| 11/17/2025 | Voleon Capital Management LP | 47,879 | $87K | 0.0% | N/A | 0.084% |  |
| 11/17/2025 | Susquehanna International Group LLP | 79,760 | $0.15M | 0.0% | -44.8% | 0.141% |  |
| 11/17/2025 | Qube Research & Technologies Ltd | 27,675 | $50K | 0.0% | -59.5% | 0.049% |  |
| 11/17/2025 | Millennium Management LLC | 466,086 | $0.85M | 0.0% | -26.0% | 0.821% |  |
| 11/17/2025 | Citadel Advisors LLC | 390,747 | $0.71M | 0.0% | +78.4% | 0.689% |  |
| 11/14/2025 | Virtu Financial LLC | 60,480 | $0.11M | 0.0% | +431.1% | 0.107% |  |
| 11/14/2025 | Two Sigma Investments LP | 419,404 | $0.76M | 0.0% | +14.9% | 0.739% |  |
| 11/14/2025 | Bridgeway Capital Management LLC | 140,400 | $0.26M | 0.0% | -8.7% | 0.247% |  |
| 11/12/2025 | Propel Bio Management LLC | 1,932,304 | $3.52M | 3.5% | -7.4% | 3.405% |  |
| 11/12/2025 | Dimensional Fund Advisors LP | 87,316 | $0.16M | 0.0% | -32.8% | 0.154% |  |
| 11/7/2025 | Vanguard Group Inc. | 2,317,916 | $4.22M | 0.0% | +7.8% | 4.084% |  |
| 11/7/2025 | JPMorgan Chase & Co. | 237,750 | $0.43M | 0.0% | -17.4% | 0.419% |  |
| 11/7/2025 | Aberdeen Group plc | 1,354,820 | $2.47M | 0.0% | +52.0% | 2.387% |  |
| 10/20/2025 | Simplify Asset Management Inc. | 904,972 | $1.65M | 0.0% | -13.6% | 1.595% |  |
| 8/15/2025 | Militia Capital Partners LP | 94,300 | $0.14M | 0.1% | N/A | 0.167% |  |
| 8/15/2025 | BNP Paribas Financial Markets | 23,697 | $34K | 0.0% | -54.3% | 0.042% |  |
| 8/15/2025 | Boothbay Fund Management LLC | 24,363 | $35K | 0.0% | +50.0% | 0.043% |  |
| 8/15/2025 | Bridgeway Capital Management LLC | 153,700 | $0.22M | 0.0% | +35.7% | 0.272% |  |
| 8/15/2025 | BVF Inc. IL | 5,226,074 | $7.58M | 0.3% | +6.9% | 9.235% |  |
| 8/15/2025 | Bank of America Corp DE | 217,967 | $0.32M | 0.0% | +28.0% | 0.385% |  |
| 8/14/2025 | Jane Street Group LLC | 213,396 | $0.31M | 0.0% | N/A | 0.377% |  |
| 8/14/2025 | Qube Research & Technologies Ltd | 68,286 | $99K | 0.0% | N/A | 0.121% |  |
| 8/13/2025 | Marshall Wace LLP | 53,678 | $78K | 0.0% | N/A | 0.095% |  |
| 8/13/2025 | Quadrature Capital Ltd | 22,500 | $33K | 0.0% | N/A | 0.040% |  |
| 8/12/2025 | JPMorgan Chase & Co. | 287,743 | $0.42M | 0.0% | +8.5% | 0.508% |  |
| 8/12/2025 | Catalyst Funds Management Pty Ltd | 18,000 | $26K | 0.0% | N/A | 0.032% |  |
| 8/8/2025 | Letko Brosseau & Associates Inc. | 95,875 | $0.14M | 0.0% | +24.4% | 0.169% |  |
| 8/8/2025 | Geode Capital Management LLC | 566,371 | $0.82M | 0.0% | -44.2% | 1.001% |  |
| 8/1/2025 | Y Intercept Hong Kong Ltd | 76,660 | $0.11M | 0.0% | N/A | 0.135% |  |
| 7/25/2025 | Vanguard Personalized Indexing Management LLC | 19,892 | $29K | 0.0% | N/A | 0.035% |  |
| 6/27/2025 | Goldman Sachs Group Inc. | 170,349 | $0.24M | 0.0% | +6.0% | 0.301% |  |
| 5/16/2025 | Goldman Sachs Group Inc. | 170,349 | $0.24M | 0.0% | +6.0% | 0.301% |  |
| 5/16/2025 | EcoR1 Capital LLC | 662,833 | $0.92M | 0.1% | -86.7% | 1.171% |  |
| 5/16/2025 | Checkpoint Capital L.P. | 2,017,650 | $2.78M | 1.5% | +14.9% | 3.565% |  |
| 5/16/2025 | BVF Inc. IL | 4,889,474 | $6.75M | 0.3% | +63.6% | 8.640% |  |
| 5/15/2025 | Troluce Capital Advisors LLC | 83,758 | $0.12M | 0.0% | +58.3% | 0.148% |  |
| 5/15/2025 | Cubist Systematic Strategies LLC | 20,840 | $29K | 0.0% | -67.0% | 0.037% |  |
| 5/14/2025 | Hsbc Holdings PLC | 35,042 | $49K | 0.0% | N/A | 0.062% |  |
| 5/13/2025 | Tocqueville Asset Management L.P. | 27,000 | $37K | 0.0% | -89.7% | 0.048% |  |
| 5/13/2025 | Aberdeen Group plc | 891,448 | $1.23M | 0.0% | +0.9% | 1.575% |  |
| 5/12/2025 | Nuveen LLC | 69,962 | $97K | 0.0% | N/A | 0.124% |  |
| 5/9/2025 | Deutsche Bank AG | 52,559 | $73K | 0.0% | +149.4% | 0.093% |  |
| 5/8/2025 | Letko Brosseau & Associates Inc. | 77,100 | $0.11M | 0.0% | +113.0% | 0.136% |  |
| 3/24/2025 | Wellington Management Group LLP | 132,895 | $0.40M | 0.0% | +5.2% | 0.235% |  |
| 2/25/2025 | Heck Capital Advisors LLC | 20,120 | $61K | 0.0% | N/A | 0.038% |  |
| 2/17/2025 | Woodline Partners LP | 115,866 | $0.35M | 0.0% | +6.7% | 0.217% |  |
| 2/17/2025 | Squarepoint Ops LLC | 19,461 | $59K | 0.0% | N/A | 0.036% |  |
| 2/17/2025 | Tang Capital Management LLC | 117,847 | $0.36M | 0.0% | N/A | 0.221% |  |
| 2/17/2025 | Shay Capital LLC | 21,363 | $65K | 0.0% | N/A | 0.040% |  |
| 2/17/2025 | ProShare Advisors LLC | 13,140 | $40K | 0.0% | N/A | 0.025% |  |
| 2/17/2025 | Letko Brosseau & Associates Inc. | 36,200 | $0.11M | 0.0% | +74.9% | 0.068% |  |
| 2/17/2025 | Jacobs Levy Equity Management Inc. | 18,951 | $58K | 0.0% | -81.7% | 0.036% |  |
| 2/17/2025 | Cubist Systematic Strategies LLC | 63,095 | $0.19M | 0.0% | +96.3% | 0.118% |  |
| 2/17/2025 | Bridgeway Capital Management LLC | 105,900 | $0.32M | 0.0% | +176.5% | 0.198% |  |
| 2/17/2025 | Bank of America Corp DE | 150,114 | $0.46M | 0.0% | +54.4% | 0.281% |  |
| 2/17/2025 | BNP Paribas Financial Markets | 65,139 | $0.20M | 0.0% | N/A | 0.122% |  |
| 2/14/2025 | Lynx1 Capital Management LP | 5,357,347 | $16.29M | 6.1% | +2.5% | 10.038% |  |
| 2/14/2025 | Dauntless Investment Group LLC | 110,345 | $0.34M | 0.4% | N/A | 0.207% |  |
| 2/14/2025 | Adage Capital Partners GP L.L.C. | 3,500,000 | $10.64M | 0.0% | -20.5% | 6.558% |  |
| 2/14/2025 | Stifel Financial Corp | 109,700 | $0.33M | 0.0% | +10.7% | 0.206% |  |
| 2/14/2025 | Dimensional Fund Advisors LP | 280,028 | $0.85M | 0.0% | +108.5% | 0.525% |  |
| 2/13/2025 | Marshall Wace LLP | 43,969 | $0.13M | 0.0% | -73.4% | 0.082% |  |
| 2/13/2025 | Barclays PLC | 67,508 | $0.21M | 0.0% | +16.3% | 0.126% |  |
| 2/13/2025 | Renaissance Technologies LLC | 10,600 | $32K | 0.0% | -85.7% | 0.020% |  |
| 2/13/2025 | Wells Fargo & Company MN | 19,540 | $59K | 0.0% | +41.1% | 0.037% |  |
| 2/12/2025 | Geode Capital Management LLC | 963,257 | $2.93M | 0.0% | -1.0% | 1.805% |  |
| 2/12/2025 | Wellington Management Group LLP | 132,895 | $0.40M | 0.0% | +5.2% | 0.249% |  |
| 2/12/2025 | JPMorgan Chase & Co. | 66,756 | $0.20M | 0.0% | +109.9% | 0.125% |  |
| 2/11/2025 | Prudential Financial Inc. | 10,415 | $32K | 0.0% | N/A | 0.020% |  |
| 2/10/2025 | Tocqueville Asset Management L.P. | 260,870 | $0.79M | 0.0% | +26.8% | 0.489% |  |
| 1/24/2025 | abrdn plc | 883,704 | $2.69M | 0.0% | +137.8% | 1.656% |  |
| 1/24/2025 | China Universal Asset Management Co. Ltd. | 10,410 | $32K | 0.0% | N/A | 0.020% |  |
| 1/23/2025 | Heck Capital Advisors LLC | 20,120 | $61K | 0.0% | N/A | 0.038% |  |
| 1/17/2025 | SG Americas Securities LLC | 20,415 | $62K | 0.0% | +31.2% | 0.038% |  |
| 12/26/2024 | JPMorgan Chase & Co. | 31,805 | $0.16M | 0.0% | +94.4% | 0.060% |  |
| 11/19/2024 | Barclays PLC | 58,067 | $0.29M | 0.0% | +341.1% | 0.109% |  |
| 11/16/2024 | Geode Capital Management LLC | 973,466 | $4.85M | 0.0% | +8.1% | 1.838% |  |
| 11/15/2024 | Barclays PLC | 58,067 | $0.29M | 0.0% | +341.1% | 0.110% |  |
| 11/15/2024 | XTX Topco Ltd | 22,438 | $0.11M | 0.0% | N/A | 0.042% |  |
| 11/15/2024 | Jane Street Group LLC | 93,876 | $0.47M | 0.0% | -5.2% | 0.177% |  |
| 11/15/2024 | Wellington Management Group LLP | 126,345 | $0.63M | 0.0% | +38.9% | 0.239% |  |
| 11/15/2024 | State Street Corp | 756,499 | $3.77M | 0.0% | +24.4% | 1.428% |  |
| 11/15/2024 | Stifel Financial Corp | 99,133 | $0.49M | 0.0% | +3.9% | 0.187% |  |
| 11/15/2024 | Jacobs Levy Equity Management Inc. | 103,440 | $0.52M | 0.0% | N/A | 0.195% |  |
| 11/15/2024 | Checkpoint Capital L.P. | 825,341 | $4.11M | 2.0% | N/A | 1.558% |  |
| 11/14/2024 | Walleye Capital LLC | 84,699 | $0.42M | 0.0% | -21.3% | 0.160% |  |
| 11/14/2024 | MetLife Investment Management LLC | 23,363 | $0.12M | 0.0% | +129.1% | 0.044% |  |
| 11/13/2024 | Great Point Partners LLC | 1,016,375 | $5.06M | 1.5% | +8.0% | 1.919% |  |
| 11/13/2024 | Brown Brothers Harriman & Co. | 143,051 | $0.71M | 0.0% | +88.2% | 0.270% |  |
| 11/7/2024 | LMR Partners LLP | 71,800 | $0.36M | 0.0% | -89.2% | 0.136% |  |
| 11/6/2024 | Cornercap Investment Counsel Inc. | 10,788 | $54K | 0.0% | -53.0% | 0.020% |  |
| 10/25/2024 | abrdn plc | 371,655 | $1.85M | 0.0% | +27.2% | 0.702% |  |
| 10/3/2024 | SG Americas Securities LLC | 15,563 | $78K | 0.0% | N/A | 0.029% |  |
| 8/15/2024 | The Manufacturers Life Insurance Company | 15,383 | $90K | 0.0% | N/A | 0.029% |  |
| 8/15/2024 | Troluce Capital Advisors LLC | 92,832 | $0.54M | 0.1% | N/A | 0.176% |  |
| 8/14/2024 | Great Point Partners LLC | 940,831 | $5.50M | 1.1% | N/A | 1.780% |  |
| 8/14/2024 | Marshall Wace LLP | 307,487 | $1.80M | 0.0% | +60.8% | 0.582% |  |
| 8/14/2024 | Bank of Montreal Can | 120,454 | $0.75M | 0.0% | N/A | 0.228% |  |
| 8/12/2024 | Marathon Trading Investment Management LLC | 13,600 | $80K | 0.0% | -73.3% | 0.026% |  |
| 8/9/2024 | Renaissance Technologies LLC | 80,000 | $0.47M | 0.0% | +70.2% | 0.151% |  |