement Fund | 9,495 | $0.11M | 0.0% | +475.1% | 0.025% |  |
| 2/19/2022 | Woodline Partners LP | 250,000 | $3.17M | 0.0% | N/A | 0.646% |  |
| 2/15/2022 | Laurion Capital Management LP | 205,021 | $2.60M | 0.0% | N/A | 0.530% |  |
| 2/15/2022 | Lynx1 Capital Management LP | 409,358 | $5.19M | 4.5% | N/A | 1.058% |  |
| 2/15/2022 | Adage Capital Partners GP L.L.C. | 761,589 | $9.66M | 0.0% | N/A | 1.968% |  |
| 2/14/2022 | Boxer Capital LLC | 892,057 | $11.31M | 0.4% | N/A | 2.305% |  |
| 2/14/2022 | Nextech Invest AG | 611,310 | $7.75M | 1.8% | N/A | 1.579% |  |
| 2/14/2022 | DAFNA Capital Management LLC | 97,500 | $1.24M | 0.3% | N/A | 0.252% |  |
| 2/14/2022 | Omega Fund Management LLC | 711,479 | $9.02M | 1.3% | N/A | 1.838% |  |
| 2/11/2022 | Foresite Capital Opportunity Management V LLC | 468,820 | $5.95M | 4.0% | N/A | 1.211% |  |
| 2/11/2022 | Ensign Peak Advisors Inc | 250,000 | $3.17M | 0.0% | N/A | 0.646% |  |
| 2/10/2022 | TD Asset Management Inc. | 56,202 | $0.71M | 0.0% | N/A | 0.145% |  |
| 2/8/2022 | Northern Trust Corp | 96,884 | $1.23M | 0.0% | N/A | 0.250% |  |
| 1/24/2022 | Strs Ohio | 2,700 | $34K | 0.0% | N/A | 0.007% |  |