| 12/1/2025 | Cantor Fitzgerald L. P. | 50,861 | $0.47M | 0.0% | -49.1% | 0.040% |  |
| 11/17/2025 | Woodline Partners LP | 100,282 | $0.92M | 0.0% | -97.5% | 0.078% |  |
| 11/17/2025 | Vivo Capital LLC | 5,094,668 | $46.62M | 3.8% | +13.5% | 3.973% |  |
| 11/17/2025 | Velan Capital Investment Management LP | 205,000 | $1.88M | 1.8% | N/A | 0.160% |  |
| 11/17/2025 | Qube Research & Technologies Ltd | 651,679 | $5.96M | 0.0% | +45.5% | 0.508% |  |
| 11/17/2025 | Millennium Management LLC | 727,596 | $6.66M | 0.0% | +362.7% | 0.567% |  |
| 11/17/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 40,625 | $0.37M | 0.0% | -2.2% | 0.032% |  |
| 11/17/2025 | Fred Alger Management LLC | 191,045 | $1.75M | 0.0% | +221.5% | 0.149% |  |
| 11/17/2025 | Cantor Fitzgerald L. P. | 50,861 | $0.47M | 0.0% | -49.1% | 0.040% |  |
| 11/17/2025 | Bank of America Corp DE | 1,836,839 | $16.81M | 0.0% | +67.4% | 1.432% |  |
| 11/17/2025 | Alliancebernstein L.P. | 4,292,451 | $39.28M | 0.0% | +0.3% | 3.347% |  |
| 11/14/2025 | Creative Planning | 26,175 | $0.24M | 0.0% | +29.3% | 0.021% |  |
| 11/14/2025 | Viking Global Investors LP | 5,128,875 | $46.93M | 0.1% | +232.4% | 4.212% |  |
| 11/14/2025 | Raymond James Financial Inc. | 1,411,037 | $12.91M | 0.0% | +31.1% | 1.159% |  |
| 11/14/2025 | California State Teachers Retirement System | 81,697 | $0.75M | 0.0% | +1,716.7% | 0.067% |  |
| 11/14/2025 | Zurcher Kantonalbank Zurich Cantonalbank | 25,178 | $0.23M | 0.0% | +877.4% | 0.021% |  |
| 11/14/2025 | UBS AM A Distinct Business Unit of UBS Asset Management Americas LLC | 116,477 | $1.07M | 0.0% | N/A | 0.096% |  |
| 11/14/2025 | Wellington Management Group LLP | 3,253,888 | $29.77M | 0.0% | +1,792.0% | 2.672% |  |
| 11/14/2025 | Pivotal bioVenture Partners Investment Advisor LLC | 1,256,782 | $11.50M | 6.6% | +9.7% | 1.032% |  |
| 11/13/2025 | Marshall Wace LLP | 4,841,751 | $44.30M | 0.0% | +95.4% | 3.976% |  |
| 11/13/2025 | Kennedy Capital Management LLC | 54,933 | $0.50M | 0.0% | +97.2% | 0.045% |  |
| 11/13/2025 | Rosalind Advisors Inc. | 100,000 | $0.92M | 0.3% | -66.7% | 0.082% |  |
| 11/13/2025 | Invesco Ltd. | 483,070 | $4.42M | 0.0% | +49.9% | 0.397% |  |
| 11/13/2025 | Sei Investments Co. | 85,798 | $0.79M | 0.0% | N/A | 0.070% |  |
| 11/13/2025 | UBS Group AG | 298,612 | $2.73M | 0.0% | -15.7% | 0.245% |  |
| 11/13/2025 | BNP Paribas Financial Markets | 18,212 | $0.17M | 0.0% | -41.2% | 0.015% |  |
| 11/13/2025 | Legal & General Group Plc | 81,972 | $0.75M | 0.0% | +870.5% | 0.067% |  |
| 11/13/2025 | Russell Investments Group Ltd. | 56,460 | $0.52M | 0.0% | +1,144.7% | 0.046% |  |
| 11/13/2025 | DLD Asset Management LP | 55,000 | $0.50M | 0.0% | N/A | 0.045% |  |
| 11/12/2025 | Barclays PLC | 216,885 | $1.98M | 0.0% | -57.9% | 0.178% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 41,443 | $0.38M | 0.0% | -67.3% | 0.034% |  |
| 11/12/2025 | Rafferty Asset Management LLC | 13,566 | $0.12M | 0.0% | +23.5% | 0.011% |  |
| 11/12/2025 | Intech Investment Management LLC | 25,329 | $0.23M | 0.0% | -41.1% | 0.021% |  |
| 11/10/2025 | MAI Capital Management | 98,492 | $0.90M | 0.0% | -88.4% | 0.081% |  |
| 11/10/2025 | AXQ Capital LP | 15,524 | $0.14M | 0.1% | -62.6% | 0.013% |  |
| 11/10/2025 | Ameritas Investment Partners Inc. | 7,632 | $70K | 0.0% | +20.5% | 0.006% |  |
| 11/10/2025 | China Universal Asset Management Co. Ltd. | 21,346 | $0.20M | 0.0% | +4.5% | 0.018% |  |
| 11/10/2025 | BIT Capital GmbH | 6,739 | $62K | 0.0% | +32.0% | 0.006% |  |
| 11/10/2025 | Persistent Asset Partners Ltd | 19,688 | $0.18M | 0.1% | -54.0% | 0.016% |  |
| 11/7/2025 | Readystate Asset Management LP | 34,399 | $0.32M | 0.0% | N/A | 0.028% |  |
| 11/7/2025 | GSA Capital Partners LLP | 43,506 | $0.40M | 0.0% | N/A | 0.036% |  |
| 11/7/2025 | Vanguard Group Inc. | 5,826,986 | $53.32M | 0.0% | +9.6% | 4.785% |  |
| 11/6/2025 | Rhumbline Advisers | 115,022 | $1.05M | 0.0% | +8.1% | 0.094% |  |
| 11/6/2025 | Profund Advisors LLC | 20,103 | $0.18M | 0.0% | +11.3% | 0.017% |  |
| 11/6/2025 | Oppenheimer & Co. Inc. | 98,668 | $0.90M | 0.0% | -1.2% | 0.081% |  |
| 11/5/2025 | Alps Advisors Inc. | 58,292 | $0.53M | 0.0% | -9.3% | 0.048% |  |
| 11/5/2025 | Optimize Financial Inc | 60,599 | $0.55M | 0.3% | N/A | 0.050% |  |
| 11/4/2025 | Tejara Capital Ltd | 37,200 | $0.34M | 0.2% | -88.6% | 0.031% |  |
| 11/4/2025 | Nan Fung Trinity HK Ltd. | 89,575 | $0.82M | 0.1% | N/A | 0.074% |  |
| 11/3/2025 | AlphaQuest LLC | 8,697 | $80K | 0.0% | N/A | 0.007% |  |
| 11/3/2025 | Arizona State Retirement System | 24,662 | $0.23M | 0.0% | N/A | 0.020% |  |
| 11/3/2025 | New York State Common Retirement Fund | 27,765 | $0.25M | 0.0% | +81.9% | 0.023% |  |
| 10/30/2025 | Strs Ohio | 32,300 | $0.30M | 0.0% | +34.6% | 0.027% |  |
| 10/28/2025 | Campbell & CO Investment Adviser LLC | 24,885 | $0.23M | 0.0% | +81.0% | 0.020% |  |
| 10/23/2025 | Peregrine Capital Management LLC | 620,464 | $5.68M | 0.2% | N/A | 0.509% |  |
| 10/23/2025 | Kingswood Wealth Advisors LLC | 10,907 | $100K | 0.0% | -25.5% | 0.009% |  |
| 10/23/2025 | SG Americas Securities LLC | 64,545 | $0.59M | 0.0% | N/A | 0.053% |  |
| 10/23/2025 | KLP Kapitalforvaltning AS | 17,400 | $0.16M | 0.0% | N/A | 0.014% |  |
| 10/16/2025 | PFS Partners LLC | 79,000 | $0.72M | 0.3% | -8.9% | 0.065% |  |
| 10/15/2025 | Vontobel Holding Ltd. | 21,859 | $0.20M | 0.0% | -12.2% | 0.018% |  |
| 10/10/2025 | Flputnam Investment Management Co. | 1,048,102 | $9.59M | 0.1% | +1,105.4% | 0.861% |  |
| 10/9/2025 | Voya Investment Management LLC | 15,180 | $0.14M | 0.0% | -29.5% | 0.012% |  |
| 10/9/2025 | Harbour Capital Advisors LLC | 27,500 | $0.26M | 0.1% | N/A | 0.023% |  |
| 10/9/2025 | Chapin Davis Inc. | 35,100 | $0.32M | 0.1% | N/A | 0.029% |  |
| 8/28/2025 | China Universal Asset Management Co. Ltd. | 20,435 | $0.11M | 0.0% | +14.0% | 0.017% |  |
| 8/15/2025 | Soleus Capital Management L.P. | 700,000 | $3.83M | 0.3% | N/A | 0.575% |  |
| 8/15/2025 | Rafferty Asset Management LLC | 10,983 | $60K | 0.0% | N/A | 0.009% |  |
| 8/15/2025 | Rosalind Advisors Inc. | 300,000 | $1.64M | 0.7% | -51.1% | 0.246% |  |
| 8/15/2025 | Rubric Capital Management LP | 8,531,860 | $46.67M | 0.7% | +88.0% | 7.006% |  |
| 8/15/2025 | Octagon Capital Advisors LP | 3,672,000 | $20.09M | 4.4% | +10.5% | 3.015% |  |
| 8/15/2025 | Opaleye Management Inc. | 390,000 | $2.13M | 0.4% | -50.9% | 0.320% |  |
| 8/15/2025 | Eventide Asset Management LLC | 1,381,324 | $7.56M | 0.1% | N/A | 1.134% |  |
| 8/15/2025 | Engineers Gate Manager LP | 28,162 | $0.15M | 0.0% | N/A | 0.023% |  |
| 8/15/2025 | BNP Paribas Financial Markets | 30,996 | $0.17M | 0.0% | +456.5% | 0.025% |  |
| 8/15/2025 | Bridgeway Capital Management LLC | 44,981 | $0.25M | 0.0% | -43.8% | 0.037% |  |
| 8/15/2025 | Balyasny Asset Management L.P. | 2,354,402 | $12.88M | 0.0% | +33.9% | 1.933% |  |
| 8/15/2025 | Bank of America Corp DE | 1,097,497 | $6M | 0.0% | +732.9% | 0.901% |  |
| 8/15/2025 | Ameriprise Financial Inc. | 154,854 | $0.85M | 0.0% | +31.3% | 0.127% |  |
| 8/14/2025 | MPM Bioimpact LLC | 3,406,955 | $18.64M | 3.2% | -0.6% | 2.798% |  |
| 8/14/2025 | Orbimed Advisors LLC | 3,308,400 | $18.10M | 0.5% | +195.4% | 2.717% |  |
| 8/14/2025 | Viking Global Investors LP | 1,543,000 | $8.44M | 0.0% | -52.2% | 1.267% |  |
| 8/14/2025 | Acuta Capital Partners LLC | 493,735 | $2.70M | 3.8% | -37.2% | 0.405% |  |
| 8/14/2025 | Raymond James Financial Inc. | 1,076,683 | $5.89M | 0.0% | +111.4% | 0.884% |  |
| 8/14/2025 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 41,545 | $0.23M | 0.0% | -5.9% | 0.034% |  |
| 8/14/2025 | Alliancebernstein L.P. | 4,281,355 | $23.42M | 0.0% | +19,064.5% | 3.516% |  |
| 8/14/2025 | The Manufacturers Life Insurance Company | 28,319 | $0.16M | 0.0% | +16.0% | 0.023% |  |
| 8/14/2025 | Diadema Partners LP | 185,830 | $1.02M | 0.3% | +3.2% | 0.153% |  |
| 8/14/2025 | Qube Research & Technologies Ltd | 447,852 | $2.45M | 0.0% | +254.8% | 0.368% |  |
| 8/14/2025 | Vivo Capital LLC | 4,487,903 | $24.55M | 2.5% | +28.7% | 3.685% |  |
| 8/13/2025 | Affinity Asset Advisors LLC | 2,534,058 | $13.86M | 1.9% | +102.7% | 2.081% |  |
| 8/13/2025 | Marshall Wace LLP | 2,477,916 | $13.55M | 0.0% | -3.0% | 2.035% |  |
| 8/13/2025 | Invesco Ltd. | 322,339 | $1.76M | 0.0% | -62.2% | 0.265% |  |
| 8/13/2025 | OMERS ADMINISTRATION Corp | 35,000 | $0.19M | 0.0% | N/A | 0.029% |  |
| 8/13/2025 | Panagora Asset Management Inc. | 569,702 | $3.12M | 0.0% | +67.6% | 0.468% |  |
| 8/13/2025 | Tejara Capital Ltd | 326,395 | $1.79M | 0.8% | +81.8% | 0.268% |  |
| 8/13/2025 | WealthTrust Axiom LLC | 61,500 | $0.34M | 0.1% | -3.1% | 0.051% |  |
| 8/13/2025 | Quadrature Capital Ltd | 25,848 | $0.14M | 0.0% | -70.2% | 0.021% |  |
| 8/13/2025 | Hsbc Holdings PLC | 62,439 | $0.34M | 0.0% | +125.0% | 0.051% |  |
| 8/13/2025 | Russell Investments Group Ltd. | 4,536 | $25K | 0.0% | +194.5% | 0.004% |  |
| 8/12/2025 | XTX Topco Ltd | 64,589 | $0.35M | 0.0% | +522.2% | 0.055% |  |